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Article: Ein langer Weg zur Diagnose

Gundacker, Stefanie

2022 Volume 17, Issue 03, Page(s) 36–40

Abstract: Im vorgestellten Fall leidet eine junge Frau seit Monaten insbesondere unter Einschränkungen wie Konzentrationsmangel, wodurch ihr berufliches und privates Leben beeinträchtigt werden. Der Hausarzt der Patientin konnte keine körperliche Ursache für ihre ... ...

Abstract	Im vorgestellten Fall leidet eine junge Frau seit Monaten insbesondere unter Einschränkungen wie Konzentrationsmangel, wodurch ihr berufliches und privates Leben beeinträchtigt werden. Der Hausarzt der Patientin konnte keine körperliche Ursache für ihre Beschwerden finden und verschreibt ihr Psychopharmaka. Da sich keine Besserung einstellt, sucht sie die Naturheilpraxis der Autorin auf. Durch eine Blutuntersuchung in der Naturheilpraxis ergibt sich die mutmaßliche Diagnose Hashimoto-Thyreoiditis, die fachärztlich bestätigt und behandelt wird. Eine naturheilkundliche Unterstützung soll folgen.
Keywords	Konzentrationsstörungen ; Arbeitsunfähigkeit ; Fallbericht ; Lustlosigkeit ; Traurigkeit ; Schlafstörungen ; Schwitzen ; Frösteln ; Hausarzt ; Blutwerte ; Cholesterin ; Schilddrüse ; Schilddrüsenunterfunktion ; Tagesmüdigkeit ; Burnout ; depressive Verstimmung ; Psychopharmaka ; Anamnese ; Schilddrüsenwerte ; TSH ; fT3 ; fT4 ; T3 ; T4 ; TPO-AK ; TAK ; TRAK ; Vitamin-D-Mangel ; Hashimoto-Thyreoiditis ; Endokrinologe
Language	German
Publishing date	2022-03-01
Publisher	© Karl F. Haug Verlag in Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266301-0
ISSN	1862-2275 ; 1862-2267
ISSN (online)	1862-2275
ISSN	1862-2267
DOI	10.1055/a-1780-1236
Database	Thieme publisher's database

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Article: Kopfkino: Angst, nicht mehr zu können

Gundacker, Stefanie

Deutsche Heilpraktiker-Zeitschrift

2020 Volume 15, Issue 02, Page(s) 46–51

Abstract: Samuel B. leidet an einer Hodenentzündung, die neben anderen Symptomen Schmerzen bei der Erektion auslöst. Die Erkrankung provoziert beim Patienten eine Reihe von Ängsten, unter anderem davor, seine Ehefrau nie wieder befriedigen zu können. Die ... ...

Abstract	Samuel B. leidet an einer Hodenentzündung, die neben anderen Symptomen Schmerzen bei der Erektion auslöst. Die Erkrankung provoziert beim Patienten eine Reihe von Ängsten, unter anderem davor, seine Ehefrau nie wieder befriedigen zu können. Die Hypnosetherapie deckt eine grundlegende Ursache der Ängste auf – ein traumatisches Erlebnis aus Samuel B.s früher Kindheit.
Keywords	Hodenentzündung ; Erektion ; Ängste ; Hypnosetherapie ; Leistenbruch-OP ; Scham ; Orchitis ; Darmsanierung ; Gefühle ; Gespräch ; Glaubenssätze ; Selbstsicherheit ; Sexualität
Language	German
Publishing date	2020-02-01
Publisher	© Karl F. Haug Verlag in Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266301-0
ISSN	1862-2275 ; 1862-2267
ISSN (online)	1862-2275
ISSN	1862-2267
DOI	10.1055/a-1071-2031
Database	Thieme publisher's database

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Article: Stille Begleiter

Gundacker, Stefanie

Deutsche Heilpraktiker-Zeitschrift

2019 Volume 14, Issue 06, Page(s) 44–48

Abstract: Überhöhte Konzentrationen gelöster Substanzen oder Abflusshindernisse führen im Körper zur Steinbildung, am häufigsten in Form von Gallen- und Nierensteinen. Steine können über längere Zeit symptomlos bleiben, führen jedoch zu plötzlichen und heftigen ... ...

