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Article ; Online: Effect of 1 + N Extended Nursing Service on Functional Recovery of Colostomy Patients.

Feng, Chunlan / Lv, Caixia / Zhang, Xia / Guo, Yumei / Li, Xiaojun

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 2645528

Abstract: To many hospitals' management as well as to patients, the nursing service is one of the most important aspects. Many diseases like sugar, blood pressure, urine passage, and gas are a little bit dangerous to handle by patients themselves. The earlier ... ...

Abstract	To many hospitals' management as well as to patients, the nursing service is one of the most important aspects. Many diseases like sugar, blood pressure, urine passage, and gas are a little bit dangerous to handle by patients themselves. The earlier stage models are unable to give good services to patients; therefore, an advanced JHE: Effect of 1 + N extended nursing service is necessary to crossover the above limitations. Colostomy and colorectal cancers are very dangerous syndromes thus, disease monitoring is so difficult. In this research work, an extended JHE: Effect of 1 + N extended nursing service modeling is discussed with experimental modeling. Apart from conventional nursing care provided by the observation group, it was given online training as well as service providing. Self-efficacy and self-care competence were assessed in both groups 6 months after the discharge. Quality of life and mental health were also assessed. Besides, their dimensional and total self-care ability scores, and the observation group's self-efficacy ratings were substantially higher than those of the control group (
MeSH term(s)	Colostomy/psychology ; Humans ; Nursing Services ; Quality of Life ; Self Efficacy
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/2645528
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Article ; Online: The second cutaneous anthrax infection diagnosed by metagenomic next-generation sequencing: A case report.

Zheng, Cuiying / Ye, Jiaqing / Song, Minghui / Guo, Yumei / Gao, Weili / Hao, Jiahao / Feng, Zhongjun / Zhang, Lijie

Medicine

2024 Volume 103, Issue 3, Page(s) e36921

Abstract: Rationale: Anthrax is a severe zoonotic infectious disease caused by Bacillus anthracis. Most reported cases were traditionally diagnosed through culture and microscopy. We reported here the second case of cutaneous anthrax diagnosed by metagenomic next- ...

Abstract	Rationale: Anthrax is a severe zoonotic infectious disease caused by Bacillus anthracis. Most reported cases were traditionally diagnosed through culture and microscopy. We reported here the second case of cutaneous anthrax diagnosed by metagenomic next-generation sequencing (mNGS). Patient concerns: A 63-year-old man had a history of contact with an unwell sheep, developing local redness and swelling on wrist. The dorsal side of the left hand and forearm, with tension blisters on the back of the left. Diagnosis: B anthracis was detected from culturing and mNGS of tension blisters. Interventions: On the second day of admission, the patient was administered 3.2 million units of penicillin every 6 hours, and isolated and closely observed. Outcomes: The patient improves and is discharged. Lessons: Traditional bacterial cultures are time-consuming, while mNGS offers the advantage of accurate, quick, high-throughput, unbiased sequencing of all genetic material in a sample, which is a good technical tool for assisting in the diagnosis of rare pathogen infections.
MeSH term(s)	Male ; Humans ; Animals ; Sheep ; Middle Aged ; Anthrax/diagnosis ; Anthrax/microbiology ; Blister ; Skin Diseases, Bacterial/diagnosis ; Bacillus anthracis/genetics ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036921
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Article ; Online: Omni-media health education combined with nanodrug therapy on the creation of gastrointestinal microenvironment and the improvement of treatment compliance in patients with gastrointestinal tumors.

Feng, Chunlan / Guo, Yumei / Zhang, Xia / Lv, Caixia / Li, Xiaojun / Li, Xiaowei

Preventive medicine

2023 Volume 173, Page(s) 107567

Abstract: According to the randomization method, 82 patients can be divided into two groups, the control group and the study group, each with 41 patients participating in the investigation. All patients in the control group were cared for, and the study group used ...

Abstract	According to the randomization method, 82 patients can be divided into two groups, the control group and the study group, each with 41 patients participating in the investigation. All patients in the control group were cared for, and the study group used a health education model. The treatment mode of each group needs to adopt adherence, and it is necessary to maintain a healthy diet, smoking cessation and alcohol cessation, and regular review during the treatment of regular exercise and emotional regulation. To enable patients to accurately grasp health knowledge during treatment, score self-management ability (ESCA), and maintain a level of satisfaction with care. (1) In the study group, the standard treatment of patients directly reached 97.56%, regular review reached 95.12%, regular exercise reached 90.24%, the degree of smoking cessation reached 92.68%. (2) The mastery of disease and health knowledge in the first group (95.12%) was significantly higher than that of (78.05%) (P < 0.05). (3) After the intervention, the first group scored higher for self-responsibility (27.07 ± 3.15), self-awareness (25.59 ± 3.11), health knowledge (40.38 ± 4.54), and self-care skills (36.45 ± 3.19). (4) The nursing satisfaction level of the first group was (92.68%), which was significantly higher than that of the other group (75.61%). According to the conclusions, it can be shown that health education for tumor patients can improve patients' compliance with treatment and mastery of disease health knowledge, which is conducive to improving patients' self-management ability.
MeSH term(s)	Humans ; Gastrointestinal Neoplasms ; Health Behavior ; Health Education ; Nanoparticles/therapeutic use ; Patient Compliance ; Tumor Microenvironment
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2023.107567
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Article ; Online: Rare occurrence of pulmonary coinfection involving Aspergillus fumigatus and Nocardia cyriacigeorgica in immunocompetent patients based on NGS: A case report and literature review.

