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  1. Book ; Thesis: Comparative studies on the influence of the short-chain fatty acid butyrate on aortic endothelial cells

    Guo, Jiangang

    2023  

    Institution Westfälische Wilhelms-Universität Münster
    Author's details vorgelegt von Guo JianGang aus ShanDong, China
    Language English
    Size 83, 3 Blätter, Illustrationen
    Publishing place Münster
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Westfälische Wilhelms-Universität Münster, 2023
    HBZ-ID HT021861165
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 792 order for loan Magazin

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  2. Article ; Online: High-

    Chen, Zhaoxu / Yang, Yuxin / Ying, Tianping / Guo, Jian-Gang

    Nano letters

    2024  Volume 24, Issue 3, Page(s) 993–1000

    Abstract: Emergent phenomena in exfoliated layered transition metal compounds have attracted much attention in the past several years. Especially, pursuing a ferromagnetic insulator is one of the exciting goals for stimulating a high-performance magnetoelectrical ... ...

    Abstract Emergent phenomena in exfoliated layered transition metal compounds have attracted much attention in the past several years. Especially, pursuing a ferromagnetic insulator is one of the exciting goals for stimulating a high-performance magnetoelectrical device. Here, we report the transition from a metallic to high-
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c04462
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  3. Article ; Online: Modeling of spatial stratified heterogeneity

    Guo, Jiangang / Wang, Jinfeng / Xu, Chengdong / Song, Yongze

    GIScience & Remote Sensing. 2022 Dec. 31, v. 59, no. 1 p.1660-1677

    2022  

    Abstract: Spatial stratified heterogeneity (SSH) refers to the geographical phenomena in which the geographical attributes within-strata are more similar than the between-strata, which is ubiquitous in the real world and offers information implying the causation ... ...

    Abstract Spatial stratified heterogeneity (SSH) refers to the geographical phenomena in which the geographical attributes within-strata are more similar than the between-strata, which is ubiquitous in the real world and offers information implying the causation of nature. Stratification, a primary approach to SSH, generates strata using a priori knowledge or thousands of supervised and unsupervised learning methods. Selecting reasonable stratification methods for spatial analysis in specific domains without prior knowledge is challenging because no method is optimal in a general sense. However, a systematic review of a large number of stratification methods is still lacking. In this article, we review the methods for stratification, categorize the existing typical stratification methods into four classes – univariate stratification, cluster-based stratification, multicriteria stratification, and supervised stratification – and construct their taxonomy. Finally, we present a summary of the software and tools used to compare and perform stratification methods. Given that different stratification methods reflect distinct human understandings of spatial distributions and associations, we suggest that further studies are needed to reveal the nature of geographical attributes by integrating SSH, advanced algorithms, and interdisciplinary methods.
    Keywords computer software ; humans ; systematic review ; taxonomy ; Spatial stratified heterogeneity ; stratification ; cluster analysis ; spatial statistics ; geographical detector
    Language English
    Dates of publication 2022-1231
    Size p. 1660-1677.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2209042-3
    ISSN 1943-7226 ; 1548-1603
    ISSN (online) 1943-7226
    ISSN 1548-1603
    DOI 10.1080/15481603.2022.2126375
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  4. Article: The short-chain fatty acid butyrate exerts a specific effect on VE-cadherin phosphorylation and alters the integrity of aortic endothelial cells.

    Guo, Jiangang / Terhorst, Inka / Stammer, Paul / Ibrahim, Abdulhakim / Oberhuber, Alexander / Eierhoff, Thorsten

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1076250

    Abstract: Short-chain fatty acids (SCFAs) like butyrate (BUT) largely influence vascular integrity and are closely associated with the onset and progression of cardiovascular diseases. However, their impact on vascular endothelial cadherin (VEC), a major vascular ... ...

    Abstract Short-chain fatty acids (SCFAs) like butyrate (BUT) largely influence vascular integrity and are closely associated with the onset and progression of cardiovascular diseases. However, their impact on vascular endothelial cadherin (VEC), a major vascular adhesion and signaling molecule, is largely unknown. Here, we explored the effect of the SCFA BUT on the phosphorylation of specific tyrosine residues of VEC (Y731, Y685, and Y658), which are reported to be critical for VEC regulation and vascular integrity. Moreover, we shed light on the signaling pathway engaged by BUT to affect the phosphorylation of VEC. Thereby, we used phospho-specific antibodies to evaluate the phosphorylation of VEC in response to the SCFA sodium butyrate in human aortic endothelial cells (HAOECs) and performed dextran assays to analyze the permeability of the EC monolayer. The role of c-Src and SCFA receptors FFAR2 and FFAR3 in the induction of VEC phosphorylation was analyzed using inhibitors and antagonists for c-Src family kinases and FFAR2/3, respectively, as well as by RNAi-mediated knockdown. Localization of VEC in response to BUT was assessed by fluorescence microscopy. BUT treatment of HAOEC resulted in the specific phosphorylation of Y731 at VEC with minor effects on Y685 and Y658. Thereby, BUT engages FFAR3, FFAR2, and c-Src kinase to induce phosphorylation of VEC. VEC phosphorylation correlated with enhanced endothelial permeability and c-Src-dependent remodeling of junctional VEC. Our data suggest that BUT, an SCFA and gut microbiota-derived metabolite, impacts vascular integrity by targeting VEC phosphorylation with potential impact on the pathophysiology and therapy of vascular diseases.
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1076250
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  5. Article: Numerical Investigation of the Fracture Properties of Pre-Cracked Monocrystalline/Polycrystalline Graphene Sheets.