Abstract	Überhöhte Konzentrationen gelöster Substanzen oder Abflusshindernisse führen im Körper zur Steinbildung, am häufigsten in Form von Gallen- und Nierensteinen. Steine können über längere Zeit symptomlos bleiben, führen jedoch zu plötzlichen und heftigen Beschwerden, wenn sie Ausführgänge oder andere flüssigkeitsführende Gefäße verlegen. Im akuten Fall müssen die Ursachen ärztlich abgeklärt und die Steine eventuell chirurgisch entfernt werden, ansonsten stehen naturheilkundliche Therapien wie entkrampfende oder durchspülende Tees zur Verfügung.
Keywords	Steinbildung ; Gallenstein ; Nierenstein ; Schmerz ; Cholezystektomie ; Cholesterin ; Bilirubin ; Gallengrieß ; Vatersche Papille ; Gallenblase ; Cholezystitis ; Pankreatitis ; 6-F-Regel ; Cholesterinpumpe ; Krampflösung ; Durchspülung ; Harnleiter ; Nierengrieß ; Harn ; Trinken ; Harnwege ; Litholyse ; Nephrolith ; Kotstein ; Mandelstein ; Tonsillenstein ; Speichelstein
Language	German
Publishing date	2019-06-01
Publisher	© Karl F. Haug Verlag in Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266301-0
ISSN	1862-2275 ; 1862-2267
ISSN (online)	1862-2275
ISSN	1862-2267
DOI	10.1055/a-5866-1157
Database	Thieme publisher's database

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Article: Den Schalter umlegen

Gundacker, Stefanie

Deutsche Heilpraktiker-Zeitschrift

2019 Volume 14, Issue 01, Page(s) 54–58

Abstract: Die Trigeminusneuralgie tritt häufig mit plötzlichen heftigen Schmerzattacken auf, die Lebensqualität und Schlaf massiv beeinträchtigen – so auch in dem hier vorgestellten Fall. 50–70-mal pro Tag schoss der Schmerz bei Leon L. mit hoher Intensität in den ...

Abstract	Die Trigeminusneuralgie tritt häufig mit plötzlichen heftigen Schmerzattacken auf, die Lebensqualität und Schlaf massiv beeinträchtigen – so auch in dem hier vorgestellten Fall. 50–70-mal pro Tag schoss der Schmerz bei Leon L. mit hoher Intensität in den Gesichtsbereich ein – nach einer erfolglosen Behandlung mit Antiepileptika stand eine komplizierte Operation bevor. Eine Kombination aus hochdosierten Vitaminen, Schmerzöl, Blutegeltherapie und Hypnose konnte die Zahl und Intensität der Anfälle auf ein annehmbares Maß reduzieren und einen chirurgischen Eingriff entbehrlich machen.
Keywords	Hypnose ; Blutegeltherapie ; B-Vitamine ; Trigeminusneuralgie ; Schmerzattacke ; Schmerz ; Antiepileptika ; Schmerzöl ; Nervreizung ; Vitamin B6 ; Folsäure ; Vitamin B12 ; Vitamin D ; Augenkatalepsietest ; Armkatalepsietest ; Hypnosetherapie ; Suggestion ; Schmerztherapie ; Schalter ; Codewort
Language	German
Publishing date	2019-01-01
Publisher	© Karl F. Haug Verlag in Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266301-0
ISSN	1862-2275 ; 1862-2267
ISSN (online)	1862-2275
ISSN	1862-2267
DOI	10.1055/a-0765-6932
Database	Thieme publisher's database

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Article: A time-based double-sided readout concept of 100 mm LYSO:Ce,Ca fibres for future axial TOF-PET.