Ye, Jiaqing / Li, Yahua / Hao, Jiahao / Song, Minghui / Guo, Yumei / Gao, Weili / Zheng, Cuiying / Huang, Yinqi / Feng, Zhongjun / Zhang, Lijie

Medicine

2023 Volume 102, Issue 51, Page(s) e36692

Abstract: Rationale: In our search on PubMed, we found that reports of co-infections involving Aspergillus fumigatus and Nocardia cyriacigeorgica in the literature are notably scarce. Most cases have been documented in patients with compromised immune systems or ... ...

Abstract	Rationale: In our search on PubMed, we found that reports of co-infections involving Aspergillus fumigatus and Nocardia cyriacigeorgica in the literature are notably scarce. Most cases have been documented in patients with compromised immune systems or underlying pulmonary conditions. In contrast, our patient did not present with any of these risk factors. Furthermore, there have been no recent incidents such as near-drowning or other accidents in the patient history. To the best of our knowledge, this case represents a hitherto unreported clinical scenario. To enhance comprehension, we conducted a comprehensive literature review by compiling a total of 20 case reports (spanning from 1984 to 2023) on co-infections involving Aspergillus and Nocardia species, retrieved from PubMed. Patient concerns and diagnosis: Chest CT revealed the presence of multiple nodules and clustered high-density shadows in both lungs. Bronchoscopy revealed mucosal congestion and edema in the apical segment of the right upper lobe of the lung, along with the presence of 2 spherical polypoid new organisms. The pathological analysis reported severe chronic inflammation with evidence of Aspergillus within the tissue. Next-Generation Sequencing of bronchoalveolar lavage fluid revealed the presence of reads corresponding to A fumigatus and N cyriacigeorgica. Positive cultures for A fumigatus and the Nocardia genus were yielded by prolonging the incubation of samples in the microbiology laboratory. Interventions: Treatment with voriconazole for A fumigatus and sulfamethoxazole-trimethoprim for N cyriacigeorgica infection was given. Outcomes: The patient improved and was discharged. After 6 months of telephone follow-up, the patient reported no clinical symptoms, discontinued the medication on his own. Lessons: A fumigatus and N cyriacigeorgica can manifest as a co-infection in immunocompetent patients. Clinicians should prioritize the significant advantages and value of NGS in detecting rare and mixed pathogens associated with pulmonary infections.
MeSH term(s)	Humans ; Coinfection/diagnosis ; Coinfection/drug therapy ; Aspergillus fumigatus ; Nocardia Infections/complications ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Nocardia ; Lung
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036692
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Article ; Online: Virulence, antimicrobial resistance, and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae in a hospital in Shijiazhuang City from China.

Guo, Yumei / Liu, Faqiang / Zhang, Yulan / Wang, Xiaoli / Gao, Weili / Xu, Baohong / Li, Yuxue / Song, Ning

International microbiology : the official journal of the Spanish Society for Microbiology

2023 Volume 26, Issue 4, Page(s) 1073–1085

Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP), as one of the most common drug-resistant bacteria threatening human health, is hyper-resistant to multiple antimicrobial drugs and carbapenems, which can be dealt with only limited clinical treatment ... ...

