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Article: [Effect of "

Guo, Yun-Ping / Shi, Xue-Min

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2019 Volume 39, Issue 4, Page(s) 349–354

Abstract: Objective: To observe the effects of ": Methods: Seventy patients with stroke complicated with hypertension were randomly divided into an observation group and a control group, 35 cases in each group. ": Results: The systolic and diastolic blood ... ...

Abstract	Objective: To observe the effects of " Methods: Seventy patients with stroke complicated with hypertension were randomly divided into an observation group and a control group, 35 cases in each group. " Results: The systolic and diastolic blood pressures were significantly lower than those before treatment in the two groups (all Conclusion: On the basis of "
MeSH term(s)	Acupuncture Therapy ; Aged ; Blood Pressure ; Humans ; Hypertension/therapy ; Stroke
Language	Chinese
Publishing date	2019-04-08
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.2019.04.002
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Article: The link between immunity and hypertension in the kidney and heart.

Benson, Lance N / Guo, Yunping / Deck, Katherine / Mora, Christoph / Liu, Yunmeng / Mu, Shengyu

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1129384

Abstract: Hypertension is the primary cause of cardiovascular disease, which is a leading killer worldwide. Despite the prevalence of this non-communicable disease, still between 90% and 95% of cases are of unknown or multivariate cause ("essential hypertension"). ...

Abstract	Hypertension is the primary cause of cardiovascular disease, which is a leading killer worldwide. Despite the prevalence of this non-communicable disease, still between 90% and 95% of cases are of unknown or multivariate cause ("essential hypertension"). Current therapeutic options focus primarily on lowering blood pressure through decreasing peripheral resistance or reducing fluid volume, but fewer than half of hypertensive patients can reach blood pressure control. Hence, identifying unknown mechanisms causing essential hypertension and designing new treatment accordingly are critically needed for improving public health. In recent years, the immune system has been increasingly implicated in contributing to a plethora of cardiovascular diseases. Many studies have demonstrated the critical role of the immune system in the pathogenesis of hypertension, particularly through pro-inflammatory mechanisms within the kidney and heart, which, eventually, drive a myriad of renal and cardiovascular diseases. However, the precise mechanisms and potential therapeutic targets remain largely unknown. Therefore, identifying which immune players are contributing to local inflammation and characterizing pro-inflammatory molecules and mechanisms involved will provide promising new therapeutic targets that could lower blood pressure and prevent progression from hypertension into renal or cardiac dysfunction.
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1129384
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Article ; Online: P2X7

Benson, Lance N / Deck, Katherine S / Mora, Christoph J / Guo, Yunping / Rafferty, Tonya M / Li, Lin-Xi / Huang, Lu / Andrews, J Tucker / Qin, Zhiqiang / Trott, Daniel W / Hoover, Robert S / Liu, Yunmeng / Mu, Shengyu

Hypertension (Dallas, Tex. : 1979)

2024 Volume 81, Issue 3, Page(s) 530–540

Abstract: Background: CD8: Methods: We used mouse models of hypertension. Wild type were used as genetic controls, OT1 and Rag2/OT1 mice were utilized to determine antigen dependency, and P2X7-knockout mice were studied to define the role of P2X7 in activating ...

