LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Selenium-Rich Yeast Peptide Fraction Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Inhibiting Inflammation via MAPK and NF-κB Signaling Pathways.

    Guo, Hengke / Li, Min / Liu, Hongmei

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Psoriasis, a chronic and immune-mediated inflammatory disease, adversely affects patients' lives. We previously prepared selenium-rich yeast peptide fraction (SeP) from selenium-rich yeast protein hydrolysate and found that SeP could effectively ... ...

    Abstract Psoriasis, a chronic and immune-mediated inflammatory disease, adversely affects patients' lives. We previously prepared selenium-rich yeast peptide fraction (SeP) from selenium-rich yeast protein hydrolysate and found that SeP could effectively alleviate ultraviolet radiation-induced skin damage in mice and inhibited H
    MeSH term(s) Animals ; Cell Line ; Dermatitis/drug therapy ; Dermatitis/metabolism ; Disease Models, Animal ; Female ; Humans ; Hydrogen Peroxide/pharmacology ; Imiquimod/pharmacology ; Inflammation/drug therapy ; Inflammation/metabolism ; Interleukin-17/metabolism ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Mice ; Mice, Inbred BALB C ; NF-kappa B/metabolism ; Peptides/pharmacology ; Psoriasis/chemically induced ; Psoriasis/drug therapy ; Psoriasis/metabolism ; RAW 264.7 Cells ; Selenium/pharmacology ; Signal Transduction/drug effects ; Skin/drug effects ; Skin/metabolism ; Yeasts/metabolism
    Chemical Substances Interleukin-17 ; NF-kappa B ; Peptides ; Hydrogen Peroxide (BBX060AN9V) ; Selenium (H6241UJ22B) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042112
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Antioxidant activity and inhibition of ultraviolet radiation-induced skin damage of Selenium-rich peptide fraction from selenium-rich yeast protein hydrolysate.

    Guo, Hengke / Guo, Siyu / Liu, Hongmei

    Bioorganic chemistry

    2020  Volume 105, Page(s) 104431

    Abstract: The bioactive peptides and trace element selenium (Se) both have good antioxidant activity. However, whether combined Se and bioactive peptides have more excellent antioxidant activity remain unknown. The aim of this study is to prepare a Se-rich peptide ...

    Abstract The bioactive peptides and trace element selenium (Se) both have good antioxidant activity. However, whether combined Se and bioactive peptides have more excellent antioxidant activity remain unknown. The aim of this study is to prepare a Se-rich peptide fraction containing both Se and peptides from Se-rich yeast protein hydrolysate and investigated its antioxidant activity and effect on ultraviolet B (UVB) radiation-induced skin oxidative damage. The peptide fractions with different molecular weight (MW) and Se content were obtained by enzymatically hydrolyzing normal or Se-rich yeast proteins followed by a filtration process. In vitro free radical scavenging and lipid peroxidation inhibition assays showed that Se-rich peptides fraction with lower MW of <1 kDa (sSeP) had the highest antioxidant activity compared with Se-rich peptide fractions with higher MW of <3 kDa or normal peptide fractions. Oral administration of sSeP significantly decreased the level of malonaldehyde (MDA) in liver and serum, and increased the activity of glutathione peroxidase (GPx) in liver and serum in normal mice. When topically applied on the dorsal skin of mice, sSeP effectively alleviate UVB radiation-induced skin damage and oxidative stress by increasing GPx and catalase activities and glutathione content in skin or serum. Furthermore, sSeP showed a protective effect against H
    MeSH term(s) Administration, Oral ; Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Benzothiazoles/antagonists & inhibitors ; Biphenyl Compounds/antagonists & inhibitors ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/pharmacology ; Mice ; Mice, Inbred Strains ; Molecular Structure ; Oxidative Stress/drug effects ; Peptides/administration & dosage ; Peptides/pharmacology ; Picrates/antagonists & inhibitors ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; Protein Hydrolysates/chemistry ; Protein Hydrolysates/metabolism ; Saccharomyces cerevisiae/chemistry ; Saccharomyces cerevisiae/metabolism ; Selenium/administration & dosage ; Selenium/pharmacology ; Skin/drug effects ; Skin/pathology ; Skin/radiation effects ; Structure-Activity Relationship ; Sulfonic Acids/antagonists & inhibitors ; Ultraviolet Rays
    Chemical Substances Antioxidants ; Benzothiazoles ; Biphenyl Compounds ; Peptides ; Picrates ; Protective Agents ; Protein Hydrolysates ; Sulfonic Acids ; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; Hydrogen Peroxide (BBX060AN9V) ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2020.104431
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Unraveling Intracellular Protein Corona Components of Nanoplastics via Photocatalytic Protein Proximity Labeling.

