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Article: [Change of Regulatory Requirement on Cohort Grouping and Endpoint Seting for Intervertebral Fusion Device Clinical Trial].

Guo Xiaolei

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2015 Volume 39, Issue 4, Page(s) 279–281

Abstract: Combining technical requirement from main international administration and status quo of China administration, current regulatory requirement on clinical trail of conventional intervertebral fusion devices has been simplified. Cervical, thoracic and ... ...

Abstract	Combining technical requirement from main international administration and status quo of China administration, current regulatory requirement on clinical trail of conventional intervertebral fusion devices has been simplified. Cervical, thoracic and lumbar cases can be grouped into the same cohort, and primary endpoints are mainly based on imageology rather than clinical score. This is an attempt to rationally lessen industrial burdensome.
MeSH term(s)	China ; Clinical Trials as Topic/standards ; Cohort Studies ; Endpoint Determination ; Humans ; Research Design/standards ; Spinal Fusion/instrumentation
Language	Chinese
Publishing date	2015-07
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-7104
ISSN	1671-7104
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The study on surface morphology and decorative properties of Magnesium-glass-board (MGB).

Song, Chaojun / Wang, Jinxin / Wu, Zhanwen / Zhang, Feng / Zhu, Zhaolong / Guo, Xiaolei / Cao, Pingxiang

PloS one

2024 Volume 19, Issue 1, Page(s) e0296288

Abstract: In order to improve the decorative properties of Magnesium-Glass-Board (MGB), the surface morphology and decoration performance of MGB, are studied in detail by using profilometer, microscope and SEM, and the influence of its characterization, such as ... ...

Abstract	In order to improve the decorative properties of Magnesium-Glass-Board (MGB), the surface morphology and decoration performance of MGB, are studied in detail by using profilometer, microscope and SEM, and the influence of its characterization, such as surface roughness, surface porosity and wettability, on decorative properties of MGB is analyzed by comparing with medium density fiberboard (MDF) and medium density particleboard (MDP). The results first showed that the surface of MGB has a porous structure, but MDF and MDP are not, resulting in a poor decorative performance of MGB. Second, it is found that the surface wettability of MGB is better than others. Third, the hot-pressing parameters including pressure, temperature and time have different influence on decorative performance of MGB during hot-pressing experiment. Finally, the surface bonding strength is positively correlated with pressure, but not with temperature and time. In general, a higher surface bonding strength led to a better decorative performance of MGB. The furthermore research can concentrate on the modification method of the MGB's surface according to this paper's conclusion to improve the lamination performance of melamine paper.
MeSH term(s)	Magnesium ; Glass/chemistry ; Wettability ; Temperature ; Surface Properties
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296288
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Article ; Online: Greenness mitigate cause-specific mortality associated with air pollutants in ischemic and hemorrhagic stroke patients: An ecological health cohort study.

Jia, Xianjie / Zhang, Bingyin / Yu, Ying / Xia, Wanning / Lu, Zilong / Guo, Xiaolei / Xue, Fuzhong

Environmental research

2024 Volume 251, Issue Pt 2, Page(s) 118512

Abstract: Background: Air pollution is one of the most serious environmental risks to mortality of stroke. However, there exists a noteworthy knowledge gap concerning the different stroke subtypes, causes of death, the susceptibility of stroke patient, and the ... ...

Abstract	Background: Air pollution is one of the most serious environmental risks to mortality of stroke. However, there exists a noteworthy knowledge gap concerning the different stroke subtypes, causes of death, the susceptibility of stroke patient, and the role of greenness in this context. Methods: We analyzed data from an ecological health cohort, which included 334,261 patients aged ≥40 years with stroke (comprising 288,490 ischemic stroke and 45,771 hemorrhagic stroke) during the period 2013-2019. We used Cox proportional hazards models with time-varying exposure to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the associations of annual average fine particulate matter (PM Result: In multivariable-adjusted models, long-term exposure to PM Conclusion: Increasing residential greenness attenuates the increased risk of mortality with different patterns due to chronic air pollutants for ischemic and hemorrhagic stroke, offering valuable insights for precise tertiary stroke prevention strategies.
Language	English
Publishing date	2024-03-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118512
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Zs.A 726: Show issues

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Article ; Online: P300 reduces TUBB4B expression to facilitate the biological process of migration and invasion of non-small cell lung cancer cells.

