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Article ; Online: [Retracted] LncRNA GAS6 antisense RNA 1 facilitates the tumorigenesis of clear cell renal cell carcinoma by regulating the AMP‑activated protein kinase/mTOR signaling pathway.

Guo, Xiaoyun / Li, Hongjun / Zhang, Mei / Li, Rong

2024 Volume 27, Issue 3, Page(s) 126

Abstract: This retracts the article DOI: 10.3892/ol.2021.12988.]. ...

Abstract	[This retracts the article DOI: 10.3892/ol.2021.12988.].
Language	English
Publishing date	2024-01-29
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14259
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Article: Intracranial infection accompanied sweet's syndrome in a patient with anti-interferon-γ autoantibodies: A case report.

Zheng, Jun-Hui / Wu, Dan / Guo, Xiao-Yun

World journal of clinical cases

2023 Volume 11, Issue 32, Page(s) 7926–7934

Abstract: Background: Several reports of adult-onset immunodeficiency syndrome have been associated with anti-interferon-gamma (IFN-γ) autoantibodies (AIGAs). However, it is rare to find AIGAs with intracranial infections.: Case summary: In this case study, we ...

Abstract	Background: Several reports of adult-onset immunodeficiency syndrome have been associated with anti-interferon-gamma (IFN-γ) autoantibodies (AIGAs). However, it is rare to find AIGAs with intracranial infections. Case summary: In this case study, we report a case of an AIGAs with intracranial infection and hand rashes considered Sweet's syndrome. The patient presented to our hospital with a persistent cough, a fever that had been going on for 6 mo, and a rash that had been going on for a week. The patient started losing consciousness gradually on the fourth day after admission, with neck stiffness and weakened limb muscles. The upper lobe of the left lung had a high-density mass with no atypia and a few inflammatory cells in the interstitium. Brain magnetic resonance imaging and cerebrospinal fluid suggest intracranial infection. The pathology of the skin damage on the right upper extremity revealed an infectious lesion that was susceptible to Sweet's disease. It has an anti-IFN-γ autoantibody titer of 1:2500. She was given empirical anti-non-tuberculous mycobacterial and antifungal treatments. The patient had no fever, obvious cough, headache, or rash on the hand. She got out of bed and took care of herself following hospitalization and discharge with medicine. Conclusion: Adults with severe and recurrent infections of several organs should be considered for AIGAs if no other known risk factors exist. AIGAs are susceptible to subsequent intracranial infections and Sweet's syndrome.
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i32.7926
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Article ; Online: Anisotropic composite aerogel with thermal insulation and flame retardancy from cellulose nanofibers, calcium alginate and boric acid.

Zhu, Jintao / Wang, Yangyang / Zhao, Xiaoyi / Li, Nan / Guo, Xiaoyun / Zhao, Liang / Yin, Yuanyuan

International journal of biological macromolecules

2024 Volume 267, Issue Pt 1, Page(s) 131450

Abstract: With the increasing severity of energy shortages and environmental pollution, there is an urgent need for advanced thermal insulation materials with excellent comprehensive performance, including low thermal conductivity, high flame resistance, and ... ...

Abstract	With the increasing severity of energy shortages and environmental pollution, there is an urgent need for advanced thermal insulation materials with excellent comprehensive performance, including low thermal conductivity, high flame resistance, and strong compressive strength. Herein, an anisotropic composite aerogel based on cellulose nanofibers (CNF), calcium alginate (CA), and boric acid (BA) is fabricated using a directional freeze-drying strategy. The CA and BA, as double cross-linking agents, associated with oriented porous structure provide the resultant aerogel with good mechanical strength. Additionally, self-flame retardant CA and BA act as synergistic flame retardants that endow the aerogel with excellent flame retardance properties such as a limiting oxygen index value of 44.2 %, UL-94 V-0 rating, and low heat release. Furthermore, this composite aerogel exhibits outstanding thermal insulation performance with a low thermal conductivity of approximately 30 mW m
MeSH term(s)	Nanofibers/chemistry ; Boric Acids/chemistry ; Flame Retardants ; Cellulose/chemistry ; Alginates/chemistry ; Thermal Conductivity ; Gels/chemistry ; Anisotropy ; Porosity
Chemical Substances	Boric Acids ; Flame Retardants ; Cellulose (9004-34-6) ; Alginates ; boric acid (R57ZHV85D4) ; Gels
Language	English
Publishing date	2024-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131450
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Article ; Online: Necroptosis in heart disease: Molecular mechanisms and therapeutic implications.

