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Article ; Online: Small Extracellular Vesicles Derived from Induced Pluripotent Stem Cells in the Treatment of Myocardial Injury.

Meng, Wan-Ting / Guo, Hai-Dong

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: Induced pluripotent stem cell (iPSC) therapy brings great hope to the treatment of myocardial injuries, while extracellular vesicles may be one of the main mechanisms of its action. iPSC-derived small extracellular vesicles (iPSCs-sEVs) can carry genetic ...

Abstract	Induced pluripotent stem cell (iPSC) therapy brings great hope to the treatment of myocardial injuries, while extracellular vesicles may be one of the main mechanisms of its action. iPSC-derived small extracellular vesicles (iPSCs-sEVs) can carry genetic and proteinaceous substances and mediate the interaction between iPSCs and target cells. In recent years, more and more studies have focused on the therapeutic effect of iPSCs-sEVs in myocardial injury. IPSCs-sEVs may be a new cell-free-based treatment for myocardial injury, including myocardial infarction, myocardial ischemia-reperfusion injury, coronary heart disease, and heart failure. In the current research on myocardial injury, the extraction of sEVs from mesenchymal stem cells induced by iPSCs was widely used. Isolation methods of iPSCs-sEVs for the treatment of myocardial injury include ultracentrifugation, isodensity gradient centrifugation, and size exclusion chromatography. Tail vein injection and intraductal administration are the most widely used routes of iPSCs-sEV administration. The characteristics of sEVs derived from iPSCs which were induced from different species and organs, including fibroblasts and bone marrow, were further compared. In addition, the beneficial genes of iPSC can be regulated through CRISPR/Cas9 to change the composition of sEVs and improve the abundance and expression diversity of them. This review focused on the strategies and mechanisms of iPSCs-sEVs in the treatment of myocardial injury, which provides a reference for future research and the application of iPSCs-sEVs.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells/metabolism ; Myocardial Infarction/metabolism ; Myocardial Reperfusion Injury/metabolism ; Heart Injuries ; Extracellular Vesicles/metabolism
Language	English
Publishing date	2023-02-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054577
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Delivery of Stem Cells and BMP-2 With Functionalized Self-Assembling Peptide Enhances Regeneration of Infarcted Myocardium.

Guo, Hai-Dong / Wu, Jin-Hong / Wang, Hai-Jie / Tan, Yu-Zhen

Stem cell reviews and reports

2024

Abstract: Stem cell transplantation is a promising therapeutic strategy for myocardial infarction (MI). However, engraftment, survival and differentiation of the transplanted stem cells in ischemic and inflammatory microenvironment are poor. We designed a novel ... ...

Abstract	Stem cell transplantation is a promising therapeutic strategy for myocardial infarction (MI). However, engraftment, survival and differentiation of the transplanted stem cells in ischemic and inflammatory microenvironment are poor. We designed a novel self-assembly peptide (SAP) by modifying the peptide RADA16 with cell-adhesive motif and BMP-2 (bone morphogenetic protein-2)-binding motif. Effects of the functionalized SAP on adhesion, survival and differentiation of c-kit
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-024-10721-7
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Article: Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.

Wang, Yu / Xue, Yuezhen / Guo, Hai-Dong

Frontiers in pharmacology

2022 Volume 13, Page(s) 1013740

Abstract: Cardiovascular diseases are the leading cause of global mortality, in which myocardial infarction accounts for 46% of total deaths. Although good progress has been achieved in medication and interventional techniques, a proven method to repair the ... ...

Abstract	Cardiovascular diseases are the leading cause of global mortality, in which myocardial infarction accounts for 46% of total deaths. Although good progress has been achieved in medication and interventional techniques, a proven method to repair the damaged myocardium has not yet been determined. Stem cell therapy for damaged myocardial repair has evolved into a promising treatment for ischemic heart disease. However, low retention and poor survival of the injected stem cells are the major obstacles to achieving the intended therapeutic effects. Chinese botanical and other natural drug substances are a rich source of effective treatment for various diseases. As such, numerous studies have revealed the role of Chinese medicine in stem cell therapy for myocardial infarction treatment, including promoting proliferation, survival, migration, angiogenesis, and differentiation of stem cells. Here, we discuss the potential and limitations of stem cell therapy, as well as the regulatory mechanism of Chinese medicines underlying stem cell therapy. We focus on the evidence from pre-clinical trials and clinical practices, and based on traditional Chinese medicine theories, we further summarize the mechanisms of Chinese medicine treatment in stem cell therapy by the commonly used prescriptions. Despite the pre-clinical evidence showing that traditional Chinese medicine is helpful in stem cell therapy, there are still some limitations of traditional Chinese medicine therapy. We also systematically assess the detailed experimental design and reliability of included pharmacological research in our review. Strictly controlled animal models with multi-perspective pharmacokinetic profiles and high-grade clinical evidence with multi-disciplinary efforts are highly demanded in the future.
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1013740
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Article: Effects and Mechanisms of Taohong Siwu Decoction on the Prevention and Treatment of Myocardial Injury.

