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  1. Article ; Online: Na

    Fu, Wenyu / Vasylyev, Dmytro / Bi, Yufei / Zhang, Mingshuang / Sun, Guodong / Khleborodova, Asya / Huang, Guiwu / Zhao, Libo / Zhou, Renpeng / Li, Yonggang / Liu, Shujun / Cai, Xianyi / He, Wenjun / Cui, Min / Zhao, Xiangli / Hettinghouse, Aubryanna / Good, Julia / Kim, Ellen / Strauss, Eric /
    Leucht, Philipp / Schwarzkopf, Ran / Guo, Edward X / Samuels, Jonathan / Hu, Wenhuo / Attur, Mukundan / Waxman, Stephen G / Liu, Chuan-Ju

    Nature

    2024  Volume 625, Issue 7995, Page(s) 557–565

    Abstract: Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce ... ...

    Abstract Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain
    MeSH term(s) Animals ; Humans ; Mice ; Calcium/metabolism ; Calcium Signaling/drug effects ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Disease Progression ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; NAV1.7 Voltage-Gated Sodium Channel/deficiency ; NAV1.7 Voltage-Gated Sodium Channel/genetics ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Neurons/metabolism ; Osteoarthritis/complications ; Osteoarthritis/drug therapy ; Osteoarthritis/genetics ; Osteoarthritis/metabolism ; Pain/complications ; Pain/drug therapy ; Pain/metabolism ; Voltage-Gated Sodium Channel Blockers/pharmacology ; Voltage-Gated Sodium Channel Blockers/therapeutic use
    Chemical Substances Calcium (SY7Q814VUP) ; NAV1.7 Voltage-Gated Sodium Channel ; Voltage-Gated Sodium Channel Blockers ; Nav1 protein, mouse ; NAV1 protein, human
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06888-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spine Trabecular Bone Score as an Indicator of Bone Microarchitecture at the Peripheral Skeleton in Kidney Transplant Recipients.

    Luckman, Matthew / Hans, Didier / Cortez, Natalia / Nishiyama, Kyle K / Agarawal, Sanchita / Zhang, Chengchen / Nikkel, Lucas / Iyer, Sapna / Fusaro, Maria / Guo, Edward X / McMahon, Donald J / Shane, Elizabeth / Nickolas, Thomas L

    Clinical journal of the American Society of Nephrology : CJASN

    2017  Volume 12, Issue 4, Page(s) 644–652

    Abstract: Background and objectives: Studies using high-resolution peripheral quantitative computed tomography showed progressive abnormalities in cortical and trabecular microarchitecture and biomechanical competence over the first year after kidney ... ...

    Abstract Background and objectives: Studies using high-resolution peripheral quantitative computed tomography showed progressive abnormalities in cortical and trabecular microarchitecture and biomechanical competence over the first year after kidney transplantation. However, high-resolution peripheral computed tomography is a research tool lacking wide availability. In contrast, the trabecular bone score is a novel and widely available tool that uses gray-scale variograms of the spine image from dual-energy x-ray absorptiometry to assess trabecular quality. There are no studies assessing whether trabecular bone score characterizes bone quality in kidney transplant recipients.
    Design, settings, participants, & measurements: Between 2009 and 2010, we conducted a study to assess changes in peripheral skeletal microarchitecture, measured by high-resolution peripheral computed tomography, during the first year after transplantation in 47 patients managed with early corticosteroid-withdrawal immunosuppression. All adult first-time transplant candidates were eligible. Patients underwent imaging with high-resolution peripheral computed tomography and dual-energy x-ray absorptiometry pretransplantation and 3, 6, and 12 months post-transplantation. We now test if, during the first year after transplantation, trabecular bone score assesses the evolution of bone microarchitecture and biomechanical competence as determined by high-resolution peripheral computed tomography.
    Results: At baseline and follow-up, among the 72% and 78%, respectively, of patients having normal bone mineral density by dual-energy x-ray absorptiometry, 53% and 50%, respectively, were classified by trabecular bone score as having high fracture risk. At baseline, trabecular bone score correlated with spine, hip, and ultradistal radius bone mineral density by dual-energy x-ray absorptiometry and cortical area, density, thickness, and porosity; trabecular density, thickness, separation, and heterogeneity; and stiffness and failure load by high-resolution peripheral computed tomography. Longitudinally, each percentage increase in trabecular bone score was associated with increases in trabecular number (0.35%±1.4%); decreases in trabecular thickness (-0.45%±0.15%), separation (-0.40%±0.15%), and network heterogeneity (-0.48%±0.20%); and increases in failure load (0.22%±0.09%) by high-resolution peripheral computed tomography (all
    Conclusions: Trabecular bone score may be a useful method to assess and monitor bone quality and strength and classify fracture risk in kidney transplant recipients.
    MeSH term(s) Absorptiometry, Photon ; Adolescent ; Adult ; Aged ; Biomechanical Phenomena ; Bone Density ; Cancellous Bone/diagnostic imaging ; Female ; Femur Head/diagnostic imaging ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Porosity ; Radius/diagnostic imaging ; Spine/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Young Adult
    Language English
    Publishing date 2017-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.09850916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1