Abstract	Background: CD8 Methods: We used mouse models of hypertension. Wild type were used as genetic controls, OT1 and Rag2/OT1 mice were utilized to determine antigen dependency, and P2X7-knockout mice were studied to define the role of P2X7 in activating CD8Ts and promoting hypertension. Blood pressure was monitored continuously and kidneys were obtained at different experimental end points. Freshly isolated CD8Ts from mice for activation assays and ATP stimulation. CD8T activation-induced promotion of sodium retention was explored in cocultures of CD8Ts and mouse DCTs. Results: We found that OT1 and Rag2/OT1 mice, which are nonresponsive to common antigens, still developed hypertension and CD8T-activation in response to deoxycorticosterone acetate/salt treatment, similar to wild-type mice. Further studies identified the P2X7 receptor on CD8Ts as a possible mediator of this antigen-independent activation of CD8Ts in hypertension. Knockout of the P2X7 receptor prevented calcium influx and cytokine production in CD8Ts. This finding was associated with reduced CD8T-DCT stimulation, reversal of excessive salt retention in DCTs, and attenuated development of salt-sensitive hypertension. Conclusions: Our findings suggest a novel mechanism by which CD8Ts are activated in hypertension to exacerbate salt retention and infer that the P2X7 receptor on CD8Ts may represent a new therapeutic target to attenuate T-cell-mediated immunopathology in hypertension.
MeSH term(s)	Mice ; Animals ; CD8-Positive T-Lymphocytes ; Receptors, Purinergic P2X7/genetics ; Mice, Knockout ; Hypertension ; Sodium Chloride, Dietary ; Sodium ; Adenosine Triphosphate ; Mice, Inbred C57BL
Chemical Substances	Receptors, Purinergic P2X7 ; Sodium Chloride, Dietary ; Sodium (9NEZ333N27) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.123.21819
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Article: [Effect of acupuncture at Renying (ST 9) on blood pressure in patients with ischemic stroke complicated with essential hypertension].

Feng, Shan-Shan / Sun, Chao-Jun / Guo, Yun-Ping / Shi, Xue-Min

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2019 Volume 39, Issue 11, Page(s) 1160–1163

Abstract: Objective: To observe the effect of acupuncture at Renying (ST 9) on morning blood pressure, daytime peak blood pressure and 24-hour blood pressure load in patients with ischemic stroke complicated with essential hypertension.: Methods: A total of 80 ...

Abstract	Objective: To observe the effect of acupuncture at Renying (ST 9) on morning blood pressure, daytime peak blood pressure and 24-hour blood pressure load in patients with ischemic stroke complicated with essential hypertension. Methods: A total of 80 patients (3 cases dropped off) were randomized into an observation group (39 cases) and a control group (38 cases). Results: Compared before treatment, morning blood pressure, daytime peak blood pressure and blood pressure load after treatment were reduced in the two groups (all Conclusion: On the basis of
MeSH term(s)	Acupuncture Points ; Acupuncture Therapy/methods ; Blood Pressure ; Brain Ischemia ; Essential Hypertension/therapy ; Humans ; Stroke ; Treatment Outcome
Language	Chinese
Publishing date	2019-11-14
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.2019.11.006
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Article ; Online: Commentary on "Urtica dioica in comparison with placebo and acupuncture: A new possibility for menopausal hot flashes: A randomized clinical trial" by Rahele Kargozar et al., 2019.

Lu, Hai / Hu, Jiahui / Han, Lisha / Guo, Yunping / Zhang, Chunhong

Complementary therapies in medicine

2019 Volume 54, Page(s) 102212

MeSH term(s)	Acupuncture ; Acupuncture Therapy ; Hot Flashes/therapy ; Humans ; Urtica dioica
Language	English
Publishing date	2019-11-02
Publishing country	Scotland
Document type	Letter ; Comment
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2019.102212
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Article ; Online: Response to "The Effect of Neiguan Point (P6) Acupressure With Wristband on Postoperative Nausea, Vomiting, and Comfort Level: A Randomized Controlled Study" from Lu et al.

Lu, Hai / Han, Lisha / Hu, Jiahui / Guo, Yunping / Zhang, Chunhong

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2019 Volume 34, Issue 4, Page(s) 676–677

MeSH term(s)	Acupressure ; Acupuncture Points ; Humans ; Postoperative Nausea and Vomiting ; Research Design ; Vomiting
Language	English
Publishing date	2019-08-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2019.01.006
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Article: Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease

Gu, Danshan / Yi, Haoan / Jiang, Kerong / Fakhar, Syed Hassam / Shi, Jing / He, Yongshu / Liu, Bo / Guo, Yunping / Fan, Xiaoming / Li, Shude