Guo, Xiaoyun / Chen, Yi / Liu, Qinghang

Journal of molecular and cellular cardiology

2022 Volume 169, Page(s) 74–83

Abstract: Cell death is a crucial event underlying cardiac ischemic injury, pathological remodeling, and heart failure. Unlike apoptosis, necrosis had long been regarded as a passive and unregulated process. However, recent studies demonstrate that a significant ... ...

Abstract	Cell death is a crucial event underlying cardiac ischemic injury, pathological remodeling, and heart failure. Unlike apoptosis, necrosis had long been regarded as a passive and unregulated process. However, recent studies demonstrate that a significant subset of necrotic cell death is actively mediated through regulated pathways - a process known as "regulated necrosis". As a form of regulated necrosis, necroptosis is mediated by death receptors and executed through the activation of receptor interacting protein kinase 3 (RIPK3) and its downstream substrate mixed lineage kinase-like domain (MLKL). Recent studies have provided compelling evidence that necroptosis plays an important role in myocardial homeostasis, ischemic injury, pathological remodeling, and heart failure. Moreover, it has been shown that genetic and pharmacological manipulations of the necroptosis signaling pathway elicit cardioprotective effects. Important progress has also been made regarding the molecular mechanisms that regulate necroptotic cell death in vitro and in vivo. In this review, we discuss molecular and cellular mechanisms of necroptosis, potential crosstalk between necroptosis and other cell death pathways, functional implications of necroptosis in heart disease, and new therapeutic strategies that target necroptosis signaling.
MeSH term(s)	Apoptosis ; Heart Diseases ; Heart Failure ; Humans ; Necroptosis ; Necrosis ; Protein Kinases/metabolism
Chemical Substances	Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2022.05.006
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Article ; Online: Estimating canopy stomatal conductance and photosynthesis in apple trees by upscaling parameters from the leaf scale to the canopy scale in Jinzhong Basin on Loess Plateau

Gao, Guanlong / Hao, Yulian / Feng, Qi / Guo, Xiaoyun / Shi, Junxi / Wu, Bo

Plant Physiology and Biochemistry. 20232023 Sept. 05, Aug. 05, v. 202 p.107939-

2023

Abstract: The estimations of stomatal conductance and photosynthesis performed by upscaling the parameters from the leaf scale to the canopy scale are key points in the fields of forest ecohydrology and physiology. The foundation for solving this scientific ... ...

Abstract	The estimations of stomatal conductance and photosynthesis performed by upscaling the parameters from the leaf scale to the canopy scale are key points in the fields of forest ecohydrology and physiology. The foundation for solving this scientific problem is determining the optimal models for calculating the leaf stomatal conductance (gₗ) and photosynthetic rate (Pₗ). In this study, we used the Jarvis model combined with modification factors, including leaf–air temperature (ΔT) and CO₂ concentration inside and outside the stomata (ΔC), to estimate gₗ and the new Ye light–response model to estimate the Pₗ of apple trees in Jinzhong Basin on Loess Plateau. The results show that the modified Jarvis (JarvisΔT₋ΔC) model and the new Ye light–response model could estimate gₗ and Pₗ, respectively, with very high accuracy, with R² values of 0.926 and 0.959 for the former, and 0.987 and 0.983 for the latter in 2019 and 2021, respectively. Then, we estimated the canopy stomatal conductance (gc) and photosynthetic rate (Pc) by first dividing the apple tree canopy into sunlit and shaded leaves and then summing the contribution of sunlit and shaded gₗ, Pₗ and leaf area index. Our efforts will be a valid reference for estimating the gc and Pc of other tree or crop species in the future.
Keywords	apples ; basins ; canopy ; carbon dioxide ; crops ; forests ; hydrology ; leaf area index ; leaves ; models ; photosynthesis ; stomatal conductance ; temperature ; trees ; China ; Upscaling ; Jarvis model ; Light–response
Language	English
Dates of publication	2023-0805
Publishing place	Elsevier Masson SAS
Document type	Article ; Online
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107939
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Article ; Online: LncRNA GAS6 antisense RNA 1 facilitates the tumorigenesis of clear cell renal cell carcinoma by regulating the AMP-activated protein kinase/mTOR signaling pathway.

