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Article ; Online: Self-regulated reversal deformation and locomotion of structurally homogenous hydrogels subjected to constant light illumination.

Guo, Kexin / Yang, Xuehan / Zhou, Chao / Li, Chuang

2024 Volume 15, Issue 1, Page(s) 1694

Abstract: Environmentally adaptive hydrogels that are capable of reconfiguration in response to external stimuli have shown great potential toward bioinspired actuation and soft robotics. Previous efforts have focused mainly on either the sophisticated design of ... ...

Abstract	Environmentally adaptive hydrogels that are capable of reconfiguration in response to external stimuli have shown great potential toward bioinspired actuation and soft robotics. Previous efforts have focused mainly on either the sophisticated design of heterogeneously structured hydrogels or the complex manipulation of external stimuli, and achieving self-regulated reversal shape deformation in homogenous hydrogels under a constant stimulus has been challenging. Here, we report the molecular design of structurally homogenous hydrogels containing simultaneously two spiropyrans that exhibit self-regulated transient deformation reversal when subjected to constant illumination. The deformation reversal mechanism originates from the molecular sequential descending-ascending charge variation of two coexisting spiropyrans upon irradiation, resulting in a macroscale volumetric contraction-expansion of the hydrogels. Hydrogel film actuators were developed to display complex temporary bidirectional shape transformations and self-regulated reversal rolling under constant illumination. Our work represents an innovative strategy for programming complex shape transformations of homogeneous hydrogels using a single constant stimulus.
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46100-6
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Article ; Online: A Bio-Inspired Safety Control System for UAVs in Confined Environment With Disturbance.

Guo, Kexin / Liu, Cai / Zhang, Xiao / Yu, Xiang / Zhang, Youmin / Xie, Lihua / Guo, Lei

IEEE transactions on cybernetics

2024 Volume 54, Issue 2, Page(s) 1308–1320

Abstract: This article presents a bio-inspired safety control scheme for unmanned aerial vehicles (UAVs) in confined environments with disturbance. Although there has been some existing research on the effect of disturbance for a single UAV, multi-UAV formation ... ...

Abstract	This article presents a bio-inspired safety control scheme for unmanned aerial vehicles (UAVs) in confined environments with disturbance. Although there has been some existing research on the effect of disturbance for a single UAV, multi-UAV formation under external wind disturbances remains challenging, especially in a tight and confined environment. Inspired by nature, this study concentrates on an anti-disturbance mechanism for safe multi-UAV formation in a tight environment. The presented safety control system combines disturbance observer-based control (DOBC), bionic formation switching (BFS) strategy, and safety evaluation. Two safety issues are considered in this article. For a single UAV, the estimated disturbance is compensated in the inner-loop controller. While for multi-UAV formation, the BFS strategy attenuates the effect of external wind disturbance leveraging the formation configuration. The so-called group perturbation immune factor (GPIF) is designed to analyze and evaluate the safety of the overall formation. The experimental results validate the comprehensiveness and anti-disturbance capability of the system.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2022.3217982
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Article ; Online: Compound heterozygous ABCA12 variants identified in a Chinese patient with congenital ichthyosiform erythroderma: Advancing genotype-phenotype correlations and literature review.

Liu, Jia-Wei / Guo, Kexin / Zhang, Rui / Wang, Rongrong / Ma, Dong-Lai / Zhang, Xue

Molecular genetics & genomic medicine

2024 Volume 12, Issue 5, Page(s) e2431

Abstract: Background: Ichthyosis is a common keratotic skin disease with high clinical, etiological and genetic heterogeneity. There are four types of non-syndromic hereditary ichthyoses, among which autosomal recessive congenital ichthyosis (ARCI) is a ... ...