Shao, Chang-Le / Cui, Guo-Hong / Guo, Hai-Dong

Frontiers in pharmacology

2022 Volume 13, Page(s) 816347

Abstract: Taohong Siwu decoction (THSWD) is one of the classic prescriptions for promoting blood circulation and removing blood stasis. With the continuous in-depth excavation in basic and clinical research, it has been found that THSWD has made greater progress ... ...

Abstract	Taohong Siwu decoction (THSWD) is one of the classic prescriptions for promoting blood circulation and removing blood stasis. With the continuous in-depth excavation in basic and clinical research, it has been found that THSWD has made greater progress in the prevention and treatment of cardiovascular diseases. Mechanisms of the current studies have shown that it could prevent and treat the myocardial injury by inhibiting inflammatory reaction, antioxidant stress, inhibiting platelet aggregation, prolonging clotting time, anti-fibrosis, reducing blood lipids, anti-atherosclerosis, improving hemorheology and vascular pathological changes, regulating related signal pathways and other mechanisms to prevent and treat the myocardial injury, so as to protect cardiomyocytes and improve cardiac function. Many clinical studies have shown that THSWD is effective in the prevention and treatment of cardiovascular diseases related to myocardial injuries, such as coronary heart disease angina pectoris (CHD-AP), and myocardial infarction. In clinical practice, it is often used by adding and subtracting prescriptions, the combination of compound prescriptions and combinations of chemicals and so on. However, there are some limitations and uncertainties in both basic and clinical research of prescriptions. According to the current research, although the molecular biological mechanism of various active ingredients needs to be further clarified, and the composition and dose of the drug have not been standardized and quantified, this study still has exploration for scientific research and clinical practice. Therefore, this review mainly discusses the basic mechanisms and clinical applications of THSWD in the prevention and treatment of the myocardial injury caused by CHD-AP and myocardial infarction. The authors hope to provide valuable ideas and references for researchers and clinicians.
Language	English
Publishing date	2022-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.816347
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Article ; Online: Correction: Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury.

Tian, Ming-Yue / Yang, Yi-Duo / Qin, Wan-Ting / Liu, Bao-Nian / Mou, Fang-Fang / Zhu, Jing / Guo, Hai-Dong / Shao, Shui-Jin

Molecular neurobiology

2024 Volume 61, Issue 2, Page(s) 950–952

Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Published Erratum
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-03932-z
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Zs.A 2411: Show issues

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Article ; Online: Dihydrotanshinone I reduces H9c2 cell damage by regulating AKT and MAPK signaling pathways.

Wang, Ya-Chao / Shao, Yi-da / Shao, Chang-le / Guan, Xiao-Qi / Lu, Ping-Ping / Ning, Ke / Liu, Bao-Nian / Guo, Hai-Dong

In vitro cellular & developmental biology. Animal

2024 Volume 60, Issue 1, Page(s) 89–97

Abstract: Cardiovascular disease is the deadliest disease in the world. Previous studies have shown that Dihydrotanshinone I (DHT) can improve cardiac function after myocardial injury. This study aimed to observe the protective effect and mechanism of DHT on H9c2 ... ...

Abstract	Cardiovascular disease is the deadliest disease in the world. Previous studies have shown that Dihydrotanshinone I (DHT) can improve cardiac function after myocardial injury. This study aimed to observe the protective effect and mechanism of DHT on H9c2 cells by establishing an oxygen-glucose deprivation/reoxygenation (OGD/R) injury model. By constructing OGD/R injury simulation of H9c2 cells in a myocardial injury model, the proliferation of H9c2 cells treated with DHT concentrations of 0.1 μmol/L were not affected at 24, 48, and 72 h. DHT can significantly reduce the apoptosis of H9c2 cells caused by OGD/R. Compared with the OGD/R group, DHT treatment significantly reduced the level of MDA and increased the level of SOD in cells. DHT treatment of cells can significantly reduce the levels of ROS and Superoxide in mitochondria in H9c2 cells caused by OGD/R and H
MeSH term(s)	Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Line ; Hydrogen Peroxide/metabolism ; Signal Transduction ; Oxygen/pharmacology ; Oxygen/metabolism ; Apoptosis ; Glucose/metabolism ; Myocytes, Cardiac/metabolism ; Furans ; Phenanthrenes ; Quinones
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; dihydrotanshinone I (562G9360V6) ; Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065) ; Glucose (IY9XDZ35W2) ; Furans ; Phenanthrenes ; Quinones
Language	English
Publishing date	2024-01-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-023-00839-2
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Zs.A 851: Show issues

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Article ; Online: Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer's disease.