Hu, Haifeng / Zhang, Yun / Zhai, Haibo / Dong, Juanjuan / Zuo, Lei / Guo, Xiaolei / Wang, Chao

Tissue & cell

2024 Volume 88, Page(s) 102386

Abstract: This article explored the mechanism of E1A binding protein p300 (P300) and beta-tubulin 4B isotype-encoding gene (TUBB4B) in regulating the migration and invasion of non-small cell lung cancer (NSCLC) cells. TUBB4B and P300 expression in NSCLC tissues ... ...

Abstract	This article explored the mechanism of E1A binding protein p300 (P300) and beta-tubulin 4B isotype-encoding gene (TUBB4B) in regulating the migration and invasion of non-small cell lung cancer (NSCLC) cells. TUBB4B and P300 expression in NSCLC tissues and cells was monitored by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blot. TUBB4B function on NSCLC cell migration, invasion and epithelial-mesenchymal transition (EMT) was monitored by wound healing assay, Transwell experiment and Western blot. The regulation of P300 on TUBB4B was monitored by qRT-PCR and Western blot. Mechanism of P300 and TUBB4B in regulating NSCLC cell migration and invasion was explored by rescue experiment. A xenograft tumor model was established by using nude mouse. As a result, low TUBB4B expression and high P300 expression was discovered in NSCLC tissues and cells. TUBB4B and P300 expression showed a negative correlation in NSCLC tissues. Lower TUBB4B but higher P300 was observed in tumor tissues of NSCLC patients with metastasis. TUBB4B overexpression suppressed NSCLC cell migration, invasion and EMT. TUBB4B silencing had opposite results. P300 overexpression inhibited TUBB4B expression, and P300 silencing facilitated TUBB4B overexpression in NSCLC cells. TUBB4B overexpression counteracted the promotion of P300 overexpression on NSCLC cell invasion and migration. TUBB4B silencing abrogated the inhibition of P300 knockdown on NSCLC cell invasion and migration. TUBB4B overexpression suppressed NSCLC cell in vivo growth. Thus, TUBB4B could be reduced by P300 in NSCLC. It exerted suppression role on NSCLC cell migration, invasion and EMT. TUBB4B may be a novel target for NSCLC treatment.
Language	English
Publishing date	2024-04-12
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2024.102386
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Zs.A 1016: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Impacts of heatwaves on type 2 diabetes mortality in China: a comparative analysis between coastal and inland cities.

Zheng, Wenxiu / Chu, Jie / Bambrick, Hilary / Wang, Ning / Mengersen, Kerrie / Guo, Xiaolei / Hu, Wenbiao

International journal of biometeorology

2024 Volume 68, Issue 5, Page(s) 939–948

Abstract: The impacts of extreme temperatures on diabetes have been explored in previous studies. However, it is unknown whether the impacts of heatwaves appear variations between inland and coastal regions. This study aims to quantify the associations between ... ...

Abstract	The impacts of extreme temperatures on diabetes have been explored in previous studies. However, it is unknown whether the impacts of heatwaves appear variations between inland and coastal regions. This study aims to quantify the associations between heat exposure and type 2 diabetes mellitus (T2DM) deaths in two cities with different climate features in Shandong Province, China. We used a case-crossover design by quasi-Poisson generalized additive regression with a distributed lag model with lag 2 weeks, controlling for relative humidity, the concentration of air pollution particles with a diameter of 2.5 µm or less (PM
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/mortality ; China/epidemiology ; Female ; Cities/epidemiology ; Male ; Middle Aged ; Aged ; Extreme Heat/adverse effects ; Adult ; Hot Temperature/adverse effects ; Particulate Matter/analysis ; Cross-Over Studies
Chemical Substances	Particulate Matter
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article ; Comparative Study
ZDB-ID	280324-0
ISSN	1432-1254 ; 0020-7128
ISSN (online)	1432-1254
ISSN	0020-7128
DOI	10.1007/s00484-024-02638-0
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Zs.A 998: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: ManiLoco: A VR-Based Locomotion Method for Concurrent Object Manipulation.

Wan, Dayu / Guo, Xiaolei / Dong, Jiahui / Mousas, Christos / Chen, Yingjie

Proceedings of the ACM on computer graphics and interactive techniques

2023 Volume 6, Issue 1

Abstract: The use of virtual reality (VR) in laboratory skill training is rapidly increasing. In such applications, users often need to explore a large virtual environment within a limited physical space while completing a series of hand-based tasks (e.g., object ... ...