Weindel, Konstantin / Nadig, Vanessa / Herweg, Katrin / Schulz, Volkmar / Gundacker, Stefan

EJNMMI physics

2023 Volume 10, Issue 1, Page(s) 43

Abstract: Background: Positron emission tomography (PET) requires a high signal-to-noise ratio (SNR) to improve image quality, with time-of-flight (TOF) being an effective way to boost the SNR. However, the scanner sensitivity and resolution must be maintained. ... ...

Abstract	Background: Positron emission tomography (PET) requires a high signal-to-noise ratio (SNR) to improve image quality, with time-of-flight (TOF) being an effective way to boost the SNR. However, the scanner sensitivity and resolution must be maintained. The use of axially aligned 100-mm LYSO:Ce,Ca scintillation crystals with double-sided readout has the potential of ground-breaking TOF and sensitivity, while reducing parallax errors through depth-of-interaction (DOI) estimation, and also allowing a reduction in the number of readout channels required, resulting in cost benefits. Due to orientation, these fibres may also facilitate the integration of TOF-PET with magnetic resonance imaging (MRI) in hybrid imaging systems. The challenge of achieving a good spatial resolution with such long axial fibres is directly related to the achievable TOF resolution. In this study, the timing performance and DOI resolution of emerging high-performance materials were investigated to assess the merits of this approach in organ-dedicated or total-body/large-scale PET imaging systems. Methods: LYSO:Ce,Ca scintillation fibres of 20 mm and 100 mm length were tested in various operating and readout configurations to determine the best achievable coincidence time resolution (CTR) and DOI resolution. The tests were performed using state-of-the-art high-frequency (HF) readout and commercially available silicon photomultipliers (SiPMs) from Broadcom Inc. Results: For the 100-mm fibre, an average CTR performance of [Formula: see text] ps FWHM and an average depth-of-interaction resolution within the fibre of [Formula: see text] mm FWHM could be obtained. The 20-mm fibre showed a sub-100 ps CTR of [Formula: see text] ps FWHM and a fibre resolution of [Formula: see text] mm FWHM in the double-sided readout configuration. Conclusion: With modern SiPMs and crystals, a double-sided readout of long fibres can achieve excellent timing resolution and field-advancing TOF resolution, outperforming commercial PET systems. With 100-mm fibres, an electronic channel reduction of about a factor 2.5 is inherent, with larger reduction factors conceivable, which can lead to lower production costs. The spatial resolution was shown to be limited in the axial direction with 12 mm, but is defined to 3 mm in all other directions. Recent SiPM and scintillator developments are expected to improve on the time and spatial resolution to be investigated in future prototypes.
Language	English
Publishing date	2023-07-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00563-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The SNR of Positron Emission Data With Gaussian and Non-Gaussian Time-of-Flight Kernels, With Application to Prompt Photon Coincidence.

Nuyts, Johan / Defrise, Michel / Gundacker, Stefan / Roncali, Emilie / Lecoq, Paul

IEEE transactions on medical imaging

2023 Volume 42, Issue 5, Page(s) 1254–1264

Abstract: It is well known that measurement of the time-of-flight (TOF) increases the information provided by coincident events in positron emission tomography (PET). This information increase propagates through the reconstruction and improves the signal-to-noise ... ...

Abstract	It is well known that measurement of the time-of-flight (TOF) increases the information provided by coincident events in positron emission tomography (PET). This information increase propagates through the reconstruction and improves the signal-to-noise ratio in the reconstructed images. Takehiro Tomitani has analytically computed the gain in variance in the reconstructed image, provided by a particular TOF resolution, for the center of a uniform disk and for a Gaussian TOF kernel. In this paper we extend this result, by computing the signal-to-noise ratio (SNR) contributed by individual coincidence events for two different tasks. One task is the detection of a hot spot in the center of a uniform cylinder. The second one is the same as that considered by Tomitani, i.e. the reconstruction of the central voxel in the image of a uniform cylinder. In addition, we extend the computation to non-Gaussian TOF kernels. It is found that a modification of the TOF-kernel changes the SNR for both tasks in almost exactly the same way. The proposed method can be used to compare TOF-systems with different and possibly event-dependent TOF-kernels, as encountered when prompt photons, such as Cherenkov photons are present, or when the detector is composed of different scintillators. The method is validated with simple 2D simulations and illustrated by applying it to PET detectors producing optical photons with event-dependent timing characteristics.
MeSH term(s)	Signal-To-Noise Ratio ; Electrons ; Tomography, X-Ray Computed ; Positron-Emission Tomography/methods ; Time Factors ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2022.3225433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dysbiose: Von der Therapie zur Abrechnung

