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Article ; Online: B4GALNT1 promotes carcinogenesis by regulating epithelial-mesenchymal transition in hepatocellular carcinoma based on pan-cancer analysis.

Liu, Wenli / Chen, Yutong / Yang, Jinqiang / Guo, Mingliang / Wang, Li

2023 Volume 25, Issue 11, Page(s) e3552

Abstract: Background: β-1,4-N-Acetyl galactosaminyltransferase1 (B4GALNT1) has been reported to play important roles in tumor progression and metastasis. Herein, we investigate the oncogenic roles of B4GALNT1 for hepatocellular carcinoma (HCC) based on immune ... ...

Abstract	Background: β-1,4-N-Acetyl galactosaminyltransferase1 (B4GALNT1) has been reported to play important roles in tumor progression and metastasis. Herein, we investigate the oncogenic roles of B4GALNT1 for hepatocellular carcinoma (HCC) based on immune microenvironment. Methods: The Cancer Genome Atlas database and Genotype-Tissue Expression, cBioportal, ImmuCellAI, TIMER2 and other databases were searched to analyze the expression and clinical applications of B4GALNT1 in liver cancer patients. Kaplan-Meier survival analysis, Cox regression analysis, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analysis were utilized. Moreover, western blot assay, immune histochemistry staining, Cell Counting Kit-8 (CCK-8) assay, invasion and migration assay were performed to evaluate the function of B4GALNT1 in HCC. Results: B4GALNT1 is overexpressed in 14 tumors, and the mRNA expression levels of B4GALNT1 were remarkably elevated in most tumor types, including HCC. In addition, B4GALNT1 expression was an independent prognostic factor, and a low expression of B4GALNT1 showed a better overall survival and disease-specific recurrence-free survival in patients with HCC. Gene set variation analysis indicated that B4GALNT1 presented a positive correlation with the epithelial-mesenchymal transition (EMT) pathway in HCC. B4GALNT1 expression was closely associated with immune activation genes in the HCC microenvironment. Moreover, B4GALNT1 expression was higher in HCC tissue than that in surrounding tissues. B4GALNT1 promoted the expression of apoptosis-related or EMT-related proteins and then decreased the expression of Bcl-2 and Bcl-xl in HCC cells, suggesting that B4GALNT1 knockdown significantly inhibited the proliferation and invasion of HCC cells. Conclusions: B4GALNT1 may promote HCC development through regulating the EMT pathway, which suggests that B4GALNT1 may serve as a promising predictive biomarker and a potential therapeutic target for HCC.
MeSH term(s)	Humans ; Biomarkers ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Liver Neoplasms/pathology ; Tumor Microenvironment/genetics
Chemical Substances	Biomarkers ; B4GAT1 protein, human (EC 2.4.1.149)
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1458024-x
ISSN	1521-2254 ; 1099-498X
ISSN (online)	1521-2254
ISSN	1099-498X
DOI	10.1002/jgm.3552
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Article ; Online: Rosa roxburghii

Fei, Peng / Xu, Jing / Xie, Jinlan / Huang, Jicheng / Feng, Hongxia / Chen, Xi / Jiang, Peiyi / Guo, Mingliang / Chang, Yunhe

Foodborne pathogens and disease

2024 Volume 21, Issue 4, Page(s) 268–274

Abstract: Cronobacter ... ...

Abstract	Cronobacter sakazakii
MeSH term(s)	Humans ; Infant ; Cronobacter sakazakii ; Infant Formula ; Rosa ; Reactive Oxygen Species/pharmacology ; Adenosine Triphosphate ; Disinfectants/pharmacology ; Food Microbiology ; Cronobacter
Chemical Substances	Reactive Oxygen Species ; Adenosine Triphosphate (8L70Q75FXE) ; Disinfectants
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2148479-X
ISSN	1556-7125 ; 1535-3141
ISSN (online)	1556-7125
ISSN	1535-3141
DOI	10.1089/fpd.2023.0088
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Article: BcHTT4 Inhibits Branching of Non-Heading Chinese Cabbage at the Vegetative Stage

Guo, Mingliang / Xu, Lanlan / Long, Yan / Huang, Feiyi / Liu, Tongkun / Li, Ying / Hou, Xilin

Plants. 2021 Mar. 09, v. 10, no. 3

2021

Abstract: Branching is speculated to contribute to the plant architecture and crop yield. As a quantitative trait, branching is regulated by multiple genes in non-heading Chinese cabbage (NHCC). Several related candidate genes have been discovered in previous ... ...