    Zhang, Zhenduo / Dong, Xuepeng / Wan, Wang / Guo, Hengke / Sun, Rui / Feng, Huan / Wang, Mengdie / Wang, Zhiming / Jin, Hao / Sun, Jialu / Xia, Qiuxuan / Zhao, Qi / Shen, Di / Gao, Zhenming / Liu, Yu

    Analytical chemistry

    2024  Volume 96, Issue 12, Page(s) 4978–4986

    Abstract: Bioaccumulation of nanoplastic particles has drawn increasing attention regarding environmental sustainability and biosafety. How nanoplastic particles interact with the cellular milieu still remains elusive. Herein, we exemplify a general approach to ... ...

    Abstract Bioaccumulation of nanoplastic particles has drawn increasing attention regarding environmental sustainability and biosafety. How nanoplastic particles interact with the cellular milieu still remains elusive. Herein, we exemplify a general approach to profile the composition of a "protein corona" interacting with nanoparticles via the photocatalytic protein proximity labeling method. To enable photocatalytic proximity labeling of the proteome interacting with particles, iodine-substituted BODIPY (I-BODIPY) is selected as the photosensitizer and covalently conjugated onto amino-polystyrene nanoparticles as a model system. Next, selective proximity labeling of interacting proteins is demonstrated using I-BODIPY-labeled nanoplastic particles in both
    MeSH term(s) Animals ; Mice ; Protein Corona ; Microplastics ; Proteome ; Proteomics ; Polystyrenes ; Nanoparticles ; Boron Compounds
    Chemical Substances 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Protein Corona ; Microplastics ; Proteome ; Polystyrenes ; Boron Compounds
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.4c00050
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication.

    Guo, Xiaozhen / Zhang, Mengjia / Zhang, Xiaoqian / Tan, Xin / Guo, Hengke / Zeng, Wei / Yan, Guokai / Memon, Atta Muhammad / Li, Zhonghua / Zhu, Yinxing / Zhang, Bingzhou / Ku, Xugang / Wu, Meizhou / Fan, Shengxian / He, Qigai

    Viruses

    2017  Volume 9, Issue 3

    Abstract: The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic ... ...

    Abstract The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic diarrhea virus (PEDV) infection has not been reported. In this study, autophagy was demonstrated to be triggered by the effective replication of PEDV through transmission electron microscopy, confocal microscopy, and Western blot analysis. Moreover, autophagy was confirmed to benefit PEDV replication by using autophagy regulators and RNA interference. Furthermore, autophagy might be associated with the expression of inflammatory cytokines and have a positive feedback loop with the NF-κB signaling pathway during PEDV infection. This work is the first attempt to explore the complex interplay between autophagy and PEDV infection. Our findings might accelerate our understanding of the pathogenesis of PEDV infection and provide new insights into the development of effective therapeutic strategies.
    MeSH term(s) Animals ; Autophagy ; Blotting, Western ; Cercopithecus aethiops ; Host-Pathogen Interactions ; Microscopy, Confocal ; Microscopy, Electron, Transmission ; Porcine epidemic diarrhea virus/physiology ; Vero Cells ; Virus Replication
    Keywords covid19
    Language English
    Publishing date 2017-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v9030053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top