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  1. AU="Guocan Wang"
  2. AU="Catherine Crenn-Hebert"
  3. AU="Alistar, Cristina F"
  4. AU="Makhani, Sarah S"
  5. AU="Tayyeb Pourfallah"
  6. AU="Mauad, Thais"

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  1. Artikel ; Online: Tectonic and Climatic Control on Quaternary Exhumation in the Eastern Pamir Domes, Western China

    Kai Cao / Hongtao Mai / Marie-Luce Chevalier / Guocan Wang

    Frontiers in Earth Science, Vol

    Insights From Geomorphic Approaches

    2022  Band 10

    Abstract: The Kongur Shan and Muztaghata massifs, bounded by the Kongur Shan extensional system (KES), represent tectonic and topographic anomalies in the eastern Pamir region. They are ideal examples to study how normal faulting and surface erosion influence ... ...

    Abstract The Kongur Shan and Muztaghata massifs, bounded by the Kongur Shan extensional system (KES), represent tectonic and topographic anomalies in the eastern Pamir region. They are ideal examples to study how normal faulting and surface erosion influence Quaternary exhumation of the dome system. We apply multiple geomorphic parameters, including hypsometric integral, stream length-gradient index, drainage basin shape, drainage basin asymmetry and ratio of valley floor width to valley height, for the catchments on both sides of the range. We first evaluated the validity of various indices and chose three active tectonic-sensitive indices to establish a newly-integrated parameter (Iat) that is used to measure relative intensities of tectonic activity in active orogens. Results suggest stronger tectonic activity west of the domes along the Kongur Shan normal fault (KSF) and Muji dextral strike-slip fault, compared to the eastern side, along the Ghez and Kalagile faults. This first-order observation reflects tectonic control on the topographic development of the domal structure, consistent with eastward crustal tilting, attested by older thermochronology ages to the east. On the western flank of the range, stronger tectonic activity occurs mostly on the Muji fault, Kingata Tagh - Kongur Shan fault segment, as well as along the western and southern Muztaghata segments of the Kongur Shan fault. This is consistent with field investigations of Quaternary offsets of landforms, which suggest continuous activity of the Muji fault and KSF since the late Miocene. Average basin-wide erosion rates derived from stream power models are highest near the Kongur Shan dome, and gradually decrease southwards and northwards, in agreement with the spatial pattern of long-term exhumation rates in the footwall of the KSF obtained by low-temperature thermochronology data. Positive correlation between exhumation/erosion rates and extensional rates along the active faults located west of the domes indicates that extensional deformation likely plays a dominant role in controlling focused dome exhumation/erosion. However, considering peaked exhumation/erosion rates, stronger rock resistivity and steeper glacial landforms, attest to the important role of glacial buzz-saw in reshaping the recent dome’s landscape.
    Schlagwörter Pamir ; gneiss dome ; Kongur Shan extensional system ; geomorphic indices ; active tectonics ; stream power erosion model ; Science ; Q
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Reconstructed ocean plate stratigraphy sequences from the Permian subduction-accretionary complex in the Qinghai-Tibet Plateau

    Kexin Zhang / Jiaxuan Wang / Weihong He / Shengdong Wang / Yadong Xu / Xionghua Zhang / Bowen Song / Xiaohu Kou / Guocan Wang

    Geosystems and Geoenvironment, Vol 1, Iss 2, Pp 100034- (2022)

    2022  

    Abstract: The Permian Tethys subduction-accretionary complex (SAC) in the Qinghai-Tibet Plateau (QTP) is distributed in six geotectonic provinces, which are known as the Zongwulong-Ganjia, the Western Kunlun, the Eastern Kunlun, the Ganzi-Litang, the Xijinwulan- ... ...