Abstract	Branching is speculated to contribute to the plant architecture and crop yield. As a quantitative trait, branching is regulated by multiple genes in non-heading Chinese cabbage (NHCC). Several related candidate genes have been discovered in previous studies on the branching of NHCC, but their specific functions and regulatory mechanisms still need to be verified and explored. In this study, we found that the expression of BcHTT4, the ortholog to HEAT-INDUCED TAS1 TARGET4 (HTT4) in Arabidopsis, was significantly different between ‘Suzhouqing’ (common type) and ‘Maertou’ (multiple shoot branching type) in NHCC, which was consistent with the previous transcriptome sequencing results. The silencing of BcHTT4 expression in non-heading Chinese cabbage promotes axillary bud growth at the vegetative stage. When BcHTT4 is overexpressed in Arabidopsis, branching will decrease. In further study, we found that BcHTT4 interacts with immunophilin BcFKBP13 in vivo and in vitro through yeast two-hybrid analysis and bimolecular fluorescence complementation (BiFC) assays. Moreover, quantitative real-time PCR analysis showed that when the expression of BcHTT4 was silenced in ‘Suzhouqing’, the expression of BcFKBP13 also decreased significantly. Our findings reveal that BcHTT4 is involved in the branching mechanism and interacts with immunophilin BcFKBP13 in NHCC.
Keywords	Arabidopsis ; Chinese cabbage ; crop yield ; fluorescence ; plant architecture ; quantitative polymerase chain reaction ; quantitative traits ; transcriptome ; two hybrid system techniques ; vegetative growth
Language	English
Dates of publication	2021-0309
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10030510
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Article: BcHTT4

Guo, Mingliang / Xu, Lanlan / Long, Yan / Huang, Feiyi / Liu, Tongkun / Li, Ying / Hou, Xilin

Plants (Basel, Switzerland)

2021 Volume 10, Issue 3

Abstract	Branching is speculated to contribute to the plant architecture and crop yield. As a quantitative trait, branching is regulated by multiple genes in non-heading Chinese cabbage (NHCC). Several related candidate genes have been discovered in previous studies on the branching of NHCC, but their specific functions and regulatory mechanisms still need to be verified and explored. In this study, we found that the expression of
Language	English
Publishing date	2021-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10030510
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Article: CELL CYCLE SEITCH 52 regulates tillering by interacting with LATERAL SUPPRESSOR in non-heading Chinese cabbage

Guo, Mingliang / Long, Yan / Xu, Lanlan / Zhang, Wei / Liu, Tongkun / Zhang, Changwei / Hou, Xilin / Li, Ying

Plant science. 2021 Aug., v. 309

2021

Abstract: With the discovery of essential genes regulating tillering, such as MONOCULM 1 (MOC1) in rice and LATERAL SUPPRESSOR (LAS in Arabidopsis, LS in tomato), research on tillering mechanisms has made great progress; however, the study of tillering in non- ... ...

Abstract	With the discovery of essential genes regulating tillering, such as MONOCULM 1 (MOC1) in rice and LATERAL SUPPRESSOR (LAS in Arabidopsis, LS in tomato), research on tillering mechanisms has made great progress; however, the study of tillering in non-heading Chinese cabbage (NHCC) is rare. Here, we report that BcLAS, as a member of the GRAS family, plays an important role in the tillering of NHCC during its vegetative growth. BcLAS was almost not expressed in other examed parts except leaf axils throughout life. When the expression of BcLAS was silenced utilizing virus-induced gene silencing (VIGS) technology, we found that the tiller number of ‘Maertou’ decreased sharply. In ‘Suzhouqing’, overexpression of BcLAS significantly promoted tillering. BcCCS52, the orthologue to CELL CYCLE SEITCH 52 (CCS52), interacts with BcLAS. Downregulation of the expression of BcCCS52 promoted tillering of ‘Suzhouqing’; therefore, we conclude that BcCCS52 plays a negative role in tillering regulation. Our findings reveal the tillering regulation mechanism of NHCCs at the vegetative stage and report an orthologue of CCS52 regulating tillering in NHCC.
Keywords	Arabidopsis ; Chinese cabbage ; cell cycle ; leaves ; rice ; tillering ; tomatoes ; vegetative growth
Language	English
Dates of publication	2021-08
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2021.110934
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Article ; Online: Genome-wide characterization and expression profiling of Eucalyptus grandis HD-Zip gene family in response to salt and temperature stress