Guo, Xiaoyun / Li, Hongjun / Zhang, Mei / Li, Rong

publication RETRACTED

Oncology letters

2021 Volume 22, Issue 4, Page(s) 727

Abstract: The role of GAS6 antisense RNA 1 (GAS6-AS1) in clear cell renal cell carcinoma (ccRCC) remains unclear. The aim of the present study was to investigate the role and molecular mechanisms of GAS6-AS1 in the progression of ccRCC. GAS6-AS1 was found to be ... ...

Abstract	The role of GAS6 antisense RNA 1 (GAS6-AS1) in clear cell renal cell carcinoma (ccRCC) remains unclear. The aim of the present study was to investigate the role and molecular mechanisms of GAS6-AS1 in the progression of ccRCC. GAS6-AS1 was found to be upregulated in ccRCC tissues and cell lines, and patients with high GAS6-AS1 expression levels exhibited a poor prognosis. Small interfering (si)RNA GAS6-AS1 inhibited the activity, colony formation, invasiveness and glycolysis of OSRC-2 and SW839 cells, while GAS6-AS1 overexpression promoted these functions. Moreover, si-GAS6-AS1 increased the phosphorylation level of AMP-activated protein kinase (AMPK) and decreased that of mTOR, as well as decreasing proliferating cell nuclear antigen (PCNA), MMP-2 and hexokinase-2 (HK2) expression, which were reversed by inhibiting AMPK or mTOR. In addition, the silencing of GAS6-AS1 suppressed the growth of xenografted tumors and attenuated the expression of PCNA, MMP-2 and HK2 in tumor tissues. These findings conclude that GAS6-AS1 regulated the proliferation, invasiveness and glycolysis of ccRCC cells by regulating the AMPK/mTOR signaling pathway, and suggest that GAS6-AS1 may be a potential therapeutic target for ccRCC.
Language	English
Publishing date	2021-08-10
Publishing country	Greece
Document type	Journal Article ; Retracted Publication
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2021.12988
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Article ; Online: Circ_0128846/miR-140-3p/JAK2 Network in Osteoarthritis Development.

Li, Hongjun / Liu, Zhongyu / Guo, Xiaoyun / Zhang, Mei

Immunological investigations

2021 Volume 51, Issue 6, Page(s) 1529–1547

Abstract: Circular RNAs (circRNAs) titrate the function of microRNAs (miRNAs), regulate transcription, and interfere with splicing. This study attempted to confirm the role of a novel circRNA circ_0128846 during osteoarthritis (OA) progression. Tissues and ... ...

Abstract	Circular RNAs (circRNAs) titrate the function of microRNAs (miRNAs), regulate transcription, and interfere with splicing. This study attempted to confirm the role of a novel circRNA circ_0128846 during osteoarthritis (OA) progression. Tissues and chondrocytes were isolated from OA patients. Overexpression and knockdown of target genes were generated using cell transfection and siRNA interference. Expression levels of genes were measured by qRT-PCR, Western blot, and immunohistochemistry, respectively. The interactions among circ_0128846, miR-140-3p, and JAK2 were verified by bioinformatics prediction, a dual-luciferase reporter assay, and RNA immunoprecipitation assay. The role of circ_0128846 in vivo was confirmed by the construction of experimental OA rats. Pathological changes were evaluated by hematoxylin and eosin and Safranin O staining. In OA patients, the level of circ_0128846 and JAK2 were up-regulated with down-regulated level of miR-140-3p. Circ_0128846 was principally located in the cytoplasm. Circ_0128846 silence enhanced cells viability, but reduced apoptosis rate and inflammatory response, which was obviously reversed by miR-140-3p knockdown. The overexpression of JAK2 reversed the effects of miR-140-3p on cell phenotypes. Circ_0128846 silence suppressed the level of MMP-13 and promoted the expression of collagen II by up-regulating miR-140-3p and down-regulating JAK2 in OA cells. Results of animal experiments demonstrated that circ_0128846 silence promoted collagen II expression and attenuated the OA progression by regulating the miR-140-3p/JAK2 axis. Circ_0128846 contributes to OA development through acting as a sponge RNA for miR-140-3p and thereby increasing JAK2 expression. Results indicated that targeting circ_0128846 may have the potential to alleviate OA progression.
MeSH term(s)	Animals ; Apoptosis/genetics ; Cell Proliferation/genetics ; Eosine Yellowish-(YS) ; Hematoxylin ; Janus Kinase 2/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteoarthritis/genetics ; RNA, Circular/genetics ; Rats ; Rats, Sprague-Dawley
Chemical Substances	MIRN140 microRNA, rat ; MicroRNAs ; RNA, Circular ; Jak2 protein, rat (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
Language	English
Publishing date	2021-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2021.1981930
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Article: Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac Ca