    Abstract The Permian Tethys subduction-accretionary complex (SAC) in the Qinghai-Tibet Plateau (QTP) is distributed in six geotectonic provinces, which are known as the Zongwulong-Ganjia, the Western Kunlun, the Eastern Kunlun, the Ganzi-Litang, the Xijinwulan-Jinshajiang-Ailaoshan and the Longmucuo-Shuanghu-Nujiang from north to south. The SAC is a set of mélange generated by subduction of oceanic crust at trenches, which consists of relics from mid-ocean ridge, abyssal plains, oceanic island-seamounts, intra-oceanic arcs and trench turbidites. In this paper, we apply the ocean plate stratigraphy (OPS) theory to reconstruct the OPS sequence of the Permian SAC in the QTP. We divided the Permian SAC in the QTP into two types, i.e., convergent zone and accretionary zone according to their tectonic environments. Six relics from mid-ocean ridge, five relics from abyssal plain, five relics from seamount, two relics from intra-oceanic arc, two relics from fore-arc trench, and seven relics from continental fore-arc trench were recognized and then the OPS sequences from different tectonic environments were reconstructed. The spatial-temporal distributions and evolution of ocean basins during the Permian represented by six SACs are discussed.
    Schlagwörter Subduction-accretionary complex ; Permian ; Ocean plate stratigraphy ; Sequence reconstruction ; Qinghai-Tibet Plateau ; Physical geography ; GB3-5030
    Thema/Rubrik (Code) 551
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Endothelial-to-osteoblast transition in normal mouse bone development

    Song-Chang Lin / Guoyu Yu / Yu-Chen Lee / Jian H. Song / Xingzhi Song / Jianhua Zhang / Theocharis Panaretakis / Christopher J. Logothetis / Yoshihiro Komatsu / Li-Yuan Yu-Lee / Guocan Wang / Sue-Hwa Lin

    iScience, Vol 26, Iss 2, Pp 105994- (2023)

    2023  

    Abstract: Summary: Metastatic prostate cancer (PCa) in bone induces bone-forming lesions. We have previously shown that PCa-induced bone originates from endothelial cells (ECs) that have undergone EC-to-osteoblast (OSB) transition. Here, we investigated whether EC- ...

    Abstract Summary: Metastatic prostate cancer (PCa) in bone induces bone-forming lesions. We have previously shown that PCa-induced bone originates from endothelial cells (ECs) that have undergone EC-to-osteoblast (OSB) transition. Here, we investigated whether EC-to-OSB transition also occurs during normal bone formation. We developed an EC and OSB dual-color reporter mouse (DRM) model that marks EC-OSB hybrid cells with red and green fluorescent proteins. We observed EC-to-OSB transition (RFP and GFP co-expression) in both endochondral and intramembranous bone formation during embryonic development and in adults. Co-expression was confirmed in cells isolated from DRM. Bone marrow– and lung-derived ECs underwent transition to OSBs and mineralization in osteogenic medium. RNA-sequencing revealed GATA family transcription factors were upregulated in EC-OSB hybrid cells and knockdown of GATA3 inhibited BMP4-induced mineralization. Our findings support that EC-to-OSB transition occurs during normal bone development and suggest a new paradigm regarding the endothelial origin of OSBs.
    Schlagwörter Biological sciences ; Cell biology ; Cancer ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Elsevier
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  4. Artikel ; Online: PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

    Yunxing Shi / Yi Niu / Yichuan Yuan / Kai Li / Chengrui Zhong / Zhiyu Qiu / Keren Li / Zhu Lin / Zhiwen Yang / Dinglan Zuo / Jiliang Qiu / Wei He / Chenwei Wang / Yadi Liao / Guocan Wang / Yunfei Yuan / Binkui Li

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 17

    Abstract: Despite being an effective treatment for hepatocellular carcinoma (HCC), resistance to oxaliplatin presents a major obstacle. Here, the authors identify PRMT3-induced methylation of IGF2BP1 resulting in HEG1 stabilisation as a mechanism of oxaliplatin ... ...