    Li, Xinliang / Guo, Jiangang

    Materials (Basel, Switzerland)

    2019  Volume 12, Issue 2

    Abstract: The fracture properties of pre-cracked monocrystalline/polycrystalline graphene were investigated via a finite element method based on molecular structure mechanics, and the mode I critical stress intensity factor (SIF) was calculated by the Griffith ... ...

    Abstract The fracture properties of pre-cracked monocrystalline/polycrystalline graphene were investigated via a finite element method based on molecular structure mechanics, and the mode I critical stress intensity factor (SIF) was calculated by the Griffith criterion in classical fracture mechanics. For monocrystalline graphene, the size effects of mode I fracture toughness and the influence of crack width on the mode I fracture toughness were investigated. Moreover, it was found that the ratio of crack length to graphene width has a significant influence on the mode I fracture toughness. For polycrystalline graphene, the strain energy per unit area at different positions was calculated, and the initial fracture site (near grain boundary) was deduced from the variation tendency of the strain energy per unit area. In addition, the effects of misorientation angle of the grain boundary (GB) and the distance between the crack tip and GB on mode I fracture toughness were also analyzed. It was found that the mode I fracture toughness increases with increasing misorientation angle. As the distance between the crack tip and GB increases, the mode I fracture toughness first decreases and then tends to stabilize.
    Language English
    Publishing date 2019-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma12020263
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  6. Article: Molecular Oxygen-Induced Ferromagnetism and Half-Metallicity in α-BaNaO₄: A First-Principles Study

    Deng, Jun / Guo, Jiangang / Chen, Xiaolong

    Journal of the American Chemical Society. 2020 Feb. 21, v. 142, no. 11

    2020  

    Abstract: Molecular oxygen resembles 3d and 4f metals in exhibiting long-range spin ordering and strong electron correlation behaviors in compounds. Ferromagnetic spin ordering and half-metallicity, however, are quite elusive and have not been well acknowledged. ... ...

    Abstract Molecular oxygen resembles 3d and 4f metals in exhibiting long-range spin ordering and strong electron correlation behaviors in compounds. Ferromagnetic spin ordering and half-metallicity, however, are quite elusive and have not been well acknowledged. In this Article, we address this issue by studying how spins will interact with each other if the oxygen dimers are arranged in a different way from that in the known superoxides and peroxides by first-principles calculations. Based on the results of a structure search, thermodynamic studies, and lattice dynamics, we show that tetragonal α-BaNaO₄ is a stable half-metal with a Curie temperature at 120 K, the first example in this class of compounds. Like 3d and 4f metals, the O₂ dimer carries a local magnetic moment of 0.5 μB due to the unpaired electrons in its π* orbitals. This compound can be regarded as forming from the O₂ dimer layers stacking in a head-to-head way. In contrast to the arrangement in AO₂ (A = K, Rb, Cs), the spins are ferromagnetically coupled both within and between the layers. Spin polarization occurs in π* orbitals, with spin-up electrons fully occupying the valence band and spin-down electrons partially occupying the conduction band, forming semiconducting and metallic channels, respectively. Our results highlight the importance of geometric arrangement of O₂ dimers in inducing ferromagnetism and other novel properties in O₂-dimer-containing compounds.
    Keywords cesium ; electrons ; ferromagnetism ; geometry ; oxygen ; peroxides ; potassium ; rubidium ; semiconductors ; superoxide anion ; temperature ; thermodynamics
    Language English
    Dates of publication 2020-0221
    Size p. 5234-5240.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b13295
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  7. Article ; Online: Molecular Oxygen-Induced Ferromagnetism and Half-Metallicity in α-BaNaO

    Deng, Jun / Guo, Jiangang / Chen, Xiaolong

    Journal of the American Chemical Society

    2020  Volume 142, Issue 11, Page(s) 5234–5240

    Abstract: Molecular oxygen resembles ... ...

    Abstract Molecular oxygen resembles 3
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b13295
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  8. Article ; Online: Delicate superconductivity in nodal-line NaAlGe single crystal.

