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  1. Article ; Online: Comments on: Does myopia decrease the risk of diabetic retinopathy in both type-1 and type-2 diabetes mellitus?

    Chaurasiya, Ritesh Kumar / Gupta, Akansha

    Indian journal of ophthalmology

    2023  Volume 71, Issue 5, Page(s) 2319–2320

    MeSH term(s) Humans ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Myopia/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-05-18
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2991_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on: Evaluation and correlation of corneal endothelium parameters with the severity of primary glaucoma.

    Chaurasiya, Ritesh K / Gupta, Akansha

    Indian journal of ophthalmology

    2023  Volume 71, Issue 6, Page(s) 2612–2613

    MeSH term(s) Humans ; Endothelium, Corneal ; Glaucoma/diagnosis ; Cornea ; Intraocular Pressure
    Language English
    Publishing date 2023-06-15
    Publishing country India
    Document type Letter
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2737_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Greater axial elongation associated with low accommodative lag: New insights on accommodative lag theory for myopia.

    Chaurasiya, Ritesh Kumar / Gupta, Akansha

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2022  Volume 43, Issue 2, Page(s) 284

    MeSH term(s) Humans ; Myopia/therapy ; Accommodation, Ocular ; Refraction, Ocular
    Language English
    Publishing date 2022-12-27
    Publishing country England
    Document type Letter
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.13081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comment on: Association of near work and dim light with myopia among 1400 school children in a district in North India.

    Chaurasiya, Ritesh K / Agarwal, Pradeep / Gupta, Akansha

    Indian journal of ophthalmology

    2023  Volume 71, Issue 6, Page(s) 2605–2606

    MeSH term(s) Humans ; Child ; Myopia/epidemiology ; Refraction, Ocular ; India/epidemiology
    Language English
    Publishing date 2023-06-15
    Publishing country India
    Document type Letter
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_3118_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Valorization potential of pine needle waste biomass: recent trends and future perspectives.

    Gupta, Akansha / Ghosh, Pooja / Arora, Kalpana / Sharma, Satyawati / Kumar, Sunil

    Environmental science and pollution research international

    2023  

    Abstract: Pines play a significant role in forest biodiversity globally and generate huge forest litter. Dry pine needles due to low ignition temperature and high frictional force with the ground catch fire quickly. Annual forest fires in the northern states of ... ...

    Abstract Pines play a significant role in forest biodiversity globally and generate huge forest litter. Dry pine needles due to low ignition temperature and high frictional force with the ground catch fire quickly. Annual forest fires in the northern states of India greatly impact the Indian economy besides causing huge loss to biodiversity, livelihood, and environment. Pine needles are also considered unfit for fodder consumption due to presence of tannins. Although the presence of softwood lignin in pine needles makes it difficult to degrade easily, the presence of holocellulose (68.5%) containing 45-51% cellulose makes this biomass a potential substrate to be used in pulp-making industries for low-grade paper sheets. The good fiber length of pine needles (1.3-1.4 mm) with a diameter of 30-32 μm, maybe considered important property for paper making. The use of pine needles in the pharmaceutical and food industries are due to the presence of secondary metabolites (α-pinene, β-pinene, caryophyllene etc.). The various other potential applications of pine needles are for producing bio-ethanol (yield, 3.98%; purity, 94%), biogas (yield, 23.1 L kg
    Language English
    Publishing date 2023-05-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-27440-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Enhanced lignin degradation of paddy straw and pine needle biomass by combinatorial approach of chemical treatment and fungal enzymes for pulp making.

    Gupta, Akansha / Tiwari, Abhay / Ghosh, Pooja / Arora, Kalpana / Sharma, Satyawati

    Bioresource technology

    2022  Volume 368, Page(s) 128314

    Abstract: Paddy straw (PS) and pine needles (PN) are one of the challenging biomasses in terms of disposal and compost making due to their high silica and tannin contents. Particulate air pollution, loss of biodiversity and respiratory impairments are some of ... ...