    Abstract Despite being an effective treatment for hepatocellular carcinoma (HCC), resistance to oxaliplatin presents a major obstacle. Here, the authors identify PRMT3-induced methylation of IGF2BP1 resulting in HEG1 stabilisation as a mechanism of oxaliplatin resistance in HCC.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  5. Artikel: Neogene evolution of the north-eastern Tibetan Plateau based on sedimentary, paleoclimatic and tectonic evidence

    Xu, Yadong / Kexin Zhang / Yongfeng Yang / Guocan Wang / Mansheng Luo / Junliang Ji / Bowen Song

    Palaeogeography, palaeoclimatology, palaeoecology. 2018 Dec. 26, v. 512

    2018  

    Abstract: In this study, the development of the north-eastern Tibetan Plateau is investigated via an integrated study of the sedimentology, magnetostratigraphy, palaeogeography, and cross-section comparisons of the Neogene sedimentary basins of the Tibetan Plateau. ...

    Abstract In this study, the development of the north-eastern Tibetan Plateau is investigated via an integrated study of the sedimentology, magnetostratigraphy, palaeogeography, and cross-section comparisons of the Neogene sedimentary basins of the Tibetan Plateau. From 23 to 17 Ma, this region was characterized by widespread angular unconformities and a sedimentary hiatus, indicating the comprehensive uplift of the plateau. The tectonic event that created the Tibetan Plateau triggered the evolution of sedimentary basins. During the Middle Miocene climatic optimum event, the growing Qilian Shan formed a barrier, leading to cooler and drier conditions on the western side of the mountain. However, humid and warm conditions persisted on the eastern side of the range. After this event, this region was influenced by a global cooling trend and enhanced tectonic activity in the north-eastern Tibetan Plateau. At approximately 10–8 Ma, sedimentary data, which were consistent with low-temperature thermochronological records, indicated the inversion of the surrounding mountains and rapid exhumation of the Laji Shan. Since 5.0–3.6 Ma, these intermontane basins gradually shrank and disappeared due to the overall uplift of the Tibetan Plateau and the accelerated global cooling trend and were associated with unconformities and growth strata that formed during stepwise-north-eastward thrusting tectonism.
    Schlagwörter Miocene epoch ; basins ; mountains ; palaeogeography ; tectonics ; China
    Sprache Englisch
    Erscheinungsverlauf 2018-1226
    Umfang p. 33-45.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 417718-6
    ISSN 0031-0182
    ISSN 0031-0182
    DOI 10.1016/j.palaeo.2018.05.012
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  6. Artikel ; Online: Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4

    Guoyu Yu / Pengfei Shen / Yu-Chen Lee / Jing Pan / Jian H. Song / Tianhong Pan / Song-Chang Lin / Xin Liang / Guocan Wang / Theocharis Panaretakis / Christopher J. Logothetis / Gary E. Gallick / Li-Yuan Yu-Lee / Sue-Hwa Lin

    iScience, Vol 24, Iss 4, Pp 102388- (2021)

    2021  

    Abstract: Summary: Cell type transition occurs during normal development and under pathological conditions. In prostate cancer bone metastasis, prostate cancer-secreted BMP4 induces endothelial cell-to-osteoblast (EC-to-OSB) transition. Such tumor-induced stromal ... ...

    Abstract Summary: Cell type transition occurs during normal development and under pathological conditions. In prostate cancer bone metastasis, prostate cancer-secreted BMP4 induces endothelial cell-to-osteoblast (EC-to-OSB) transition. Such tumor-induced stromal reprogramming supports prostate cancer progression. We delineate signaling pathways mediating EC-to-OSB transition using EC lines 2H11 and SVR. We found that BMP4-activated pSmad1-Notch-Hey1 pathway inhibits EC migration and tube formation. BMP4-activated GSK3β-βcatenin-Slug pathway stimulates Osx expression. In addition, pSmad1-regulated Dlx2 converges with the Smad1 and β-catenin pathways to stimulate osteocalcin expression. By co-expressing Osx, Dlx2, Slug and Hey1, we were able to achieve EC-to-OSB transition, leading to bone matrix mineralization in the absence of BMP4. In human prostate cancer bone metastasis specimens and MDA-PCa-118b and C4-2b-BMP4 osteogenic xenografts, immunohistochemical analysis showed that β-catenin and pSmad1 are detected in activated osteoblasts rimming the tumor-induced bone. Our results elucidated the pathways and key molecules coordinating prostate cancer-induced stromal programming and provide potential targets for therapeutic intervention.
    Schlagwörter Molecular Biology ; Cell Biology ; Cancer ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  7. Artikel: Paleoelevations in the Jianchuan Basin of the southeastern Tibetan Plateau based on stable isotope and pollen grain analyses