Abstract	Carbapenem-resistant Klebsiella pneumoniae (CRKP), as one of the most common drug-resistant bacteria threatening human health, is hyper-resistant to multiple antimicrobial drugs and carbapenems, which can be dealt with only limited clinical treatment options. This study described the epidemiological characteristics of CRKP in this tertiary care hospital from 2016 to 2020. Specimen sources included blood, sputum, alveolar lavage fluid, puncture fluid, secretions from a burn wound, and urine. Among the 87 carbapenem-resistant strains, ST11 was the predominant isolate, followed by ST15, ST273, ST340, and ST626. These STs were in broad agreement with the STs defined by pulsed-field gel electrophoresis clustering analysis in discriminating clusters of related strains. Most CRKP isolates contained the blaKPC-2 gene, some isolates carried the blaOXA-1, blaNDM-1, and blaNDM-5 genes, and the isolates carrying carbapenem resistance genes were more resistant to the antimicrobials of β-lactams, carbapenems, macrolides, and fluoroquinolone. The OmpK35 and OmpK37 genes were detected in all CRKP strains, and the Ompk36 gene was detected in some CRKP strains. All detected OmpK37 had 4 mutant sites, and OmpK36 had 11 mutant sites, while no mutant sites were found in OmpK35. More than half of the CRKP strains contained the OqxA and OqxB efflux pump genes. The virulence genes were most commonly combined with urea-wabG-fimH-entB-ybtS-uge-ycf. Only one CRKP isolate was detected with the K54 podoconjugate serotype. This study elucidated the clinical epidemiological features and molecular typing of CRKP, and grasped the distribution of drug-resistant genotypes, podocyte serotypes, and virulence genes of CRKP, providing some guidance for the subsequent treatment of CRKP infection.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Klebsiella pneumoniae/genetics ; beta-Lactamases/genetics ; Virulence/genetics ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Drug Resistance, Bacterial/genetics ; Microbial Sensitivity Tests ; Carbapenems/pharmacology ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Hospitals ; China/epidemiology ; Multilocus Sequence Typing
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Carbapenems
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1454951-7
ISSN	1618-1905 ; 1139-6709
ISSN (online)	1618-1905
ISSN	1139-6709
DOI	10.1007/s10123-023-00357-x
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Article ; Online: Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome.

Wang, Zhuo / Donahue, Erin K / Guo, Yumei / Renteln, Michael / Petzinger, Giselle M / Jakowec, Michael W / Holschneider, Daniel P

Brain structure & function

2023 Volume 228, Issue 8, Page(s) 1865–1884

Abstract: The basal ganglia are important modulators of the cognitive and motor benefits of exercise. However, the neural networks underlying these benefits remain poorly understood. Our study systematically analyzed exercise-associated changes in metabolic ... ...

Abstract	The basal ganglia are important modulators of the cognitive and motor benefits of exercise. However, the neural networks underlying these benefits remain poorly understood. Our study systematically analyzed exercise-associated changes in metabolic connectivity in the cortico-basal ganglia-thalamic network during the performance of a new motor task, with regions-of-interest defined based on mesoscopic domains recently defined in the mouse brain structural connectome. Mice were trained on a motorized treadmill for six weeks or remained sedentary (control), thereafter undergoing [
MeSH term(s)	Humans ; Mice ; Animals ; Connectome ; Basal Ganglia/metabolism ; Brain ; Globus Pallidus ; Prefrontal Cortex ; Neural Pathways ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-06-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-023-02659-2
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Article: A Cross-Sectional Study on Awareness of Tuberculosis Control Among Post-Treatment Tuberculosis Patients in a City in China.

Jing, Rui / Dong, Hui / Huang, Kun / Liu, Zhong / Xue, Ran / Dong, Yiran / Jiao, Mei / Li, Na / Guo, Yumei / Liu, Yun / Zhang, Wenqian / Sun, Hongyun

Infection and drug resistance

2024 Volume 17, Page(s) 1041–1049

Abstract: Purpose: This study aimed to investigate awareness of tuberculosis control among post-treatment tuberculosis patients, in order to provide a basis for future preventive and control work in this population.: Patients and methods: A cross-sectional ... ...

Abstract	Purpose: This study aimed to investigate awareness of tuberculosis control among post-treatment tuberculosis patients, in order to provide a basis for future preventive and control work in this population. Patients and methods: A cross-sectional descriptive study was conducted on post-treatment patients with tuberculosis in seven districts of Jinan City between July 2021 and December 2022. A face-to-face or telephone interviews using structured questionnaires for the research subjects were conducted by data collectors. Analyses were carried out first for all subjects, and then separately for male and female subjects. Results: A total of 837 valid questionnaires were collected, of which 495 were males and 342 were females. The awareness rate of the core TB knowledge was 82.46%. The ≥65 year group in the total group (OR=0.43, 95% CI: (0.28, 0.68)), male (OR=0.47, 95% CI: (0.27, 0.83)) and female group (OR=0.40, 95% CI: (0.19, 0.86)) was lower than that of the control group. Educational level and monthly income are the main factors of TB cognition in total group. People with university or higher education (OR=2.05, 95% CI: (1.38, 3.05)) and with a monthly income of ≥6,000 (OR=1.89, 95% CI: (1.10, 3.25)) had a higher awareness rate. The group with current residence in the city was more aware than the reference group. Conclusion: In the future, the communication of the main transmission route, suspicious symptoms, and cure of TB needs to be strengthened for the post-treatment TB patients. The elderly, those with secondary school education or below, agricultural workers and low-income people are the groups with weak knowledge of TB, and they are also the groups that need to be focused on health education. The above information should be focused on the above groups of people in order to educate them in a way that is easily acceptable to them.
Language	English
Publishing date	2024-03-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S448823
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Article ; Online: A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model.