    Chen, Zhaoxu / Yang, Yuxin / Deng, Jun / Du, Shixuan / Ying, Tianping / Guo, Jiangang / Chen, Xiaolong

    Journal of physics. Condensed matter : an Institute of Physics journal

    2022  Volume 34, Issue 49

    Abstract: Nodal-line superconductor NaAlSi with a transition temperature (Tc) of 7 K has attracted considerable attention in recent years, whereas its Ge counterpart, NaAlGe, does not superconduct down to the lowest temperature regardless of their similar atomic ... ...

    Abstract Nodal-line superconductor NaAlSi with a transition temperature (Tc) of 7 K has attracted considerable attention in recent years, whereas its Ge counterpart, NaAlGe, does not superconduct down to the lowest temperature regardless of their similar atomic and electrical structures. To tackle this enigma, we resort to the growth of NaAlGe single crystal and characterize its ground state. Interestingly, when hole doped by oxidation or extracting Na, single-crystalline NaAlGe transforms from a semimetal/semiconductor to a superconductor (Tc=1.8∼3.3 K) with zero resistivity and a diamagnetic shielding fraction over 100%, but without a thermodynamic response in heat capacity. Continuous x-ray diffraction reveals a transient new structure with a larger
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ac9adf
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  9. Article ; Online: CFD simulation study on wind load of perforated traffic sign board.

    Xu, Jinqiang / Xu, Hai / Zeng, Chenghong / Xie, Chengguang / Guo, Jiangang

    PloS one

    2020  Volume 15, Issue 10, Page(s) e0240927

    Abstract: Traffic sign boards are often blown away by strong winds, seriously endangering the safety of vehicles and pedestrians. To increase their resistance to strong winds, sign boards are perforated. Using computational fluid dynamics simulations, the wind ... ...

    Abstract Traffic sign boards are often blown away by strong winds, seriously endangering the safety of vehicles and pedestrians. To increase their resistance to strong winds, sign boards are perforated. Using computational fluid dynamics simulations, the wind load resistance of traffic signs with holes was optimised. By comparing the solutions to different turbulence models with empirical results, it was found that the simulation results of the re-normalisation group (RNG) model have the smallest error. Therefore, the RNG model is used to simulate the wind load of traffic sign boards with different perforation diameters and different hole spacings under different wind speeds. By analysing the wind pressure distribution on the surface of the perforated traffic sign board, the perforation scheme for different regions of the sign board under different wind loads was obtained. The results show that reasonable perforation diameters and hole spacings can reduce the wind load and improve the wind load resistance of sign boards. This study provides decision-makers with useful information for installing traffic signs in areas affected with strong winds, thereby improving the wind resistance of traffic signs and ensuring traffic safety.
    MeSH term(s) Automobiles ; Computer Simulation ; Environmental Monitoring/methods ; Humans ; Hydrodynamics ; Models, Theoretical ; Pedestrians ; Wind
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0240927
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  10. Article ; Online: A comparison of the vancomycin calcium sulfate implantation versus fenestration decompression for the treatment of sclerosing osteomyelitis.

    Hua, Haotian / Wang, Xinwei / Guo, Jiangang / Zhang, Lei / Guo, Zairan / Chen, Jiangfei

    BMC musculoskeletal disorders

    2021  Volume 22, Issue 1, Page(s) 993

    Abstract: Objective: To compare the clinical efficacy of vancomycin calcium sulfate implantation and fenestration decompression in the treatment of sclerosing osteomyelitis.: Method: A retrospective analysis for 46 cases of sclerosing osteomyelitis were ... ...

    Abstract Objective: To compare the clinical efficacy of vancomycin calcium sulfate implantation and fenestration decompression in the treatment of sclerosing osteomyelitis.
    Method: A retrospective analysis for 46 cases of sclerosing osteomyelitis were admitted to our department between June 2010 to June 2020. Twenty-one patients were treated with fenestration decompression, twenty-five patients were treated with vancomycin calcium sulfate implantation. The postoperative hospital stay, days of drainage tube placement, visual analogue scale scores, C-reactive protein and erythrocyte sedimentation rate were compared between the two groups.
    Results: The visual analogue scale scores of both groups were significantly lower than before treatment (p < 0.05), but the difference between them was not statistically significant. Patients treated by vancomycin calcium sulfate implantation had shorter postoperative hospital stay and days of drainage tube placement compared to those treated by fenestration decompression (p < 0.05). C-reactive protein and erythrocyte sedimentation rate in both groups were significantly lower than before treatment, but the improvement effect of vancomycin calcium sulfate implantation was better (p < 0.05).
    Conclusion: Both treatment methods can relieve pain effectively. Compared with fenestration decompression, vancomycin calcium sulfate implantation can shorten the treatment time effectively, control the infection better.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Calcium ; Calcium Sulfate ; Decompression ; Humans ; Osteomyelitis/drug therapy ; Osteomyelitis/surgery ; Retrospective Studies ; Treatment Outcome ; Vancomycin
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; Calcium (SY7Q814VUP) ; Calcium Sulfate (WAT0DDB505)
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Journal Article
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/s12891-021-04881-7
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