    Wu, Jing / Kexin Zhang / Yadong Xu / Guocan Wang / Carmala N. Garzione / John Eiler / Philippe Hervé Leloup / Philippe Sorrel / Gweltaz Mahéo

    Palaeogeography, palaeoclimatology, palaeoecology. 2018 Dec. 01, v. 510

    2018  

    Abstract: The southeastern margin of the Tibetan Plateau (TP) is a key region for understanding the region's surface uplift mechanisms. This study focused on the Jiuziyan and Shuanghe Formations (Fms) in the Jianchuan Basin, both of which include lacustrine ... ...

    Abstract The southeastern margin of the Tibetan Plateau (TP) is a key region for understanding the region's surface uplift mechanisms. This study focused on the Jiuziyan and Shuanghe Formations (Fms) in the Jianchuan Basin, both of which include lacustrine calcareous mudstones and marls. Ostracods of the genus Austrocypris found within the Jiuziyan and Shuanghe Fms constrain the age of strata to the Late Eocene. This study used two different proxies, i.e. fossil pollen coexistence and the δ¹⁸O (VPDB) values of carbonate (δ¹⁸Oc), to reconstruct paleoelevation and the extant paleoenvironment from lacustrine calcareous mudstones and marls preserved in the Eocene stratigraphy of the Jianchuan Basin. The coexistence approach (CA) using pollen data from the Shuanghe Fm indicates a paleoelevation of 1.3–2.6 km above sea level (asl), which would most probably have been associated with a vegetation cover consisting of tropical-subtropical, deciduous, coniferous, broadleaf forests. The reconstructed mean annual air temperature (MAAT) had a value of 16.8–21.7 °C, warmer than today's MAAT (~6 °C). Oxygen isotope results from the Jiuziyan Fm, with/without modification between Eocene and modern Myanmar sea level, suggested that the surface of the Jianchuan Basin was at a paleoelevation between 0.5⁺⁰.⁸–0.5 km asl and 2.5 ± 0.7 km asl (δ¹⁸Omw: −8.9 ± 1.3‰, 2σ). During the Shuanghe Fm sedimentation the paleoelevation was between 0.9 ⁺⁰.⁷–0.7 km asl and 2.9 ± 0.6 km asl (δ¹⁸Omw: −9.5 ± 1.1‰, 2σ). Our results suggest that a stepwise uplift of Jianchuan Basin and crustal thickening initiated during the Eocene was the cause of passive surface uplift of the southeastern Tibetan Plateau (TP) rather than Miocene lower crustal flow.
    Schlagwörter Eocene epoch ; Miocene epoch ; Ostracoda ; air temperature ; basins ; carbonates ; deciduous forests ; fossils ; oxygen ; pollen ; sea level ; stable isotopes ; stratigraphy ; vegetation cover ; China ; Myanmar
    Sprache Englisch
    Erscheinungsverlauf 2018-1201
    Umfang p. 93-108.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 417718-6
    ISSN 0031-0182
    ISSN 0031-0182
    DOI 10.1016/j.palaeo.2018.03.030
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  8. Artikel ; Online: K63-linked ubiquitination in kinase activation and cancer

    Hui-KuanLin / GuocanWang / GuoxiangJin / LirenLi / Jui-IChao

    Frontiers in Oncology, Vol

    2012  Band 2

    Abstract: Ubiquitination has been demonstrated to play a pivotal role in multiple biological functions, which include cell growth, proliferation, apoptosis, DNA damage response, innate immune response, and neuronal degeneration. Although the role of ubiquitination ...