Zhang, Jiashuo / Wu, Jingzhang / Guo, Mingliang / Aslam, Mohammad / Wang, Qi / Ma, Huayan / Li, Shubin / Zhang, Xingtan / Cao, Shijiang

BMC Plant Biol. 2020 Dec., v. 20, no. 1 p.451-451

2020

Abstract: BACKGROUND: The HD-Zip transcription factors are unique to plants and play an essential role in plant growth, development and stress responses. The HD-Zip transcription factor family consists of a highly conserved homeodomain (HD) and a leucine zipper ... ...

Abstract	BACKGROUND: The HD-Zip transcription factors are unique to plants and play an essential role in plant growth, development and stress responses. The HD-Zip transcription factor family consists of a highly conserved homeodomain (HD) and a leucine zipper domain (LZ) domain. Although the HD-Zip gene family has been extensively studied in many plant species, a systematic study of the Eucalyptus HD-Zip family has not been reported until today. Here, we systematically identified 40 HD-Zip genes in Eucalyptus (Eucalyptus grandis). Besides, we comprehensively analyzed the HD-Zips of Eucalyptus by studying the homology, conserved protein regions, gene structure, 3D structure of the protein, location of the genes on the chromosomes and the expression level of the genes in different tissues. RESULTS: The HD-Zip family in Eucalyptus has four subfamilies, which is consistent with other plants such as Arabidopsis and rice. Moreover, genes that are in the same group tend to have similar exon-intron structures, motifs, and protein structures. Under salt stress and temperature stress, the Eucalyptus HD-Zip transcription factors show a differential expression pattern. CONCLUSIONS: Our findings reveal the response of HD-Zip transcription factors under salt and temperature stresses, laying a foundation for future analysis of Eucalyptus HD-Zip transcription factors.
Keywords	Arabidopsis ; Eucalyptus grandis ; gene expression regulation ; genes ; leucine zipper ; plant growth ; rice ; salt stress ; temperature ; transcription factors
Language	English
Dates of publication	2020-12
Size	p. 451.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-020-02677-w
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Article: Characterization of auxin transporter

Zhao, Heming / Maokai, Yan / Cheng, Han / Guo, Mingliang / Liu, Yanhui / Wang, Lulu / Chao, Shi / Zhang, Minqian / Lai, Linyi / Qin, Yuan

PeerJ

2021 Volume 9, Page(s) e11410

Abstract: Polar auxin transport in plant is mediated by influx and efflux transporters, which are encoded ... ...

Abstract	Polar auxin transport in plant is mediated by influx and efflux transporters, which are encoded by
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.11410
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Article ; Online: CELL CYCLE SEITCH 52 regulates tillering by interacting with LATERAL SUPPRESSOR in non-heading Chinese cabbage.

Guo, Mingliang / Long, Yan / Xu, Lanlan / Zhang, Wei / Liu, Tongkun / Zhang, Changwei / Hou, Xilin / Li, Ying

Plant science : an international journal of experimental plant biology

2021 Volume 309, Page(s) 110934

Abstract	With the discovery of essential genes regulating tillering, such as MONOCULM 1 (MOC1) in rice and LATERAL SUPPRESSOR (LAS in Arabidopsis, LS in tomato), research on tillering mechanisms has made great progress; however, the study of tillering in non-heading Chinese cabbage (NHCC) is rare. Here, we report that BcLAS, as a member of the GRAS family, plays an important role in the tillering of NHCC during its vegetative growth. BcLAS was almost not expressed in other examed parts except leaf axils throughout life. When the expression of BcLAS was silenced utilizing virus-induced gene silencing (VIGS) technology, we found that the tiller number of 'Maertou' decreased sharply. In 'Suzhouqing', overexpression of BcLAS significantly promoted tillering. BcCCS52, the orthologue to CELL CYCLE SEITCH 52 (CCS52), interacts with BcLAS. Downregulation of the expression of BcCCS52 promoted tillering of 'Suzhouqing'; therefore, we conclude that BcCCS52 plays a negative role in tillering regulation. Our findings reveal the tillering regulation mechanism of NHCCs at the vegetative stage and report an orthologue of CCS52 regulating tillering in NHCC.
MeSH term(s)	Amino Acid Motifs ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Brassica rapa/genetics ; Brassica rapa/growth & development ; Brassica rapa/physiology ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Gene Expression ; Gene Expression Regulation, Plant ; Gene Silencing ; Phylogeny ; Plant Leaves/genetics ; Plant Leaves/growth & development ; Plant Leaves/physiology ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Protein Domains
Chemical Substances	Arabidopsis Proteins ; Cell Cycle Proteins ; LAS protein, Arabidopsis ; Plant Proteins
Language	English
Publishing date	2021-05-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2021.110934
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Article: Identification and Evolutionary Analysis of FAD2 Gene Family in Green Plants

