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  1. Article: In Reply: SARS-CoV-2 Vaccination Related, Pediatric Guillain-Barre Syndrome Requires the Same Management as in Adults.

    Gunawan, Pricilla Yani

    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

    2023  Volume 21, Issue 1, Page(s) 212–213

    Language English
    Publishing date 2023-01-26
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2211550-X
    ISSN 1738-1088
    ISSN 1738-1088
    DOI 10.9758/cpn.2023.21.1.212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Risk of Dementia in Patients with Diabetes Using Sodium-Glucose Transporter 2 Inhibitors (SGLT2i): A Systematic Review, Meta-Analysis, and Meta-Regression.

    Gunawan, Pricilla Yani / Gunawan, Paskalis Andrew / Hariyanto, Timotius Ivan

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2024  Volume 15, Issue 3, Page(s) 663–675

    Abstract: Introduction: Dementia is quite prevalent and among the leading causes of death worldwide. According to earlier research, diabetes may increase the possibility of developing dementia. However, the association between antidiabetic agents and dementia is ... ...

    Abstract Introduction: Dementia is quite prevalent and among the leading causes of death worldwide. According to earlier research, diabetes may increase the possibility of developing dementia. However, the association between antidiabetic agents and dementia is not yet clear. This investigation examines the association between the use of sodium-glucose transporter 2 inhibitors (SGLT2i) and the risk of dementia in patients with diabetes.
    Methods: Up to April 18, 2023, four databases-Europe PMC, Medline, Scopus, and Cochrane Library-were searched for relevant literature. We included all studies that examine dementia risk in adults with diabetes who use SGLT2i. Random-effect models were used to compute the outcomes in this investigation, producing pooled odds ratios (OR) with 95% confidence intervals (CI).
    Results: Pooled data from seven observational studies revealed that SGLT2i use was linked to a lower risk of dementia in people with diabetes (OR 0.45, 95% CI 0.34-0.61; p < 0.00001, I
    Conclusions: According to this research, taking SGLT2i reduces the incidence of dementia in people with diabetes by having a beneficial neuroprotective impact. Randomized controlled trials (RCTs) are still required in order to verify the findings of our research.
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-024-01538-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Guillain-Barre Syndrome Following SARS-CoV-2 Vaccination: A Case Report.

    Gunawan, Pricilla Yani / Tiffani, Pamela / Lalisang, Lilie

    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

    2021  Volume 20, Issue 4, Page(s) 777–780

    Abstract: After more than a year of Coronavirus disease 2019 pandemic, in 2021 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination have been made possible and vaccine was distributed globally. Since then, there have been reports of symptoms ... ...

    Abstract After more than a year of Coronavirus disease 2019 pandemic, in 2021 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination have been made possible and vaccine was distributed globally. Since then, there have been reports of symptoms following SARS-CoV-2 vaccination, including neurological symptoms of ascending paralysis known as Guillain-Barre syndrome. In this report, we describe the first case of Guillain-Barre syndrome following vaccination in Indonesia. Symptoms of ascending paralysis were of late onset after the first dose, however, were full blown after receiving the second dose followed by left-sided facial paralysis.
    Language English
    Publishing date 2021-06-14
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2211550-X
    ISSN 1738-1088
    ISSN 1738-1088
    DOI 10.9758/cpn.2022.20.4.777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Glial Fibrillary Acidic Protein Serum Level as a Predictor of Clinical Outcome in Ischemic Stroke.

    Puspitasari, Vivien / Gunawan, Pricilla Yani / Wiradarma, Hugo Dwiputra / Hartoyo, Vinson

    Open access Macedonian journal of medical sciences

    2019  Volume 7, Issue 9, Page(s) 1471–1474

    Abstract: Background: Glial Fibrillary Acidic Protein (GFAP) is a protein produced by astrocytes in response to brain injury, which then penetrates the cerebrospinal fluid and the blood stream.: Aim: We sought to determine whether GFAP serum level in acute ... ...

    Abstract Background: Glial Fibrillary Acidic Protein (GFAP) is a protein produced by astrocytes in response to brain injury, which then penetrates the cerebrospinal fluid and the blood stream.
    Aim: We sought to determine whether GFAP serum level in acute ischemic stroke could predict clinical outcome.
    Methods: As much as 64 patients with first-ever ischemic stroke had their GFAP serum level measured at 72 hours after onset. The National Institute of Health Stroke Scale (NIHSS) was assessed during the 72 hours of onset, the seventh day, and followed up 1 month after.
    Results: There were 46 men and 18 women included in the study. Mean age was 58.3 years old, and nearly half of them (46.9%) were between 50-59 years old. More than half (58.7%) presented with moderate to a severe stroke and mean GFAP serum level was 0.113 ± 0.029 ng/mL. GFAP serum levels had a significant correlation with NIHSS after 1 month (p = 0.04, r = 0.259).
    Conclusion: There is a significant correlation between GFAP serum levels with stroke severity scale after 1 month of stroke onset.
    Language English
    Publishing date 2019-05-14
    Publishing country North Macedonia
    Document type Journal Article
    ISSN 1857-9655
    ISSN 1857-9655
    DOI 10.3889/oamjms.2019.326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Karnofsky Performance Scale and Neurological Assessment of Neuro-Oncology Scale as Early Predictor in Glioma.