Hovey, Liam / Guo, Xiaoyun / Chen, Yi / Liu, Qinghang / Catterall, William A

Frontiers in physiology

2023 Volume 14, Page(s) 1049611

Abstract: The cardiac calcium channel ... ...

Abstract	The cardiac calcium channel Ca
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1049611
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Article ; Online: Estimating canopy stomatal conductance and photosynthesis in apple trees by upscaling parameters from the leaf scale to the canopy scale in Jinzhong Basin on Loess Plateau.

Gao, Guanlong / Hao, Yulian / Feng, Qi / Guo, Xiaoyun / Shi, Junxi / Wu, Bo

Plant physiology and biochemistry : PPB

2023 Volume 202, Page(s) 107939

Abstract	The estimations of stomatal conductance and photosynthesis performed by upscaling the parameters from the leaf scale to the canopy scale are key points in the fields of forest ecohydrology and physiology. The foundation for solving this scientific problem is determining the optimal models for calculating the leaf stomatal conductance (g
MeSH term(s)	Malus/physiology ; Plant Leaves/physiology ; Photosynthesis/physiology ; Trees/physiology ; Temperature ; Plant Stomata/physiology
Language	English
Publishing date	2023-08-05
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107939
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Article ; Online: Facile high-quantum-yield sulfur-quantum-dot-based photoluminescent probe for nifedipine detection

Sheng, Yilun / Huang, Zhongnan / Chen, Yaling / Guo, Xiaoyun / Chen, Lan / Peng, Huaping / Chen, Wei

Anal Bioanal Chem. 2022 Nov., v. 414, no. 26 p.7675-7681

2022

Abstract: Monitoring of dihydropyridine drugs, such as nifedipine (NIF), has attracted considerable attention owing to the side effects arising from the consumption of such drugs. Herein, a highly sensitive and facile fluorescence-sensing platform based on a high- ... ...

Abstract	Monitoring of dihydropyridine drugs, such as nifedipine (NIF), has attracted considerable attention owing to the side effects arising from the consumption of such drugs. Herein, a highly sensitive and facile fluorescence-sensing platform based on a high-quantum-yield sulfur quantum dot (SQDs) probe for NIF detection is proposed. Based on the principle of the inner filter effect, the rapid detection of NIF with high sensitivity is successfully realized on the basis of the change in the fluorescence signal due to the quenching effect of NIF on SQDs. The results show a good linear relationship between the NIF concentration and fluorescence intensity within the range of 5–150 μmol/L, with a low detection limit of 1.63 μmol/L (S/N = 3). Moreover, because no surface modification or establishment of any coupling between the receptor and the fluorophore is necessary, this approach provides considerable flexibility and simplicity for the construction of a fluorescence sensor and substantially reduces the detection time. A systematic investigation was conducted to verify the applicability of this method for the analysis of pharmaceutical components in NIF tablets. This study not only promotes the design and development of a fluorescence analysis platform for NIF detection, but also facilitates the fabrication of novel SQD-based fluorescence-sensing systems for the molecular detection of drugs. Proposal for a facile nifedipine assay method based on the inner filter effect of nifedipine to high-quantum-yield sulfur quantum dots, and realizing nifedipine detection in tablets and human urine samples.
Keywords	detection limit ; fluorescence ; fluorescent dyes ; humans ; photoluminescence ; quantum dots ; rapid methods ; sulfur ; urine
Language	English
Dates of publication	2022-11
Size	p. 7675-7681.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ISSN	1618-2642
DOI	10.1007/s00216-022-04297-9
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