Cao, Shijiang / Zhang, Jiashuo / Cheng, Han / Aslam, Mohammad / Lv, Hongwei / Dong, Wei / Hu, Anqi / Guo, Mingliang / Liu, Qing / Qin, Yuan

Tropical plant biology. 2021 Sept., v. 14, no. 3

2021

Abstract: Fatty acid desaturase 2 (FAD2) is a crucial enzyme in the biosynthesis of polyunsaturated fatty acids in plants, which introduce a double bond into oleic acid to produce linoleic acid. FAD2 is imperative to the application and nutritional value of ... ...

Abstract	Fatty acid desaturase 2 (FAD2) is a crucial enzyme in the biosynthesis of polyunsaturated fatty acids in plants, which introduce a double bond into oleic acid to produce linoleic acid. FAD2 is imperative to the application and nutritional value of vegetable oil as both oleic acid and linoleic acid are the primary constituent fatty acids and their relative proportion determines the nutritional value and oxidative stability in most temperate vegetable oils. In the study described herein, we have identified a total of 253 candidate FAD2 genes from the published genomes of 79 plants. Phylogenetic analysis showed that FAD2 genes in green plants can be divided into three categories, namely, eudicots, monocots and lower plants (except Amborella trichopoda). Through the analysis of its conserved domains, all FAD2 genes contain motifs harbouring HECGH, HRRHH and HVAHH, −the three histidine clusters that are important functional structures of FAD2 gene. According to exon/intron structure analysis, the number of introns varies greatly in lower plants. With the evolution of green plants, the number of introns decreases. This study found that introns were mainly located in the 5’UTR and CDs regions, and their length ranged from 4 bp to 11,233 BP. In addition, about 56% of the 3 ‘and 5’ ends of FAD2 are located at Ag: GT, and the total content of a and t is generally about 60%.Through other bioinformatics methods, we concluded that FAD2 was more conservative in the process of plant evolution. This study provides theoretical support for further analysis of FAD2 gene family evolution.
Keywords	Amborella trichopoda ; Liliopsida ; bioinformatics ; biosynthesis ; exons ; fatty acid desaturase ; histidine ; introns ; linoleic acid ; nutritive value ; oleic acid ; oxidative stability ; phylogeny ; plant biology ; tropical plants ; vegetable oil ; vegetables
Language	English
Dates of publication	2021-09
Size	p. 239-250.
Publishing place	Springer US
Document type	Article
ZDB-ID	2455624-5
ISSN	1935-9764 ; 1935-9756
ISSN (online)	1935-9764
ISSN	1935-9756
DOI	10.1007/s12042-020-09276-x
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Article: OsDDM1b

Guo, Mingliang / Zhang, Wenchao / Mohammadi, Mohammad Aqa / He, Zhimei / She, Zeyuan / Yan, Maokai / Shi, Chao / Lin, Lingwei / Wang, Aqiong / Liu, Jindian / Tian, Dagang / Zhao, Heming / Qin, Yuan

Frontiers in plant science

2022 Volume 13, Page(s) 873993

Abstract: Snf2 family proteins are the crucial subunits of chromatin-remodeling complexes (CRCs), which contributes to the biological processes of transcription, replication, and DNA repair using ATP as energy. Some CRC subunits have been confirmed to be the ... ...

Abstract	Snf2 family proteins are the crucial subunits of chromatin-remodeling complexes (CRCs), which contributes to the biological processes of transcription, replication, and DNA repair using ATP as energy. Some CRC subunits have been confirmed to be the critical regulators in various aspects of plant growth and development and in epigenetic mechanisms such as histone modification, DNA methylation, and histone variants. However, the functions of Snf2 family genes in rice were poorly investigated. In this study, the relative expression profile of 40 members of Snf2 family in rice was studied at certain developmental stages of seed. Our results revealed that
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.873993
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