    Kajimura, Daisuke / Lee, Ha Won / Riley, Kyle J / Arteaga-Solis, Emilio / Ferron, Mathieu / Zhou, Bin / Clarke, Christopher J / Hannun, Yusuf A / DePinho, Ronald A / Guo, Edward X / Mann, J. John / Karsenty, Gerard

    Cell metabolism. 2013 June 4, v. 17, no. 6

    2013  

    Abstract: The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin. Here we show that adiponectin signals back in osteoblasts to hamper their proliferation and ... ...

    Abstract The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin. Here we show that adiponectin signals back in osteoblasts to hamper their proliferation and favor their apoptosis, altogether decreasing bone mass and circulating osteocalcin levels. Adiponectin fulfills these functions, independently of its known receptors and signaling pathways, by decreasing FoxO1 activity in a PI3-kinase-dependent manner. Over time, however, these local effects are masked because adiponectin signals in neurons of the locus coeruleus, also through FoxO1, to decrease the sympathetic tone, thereby increasing bone mass and decreasing energy expenditure. This study reveals that adiponectin has the unusual ability to regulate the same function in two opposite manners depending on where it acts and that it opposes, partially, leptin’s influence on the sympathetic nervous system. It also proposes that adiponectin regulation of bone mass occurs through a PI3-kinase-FoxO1 pathway.
    Keywords adiponectin ; animals ; apoptosis ; bone density ; diet ; energy expenditure ; leptin ; loci ; neurons ; osteoblasts ; osteocalcin ; receptors ; signal transduction ; sympathetic nervous system
    Language English
    Dates of publication 2013-0604
    Size p. 901-915.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2013.04.009
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Blocking FSH induces thermogenic adipose tissue and reduces body fat.

    Liu, Peng / Ji, Yaoting / Yuen, Tony / Rendina-Ruedy, Elizabeth / DeMambro, Victoria E / Dhawan, Samarth / Abu-Amer, Wahid / Izadmehr, Sudeh / Zhou, Bin / Shin, Andrew C / Latif, Rauf / Thangeswaran, Priyanthan / Gupta, Animesh / Li, Jianhua / Shnayder, Valeria / Robinson, Samuel T / Yu, Yue Eric / Zhang, Xingjian / Yang, Feiran /
    Lu, Ping / Zhou, Yu / Zhu, Ling-Ling / Oberlin, Douglas J / Davies, Terry F / Reagan, Michaela R / Brown, Aaron / Kumar, T Rajendra / Epstein, Solomon / Iqbal, Jameel / Avadhani, Narayan G / New, Maria I / Molina, Henrik / van Klinken, Jan B / Guo, Edward X / Buettner, Christoph / Haider, Shozeb / Bian, Zhuan / Sun, Li / Rosen, Clifford J / Zaidi, Mone

    Nature

    2017  Volume 546, Issue 7656, Page(s) 107–112

    Abstract: Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply ... ...

    Abstract Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.
    MeSH term(s) Adipocytes/drug effects ; Adipocytes/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue, Beige/drug effects ; Adipose Tissue, Beige/metabolism ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Adiposity/drug effects ; Animals ; Antibodies/immunology ; Antibodies/pharmacology ; Diet, High-Fat/adverse effects ; Female ; Follicle Stimulating Hormone, beta Subunit/antagonists & inhibitors ; Follicle Stimulating Hormone, beta Subunit/immunology ; Haploinsufficiency ; Male ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Obesity/drug therapy ; Obesity/prevention & control ; Osteoporosis/drug therapy ; Ovariectomy ; Oxygen Consumption/drug effects ; Receptors, FSH/antagonists & inhibitors ; Receptors, FSH/genetics ; Receptors, FSH/metabolism ; Thermogenesis/drug effects ; Uncoupling Protein 1/biosynthesis
    Chemical Substances Antibodies ; Follicle Stimulating Hormone, beta Subunit ; Receptors, FSH ; Ucp1 protein, mouse ; Uncoupling Protein 1
    Language English
    Publishing date 2017-05-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature22342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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