    Abstract Paddy straw (PS) and pine needles (PN) are one of the challenging biomasses in terms of disposal and compost making due to their high silica and tannin contents. Particulate air pollution, loss of biodiversity and respiratory impairments are some of disastrous outcomes caused by burning. However, high percentage of cellulose and hemicellulose makes them potential substrate for paper and pulp industries. The main aim of work was to study and utilize a combinatorial approach of weak chemical treatment and lignin degrading fungal species as agents of effective production of lignin modifying enzymes (LME's) for lignin depolymerisation from the biomasses. Phanerochaete chrysosporium was found to be the best degrader of lignin (47.11 % in PS + PN in 28 days) with maximum LME's production between 10th-17th days. Efficient lignin degradation in the PS and PN biomass will aid further application in pulp production supporting the transition to a circular economy in a greener way.
    MeSH term(s) Lignin/metabolism ; Biomass ; Phanerochaete/metabolism ; Cellulose/metabolism ; Secondary Metabolism
    Chemical Substances Lignin (9005-53-2) ; Cellulose (9004-34-6)
    Language English
    Publishing date 2022-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2022.128314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Knowledge, attitude, and practice of childhood myopia among Indian optometrists: A questionnaire-based study.

    Chaurasiya, Ritesh Kumar / Sutar, Samir / Gupta, Akansha / Pandey, Ramji / Agarwal, Pradeep

    Indian journal of ophthalmology

    2023  Volume 71, Issue 3, Page(s) 951–956

    Abstract: Purpose: To investigate the knowledge of myopia and its natural history including complications and clinical approaches for management adopted by optometrists across India.: Methods: An online survey was distributed to Indian optometrists. A pre- ... ...

    Abstract Purpose: To investigate the knowledge of myopia and its natural history including complications and clinical approaches for management adopted by optometrists across India.
    Methods: An online survey was distributed to Indian optometrists. A pre-validated questionnaire was adopted from previous literature. Respondents provided information about their demographics (gender, age, practice location, and modality), myopia knowledge, self-reported practice behaviors relating to childhood myopia, the information and evidence base used to guide their practice, and perceived extent of adult caregiver engagement in making management decisions for myopic children.
    Results: A total of 302 responses were collected from different regions of the country. Most respondents demonstrated knowledge of the association between high myopia and retinal breaks, retinal detachment and primary open-angle glaucoma. Optometrists used a range of techniques to diagnose childhood myopia, with a preference for non-cycloplegic refractive measures. The most common approaches to management were single-vision distance despite most optometrists identifying orthokeratology and low-dose (0.01%) topical atropine as two potentially more effective therapeutic interventions for controlling childhood myopia progression. Almost 90% of respondents considered increasing the time spent outdoors to be beneficial for reducing the rate of myopia progression. The main sources of information used to guide clinical practice were continuing education conferences, seminars, research articles, and workshops.
    Conclusion: : Indian optometrists appear to be aware of emerging evidence and practices, but are not routinely adopting measures. Clinical guidelines, regulatory approval, and sufficient consultation time may be of value for assisting practitioners in making clinical decisions based on the current available research evidence.
    MeSH term(s) Adult ; Child ; Humans ; Glaucoma, Open-Angle ; Health Knowledge, Attitudes, Practice ; Optometrists ; Myopia ; Self Report
    Language English
    Publishing date 2023-03-05
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2660_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Non-pathologic components are associated with reduced visual acuity in myopes after spectacle correction.

    Gupta, Akansha / Agarwal, Pradeep / Sapra, Himanshu / Sutar, Samir / Chaurasiya, Ritesh Kumar

    Indian journal of ophthalmology

    2023  Volume 71, Issue 7, Page(s) 2862–2865

    Abstract: Purpose: To find the association between reduced best-corrected visual acuity and non-pathologic components after optical correction in individuals with low to high myopia.: Methods: Myopic children under 16 years of age were reviewed using ... ...