Life sciences. 2021 Feb. 15, v. 267

2021

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease and lacks for safe and effective drug to therapy completely. Ginsenoside-Rg1 is one of the main components of ginseng and has been proved to counteract a variety of diseases. ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease and lacks for safe and effective drug to therapy completely. Ginsenoside-Rg1 is one of the main components of ginseng and has been proved to counteract a variety of diseases. However, there is currently a lack of sufficient evidence to support the efficacy of ginsenoside-Rg1 in the treatment of NAFLD. Our aim was to investigate whether Ginsenoside-Rg1 is a potential drug for NAFLD.NAFLD model in rats was established by giving a high-fat diet (HFD), ginsenoside-Rg1 was intragastrically administered 100 mg/kg/d for 8 weeks in NAFLD rat. Serum biochemical indices were measured. Liver tissues were stained with hematoxylin and eosin (HE) and oil red O. Total RNA was extracted from liver and was used for high throughput sequencing to identify the changes of transcriptome. The relevant hub genes were verified by quantitative real-time PCR and western blot.Serum biochemical analysis indicated that ginsenoside-Rg1 improved liver function. Additionally, the staining of HE and oil red O indicated ginsenoside-Rg1 could remit pathology process of NAFLD. The transcriptome changes also support this result and reveals Atf3 and Acox2 were key genes.Taken together, these results suggest that the efficiency of ginsenoside-Rg1 against NAFLD and confirmed that ginsenoside-Rg1 is a potential effective drug in treatment of NAFLD.
Keywords	Panax ; RNA ; blood serum ; drugs ; eosin ; fatty liver ; high fat diet ; liver ; liver function ; models ; quantitative polymerase chain reaction ; rats ; therapeutics ; transcriptome ; transcriptomics
Language	English
Dates of publication	2021-0215
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118986
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension.

Benson, Lance N / Liu, Yunmeng / Wang, Xiangting / Xiong, Yunzhao / Rhee, Sung W / Guo, Yunping / Deck, Katherine S / Mora, Christoph J / Li, Lin-Xi / Huang, Lu / Andrews, J Tucker / Qin, Zhiqiang / Hoover, Robert S / Ko, Benjamin / Williams, Ryan M / Heller, Daniel A / Jaimes, Edgar A / Mu, Shengyu

Circulation research

2022 Volume 130, Issue 10, Page(s) 1550–1564

Abstract: Background: Renal T cells contribute importantly to hypertension, but the underlying mechanism is incompletely understood. We reported that CD8Ts directly stimulate distal convoluted tubule cells (DCTs) to increase NCC (sodium chloride co-transporter) ... ...

Abstract	Background: Renal T cells contribute importantly to hypertension, but the underlying mechanism is incompletely understood. We reported that CD8Ts directly stimulate distal convoluted tubule cells (DCTs) to increase NCC (sodium chloride co-transporter) expression and salt reabsorption. However, the mechanistic basis of this pathogenic pathway that promotes hypertension remains to be elucidated. Methods: We used mouse models of DOCA+salt (DOCA) treatment and adoptive transfer of CD8 Results: We identified critical molecular players and demonstrated their roles in augmenting the CD8T-DCT interaction leading to salt-sensitive hypertension. We found that activated CD8Ts exhibit enhanced interaction with DCTs via IFN-γ-induced upregulation of MHC-I and PDL1 in DCTs, thereby stimulating higher expression of NCC in DCTs to cause excessive salt retention and progressive elevation of blood pressure. Eliminating IFN-γ or renal tubule-specific knockdown of PDL1 prevented T cell homing into the kidney, thereby attenuating hypertension in 2 different mouse models. Conclusions: Our results identified the role of activated CD8Ts in contributing to increased sodium retention in DCTS through the IFNγ-PDL1 pathway. These findings provide a new mechanism for T cell involvement in the pathogenesis of hypertension and reveal novel therapeutic targets.
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/metabolism ; Desoxycorticosterone Acetate/metabolism ; Desoxycorticosterone Acetate/pharmacology ; Disease Models, Animal ; Hypertension/metabolism ; Kidney Tubules, Distal/metabolism ; Kidney Tubules, Distal/pathology ; Mice ; Sodium/metabolism ; Sodium Chloride Symporters/metabolism ; Sodium Chloride, Dietary
Chemical Substances	Sodium Chloride Symporters ; Sodium Chloride, Dietary ; Desoxycorticosterone Acetate (6E0A168OB8) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.121.320373
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Article ; Online: Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease.

