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  1. Book ; Online ; E-Book: Neural Interface Engineering

    Guo, Liang

    Linking the Physical World and the Nervous System

    2020  

    Abstract: This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic ... ...

    Author's details edited by Liang Guo
    Abstract This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.
    Keywords Electronic circuits ; Biomedical engineering ; Nanotechnology ; Circuits and Systems ; Biomedical Engineering and Bioengineering ; Nanotechnology and Microengineering
    Subject code 612.80285
    Language English
    Size 1 online resource (436 pages)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-41854-5 ; 3-030-41853-7 ; 978-3-030-41854-0 ; 978-3-030-41853-3
    DOI 10.1007/978-3-030-41854-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Advances in toxicology and risk assessment of nanomaterials and emerging contaminants

    Guo, Liang-Hong / Mortimer, Monika

    2022  

    Author's details Liang-Hong Guo, Monika Mortimer editors
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiii, 371 Seitgen), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021296903
    ISBN 978-981-16-9116-4 ; 9789811691157 ; 981-16-9116-9 ; 9811691150
    DOI 10.1007/978-981-16-9116-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Controversies in Radiation Oncology

    Lo, Simon S. / Teh, Bin S. / Jiang, Guo-Liang / Mayr, Nina A.

    (Radiation Oncology)

    2020  

    Abstract: This book addresses key issues of controversy in radiation oncology for each disease site, with expert commentaries from leading authorities in the field. It identifies areas of confusion arising from discrepant data in the literature regarding certain ... ...

    Author's details edited by Simon S. Lo, Bin S. Teh, Guo-Liang Jiang, Nina A. Mayr
    Series title Radiation Oncology
    Abstract This book addresses key issues of controversy in radiation oncology for each disease site, with expert commentaries from leading authorities in the field. It identifies areas of confusion arising from discrepant data in the literature regarding certain clinical scenarios for different diseases and presents high-level evidence on each issue with a view to fostering best practice. Controversies in Radiation Oncology will serve as a very useful resource for busy radiation oncology physicians, practitioners, and trainees/residents/fellows seeking to utilize evidence in the literature to guide the management of radiation therapy patients.
    Keywords Radiotherapy ; Oncology   ; Oncology
    Subject code 616.9940642
    Language English
    Size 1 online resource (VI, 298 p. 20 illus., 13 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-319-51196-3 ; 3-319-51194-7 ; 978-3-319-51196-2 ; 978-3-319-51194-8
    DOI 10.1007/978-3-319-51196-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Laparoscopic hepatopancreaticoduodenectomy for synchronous gallbladder cancer and extrahepatic cholangiocarcinoma: a case report.

    Yao, Guo-Liang

    World journal of surgical oncology

    2022  Volume 20, Issue 1, Page(s) 190

    Abstract: Background: Hepatopancreaticoduodenectomy (HPD) is one of the most complex procedures, and it is very rarely reported. Laparoscopic HPD (LHPD) is even rarer. To date, there are only 3 reports of LHPD for locally advanced gallbladder cancer (GBC) or ... ...

    Abstract Background: Hepatopancreaticoduodenectomy (HPD) is one of the most complex procedures, and it is very rarely reported. Laparoscopic HPD (LHPD) is even rarer. To date, there are only 3 reports of LHPD for locally advanced gallbladder cancer (GBC) or extrahepatic cholangiocarcinoma (ECC). This is the first report of LHPD for synchronous GBC and ECC.
    Case presentation: A 75-year-old female patient complained of jaundice for 2 weeks without fever or abdominal pain. She was diagnosed with synchronous GBC and ECC. After a comprehensive preparation, she underwent a laparoscopic pancreaticoduodenectomy and resection of hepatic segments of IVb and V, and her digestive tract reconstruction followed Child's methods. She was discharged on the 12th day postoperatively without pancreatic leakage, biliary leakage, or liver failure.
    Conclusions: LHPD is safe and feasible for selected cases of GBCs or ECCs.
    MeSH term(s) Aged ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/pathology ; Carcinoma in Situ/pathology ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/surgery ; Female ; Gallbladder Neoplasms/pathology ; Gallbladder Neoplasms/surgery ; Hepatectomy/methods ; Humans ; Laparoscopy/methods
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-022-02628-9
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  5. Article ; Online: The role of Sirtuin 2 in liver - An extensive and complex biological process.

