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  1. Article: Scientific Literacy in Communicating Science and Socio-Scientific Issues: Prospects and Challenges.

    Li, Yanyan / Guo, Mengmeng

    Frontiers in psychology

    2021  Volume 12, Page(s) 758000

    Abstract: A holistic view ... ...

    Abstract A holistic view of
    Language English
    Publishing date 2021-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.758000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectively Enhancing the Conductance of Asymmetric Molecular Wires by Aligning the Energy Level and Symmetrizing the Coupling.

    Guo, Meng-Meng / Jiang, Yuxuan / Wang, Jin-Yun / Chen, Zhong-Ning / Hou, Shimin / Zhang, Qian-Chong

    Langmuir : the ACS journal of surfaces and colloids

    2024  

    Abstract: An asymmetric structure is an important strategy for designing highly conductive molecular wires for a gap-fixed molecular circuit. As the conductance enhancement in the current strategy is still limited to about 2 times, we inserted a methylene group as ...

    Abstract An asymmetric structure is an important strategy for designing highly conductive molecular wires for a gap-fixed molecular circuit. As the conductance enhancement in the current strategy is still limited to about 2 times, we inserted a methylene group as a spacer in a conjugated structure to modulate the structural symmetry. We found that the conductance drastically enhanced in the asymmetric molecular wire to 1.5 orders of magnitude as high as that in the symmetric molecular wire. First-principles quantum transport studies attributed the effective enhancement to the synchronization of improved energy alignment and nearly symmetric coupling between the frontier orbitals and the electrodes.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c03530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Integrative Inducer Intervention and Transcriptomic Analyses Reveal the Metabolism of Paralytic Shellfish Toxins in

    Dong, Chenfan / Zheng, Guanchao / Peng, Jixing / Guo, Mengmeng / Wu, Haiyan / Tan, Zhijun

    Environmental science & technology

    2024  Volume 58, Issue 15, Page(s) 6519–6531

    Abstract: Paralytic shellfish toxins (PSTs) are widely distributed neurotoxins, and the PST metabolic detoxification mechanism in bivalves has received increasing attention. To reveal the effect of phase I (cytochrome P450)-II (GST)-III (ABC transport) metabolic ... ...

    Abstract Paralytic shellfish toxins (PSTs) are widely distributed neurotoxins, and the PST metabolic detoxification mechanism in bivalves has received increasing attention. To reveal the effect of phase I (cytochrome P450)-II (GST)-III (ABC transport) metabolic systems on the PST metabolism in
    MeSH term(s) Animals ; Rifampin/metabolism ; alpha-Tocopherol/metabolism ; Bivalvia ; Shellfish/analysis ; Colchicine/metabolism ; Dinoflagellida/metabolism
    Chemical Substances Rifampin (VJT6J7R4TR) ; alpha-Tocopherol (H4N855PNZ1) ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.4c00607
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  4. Article ; Online: Colonic stem cells from normal tissues adjacent to tumor drive inflammation and fibrosis in colorectal cancer.

    Zhao, Yuanyuan / Guo, Mengmeng / Zhao, Fuqiang / Liu, Qian / Wang, Xia

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 186

    Abstract: Background: In colorectal cancer (CRC), the normal tissue adjacent to tumor (NAT) communicates actively with the tumor. Adult stem cells from the colon play a crucial role in the development of the colonic epithelium. In the tumor microenvironment, ... ...

    Abstract Background: In colorectal cancer (CRC), the normal tissue adjacent to tumor (NAT) communicates actively with the tumor. Adult stem cells from the colon play a crucial role in the development of the colonic epithelium. In the tumor microenvironment, however, it is unclear what changes have occurred in colonic stem cells derived from NAT.
    Methods: Using an intestinal stem cell culture system, we cultured colonic cells from NAT and paired CRC tissue, as well as cells from healthy tissue (HLT). Clonogenicity and differentiation ability were used to compare the function of clones from NAT, HLT and CRC tissues. RNA high-throughput sequencing of these clones was used to identify the molecular characteristics of NAT-derived clones. Coculture of clones from HLT and CRC was used to assess molecular changes.
    Results: We found that the morphological characteristics, clonogenic ability, and differentiation ability of NAT-derived clones were consistent with those of HLT-derived clones. However, NAT-derived clones changed at the molecular level. A number of genes were specifically activated in NAT. NAT-derived clones enriched pathways related to inflammation and fibrosis, including epithelial mesenchymal transition (EMT) pathway and TGF-beta signaling pathway. Our results also confirmed that NAT-derived clones could recruit fibroblasts in mice. In addition, HLT-derived clones showed high expression of FOSB when cocultured with tumor cells.
    Conclusions: Our results demonstrate that colonic stem cells from NAT in the tumor microenvironment undergo changes at the molecular level, and these molecular characteristics can be maintained in vitro, which can induce fibrosis and an inflammatory response. Video Abstract.
    MeSH term(s) Animals ; Mice ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Stem Cells/metabolism ; Inflammation/pathology ; Fibrosis ; Gene Expression Regulation, Neoplastic ; Tumor Microenvironment
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01140-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effect of Enterprise Social Media on Employee Creativity: Social Exchange Theory Perspective.