Zhuo, Wang / Lundquist, Adam J / Donahue, Erin K / Guo, Yumei / Phillips, Derek / Petzinger, Giselle M / Jakowec, Michael W / Holschneider, Daniel P

Current research in neurobiology

2022 Volume 3, Page(s) 100039

Abstract: Cognitive impairment, particularly deficits in executive function (EF) is common in Parkinson's disease (PD) and may lead to dementia. There are currently no effective treatments for cognitive impairment. Work from our lab and others has shown that ... ...

Abstract	Cognitive impairment, particularly deficits in executive function (EF) is common in Parkinson's disease (PD) and may lead to dementia. There are currently no effective treatments for cognitive impairment. Work from our lab and others has shown that physical exercise may improve motor performance in PD but its role in cognitive function remains poorly eludicated. In this study in a rodent model of PD, we sought to examine whether exercise improves cognitive processing and flexibility, important features of EF. Rats received 6-hydroxydopamine lesions of the bilateral striatum (caudate-putamen, CPu), specifically the dorsomedial CPu, a brain region central to EF. Rats were exercised on motorized running wheels or horizontal treadmills for 6-12 weeks. EF-related behaviors including attention and processing, as well as flexibility (inhibition) were evaluated using either an operant 3-choice serial reaction time task (3-CSRT) with rule reversal (3-CSRT-R), or a T-maze task with reversal. Changes in striatal transcript expression of dopamine receptors (
Language	English
Publishing date	2022-05-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2665-945X
ISSN (online)	2665-945X
DOI	10.1016/j.crneur.2022.100039
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Article ; Online: Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats.

Wang, Zhuo / Guo, Yumei / Mayer, Emeran A / Holschneider, Daniel P

Brain research

2019 Volume 1717, Page(s) 15–26

Abstract: Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other ... ...

Abstract	Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other parts of the brain. Cerebral blood flow mapping was performed using [
MeSH term(s)	Animals ; Brain/physiology ; Brain Mapping/methods ; Brain Stem/physiology ; Cerebral Cortex/blood supply ; Cerebral Cortex/metabolism ; Cerebral Cortex/physiology ; Connectome/methods ; Female ; Male ; Neural Pathways ; Pain/metabolism ; Pain/physiopathology ; Prefrontal Cortex/physiology ; Rats ; Rats, Wistar ; Sex Characteristics ; Sex Factors
Language	English
Publishing date	2019-04-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2019.04.005
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Zs.A 161: Show issues

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Article ; Online: Fabrication of paper-based microfluidic device by recycling foamed plastic and the application for multiplexed measurement of biomarkers.

Guo, Xiaoyan / Guo, Yumei / Liu, Wei / Chen, Ying / Chu, Weiru

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2019 Volume 223, Page(s) 117341

Abstract: Microfluidic paper-based analytical devices (μPADs) are emerging as effective analytical platforms for point-of-care assays in resource-limited areas. Simple and cost-effective fabrication method still remains challenging on μPADs. A simple and cost- ... ...

Abstract	Microfluidic paper-based analytical devices (μPADs) are emerging as effective analytical platforms for point-of-care assays in resource-limited areas. Simple and cost-effective fabrication method still remains challenging on μPADs. A simple and cost-effective method for fabricating paper-based devices was presented in this work by using of dipping strategy with the recycled polystyrene in chloroform as the hydrophobic reagent. Adhesive tape was employed as mask to transfer the hydrophilic channel pattern to the paper substrate. With the single-sided adhesive tape stuck on the hydrophilic parts of the paper surface, the paper-based device was immersed in chloroform solution with dissolving recycling polystyrene for several seconds. Then the hydrophilic pattern can be achieved and all the other parts on the paper surface were hydrophobic. The adhesive tape was torn off from the hydrophilic parts. The highest contact angle value of 114° of the hydrophobic part was acquired with this simple fabrication method. By using of the sandwich-type immunoreactions and luminol-H
MeSH term(s)	Antibodies/metabolism ; Antigens/metabolism ; Biomarkers, Tumor/blood ; Calibration ; Diffusion ; Humans ; Hydrophobic and Hydrophilic Interactions ; Luminescent Measurements ; Microfluidics/instrumentation ; Microfluidics/methods ; Paper ; Plastics/chemistry
Chemical Substances	Antibodies ; Antigens ; Biomarkers, Tumor ; Plastics
Language	English
Publishing date	2019-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2019.117341
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