Abstract	The use of virtual reality (VR) in laboratory skill training is rapidly increasing. In such applications, users often need to explore a large virtual environment within a limited physical space while completing a series of hand-based tasks (e.g., object manipulation). However, the most widely used controller-based teleport methods may conflict with the users' hand operation and result in a higher cognitive load, negatively affecting their training experiences. To alleviate these limitations, we designed and implemented a locomotion method called ManiLoco to enable hands-free interaction and thus avoid conflicts and interruptions from other tasks. Users can teleport to a remote object's position by taking a step toward the object while looking at it. We evaluated ManiLoco and compared it with state-of-the-art Point & Teleport in a within-subject experiment with 16 participants. The results confirmed the viability of our foot- and head-based approach and better support concurrent object manipulation in VR training tasks. Furthermore, our locomotion method does not require any additional hardware. It solely relies on the VR head-mounted display (HMD) and our implementation of detecting the user's stepping activity, and it can be easily applied to any VR application as a plugin.
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article
ISSN	2577-6193
ISSN (online)	2577-6193
DOI	10.1145/3585502
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Article ; Online: Socioeconomic status and quality of life among older adults with hypertension in rural Shandong, China: a mediating effect of social capital.

Fu, Yingjie / Zhang, Shuo / Guo, Xiaolei / Lu, Zilong / Sun, Xiaojie

Frontiers in public health

2023 Volume 11, Page(s) 1248291

Abstract: Background: Improving the quality of life (QoL) of older adults is becoming an important global issue. However, very few studies have been focused on the relationship between socioeconomic status (SES) and QoL in older adults with hypertension. The ... ...

Abstract	Background: Improving the quality of life (QoL) of older adults is becoming an important global issue. However, very few studies have been focused on the relationship between socioeconomic status (SES) and QoL in older adults with hypertension. The purpose of this study is to investigate (a) the status of QoL and (b) the mediating effect of social capital in the relationship between SES and QoL, among rural older adults with hypertension in China. Methods: Using multistage stratified random sampling, a face-to-face questionnaire survey was conducted among rural older adults with hypertension in Shandong province of China from June to July 2021. Three typical measures representing SES were used, namely, annual household income, educational level, and employment status. Individual social capital and QoL were assessed by the Resource Generator-China Scale (RG-China) and a 34-item simplified Patient Report Outcome (PRO)-specific scale for older adults with hypertension, respectively. A total of 950 rural older adults with hypertension were included in the analysis. The mediation model based on bootstrap analyses was employed to explore the relationship between SES and QoL and the mediating role of social capital in the SES-QoL nexus. Results: The sampled rural older adults with hypertension had an upper-middle level of QoL, and the average score was 132.57 ± 19.40. SES was positively correlated with both QoL and individual social capital; individual social capital was significantly positively correlated with QoL. Controlling for sociodemographic variables, SES was still significantly associated with individual social capital (β = 0.140, Conclusion: This study provides evidence that the effect of SES on QoL was partially mediated by individual social capital among rural older adults with hypertension in China. The government should pay more attention to the rural older hypertensive population with lower SES and strive to reduce the negative impact of poor SES on their QoL, based on effective strategies including improving their individual social capital.
MeSH term(s)	Humans ; Aged ; Quality of Life ; Social Capital ; Social Class ; China/epidemiology ; Hypertension/epidemiology
Language	English
Publishing date	2023-10-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1248291
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Article: Discharge characteristics of non-gravity-driven powder in horizontal silos

Tang, Jie / Lu, Haifeng / Guo, Xiaolei / Liu, Haifeng

Powder technology. 2022 Mar., v. 400

2022

Abstract: Powder flow inside horizontal silos is essential to ensure the efficient operation of the spacecraft using powder engines under horizontal flight positions. In the present work, the discharge characteristics of non-gravity-driven powder in the horizontal ...

Abstract	Powder flow inside horizontal silos is essential to ensure the efficient operation of the spacecraft using powder engines under horizontal flight positions. In the present work, the discharge characteristics of non-gravity-driven powder in the horizontal silo were investigated experimentally, with an emphasis on the half cone angle, aeration position, and additional pressure. The experimental results show that the mass flow rate first increases with decreasing half cone angle and then approaches saturation. Aerating at the cylinder was proved to be able to significantly increase the mass flow rate compared with the previous aeration at the cone. Increasing the additional pressure can effectively improve the mass flow rate, but there is a limit value called pressure surcharge limit to maximize the discharge rate. And aerating at the cylinder can further increase the pressure surcharge limit as well as the maximum mass flow rate, which is close to the ideal flow rate based on the liquid-like hypothesis. Finally, an index η is proposed to evaluate the overall flow-promoting effect to determine the optimal aeration position.
Keywords	aeration ; flight ; mass flow ; silos ; spacecraft ; technology
Language	English
Dates of publication	2022-03
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0032-5910
DOI	10.1016/j.powtec.2022.117234
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Investigation of the orthogonal cutting of wood-plastic composites for obtaining better stability and quality