Gundacker, Stefanie

Deutsche Heilpraktiker-Zeitschrift

2018 Volume 13, Issue 02, Page(s) 26–30

Abstract: Traditionelle Naturheilverfahren liefern für alltägliche Praxisfälle eine Fülle wirksamer Instrumente und multimodaler Therapiestrategien. Bei Eva B. konnten unter anderem Ausleitungsverfahren nach gezielten regulatorischen Impulsen und Basentherapien ... ...

Abstract	Traditionelle Naturheilverfahren liefern für alltägliche Praxisfälle eine Fülle wirksamer Instrumente und multimodaler Therapiestrategien. Bei Eva B. konnten unter anderem Ausleitungsverfahren nach gezielten regulatorischen Impulsen und Basentherapien Magen-Darm-Störungen zum Abheilen bringen. Kenntnisse über das GebüH und die Erstattungspraxis von privaten Krankenversicherungen und Beihilfe erleichtern die Abrechnung und gewährleisten die Wirtschaftlichkeit der Praxis.
Keywords	Dysbiose ; Abrechnung ; Traditionelle Heilverfahren ; GebüH ; Magen-Darm-Störungen ; Ausleitung ; private Krankenversicherung ; Beihilfe ; Psychosomatik ; Durchfall ; Blähungen ; Verstopfung ; Bauchkrämpfe ; Vitamin-D-Mangel ; Dunkelfeldmikroskopie ; Basentherapie ; Ernährung ; Schröpfen ; Blutegel
Language	German
Publishing date	2018-02-01
Publisher	© Karl F. Haug Verlag in Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266301-0
ISSN	1862-2275 ; 1862-2267
ISSN (online)	1862-2275
ISSN	1862-2267
DOI	10.1055/a-0554-0502
Database	Thieme publisher's database

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Article: Gerüstet für den Notfall: Die Anaphylaxie-Strategie

Gundacker, Stefanie

Deutsche Heilpraktiker-Zeitschrift

2018 Volume 13, Issue 06, Page(s) 60–64

Abstract: Dieser Artikel ist vorübergehend nicht im Volltext verfügbar. ...

Abstract	Dieser Artikel ist vorübergehend nicht im Volltext verfügbar.
Keywords	Notfall ; Anaphylaxie ; anaphylaktischer Schock ; Blutegel ; allergische Reaktion ; Nebenwirkung ; Notfallplan ; Verschreibungspflicht ; Notfallkoffer ; Notfalltasche ; Antihistaminika ; Kortikosteroide ; Adrenalin ; Blutdruck ; Puls ; Schock
Language	German
Publishing date	2018-09-01
Publisher	© Karl F. Haug Verlag in Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266301-0
ISSN	1862-2275 ; 1862-2267
ISSN (online)	1862-2275
ISSN	1862-2267
DOI	10.1055/a-0712-2822
Database	Thieme publisher's database

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Article ; Online: The silicon photomultiplier: fundamentals and applications of a modern solid-state photon detector.

Gundacker, Stefan / Heering, Arjan

Physics in medicine and biology

2020 Volume 65, Issue 17, Page(s) 17TR01

Abstract: The silicon photomultiplier (SiPM) is an established device of choice for a variety of applications, e.g. in time of flight positron emission tomography (TOF-PET), lifetime fluorescence spectroscopy, distance measurements in LIDAR applications, ... ...