    Gunawan, Pricilla Yani / Islam, Andi Asadul / July, Julius / Patellongi, Ilhamjaya / Nasrum, Muhammad / Aninditha, Tiara

    Asian Pacific journal of cancer prevention : APJCP

    2020  Volume 21, Issue 11, Page(s) 3387–3392

    Abstract: Objective: Glioma is one of the most frequent and disabling primary brain tumour. Patients are not only dealing with survival, but also quality of life, which remains another major concern. Karnofsky Performance Scale (KPS) is one of the most commonly ... ...

    Abstract Objective: Glioma is one of the most frequent and disabling primary brain tumour. Patients are not only dealing with survival, but also quality of life, which remains another major concern. Karnofsky Performance Scale (KPS) is one of the most commonly used scale to assess patients' quality of life. A recent scale, known as Neurological Assessment of Neuro-Oncology Scale, has surfaced to examine neurological disability caused by brain tumour. Previous study showed this scale to be superior to KPS in predicting survival. However, these scales have never been used to foresee functional scale improvement during disease progression. We sought to determine whether initial KPS and NANO Scale can predict functional scale improvement 2 months after surgery.
    Methods: Patients with glioma grade II-IV were included in the study. IDH mutation and MGMT methylation were tested. KPS and NANO scale were examined before surgery and 2 months after surgery. Favorable outcome (FO) was defined as improvement in functional scale 2 months after surgery. Patients initial functional scales were analyzed towards favorable outcome.
    Results: Glioma WHO grade II, III and IV was found in 17 patients (36.2%), 3 patients (6.4%) and 27 patients (57.4%) respectively. Median KPS before and 2 months after surgery were 50 (30-80) and 60 (0-100), whereas median NANO scale before and 2 months after surgery were 5 (0-12) and 3 (0-12). Favorable outcome was found in 63.8% (KPS) and 78.7% (NANO Scale). Patients initial functional scales were significantly related to FO.
    Conclusion: Good initial functional scales are 4 to 5 times likely of having a favorable outcome 2 months after surgery.
    MeSH term(s) Adult ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Female ; Follow-Up Studies ; Glioma/mortality ; Glioma/pathology ; Glioma/surgery ; Humans ; Karnofsky Performance Status/statistics & numerical data ; Male ; Middle Aged ; Neurologic Examination/methods ; Prognosis ; Quality of Life ; Severity of Illness Index ; Survival Rate
    Language English
    Publishing date 2020-11-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2020.21.11.3387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinicopathological associations and prognostic values of IDH1 gene mutation, MGMT gene promoter methylation, and PD-L1 expressions in high-grade glioma treated with standard treatment.

    July, Julius / Patricia, Diana / Gunawan, Pricilla Yani / Setiajaya, Handrianto / Ginting, Teridah Ernala / Putra, Teguh Pribadi / Wuisan, Zerlina / Budhiarko, Dini / Masykura, Najmiatul / Prayogi, Gintang / Utomo, Ahmad Rusdan / Tandean, Steven / Loe, Michael Lumintang

    The Pan African medical journal

    2020  Volume 36, Page(s) 309

    Abstract: Introduction: the objective was to evaluate the impact of IDH1 R132H mutation, MGMT methylation and PD-L1 expression in high grade glioma that received standard therapy (surgery, radiation and chemotherapy) to overall survival (OS).: Methods: this is ...

    Abstract Introduction: the objective was to evaluate the impact of IDH1 R132H mutation, MGMT methylation and PD-L1 expression in high grade glioma that received standard therapy (surgery, radiation and chemotherapy) to overall survival (OS).
    Methods: this is a retrospective study of 35 high grade glioma cases. Genotyping of IDH1 gene alteration on the mutation hotspot R132 (Sanger sequencing method with Applied Biosystems 3500 Genetic Analyzer), EZ DNA Methylation-Gold kit (Zymo Research) is used to study the methylation, Cell line BT549 (ATCC HTB-122) and HCT-116 (ATCC CCL-247) were used as unmethylated control and partially methylated control respectively. Anti-human PD-L1 antibody clone E1L3N
    Results: anaplastic astrocytoma cases had more MGMT promoter methylation (50%) than glioblastoma multiforme (GBM) (20%), more IDH1 R132H mutation (42%) than GBM (4.3%). Immunohistochemistry tumor proportion score method (TPS) identified 17% and 8.7% were PD-L1 positive in AA and GBM groups, respectively. Cases with IDH1 R132H mutation and MGMT methylation still showed better OS although with high PD-L1 expression.
    Conclusion: IDH1 R132H mutation and MGMT methylation were good prognostic markers. High expression of PD-L1 apparently might not indicate poor overall survival in the presence of IDH1 R132 mutation and MGMT methylation.
    MeSH term(s) Adolescent ; Adult ; Aged ; Astrocytoma/genetics ; Astrocytoma/pathology ; Astrocytoma/therapy ; B7-H1 Antigen/genetics ; DNA Methylation ; DNA Modification Methylases/genetics ; DNA Repair Enzymes/genetics ; Female ; Glioblastoma/genetics ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Isocitrate Dehydrogenase/genetics ; Male ; Middle Aged ; Mutation ; Prognosis ; Promoter Regions, Genetic/genetics ; Retrospective Studies ; Survival Rate ; Tumor Suppressor Proteins/genetics ; Young Adult
    Chemical Substances B7-H1 Antigen ; CD274 protein, human ; Tumor Suppressor Proteins ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.) ; DNA Modification Methylases (EC 2.1.1.-) ; MGMT protein, human (EC 2.1.1.63) ; DNA Repair Enzymes (EC 6.5.1.-)
    Language English
    Publishing date 2020-08-20
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2020.36.309.24831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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