    Wang, Zhiwei / Hangeldiyeva, Mahri / Ali, Asad / Guo, Mengmeng

    Frontiers in psychology

    2022  Volume 12, Page(s) 812490

    Abstract: This study applied an artifact-centric view to investigate the consequences of enterprise social media usage. It investigates how enterprise social media usage influences employee creativity. A moderated mediation model is developed based on social ... ...

    Abstract This study applied an artifact-centric view to investigate the consequences of enterprise social media usage. It investigates how enterprise social media usage influences employee creativity. A moderated mediation model is developed based on social exchange theory. The empirical sample of 238 employees is used to test the proposed model. Results of the empirical analysis performed using PROCESS macro of SPSS indicate that enterprise social media usage positively impacts employee creativity via the mediating mechanisms (i.e., leader-member exchange and support for innovation). Furthermore, social media usage frequency negatively moderates this impact of enterprise social media usage on employee creativity via leader-member exchange. Interestingly, the empirical analysis reveals that the impact of enterprise social media usage frequency strengthens the indirect effect that enterprise social media usage has on employee creativity via perceived support for innovation.
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.812490
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  6. Article: The Mechanical and Energy Release Performance of THV-Based Reactive Materials.

    Guo, Mengmeng / Wang, Yanxin / Wang, Haifu / Xiao, Jianguang

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 17

    Abstract: A polymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride- (THV) based reactive materials (RMs) was designed to improve their density and energy release efficiency. The mechanical performances, fracture mechanisms, thermal behavior, ... ...

    Abstract A polymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride- (THV) based reactive materials (RMs) was designed to improve their density and energy release efficiency. The mechanical performances, fracture mechanisms, thermal behavior, energy release behavior, and reaction energy of four types of RMs (26.5% Al/73.5% PTFE, 5.29% Al/80% W/14.71% PTFE, 62% Hf/38% THV, 88% Hf/12% THV) were systematically researched by conducting compressive tests, scanning electron microscope (SEM), differential scanning calorimeter, thermogravimetric (DSC/TG) tests and ballistic experiments. The results show that the THV-based RMs have a unique strain softening effect, whereas the PTFE-based RMs have a remarkable strain strengthening effect, which is mainly caused by the different glass transition temperatures. Thermal analysis indicates that the THV-based RMs have more than one exothermic peak because of the complex component in THV. The energy release behavior of RMs is closely related to their mechanical properties, which could dominate the fragmentation behavior of materials. The introduction of tungsten (W) particles to PTFE RMs could not only enhance the density but also elevate the reaction threshold of RMs, whereas the reaction threshold of THV-based RMs is decreased when increasing Hf particles content. As such, under current conditions, the THV-based RMs (88% Hf/12% THV) with a high density of 7.83 g/cm
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15175975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis.

    Zeng, Wei / Guo, Mengmeng / Yao, Lin / Deng, Zhang

    Bioengineered

    2021  Volume 12, Issue 1, Page(s) 4111–4122

    Abstract: Oral squamous cell carcinoma is one of the most common malignant tumors of the head and neck. Increasing evidence suggests that various non-coding RNAs, such as circRNAs, are implicated in a myriad of biological processes supporting tumor progression. ... ...

