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  1. Article ; Online: Ultra-processed foods and colorectal neoplasia: is there a link?

    Cross, Amanda J / Gunter, Marc J

    Journal of the National Cancer Institute

    2022  Volume 115, Issue 2, Page(s) 117–119

    MeSH term(s) Humans ; Food, Processed ; Diet ; Colorectal Neoplasms ; Energy Intake
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djac222
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  2. Article: Adiposity and cancer: meta-analysis, mechanisms, and future perspectives.

    Watts, Eleanor L / Moore, Steven C / Gunter, Marc J / Chatterjee, Nilanjan

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Obesity is a recognised risk factor for many cancers and with rising global prevalence, has become a leading cause of cancer. Here we summarise the current evidence from both population-based epidemiologic investigations and experimental studies on the ... ...

    Abstract Obesity is a recognised risk factor for many cancers and with rising global prevalence, has become a leading cause of cancer. Here we summarise the current evidence from both population-based epidemiologic investigations and experimental studies on the role of obesity in cancer development. This review presents a new meta-analysis using data from 40 million individuals and reports positive associations with 19 cancer types. Utilising major new data from East Asia, the meta-analysis also shows that the strength of obesity and cancer associations varies regionally, with stronger relative risks for several cancers in East Asia. This review also presents current evidence on the mechanisms linking obesity and cancer and identifies promising future research directions. These include the use of new imaging data to circumvent the methodological issues involved with body mass index and the use of omics technologies to resolve biologic mechanisms with greater precision and clarity.
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.16.24302944
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  3. Article ; Online: Application of Metabolomics to Epidemiologic Studies of Breast Cancer: New Perspectives for Etiology and Prevention.

    His, Mathilde / Gunter, Marc J / Keski-Rahkonen, Pekka / Rinaldi, Sabina

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 1, Page(s) 103–115

    Abstract: Purpose: To provide an overview on how the application of metabolomics (high-throughput characterization of metabolites from cells, organs, tissues, or biofluids) to population-based studies may inform our understanding of breast cancer etiology.: ... ...

    Abstract Purpose: To provide an overview on how the application of metabolomics (high-throughput characterization of metabolites from cells, organs, tissues, or biofluids) to population-based studies may inform our understanding of breast cancer etiology.
    Methods: We evaluated studies that applied metabolomic analyses to prediagnostic blood samples from prospective epidemiologic studies to identify circulating metabolites associated with breast cancer risk, overall and by breast cancer subtype and menopausal status. We provide some important considerations for the application and interpretation of metabolomics approaches in this context.
    Results: Overall, specific lipids and amino acids were indicated as the most common metabolite classes associated with breast cancer development. However, comparison of results across studies is challenging because of heterogeneity in laboratory techniques, analytical methods, sample size, and applied statistical methods.
    Conclusion: Metabolomics is being increasingly applied to population-based studies for the identification of new etiologic hypotheses and/or mechanisms related to breast cancer development. Despite its success in applications to epidemiology, studies of larger sample size with detailed information on menopausal status, breast cancer subtypes, and repeated biologic samples collected over time are needed to improve comparison of results between studies and enhance validation of results, allowing potential clinical translation of findings.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Breast Neoplasms/prevention & control ; Prospective Studies ; Metabolomics/methods ; Epidemiologic Studies
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02754
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  4. Article ; Online: Use of menopausal hormone therapy and ovarian cancer risk in a French cohort study.

    Fournier, Agnès / Cairat, Manon / Severi, Gianluca / Gunter, Marc J / Rinaldi, Sabina / Dossus, Laure

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 6, Page(s) 671–679

    Abstract: Background: Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations ... ...

    Abstract Background: Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations between different MHT types and the risk of ovarian cancer in a prospective cohort.
    Methods: The study population included 75 606 postmenopausal women from the E3N cohort. Exposure to MHT was identified from self-reports in biennial questionnaires between 1992 and 2004 and from drug claim data matched to the cohort between 2004 and 2014. Hazard ratios and 95% confidence intervals (CIs) of ovarian cancer were estimated using multivariable Cox proportional hazards models with MHT as a time-varying exposure. Tests of statistical significance were 2-sided.
    Results: Over an average 15.3 years follow-up, 416 ovarian cancers were diagnosed. Hazard ratios of ovarian cancer associated with ever use of estrogens combined with progesterone or dydrogesterone and ever use of estrogens combined with other progestagen were equal to 1.28 (95% CI = 1.04 to 1.57) and 0.81 (95% CI = 0.65 to 1.00), respectively (Phomogeneity = .003), compared with never use. The hazard ratio for unopposed estrogen use was 1.09 (95% CI = 0.82 to 1.46). We found no trend according to duration of use or time since last use except for estrogens combined with progesterone or dydrogesterone, which showed decreasing risk with increasing time since last use.
    Conclusion: Different MHT types may impact ovarian cancer risk differentially. The possibility that MHT containing progestagens other than progesterone or dydrogesterone may confer some protection should be evaluated in other epidemiological studies.
    MeSH term(s) Humans ; Female ; Progesterone/adverse effects ; Cohort Studies ; Dydrogesterone ; Prospective Studies ; Postmenopause ; Risk Factors ; Progestins/adverse effects ; Estrogens/adverse effects ; Ovarian Neoplasms/chemically induced ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/drug therapy ; Menopause
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Dydrogesterone (90I02KLE8K) ; Progestins ; Estrogens
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad035
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  5. Article ; Online: RE: Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers.

