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  1. Article ; Online: Glucose levels affect MgaSpn regulation on the virulence and adaptability of Streptococcus pneumoniae.

    Suo, Weicai / Guo, Xinlin / Zhang, Xuemei / Xiao, Shengnan / Wang, Shuhui / Yin, Yibing / Zheng, Yuqiang

    Microbial pathogenesis

    2022  Volume 174, Page(s) 105896

    Abstract: Streptococcus pneumoniae can regulate virulence gene expression by sensing environmental changes, which is key to its pathogenicity. The global transcription regulator MgaSpn of Streptococcus pneumoniae regulates virulence genes expression by directly ... ...

    Abstract Streptococcus pneumoniae can regulate virulence gene expression by sensing environmental changes, which is key to its pathogenicity. The global transcription regulator MgaSpn of Streptococcus pneumoniae regulates virulence genes expression by directly binding to the promoter regions, but its role in response to different environments remains unclear. In this study, we found that glucose levels could affect phosphocholine content, which was mediated by MgaSpn. MgaSpn can also alter its anti-phagocytosis ability, depending on the availability of glucose. In addition, transcriptome analysis of wild-type D39s in low and high glucose concentrations revealed that MgaSpn was also involved in the regulation of carbon metabolism inhibition (carbon catabolite repression; CCR) and translation processes, which made S. pneumoniae highly competitive in fluctuating environments. In conclusion, MgaSpn is closely related to the virulence and environmental adaptability of Streptococcus pneumoniae.
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2022.105896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: comCDE

    Zhang, Yapeng / Zhang, Jinghui / Xiao, Jiangming / Wang, Hanyi / Yang, Rui / Guo, Xinlin / Zheng, Yuqiang / Yin, Yibing / Zhang, Xuemei

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0001223

    Abstract: Natural transformation plays an important role in the formation of drug-resistant bacteria. Exploring the regulatory mechanism of natural transformation can aid the discovery of new antibacterial targets and reduce the emergence of drug-resistant ... ...

    Abstract Natural transformation plays an important role in the formation of drug-resistant bacteria. Exploring the regulatory mechanism of natural transformation can aid the discovery of new antibacterial targets and reduce the emergence of drug-resistant bacteria. Competence is a prerequisite of natural transformation in Streptococcus pneumoniae, in which
    MeSH term(s) Humans ; Streptococcus pneumoniae/metabolism ; Staphylococcal Protein A/metabolism ; Bacterial Proteins/metabolism ; Operon ; Carbon/metabolism ; Gene Expression Regulation, Bacterial
    Chemical Substances Staphylococcal Protein A ; Bacterial Proteins ; Carbon (7440-44-0)
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00012-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-Fidelity Sensitive Tracing Circulating Tumor Cell Telomerase Activity.

    Wang, Zining / Chen, Xiaohui / Qiu, Xiaopei / Chen, Yi / Wang, Tian / Lv, Linxi / Guo, Xinlin / Yang, Fei / Tang, Miao / Gu, Wei / Luo, Yang

    Analytical chemistry

    2024  Volume 96, Issue 14, Page(s) 5527–5536

    Abstract: Dynamic tracing of intracellular telomerase activity plays a crucial role in cancer cell recognition and correspondingly in earlier cancer diagnosis and personalized precision therapy. However, due to the complexity of the required reaction system and ... ...