    Abstract Purpose: To find the association between reduced best-corrected visual acuity and non-pathologic components after optical correction in individuals with low to high myopia.
    Methods: Myopic children under 16 years of age were reviewed using electronic medical records and the following data were extracted and recorded: participant's age, gender, uncorrected visual acuity (UCVA), manifest refraction, and best corrected visual acuity (BCVA). Spherical equivalent and cylinder were classified into low, moderate, and high categories based on the magnitude range. Similarly, astigmatism was defined into with-the-rule, against-the-rule, and oblique based on the location of the steepest meridian. Reduced BCVA was defined when the decimal visual acuity was less than 0.66 (equivalent to Snellen's acuity of 6/9 or 20/30). Logistic regression was performed to test the factors associated with reduced visual acuity after optical correction in the absence of myopic pathologic changes. Statistical significance was considered if P < 0.05.
    Results: Overall 44.9% (N = 242/538) of myopes had reduced best-corrected visual acuity (BCVA) and none of the patients had pathologic myopic lesions. Using logistic regression, we found that high spherical refraction (OR 27.98, 95% CI 14.43-54.25, P < 0.001) and moderate spherical refraction (OR 5.52, 95% CI 2.56-11.91, P < 0.001) were significantly associated with reduced best corrected visual acuity despite any pathological lesions. Additionally, oblique and ATR astigmatism were associated with reduced visual acuity in myopic children with (OR 2.05, 95% CI 0.77-5.42) and (OR 1.59, 95% CI 0.82-3.08).
    Conclusion: Higher magnitude of refractive error components causes reduced visual acuity in the absence of pathologic changes.
    MeSH term(s) Child ; Humans ; Astigmatism/diagnosis ; Eyeglasses ; Refraction, Ocular ; Visual Acuity ; Myopia/diagnosis ; Myopia/therapy ; Treatment Outcome
    Language English
    Publishing date 2023-06-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Assessing the Protein-Ligand Interaction and Thermally Induced Quality Changes in Tomato-Based Pineapple Beverage

    Kaur, Rajinder / Sharma, Nitya / Bansal, Vasudha / Reenu, Reenu / Yadav, Dharmendra Kumar / Gupta, Akansha / Mahato, Dipendra Kumar

    Beverages. 2023 Feb. 01, v. 9, no. 1

    2023  

    Abstract: The intake of tomato in its natural form is comparatively restricted due to its limited shelf-life. Thereby, we investigated the willingness of consumers and optimized the proportions of beverages on the basis of the overall liking of the sensory panel. ... ...

    Abstract The intake of tomato in its natural form is comparatively restricted due to its limited shelf-life. Thereby, we investigated the willingness of consumers and optimized the proportions of beverages on the basis of the overall liking of the sensory panel. Further, molecular docking was also performed to evaluate the protein-ligand interactions of vitamin C, lycopene, and β-carotene against CR protein. These compounds showed great interactions with the protein targets leading to the enhancement of antioxidant activity. The most acceptable combination (S4 = 50:50 tomato and pineapple juices) was subjected to thermal processing at 70, 80, and 90 °C, respectively. Biochemical parameters such as acidity, vitamin C, non-enzymatic browning, antioxidant capacity, and total phenolics were found to be optimum in the beverage samples treated at 80 °C. It was revealed that the microbial shelf-life of beverages enhanced with an increase in processing temperatures. The untreated beverage samples could only retain a shelf-life of 4 days, however, samples treated at 80 °C for 60 s were rendered fit for 40 ± 2 days. Therefore, with the help of molecular docking, this manuscript assessed the protein-ligand interaction with the thermally induced quality changes in tomato-based beverages.
    Keywords acidity ; antioxidant activity ; ascorbic acid ; beverages ; lycopene ; phenolic compounds ; pineapples ; sensory evaluation ; shelf life ; tomatoes
    Language English
    Dates of publication 2023-0201
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2785444-9
    ISSN 2306-5710
    ISSN 2306-5710
    DOI 10.3390/beverages9010012
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: XRN1

    Zou, Tao / Zhou, Meng / Gupta, Akansha / Zhuang, Patrick / Fishbein, Alyssa R / Wei, Hope Y / Zhang, Zhouwei / Cherniack, Andrew D / Meyerson, Matthew

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators of dsRNA ...

    Abstract Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators of dsRNA sensing pathways. Here, we show that the exoribonuclease XRN1 is a negative regulator of the dsRNA sensor protein kinase R (PKR) in cancer cells with high interferon-stimulated gene (ISG) expression.
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.01.551488
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