Abstract	Background: Ichthyosis is a common keratotic skin disease with high clinical, etiological and genetic heterogeneity. There are four types of non-syndromic hereditary ichthyoses, among which autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of recessive Mendelian disorders. ARCI present with different phenotypes and ABCA12 pathogenic variants have been shown to cause complex ARCI phenotypes, including harlequin ichthyosis (HI), lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE). Methods: A sporadic male patient, clinically diagnosed with CIE, was enrolled in this study. Exome sequencing was combined with Sanger sequencing to confirm the diagnosis and identify the pathogenic variants. In silico predictions were made using multiple software programs, and the identified variants were interpreted using the ACMG guidelines. A review of all literature reported ABCA12 variants was performed to explore genotype-phenotype correlations. Results: Compound heterozygous ABCA12 variants [c.5381+1G>A and c.5485G>C (p.Asp1829His)] (NM_173076) were identified. The two variants were not detected in the public database. c.5381+1G>A is predicted to affect ABCA12 mRNA splicing and Asp1829 is highly conserved among various species. In silico analysis suggested that these two variants were responsible for the phenotype of the patient. Genotype-phenotype correlation analysis showed that biallelic truncation variants and/or exon/amino acid deletions in ABCA12 are the most common causes of HI. Biallelic missense variants are most common in LI and CIE. Conclusions: The compound heterozygous ABCA12 variants caused the CIE phenotype observed in the patient. The spectrum of ABCA12 pathogenic variants were broaden. Genotype-phenotype correlation analysis provided detailed evidence which can be used in future prenatal diagnosis and can inform the need for genetic counselling for patients with ABCA12-related ARCIs.
MeSH term(s)	Humans ; Male ; ATP-Binding Cassette Transporters/genetics ; Ichthyosiform Erythroderma, Congenital/genetics ; Ichthyosiform Erythroderma, Congenital/pathology ; Heterozygote ; Phenotype ; Mutation ; Mutation, Missense ; Genetic Association Studies ; East Asian People
Chemical Substances	ABCA12 protein, human ; ATP-Binding Cassette Transporters
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article ; Case Reports ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.2431
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Article ; Online: Dehydration-induced corrugated folding in

Guo, Kexin / Liu, Mingchao / Vella, Dominic / Suresh, Subra / Hsia, K Jimmy

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 17, Page(s) e2320259121

Abstract: Plant leaves, whose remarkable ability for morphogenesis results in a wide range of petal and leaf shapes in response to environmental cues, have inspired scientific studies as well as the development of engineering structures and devices. Although some ... ...

Abstract	Plant leaves, whose remarkable ability for morphogenesis results in a wide range of petal and leaf shapes in response to environmental cues, have inspired scientific studies as well as the development of engineering structures and devices. Although some typical shape changes in plants and the driving force for such shape evolution have been extensively studied, there remain many poorly understood mechanisms, characteristics, and principles associated with the vast array of shape formation of plant leaves in nature. Here, we present a comprehensive study that combines experiment, theory, and numerical simulations of one such topic-the mechanics and mechanisms of corrugated leaf folding induced by differential shrinking in
MeSH term(s)	Dehydration ; Plant Leaves ; Water/physiology ; Plants ; Arecaceae
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2320259121
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Article ; Online: E. urophylla × E. grandis high-quality genome and comparative genomics provide insights on evolution and diversification of eucalyptus.

Shen, Chao / Li, Limei / Ouyang, Lejun / Su, Min / Guo, Kexin

BMC genomics

2023 Volume 24, Issue 1, Page(s) 223

Abstract: Background: Eucalyptus urophylla × Eucalyptus grandis, an economically important forest tree, provides important raw material for energy and reduces damage to native forests. However, the absence of a high-quality E. urophylla × E. grandis reference ... ...

Abstract	Background: Eucalyptus urophylla × Eucalyptus grandis, an economically important forest tree, provides important raw material for energy and reduces damage to native forests. However, the absence of a high-quality E. urophylla × E. grandis reference genome has significantly hindered its evolution and genetic analysis. Results: We successfully presented a high-quality reference genome of E. urophylla × E. grandis (545.75 Mb; scaffold N50, 51.62 Mb) using a combination of the Illumina, PacBio HiFi, and Hi-C sequencing platforms. A total of 34,502 genes and 58.56% of the repetitive sequences in this genome were annotated. Using genome evolution analyses, we identified a recent whole-genome duplication (WGD) event in E. urophylla × E. grandis. We further found that gene families associated with starch and sucrose metabolism, flavonoid biosynthesis, and plant-pathogen interaction were significantly expanded in E. urophylla × E. grandis. Moreover, comparative genomic and evolutionary analyses showed large structural variations among the different chromosomes of the 34 Eucalyptus accessions, which were divided into six clades. Conclusions: Overall, our findings provide a valuable resource for expanding our understanding of the E. urophylla × E. grandis genome evolution, genetic improvement, and its comparative biology.
MeSH term(s)	Eucalyptus/genetics ; Genomics ; Genome, Plant
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09318-0
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Article ; Online: Identification of the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria

YANG Xueting / GUO Kexin / SUN Yang / WANG Rongrong / MA Donglai / ZHANG Xue

Jichu yixue yu linchuang, Vol 43, Iss 2, Pp 259-

2023 Volume 264

Abstract: Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH). Methods Clinical information and peripheral blood samples from three trio families with DSH ... ...