Abstract	The silicon photomultiplier (SiPM) is an established device of choice for a variety of applications, e.g. in time of flight positron emission tomography (TOF-PET), lifetime fluorescence spectroscopy, distance measurements in LIDAR applications, astrophysics, quantum-cryptography and related applications as well as in high energy physics (HEP). To fully utilize the exceptional performances of the SiPM, in particular its sensitivity down to single photon detection, the dynamic range and its intrinsically fast timing properties, a qualitative description and understanding of the main SiPM parameters and properties is necessary. These analyses consider the structure and the electrical model of a single photon avalanche diode (SPAD) and the integration in an array of SPADs, i.e. the SiPM. The discussion will include the front-end readout and the comparison between analog-SiPMs, where the array of SPADs is connected in parallel, and the digital SiPM, where each SPAD is read out and digitized by its own electronic channel. For several applications a further complete phenomenological view on SiPMs is necessary, defining several SiPM intrinsic parameters, i.e. gain fluctuation, afterpulsing, excess noise, dark count rate, prompt and delayed optical crosstalk, single photon time resolution (SPTR), photon detection effieciency (PDE) etc. These qualities of SiPMs influence directly and indirectly the time and energy resolution, for example in PET and HEP. This complete overview of all parameters allows one to draw solid conclusions on how best performances can be achieved for the various needs of the different applications.
MeSH term(s)	Electrical Equipment and Supplies ; Photons ; Silicon
Chemical Substances	Silicon (Z4152N8IUI)
Language	English
Publishing date	2020-08-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/1361-6560/ab7b2d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 199: Show issues

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Article: 16-channel SiPM high-frequency readout with time-over-threshold discrimination for ultrafast time-of-flight applications.

Nadig, Vanessa / Hornisch, Matthias / Oehm, Jakob / Herweg, Katrin / Schulz, Volkmar / Gundacker, Stefan

EJNMMI physics

2023 Volume 10, Issue 1, Page(s) 76

Abstract: Background: Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can further push the limits in light ... ...

Abstract	Background: Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can further push the limits in light detection and ranging (LiDAR), time-of-flight positron-emission tomography (TOF-PET), time-of-flight computed tomography (TOF-CT) or high-energy physics (HEP). However, upscaling these electronics to a system-applicable, multi-channel readout, has remained a challenging task, posed by the use of discrete components and a high power consumption. To this day, there are no means to exploit the high TOF resolution of these electronics on system scale or to measure the actual timing performance limits of a full detector block. Methods: In this work, we present a 16-channel HF readout board, including leading-edge discrimination and a linearized time-over-threshold (TOT) method, which is fully compatible with a high-precision time-to-digital converters (TDCs), such as the picoTDC developed at CERN. The discrete implementation allows ideal adaptation of this readout to a broad range of detection tasks. As a first step, the functionality of the circuit has been tested using the TOFPET2 ASIC as back-end electronics to emulate the TDC, also in view of its properties as a highly scalable data acquisition solution. Results: The produced board is able to mitigate influences of baseline shifts in the TOFPET2 front end, which has been shown in experiments with a pulsed laser, increasing the achievable intrinsic coincidence timing resolution (CTR) of the TOFPET2 readout electronics from 70 ps (FWHM) to 62 ps (FWHM). Single-channel coincidence experiments including a [Formula: see text]-source, 2[Formula: see text]2[Formula: see text]3 mm[Formula: see text] LYSO:Ce,Ca crystals and Broadcom NUV-MT SiPMs resulted in a CTR of 118 ps (FWHM). For a 4[Formula: see text]4 matrix of 3.88[Formula: see text]3.88[Formula: see text]19 mm[Formula: see text] LYSO:Ce,Ca crystals one-to-one coupled to a 4[Formula: see text]4 array of Broadcom NUV-MT SiPMs, an average CTR of 223 ps (FWHM) was obtained. Conclusion: The implemented 16-channel HF electronics are fully functionall and have a negligible influence on the timing performance of the back-end electronics used, here the TOFPET2 ASIC. The ongoing integration of the picoTDC with the 16-channel HF board is expected to further set the path toward sub-100 ps TOF-PET and sub-30ps TOF resolution for single-photon detection.
Language	English
Publishing date	2023-12-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00594-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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