    Abstract Dynamic tracing of intracellular telomerase activity plays a crucial role in cancer cell recognition and correspondingly in earlier cancer diagnosis and personalized precision therapy. However, due to the complexity of the required reaction system and insufficient loading of reaction components into cells, achieving a high-fidelity determination of telomerase activity is still a challenge. Herein, an Aptamer-Liposome mediated Telomerase activated poly-Molecular beacon Arborescent Nanoassembly(ALTMAN) approach was described for direct high-fidelity visualization of telomerase activity. Briefly, intracellular telomerase activates molecular beacons, causing their hairpin structures to unfold and produce fluorescent signals. Furthermore, multiple molecular beacons can self-assemble, forming arborescent nanostructures and leading to exponential amplification of fluorescent signals. Integrating the enzyme-free isothermal signal amplification successfully increased the sensitivity and reduced interference by leveraging the skillful design of the molecular beacon and the extension of the telomerase-activated TTAGGG repeat sequence. The proposed approach enabled ultrasensitive visualization of activated telomerase exclusively with a prominent detection limit of 2 cells·μL
    MeSH term(s) Humans ; Telomerase/metabolism ; Neoplastic Cells, Circulating ; Fluorescent Dyes/chemistry ; Nanostructures/chemistry ; HeLa Cells
    Chemical Substances Telomerase (EC 2.7.7.49) ; Fluorescent Dyes
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Mga

    Xiao, Shengnan / Suo, Weicai / Zhang, Jinghui / Zhang, Xuemei / Yin, Yibing / Guo, Xinlin / Zheng, Yuqiang

    Virulence

    2021  Volume 12, Issue 1, Page(s) 2366–2381

    Abstract: Global transcriptional regulators are prevalent in gram-positive pathogens. The transcriptional regulators of the Mga/AtxA family regulate target gene expression by directly binding to the promoter regions, that results in the coordinated expression of ... ...

    Abstract Global transcriptional regulators are prevalent in gram-positive pathogens. The transcriptional regulators of the Mga/AtxA family regulate target gene expression by directly binding to the promoter regions, that results in the coordinated expression of virulence factors. The
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Phosphorylcholine/metabolism ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/pathogenicity ; Transcription Factors/metabolism ; Virulence ; Virulence Factors/genetics
    Chemical Substances Bacterial Proteins ; Transcription Factors ; Virulence Factors ; Phosphorylcholine (107-73-3)
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2021.1972539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling.

    Shi, Hui / Zhao, Luping / Guo, Xinlin / Fang, Runping / Zhang, Hui / Dong, Guanjun / Fu, Jia / Yan, Fenglian / Zhang, Junfeng / Ning, Zhaochen / Ma, Qun / Li, Zhihua / Li, Chunxia / Dai, Jun / Si, Chuanping / Xiong, Huabao

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: Invasive breast cancer is highly regulated by tumor-derived cytokines in tumor microenvironment. The development of drugs that specifically target cytokines are promising in breast cancer treatment. In this study, we reported that arctigenin, a bioactive ...

    Abstract Invasive breast cancer is highly regulated by tumor-derived cytokines in tumor microenvironment. The development of drugs that specifically target cytokines are promising in breast cancer treatment. In this study, we reported that arctigenin, a bioactive compound from
    MeSH term(s) Animals ; Apoptosis ; Biomarkers, Tumor ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Movement ; Cell Proliferation ; Cytokines/genetics ; Cytokines/metabolism ; Female ; Furans/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Lignans/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; beta Catenin/genetics ; beta Catenin/metabolism
    Chemical Substances Biomarkers, Tumor ; CTNNB1 protein, human ; Cytokines ; Furans ; Lignans ; STAT3 Transcription Factor ; STAT3 protein, human ; TSLP protein, human ; beta Catenin ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; arctigenin (U76MR9VS6M)
    Language English
    Publishing date 2020-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21176357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: Shi, H., et al. Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling.

    Shi, Hui / Zhao, Luping / Guo, Xinlin / Fang, Runping / Zhang, Hui / Dong, Guanjun / Fu, Jia / Yan, Fenglian / Zhang, Junfeng / Ning, Zhaochen / Ma, Qun / Li, Zhihua / Li, Chunxia / Dai, Jun / Si, Chuanping / Xiong, Huabao

    International journal of molecular sciences

    2020  Volume 21, Issue 22

    Abstract: The authors wish to make the following correction to this paper [ ... ]. ...

    Abstract The authors wish to make the following correction to this paper [...].
    Language English
    Publishing date 2020-11-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21228850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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