Abstract	Objective To analyze the clinical features and to identify the pathogenic variants in three Chinese families with dyschromatosis symmetrica hereditaria (DSH). Methods Clinical information and peripheral blood samples from three trio families with DSH were collected. The variants were detected by whole exome sequencing and then confirmed by Sanger sequencing. Pathogenicity of the variants was evaluated with a series of bioinformatic software. Results All the probands from the three Chinese families showed a mixture of pigmented and depigmented macules on the extremities. Three heterozygote single-nucleotide-variants, c.3546T＞G (p.Tyr1182*), c.2770T＞G (p.Tyr924Asp) and c.3116A＞C (p.Lys1039Thr), in the ADAR(NM_001111.5) gene were detected by WES in the three probands respectively. The first two variants were not present in the public databases such as gnomAD and HGMD, and the third one was previously reported in HGMD but not presented in the public databases. The relevant variants were undetectable in their parents of the three probands shown by Sanger sequencing, and were consequently regarded as de novo variants. These variants located in the highly conservative sites, all of which were located in the double-stranded RNA adenosine deaminase domain of the protein encoded by ADAR. According to the American College of Medical Genetics and Genomics (ACMG) guidelines, the nonsense variant, c.3546T＞G in ADAR, was categorized as a pathogenic variant (PVS1+PS2+PM2+PP3+PP4) and the missense variants, c.2770T＞G and c.3116A＞C in ADAR, were categorized as pathogenic variants (PS2+PM1+PM2+PP3+PP4) and (PS1+PS2+PM1+PM2+PP3+PP4), respectively. Conclusions Three de novo variants in ADAR, c.3546T＞G, c.2770T＞G and c.3116A＞C are probably the genetic pathogenesis of DSH in these three probands respectively, which enriched the genetic profile of ADAR.
Keywords	dyschromatosis symmetrica hereditarian\|whole exome sequencing\|adar\|de novo variants ; Medicine ; R
Subject code	630
Language	Chinese
Publishing date	2023-02-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Establishment and application of soil hydraulic erosion model based on GIS and USLE model

Guo Ke-xin / Cao Ying-xian

E3S Web of Conferences, Vol 257, p

2021 Volume 03056

Abstract: Soil erosion is the most common form of soil degradation, which is the main problem of soil environmental destruction worldwide. Based on the USLE and GIS remote sensing inversion and superposition analysis technology, this study simulated and calculated ...

Abstract	Soil erosion is the most common form of soil degradation, which is the main problem of soil environmental destruction worldwide. Based on the USLE and GIS remote sensing inversion and superposition analysis technology, this study simulated and calculated soil hydraulic erosion in Fangshan World Geological Park, China in 2011, 2012 and 2013, analyzed its spatial-temporal dynamic changes, and explored the key points of soil erosion control in the study area. The results show that (1) The main erosion occurred at 25°-35° steep slope and 400-800m height, which accounted for more than 30% of the total soil erosion in all the three years. (2) The average erosion modulus and erosion amount in 2012 were significant higher than that in 2011 and 2013 at each slope grade, shown that the soil erosion of 2012 is influenced by natural disaster.With the increase of slope grade, the average modulus also increased.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk Assessment of China Rapeseed Supply Chain and Policy Suggestions.

Li, Fujia / Guo, Kexin / Liao, Xiaoyong

International journal of environmental research and public health

2022 Volume 20, Issue 1

Abstract: Rapeseed, as the most important oil crop in the world, not only affects national food security but also affects energy security and environmental security. It is very important to conduct a risk assessment of China's rapeseed supply chain and put forward ...