    Li, Shan / Guo, Liang

    Life sciences

    2024  Volume 339, Page(s) 122431

    Abstract: Liver disease has become one of the main causes of health issue worldwide. Sirtuin (Sirt) 2 is a nicotinamide adenine dinucleotide ( ... ...

    Abstract Liver disease has become one of the main causes of health issue worldwide. Sirtuin (Sirt) 2 is a nicotinamide adenine dinucleotide (NAD
    MeSH term(s) Humans ; Sirtuin 2/metabolism ; Oxidative Stress ; Non-alcoholic Fatty Liver Disease ; Hepatitis B
    Chemical Substances Sirtuin 2 (EC 3.5.1.-)
    Language English
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2024.122431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism.

    Li, Ruo-Ying / Guo, Liang

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Diabetic nephropathy (DN) is a serious complication of diabetes, and its progression is influenced by factors like oxidative stress, inflammation, cell death, and fibrosis. Compared to drug treatment, exercise offers a cost-effective and low-risk ... ...

    Abstract Diabetic nephropathy (DN) is a serious complication of diabetes, and its progression is influenced by factors like oxidative stress, inflammation, cell death, and fibrosis. Compared to drug treatment, exercise offers a cost-effective and low-risk approach to slowing down DN progression. Through multiple ways and mechanisms, exercise helps to control blood sugar and blood pressure and reduce serum creatinine and albuminuria, thereby alleviating kidney damage. This review explores the beneficial effects of exercise on DN improvement and highlights its potential mechanisms for ameliorating DN. In-depth understanding of the role and mechanism of exercise in improving DN would pave the way for formulating safe and effective exercise programs for the treatment and prevention of DN.
    MeSH term(s) Humans ; Diabetic Nephropathies/prevention & control ; Albuminuria ; Blood Glucose ; Blood Pressure ; Cell Death ; Diabetes Mellitus
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073605
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  7. Article ; Online: Principles of functional neural mapping using an intracortical ultra-density microelectrode array (ultra-density MEA).

    Guo, Liang

    Journal of neural engineering

    2020  Volume 17, Issue 3, Page(s) 36018

    Abstract: Objective: Intracortical electrical neural recording using solid-state electrodes is a prevalent approach in addressing neurophysiological queries and implementing brain-computer interfacing systems. As a variety of ultra-density microelectrode arrays ( ... ...

    Abstract Objective: Intracortical electrical neural recording using solid-state electrodes is a prevalent approach in addressing neurophysiological queries and implementing brain-computer interfacing systems. As a variety of ultra-density microelectrode arrays (ultra-density MEAs) are being created more recently, this paper answers to the rising demand for a more rigorous theory concerning this new type of neural electrode technology, both to guide the proper design and to inform the proper usage.
    Approach: This design and use problem of ultra-density MEAs for functional intracortical neuronal circuit mapping is approached from a signal analysis perspective. Starting with quantitative derivations of key basic concepts, the concept of ultra-density MEA is defined in the context for fully resolving the voltage sources within its view volume. Then, the principle of using such an ultra-density MEA for functional neural mapping is elaborated, and a recursive approach to completely resolve all voltage sources from the ultra-density MEA's recordings is proposed. This approach is further validated using a simulated experiment. Last, the limitations and implications of this work are discussed.
    Main results: MEAs can only be used to map the extracellular somatic action potential (esAP) sources in a neural microcircuit, and AP propagation along individual axons cannot be detected. The key for the ultra-density MEA design is to make sure that each spatial unit of analysis (SUA) contains no more than one active esAP source. The unique neural resolving capability of ultra-density MEAs comparing to conventional MEAs is to be able to spatiotemporally resolve each esAP source within its view volume.
    Significance: The ultimate capability and limitation of neural electrode array technology at such an unprecedented fabrication resolution is unraveled. This work strives to further the discussions on this topic into a more quantitative and rational direction, while providing a theoretical guideline for the rational development and neuroscientific application of an ultra-density MEA for intracortical functional mapping.
    MeSH term(s) Action Potentials ; Microelectrodes ; Neurons
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ab8fc5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6071: Show issues Location:
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  8. Article ; Online: Perspectives on electrical neural recording: a revisit to the fundamental concepts.