Liu, Jia-Jia / Long, Yun-Fan / Xu, Peng / Guo, Hai-Dong / Cui, Guo-Hong

Alzheimer's research & therapy

2023 Volume 15, Issue 1, Page(s) 122

Abstract: Alzheimer's disease (AD) is a common age-related neurodegenerative disease in the central nervous system and is the primary cause of dementia. It is clinically characterized by the memory impairment, aphasia, apraxia, agnosia, visuospatial and executive ... ...

Abstract	Alzheimer's disease (AD) is a common age-related neurodegenerative disease in the central nervous system and is the primary cause of dementia. It is clinically characterized by the memory impairment, aphasia, apraxia, agnosia, visuospatial and executive dysfunction, behavioral changes, and so on. Incidence of this disease was bound up with age, genetic factors, cardiovascular and cerebrovascular dysfunction, and other basic diseases, but the exact etiology has not been clarified. MicroRNAs (miRNAs) are small endogenous non-coding RNAs that were involved in the regulation of post-transcriptional gene expression. miRNAs have been extensively studied as noninvasive potential biomarkers for disease due to their relative stability in bodily fluids. In addition, they play a significant role in the physiological and pathological processes of various neurological disorders, including stroke, AD, and Parkinson's disease. MiR-155, as an important pro-inflammatory mediator of neuroinflammation, was reported to participate in the progression of β-amyloid peptide and tau via regulating immunity and inflammation. In this review, we put emphasis on the effects of miR-155 on AD and explore the underlying biological mechanisms which could provide a novel approach for diagnosis and treatment of AD.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; Neurodegenerative Diseases ; MicroRNAs/genetics ; Amyloid beta-Peptides/metabolism ; Risk Factors
Chemical Substances	MicroRNAs ; Amyloid beta-Peptides ; MIRN155 microRNA, human
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-023-01264-z
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Article ; Online: Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage.

Wang, Ya-Chao / Wang, Huan / Shao, Chang-le / Li, Xiu-Ya / Cui, Ji / Guo, Hai-Dong

In vitro cellular & developmental biology. Animal

2023 Volume 59, Issue 5, Page(s) 346–355

Abstract: We found that modified Taohong Siwu decoction (MTHSWD) had cardioprotective effects after myocardial ischemia-reperfusion injury. This study was to screen the effective components of MTHSWD that have protective effects on H9c2 cell injury through ... ...

Abstract	We found that modified Taohong Siwu decoction (MTHSWD) had cardioprotective effects after myocardial ischemia-reperfusion injury. This study was to screen the effective components of MTHSWD that have protective effects on H9c2 cell injury through H
MeSH term(s)	Animals ; Signal Transduction ; Proto-Oncogene Proteins c-akt/metabolism ; Hydrogen Peroxide/toxicity ; Apoptosis ; Superoxide Dismutase
Chemical Substances	tanshinone (03UUH3J385) ; dihydrotanshinone I (562G9360V6) ; ginsenoside Rb3 (68406-26-8) ; 3,4-dihydroxyphenyllactic acid (4GF33A5PAJ) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Taohong Siwu decoction II ; Hydrogen Peroxide (BBX060AN9V) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-06-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-023-00773-3
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Article ; Online: Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

YANG Yi-duo / GUO Hai-dong / SHAO Shui-jin / LIU Yu-pu

Jichu yixue yu linchuang, Vol 42, Iss 1, Pp 145-

2022 Volume 148

Abstract: Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways ...

Abstract	Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. This review discusses the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.
Keywords	peripheral nerve\|schwann cells\|signal pathway\|nerve regeneration\|repair mechanism ; Medicine ; R
Language	Chinese
Publishing date	2022-01-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy.

Liu, Yu-Pu / Shao, Shui-Jin / Guo, Hai-Dong

Life sciences

2020 Volume 248, Page(s) 117459

Abstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose ... ...

Abstract	Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the pathological processes of SCs apoptosis under high glucose, which include the following: oxidative stress, inflammatory reactions, endoplasmic reticulum stress, autophagy, nitrification and signaling pathways (PI3K/AKT, ERK, PERK/Nrf2, and Wnt/β-catenin). The clarification of mechanisms underlying SCs apoptosis induced by high glucose will help us to understand and identify more effective strategies for the treatment of T1DM DPN.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Autophagy/drug effects ; Autophagy/genetics ; Diabetic Neuropathies/complications ; Diabetic Neuropathies/genetics ; Diabetic Neuropathies/metabolism ; Diabetic Neuropathies/pathology ; Endoplasmic Reticulum Stress/drug effects ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation ; Glucose/metabolism ; Glucose/pharmacology ; Humans ; Hyperglycemia/complications ; Hyperglycemia/genetics ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Insulin/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Schwann Cells/drug effects ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Signal Transduction ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	CTNNB1 protein, human ; Insulin ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; beta Catenin ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-02-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.117459
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