Abstract	Rapeseed, as the most important oil crop in the world, not only affects national food security but also affects energy security and environmental security. It is very important to conduct a risk assessment of China's rapeseed supply chain and put forward suggestions to construct a safe, effective, and accessible supply chain. In order to accurately evaluate the safety of the rapeseed supply chain from 2010 to 2020, we applied fuzzy multiconnection theory and analytic hierarchy process model (AHP). A comprehensive risk assessment model for the rapeseed supply chain with two primary indicators and 10 secondary indicators was constructed. By establishing the rapeseed risk evaluation model, we quantitatively analyzed the risk of China's rapeseed supply chain. The domestic risk of production is still high, and the international risk under the high import dependence is alarming. We put forward risk prevention and countermeasures for China's rapeseed supply chain. The results show that China has a large demand for rapeseed products, but the increase in China production is limited and the import from other countries is unstable. The proposed suggestions are designed to optimize and enhance the stability of the rapeseed product's supply chain. It is recommended to continue to consolidate and deepen the cooperation with traditional trading partners such as Germany, Spain, the United States, and Brazil; expand other import sources to build a more diversified and efficient rapeseed product import network and extend the supply chain of rapeseed products. This research can be a basis for making decisions for promoting the sustainable and efficient development of the rapeseed supply chain.
MeSH term(s)	Brassica napus ; China ; Policy ; Risk Assessment/methods ; Brazil
Language	English
Publishing date	2022-12-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010465
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Article ; Online: Safety Flight Control Design of a Quadrotor UAV With Capability Analysis.

Zhou, Xiaobin / Yu, Xiang / Guo, Kexin / Zhou, Sicheng / Guo, Lei / Zhang, Youmin / Peng, Xiaoyan

IEEE transactions on cybernetics

2023 Volume 53, Issue 3, Page(s) 1738–1751

Abstract: This article considers the safety control problem of a quadrotor unmanned aerial vehicle (UAV) subject to actuator faults and external disturbances, based on the quantization of system capability and safety margin. First, a trajectory function is ... ...

Abstract	This article considers the safety control problem of a quadrotor unmanned aerial vehicle (UAV) subject to actuator faults and external disturbances, based on the quantization of system capability and safety margin. First, a trajectory function is constructed online with backpropagation of system dynamics. Therefore, a degraded trajectory is gracefully regenerated, via the tradeoff between the remaining system capability and the expected derivatives (velocity, jerk, and snap) of the trajectory. Second, a control-oriented model is established into a form of strict feedback, integrating actuator malfunctions and disturbances. Therefore, a retrofit dynamic surface control (DSC) scheme based on the control-oriented model is developed to improve the tracking performance. When comparing to the existing control methods, the compensation ability is analyzed to determine whether the faults and disturbances can be handled or not. Finally, simulation and experimental studies are conducted to highlight the efficiency of the proposed safety control scheme.
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2021.3113168
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Article ; Online: Genetic and phenotypic heterogeneity of multiple lentigines and precise diagnosis in four Chinese families with multiple lentigines.

Guo, Kexin / Liu, Jia-Wei / Zhang, Rui / Wang, Rongrong / Ma, Dong-Lai / Zhang, Xue

Pigment cell & melanoma research

2023 Volume 36, Issue 3-4, Page(s) 288–298

Abstract: Lentigines are well-defined, small, brown macules resulting from the accumulation of melanin content in the basement membrane zone with an increase in the number of melanocytes. Hereditary multiple lentigines (ML) can be associated with multiple genes ... ...

Abstract	Lentigines are well-defined, small, brown macules resulting from the accumulation of melanin content in the basement membrane zone with an increase in the number of melanocytes. Hereditary multiple lentigines (ML) can be associated with multiple genes and are not commonly encountered in clinical practice. Patients can solely have skin involvement or present with multisystemic deformative phenotypes. This study aimed to describe four unrelated Chinese families presenting with ML as their first visit symptom. We performed whole-exome sequencing (WES) and Sanger sequencing on all patients and immediate family members for precise molecular diagnosis. Two novel variants c.1548 T > A (p.Ser516Arg) and c.1811C > A (p.Thr604Lys) in SASH1, and two recurrent variants c.1403C > T (p.Thr468Met) and c.1493G > T (p.Arg498Leu) in PTPN11, were identified in these four families. We also summarized the genes associated with ML and differential diagnosis of pigment abnormality. We suggested that the molecular diagnosis of ML should be emphasized because it can help in the clinical differential diagnosis and further genetic counseling and prognosis.
MeSH term(s)	Humans ; East Asian People ; Lentigo/diagnosis ; Lentigo/genetics ; Melanocytes ; Mutation ; Phenotype ; Syndrome
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2409570-9
ISSN	1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
ISSN (online)	1755-148X ; 1600-0749
ISSN	0893-5785 ; 1755-1471
DOI	10.1111/pcmr.13086
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