    Guo, Liang

    Journal of neural engineering

    2020  Volume 17, Issue 1, Page(s) 13001

    Abstract: Objective: This paper aims to promote understanding on the fundamental concepts and mechanisms of extracellular electrical neural recording.: Approach: First, the electrode-electrolyte interface is reviewed to clarify some of the frequent ... ...

    Abstract Objective: This paper aims to promote understanding on the fundamental concepts and mechanisms of extracellular electrical neural recording.
    Approach: First, the electrode-electrolyte interface is reviewed to clarify some of the frequent misunderstandings. Second, analytical solutions to the extracellular field potential and recorded signal are derived based on equivalent electrical circuit models, using a planar substrate microelectrode as a particular example. And third, factors affecting the recording quality are thoroughly assessed.
    Main results: Passive neural recording electrodes function as a pure capacitor. The extracellular field potential has two phases, with its subthreshold depolarization phase proportional to the first time derivative of the membrane depolarization and its action potential phase proportional to the negative first time derivative of the intracellular action potential. The recorded signal represents a portion of the extracellular field potential with both amplitude attenuation and phase distortion according to a voltage-divider circuit formed between the recording electrode and amplifier. A larger cell, a larger cell-substrate junctional membrane area, and a tighter membrane-substrate seal all help to improve the recording quality, while the effective electrode impedance should be minimized and the effective amplifier's input impedance maximized.
    Significance: This paper develops in-depth insights to offer a clear image on the recording mechanism, nature of the signal, and interplays between key interface parameters. This work will make a foundational contribution to the field by providing such an in-depth understanding on this topic to clear the widespread ambiguities and confusions and inform rational neural electrode designs and proper interpretations of neural recordings.
    MeSH term(s) Animals ; Electric Impedance ; Electrodes, Implanted ; Electrolytes/chemistry ; Electrolytes/metabolism ; Humans ; Microelectrodes ; Neurons/physiology
    Chemical Substances Electrolytes
    Language English
    Publishing date 2020-02-25
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ab702f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6071: Show issues Location:
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  9. Article ; Online: Special Issue “Genetics, Genomics, and Breeding of Legume Crops”

    Guo-Liang Jiang

    Agronomy, Vol 11, Iss 3, p

    2021  Volume 475

    Abstract: Legume crops are grown in the world primarily for their grain seeds that are widely used for human and animal consumption or for the production of oils for industrial uses [.] ...

    Abstract Legume crops are grown in the world primarily for their grain seeds that are widely used for human and animal consumption or for the production of oils for industrial uses [.]
    Keywords n/a ; Agriculture ; S
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: The versatile role of Serpina3c in physiological and pathological processes: a review of recent studies.

    Li, Yang / Guo, Liang

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1189007

    Abstract: Murine Serpina3c belongs to the family of serine protease inhibitors (Serpins), clade "A" and its human homologue is SerpinA3. Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. In the pathophysiological ... ...

    Abstract Murine Serpina3c belongs to the family of serine protease inhibitors (Serpins), clade "A" and its human homologue is SerpinA3. Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. In the pathophysiological process, the deletion of Serpina3c leads to more severe metabolic disorders, such as aggravated non-alcoholic fatty liver disease (NAFLD), insulin resistance and obesity. In addition, Serpina3c can improve atherosclerosis and regulate cardiac remodeling after myocardial infarction. Many of these processes are directly or indirectly mediated by its inhibition of serine protease activity. Although its function has not been fully revealed, recent studies have shown its potential research value. Here, we aimed to summarize recent studies to provide a clearer view of the biological roles and the underlying mechanisms of Serpina3c.
    MeSH term(s) Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Insulin Resistance ; Obesity/metabolism ; Metabolic Diseases
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1189007
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