Wu, Zhanwen / Wang, Jinxin / Zhang, Feng / Zhu, Zhaolong / Guo, Xiaolei / Cao, Pingxiang

Eur. J. Wood Prod.. 2023 Apr., v. 81, no. 2, p. 399-410

2023 , Page(s) 399–410

Abstract: In this paper, orthogonal cutting of wood-plastic composites (WPC) was carried out experimentally, focusing on the trend and fluctuation of cutting force and temperature with the influence of cutting parameters during the cutting process and combined ... ...

Abstract	In this paper, orthogonal cutting of wood-plastic composites (WPC) was carried out experimentally, focusing on the trend and fluctuation of cutting force and temperature with the influence of cutting parameters during the cutting process and combined with the chip formation to reveal the processing mechanism of WPC. The effects of cutting parameters on cutting force and cutting temperature were strikingly similar; with the increase in rake angle and decrease in cutting depth, the numerical value and fluctuation of cutting force and cutting temperature were all decreased. In addition, a decreasing trend in the angle between chip formation and the rake face of the tool was observed by a high-speed camera. The cutting heat will be more concentrated in the chip during the cutting process because of the lower coefficient of thermal conductivity of WPC, so the cutting temperature of the cutting edge was always lower than the temperature of the chip area. After machining, the surface quality was linearly related to the tool rake angle, but not the cutting speed and cutting depth. Therefore, the established response surface model can better fit and predict surface quality. The cutting process was complex and fluctuating, so appropriate cutting parameters were required to carry out stable and efficient machining and produce good cutting quality. Thus, it is promising for WPC's high-quality and stable cutting.
Keywords	cameras ; heat ; response surface methodology ; surface quality ; temperature ; thermal conductivity ; wood
Language	English
Dates of publication	2023-04
Size	p. 399-410
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2485250-8
ISSN	1436-736X ; 0018-3768
ISSN (online)	1436-736X
ISSN	0018-3768
DOI	10.1007/s00107-022-01882-8
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Article ; Online: Frictional behaviour of wood-Plastic composites against cemented carbide during sliding contact

Zhu, Zhaolong / Buck, Dietrich / Wu, Zhanwen / Yu, Yinyue / Guo, Xiaolei

Wood Material Science & Engineering. 2023 May 04, v. 18, no. 3 p.1127-1133

2023

Abstract: This study provides guidelines for the industrial machining of wood-plastic composites, focusing on their behaviour under friction, specifically when friction is caused by sliding contact with cemented carbide. Using the response surface method (RSM) to ... ...

Abstract	This study provides guidelines for the industrial machining of wood-plastic composites, focusing on their behaviour under friction, specifically when friction is caused by sliding contact with cemented carbide. Using the response surface method (RSM) to explore the correlation between the friction coefficient and the wood-plastic composite type, loading force, and reciprocating frequency, a series of frictional tests were performed. The significant contributions of each factor and their two-factor interactions were determined by analysis of variance (ANOVA), with a significance level of 5%, while trends in the variation of the friction coefficient were investigated by using a response surface methodology. The wood-plastic composite types had the greatest impact on the friction coefficient, followed by loading force and reciprocating frequency. A mathematical model (CoF = −0.10 + 0.09ω−0.02f+0.01Fₙ−0.01ωf+2.38×10⁻³ ωFₙ−2.00×10⁻⁴ Fₙf+0.11ω²+2.96f ² −1.04×10⁻⁴ Fₙ ²) was developed to accurately predict changes in the friction coefficient during machining of such composites. According to the results of the optimisation, wood-plastic composite with polypropylene should be machined with high-speed cutting, whereas those with polyethylene and polyvinyl chloride are recommended for low-speed machining, so as to ensure the lowest friction coefficient.
Keywords	analysis of variance ; friction ; mathematical models ; poly(vinyl chloride) ; polyethylene ; polypropylenes ; response surface methodology ; wood ; wood plastic composites ; Coefficient of friction ; industrial machining ; WPC ; ANOVA ; RSM ; optimisation
Language	English
Dates of publication	2023-0504
Size	p. 1127-1133.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	1748-0280
DOI	10.1080/17480272.2022.2119432
Database	NAL-Catalogue (AGRICOLA)

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