    Abstract Oral squamous cell carcinoma is one of the most common malignant tumors of the head and neck. Increasing evidence suggests that various non-coding RNAs, such as circRNAs, are implicated in a myriad of biological processes supporting tumor progression. Recent studies have revealed that several circRNAs are dysregulated in oral squamous cell carcinoma (OSCC). However, their functional role in OSCC and the underlying mechanism remains to be further investigated. In this study, we aim to evaluate the biological role and survey the molecular mechanism of circBCL11B in regulating the progression of OSCC. We demonstrated that circBCL11B was significantly upregulated in OSCC tissues and cell lines, and the expression level was correlated with the malignancy. Silencing cirCBCL11B inhibited cell proliferation and migration, and also included cell apoptosis in OSCC cells. miR-145 was identified as a downstream target mediating the effect of circBCL11B by targeting LASP1. miR-145 negatively regulated LASP1 expression, which could be rescued by miR-145 inhibitor. Collectively, our study uncovered a functional role of circBCL11B/miR-579/LASP1 axis in OSCC, implying that targeting these molecules could be an intervention approach in OSCC treatment.
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Apoptosis/genetics ; Base Sequence ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cytoskeletal Proteins/metabolism ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Humans ; LIM Domain Proteins/metabolism ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Neoplasm Invasiveness ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Up-Regulation/genetics
    Chemical Substances Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; LASP1 protein, human ; LIM Domain Proteins ; MIRN579 microRNA, human ; MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.1953214
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  8. Article ; Online: Application of novel polypyrrole/melamine foam auxiliary electrode in promoting electrokinetic remediation of Cr(VI)-contaminated soil.

    Qu, Zhengjun / Huang, Lihui / Guo, Mengmeng / Sun, Ting / Xu, Xiaoshen / Gao, Zhenhui

    The Science of the total environment

    2023  Volume 876, Page(s) 162840

    Language English
    Publishing date 2023-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162840
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Visual and Super-Sensitive Detection of Maize Chlorotic Mottle Virus by Dot-ELISA and Au Nanoparticle-Based Immunochromatographic Test Strip.

    Zhang, Cui / Guo, Mengmeng / Dong, Jinxi / Liu, Li / Zhou, Xueping / Wu, Jianxiang

    Viruses

    2023  Volume 15, Issue 7

    Abstract: Maize chlorotic mottle virus (MCMV) is the only species in ... ...

    Abstract Maize chlorotic mottle virus (MCMV) is the only species in the
    MeSH term(s) Gold ; Plant Diseases ; Metal Nanoparticles ; Enzyme-Linked Immunosorbent Assay/methods ; Antibodies, Monoclonal
    Chemical Substances maize chlorotic mottle virus ; Gold (7440-57-5) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Engineering Characteristics and Microscopic Mechanism of Soil-Cement-Bentonite (SCB) Cut-Off Wall Backfills with a Fixed Fluidity.

    Zhou, Tan / Hu, Jianhua / Liu, Taoying / Zhao, Fengwen / Yin, Yanjun / Guo, Mengmeng

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 14

    Abstract: Soil-cement-bentonite (SCB) backfill has been widely used in constructing cut-off walls to inhibit groundwater movement in contaminated sites. This study prepares SCB backfill with fixed fluidity. We conducted a series of experiments to investigate the ... ...

    Abstract Soil-cement-bentonite (SCB) backfill has been widely used in constructing cut-off walls to inhibit groundwater movement in contaminated sites. This study prepares SCB backfill with fixed fluidity. We conducted a series of experiments to investigate the engineering characteristics and microscopic mechanism of the backfill. The results indicate that the water content in the slurry was more sensitive to the bentonite content. The unconfined compression strength (UCS) value increased with an increase in the cement content, and the change with an increase in bentonite content was not noticeable. The permeability coefficient decreased distinctly with an increase in the cement and bentonite contents. The porosity of the SCB backfill increased with increasing bentonite content and decreased with increasing cement content. The UCS of SCB backfill was linearly and negatively correlated with the porosity; the permeability coefficient was not significantly related to the porosity. The percentage of micro- and small-pore throats in the backfill increased with increasing bentonite and cement contents. As cement and bentonite content increased by 6% in the backfill, the proportion of micro- and small-pore throats increased by 0.7% and 1.2%, respectively. The percentage of micro- and small-pore throats is deduced to be more suitable as a characterization parameter for the permeability of the SCB backfill. The overall results of this study show that the reasonably proportioned SCB backfill has potential as an eco-friendly and cost-effective material. Based on the requirements of strength and permeability coefficient (UCS > 100 kPa, 28 days permeability coefficient <1 × 10
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16144971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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