    Yarmolinsky, James / Tzoulaki, Ioanna / Gunter, Marc J / Travis, Ruth C / Davey Smith, George / Smith-Byrne, Karl

    Journal of the National Cancer Institute

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djae064
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  6. Article: Risk-Predictive and Diagnostic Biomarkers for Colorectal Cancer; a Systematic Review of Studies Using Pre-Diagnostic Blood Samples Collected in Prospective Cohorts and Screening Settings.

    Harlid, Sophia / Gunter, Marc J / Van Guelpen, Bethany

    Cancers

    2021  Volume 13, Issue 17

    Abstract: This systematic review summarizes the evidence for blood-based colorectal cancer biomarkers from studies conducted in pre-diagnostic, asymptomatic settings. Of 1372 studies initially identified, the final selection included 30 studies from prospective ... ...

    Abstract This systematic review summarizes the evidence for blood-based colorectal cancer biomarkers from studies conducted in pre-diagnostic, asymptomatic settings. Of 1372 studies initially identified, the final selection included 30 studies from prospective cohorts and 23 studies from general screening settings. Overall, the investigations had high quality but considerable variability in data analysis and presentation of results, and few biomarkers demonstrated a clinically relevant discriminatory ability. One of the most promising biomarkers was the anti-p53 antibody, with consistent findings in one screening cohort and in the 3-4 years prior to diagnosis in two prospective cohort studies. Proteins were the most common type of biomarker assessed, particularly carcinoembryonic antigen (CEA) and C-reactive protein (CRP), with modest results. Other potentially promising biomarkers included proteins, such as AREG, MIC-1/GDF15, LRG1 and FGF-21, metabolites and/or metabolite profiles, non-coding RNAs and DNA methylation, as well as re-purposed routine lab tests, such as ferritin and the triglyceride-glucose index. Biomarker panels generally achieved higher discriminatory performance than single markers. In conclusion, this systematic review highlighted anti-p53 antibodies as a promising blood-based biomarker for use in colorectal cancer screening panels, together with other specific proteins. It also underscores the need for validation of promising biomarkers in independent pre-diagnostic settings.
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13174406
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  7. Article ; Online: Are sugar-sweetened beverages contributing to the rising occurrence of colorectal cancer in young adults?

    Murphy, Neil / Campbell, Peter T / Gunter, Marc J

    Gut

    2021  Volume 70, Issue 12, Page(s) 2222–2223

    MeSH term(s) Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Humans ; Sugar-Sweetened Beverages ; Young Adult
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2021-324614
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
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  8. Article ; Online: Obesity and gastrointestinal cancers - where do we go from here?

    Gunter, Marc J / Riboli, Elio

    Nature reviews. Gastroenterology & hepatology

    2018  Volume 15, Issue 11, Page(s) 651–652

    MeSH term(s) Gastrointestinal Neoplasms/etiology ; Gastrointestinal Neoplasms/prevention & control ; Humans ; Obesity/complications ; Obesity/prevention & control ; Risk Factors
    Language English
    Publishing date 2018-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-018-0073-y
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  9. Article ; Online: Coffee and Colorectal Cancer: Grounds for Prevention?

    Cross, Amanda J / Gunter, Marc J

    Gastroenterology

    2018  Volume 154, Issue 4, Page(s) 790–792

    MeSH term(s) Coffee ; Colonic Neoplasms ; Colorectal Neoplasms ; Humans
    Chemical Substances Coffee
    Language English
    Publishing date 2018-02-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2018.02.006
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  10. Article ; Online: Unraveling the Etiology of Early-Onset Colorectal Cancer.

    Murphy, Neil / Campbell, Peter T / Gunter, Marc J

    Journal of the National Cancer Institute

    2020  Volume 113, Issue 5, Page(s) 505–506

    MeSH term(s) Age of Onset ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Humans
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djaa165
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