    Abstract Ubiquitination has been demonstrated to play a pivotal role in multiple biological functions, which include cell growth, proliferation, apoptosis, DNA damage response, innate immune response, and neuronal degeneration. Although the role of ubiquitination in targeting proteins for proteasome-dependent degradation have been extensively studied and well-characterized, the critical nonproteaolytic functions of ubiquitination, such as protein trafficking and kinase activation, involved in cell survival and cancer development, just start to emerge, In this review, we will summarize recent progresses in elucidating the nonproteolytic function of ubiquitination signaling in protein kinase activation and its implications in human cancers. The advancement in the understanding of the novel functions of ubiquitination in signal transduction pathways downstream of growth factor receptors may provide novel paradigms for the treatment of human cancers.
    Schlagwörter Phosphorylation ; Ubiquitination ; Akt ; NF-kB ; protein kinase ; tumorigenesis ; TRAF6 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Wet tropical climate in SE Tibet during the Late Eocene

    Philippe Sorrel / Ines Eymard / Philippe-Herve Leloup / Gweltaz Maheo / Nicolas Olivier / Mary Sterb / Loraine Gourbet / Guocan Wang / Wu Jing / Haijian Lu / Haibing Li / Xu Yadong / Kexin Zhang / Kai Cao / Marie-Luce Chevalier / Anne Replumaz

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Band 11

    Abstract: Abstract Cenozoic climate cooling at the advent of the Eocene-Oligocene transition (EOT), ~33.7 Ma ago, was stamped in the ocean by a series of climatic events albeit the impact of this global climatic transition on terrestrial environments is still ... ...

    Abstract Abstract Cenozoic climate cooling at the advent of the Eocene-Oligocene transition (EOT), ~33.7 Ma ago, was stamped in the ocean by a series of climatic events albeit the impact of this global climatic transition on terrestrial environments is still fragmentary. Yet archival constraints on Late Eocene atmospheric circulation are scarce in (tropical) monsoonal Asia, and the paucity of terrestrial records hampers a meaningful comparison of the long-term climatic trends between oceanic and continental realms. Here we report new sedimentological data from the Jianchuan basin (SE Tibet) arguing for wetter climatic conditions in monsoonal Asia at ~35.5 Ma almost coevally to the aridification recognized northwards in the Xining basin. We show that the occurrence of flash-flood events in semi-arid to sub-humid palustrine-sublacustrine settings preceded the development of coal-bearing deposits in swampy-like environments, thus paving the way to a more humid climate in SE Tibet ahead from the EOT. We suggest that this moisture redistribution possibly reflects more northern and intensified ITCZ-induced tropical rainfall in monsoonal Asia around 35.5 Ma, in accordance with recent sea-surface temperature reconstructions from equatorial oceanic records. Our findings thus highlight an important period of climatic upheaval in terrestrial Asian environments ~2–4 millions years prior to the EOT.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2017-08-01T00:00:00Z
    Verlag Nature Portfolio
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  10. Artikel ; Online: Telomere dysfunction activates YAP1 to drive tissue inflammation

    Deepavali Chakravarti / Baoli Hu / Xizeng Mao / Asif Rashid / Jiexi Li / Jun Li / Wen-ting Liao / Elizabeth M. Whitley / Prasenjit Dey / Pingping Hou / Kyle A. LaBella / Andrew Chang / Guocan Wang / Denise J. Spring / Pingna Deng / Di Zhao / Xin Liang / Zhengdao Lan / Yiyun Lin /
    Sharmistha Sarkar / Christopher Terranova / Yonathan Lissanu Deribe / Sarah E. Blutt / Pablo Okhuysen / Jianhua Zhang / Eduardo Vilar / Ole Haagen Nielsen / Andrew Dupont / Mamoun Younes / Kalyani R. Patel / Noah F. Shroyer / Kunal Rai / Mary K. Estes / Y. Alan Wang / Alison A. Bertuch / Ronald A. DePinho

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 13

    Abstract: How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus ... ...

    Abstract How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction and initiation of intestinal inflammation.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Nature Publishing Group
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