Gu, Danshan / Yi, Haoan / Jiang, Kerong / Fakhar, Syed Hassam / Shi, Jing / He, Yongshu / Liu, Bo / Guo, Yunping / Fan, Xiaoming / Li, Shude

Life sciences

2020 Volume 267, Page(s) 118986

Abstract: Aims: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease and lacks for safe and effective drug to therapy completely. Ginsenoside-Rg1 is one of the main components of ginseng and has been proved to counteract a variety of ... ...

Abstract	Aims: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease and lacks for safe and effective drug to therapy completely. Ginsenoside-Rg1 is one of the main components of ginseng and has been proved to counteract a variety of diseases. However, there is currently a lack of sufficient evidence to support the efficacy of ginsenoside-Rg1 in the treatment of NAFLD. Our aim was to investigate whether Ginsenoside-Rg1 is a potential drug for NAFLD. Main methods: NAFLD model in rats was established by giving a high-fat diet (HFD), ginsenoside-Rg1 was intragastrically administered 100 mg/kg/d for 8 weeks in NAFLD rat. Serum biochemical indices were measured. Liver tissues were stained with hematoxylin and eosin (HE) and oil red O. Total RNA was extracted from liver and was used for high throughput sequencing to identify the changes of transcriptome. The relevant hub genes were verified by quantitative real-time PCR and western blot. Key findings: Serum biochemical analysis indicated that ginsenoside-Rg1 improved liver function. Additionally, the staining of HE and oil red O indicated ginsenoside-Rg1 could remit pathology process of NAFLD. The transcriptome changes also support this result and reveals Atf3 and Acox2 were key genes. Significance: Taken together, these results suggest that the efficiency of ginsenoside-Rg1 against NAFLD and confirmed that ginsenoside-Rg1 is a potential effective drug in treatment of NAFLD.
MeSH term(s)	Animals ; Disease Models, Animal ; Gene Expression Profiling/methods ; Ginsenosides/metabolism ; Ginsenosides/pharmacology ; Liver/drug effects ; Male ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Panax/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Ginsenosides ; ginsenoside Rg1 (PJ788634QY)
Language	English
Publishing date	2020-12-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118986
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Article ; Online: Generation of CRISPR/Cas9-mediated lactoferrin-targeted mice by pronuclear injection of plasmid pX330

Mengxu GE,Fei LIU,Fei CHANG,Zhaolin SUN,Jing FEI,Ying GUO,Yunping DAI,Zhengquan YU,Yaofeng ZHAO,Ning LI, Qingyong MENG

Frontiers of Agricultural Science and Engineering, Vol 2, Iss 3, Pp 242-

2015 Volume 248

Abstract: Lactoferrin is a member of the transferrin family of multifunctional iron binding glycoproteins. While numerous physiological functions have been described for lactoferrin, the mechanisms underlying these functions are not clear. To further study the ... ...

Abstract	Lactoferrin is a member of the transferrin family of multifunctional iron binding glycoproteins. While numerous physiological functions have been described for lactoferrin, the mechanisms underlying these functions are not clear. To further study the functions and mechanisms of lactoferrin, we modified the lactoferrin promoter of mice using the CRISPR/Cas9 system to reduce or eliminate lactoferrin expression. Seven mice with lactoferrin promoter mutations were obtained with an efficiency of 24% (7/29) by injecting the plasmid pX330, expressing a small guide RNA and human codon-optimized SpCas9, into fertilized eggs of mice. Plasmid integration and off-targeting of pX330 were not detected. These results confirmed that pronuclear injection of a circular plasmid is a feasible and efficient method for targeted mutagenesis in mice.
Keywords	lactoferrin\|promoter\|CRISPR/Cas9\|plasmid pX330 ; Agriculture (General) ; S1-972
Subject code	572
Language	English
Publishing date	2015-09-01T00:00:00Z
Publisher	Higher Education Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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