Artikel ; Online: Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD.
Clinical immunology (Orlando, Fla.)
2023 Band 255, Seite(n) 109750
Abstract: Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not ... ...
| Abstract | Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT. |
|---|---|
| Mesh-Begriff(e) | Pregnancy ; Female ; Humans ; Copper ; Levonorgestrel/pharmacology ; Intrauterine Devices, Copper ; Contraceptive Agents ; Systems Analysis |
| Chemische Substanzen | Copper (789U1901C5) ; Levonorgestrel (5W7SIA7YZW) ; Contraceptive Agents |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-09-03 |
| Erscheinungsland | United States |
| Dokumenttyp | Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 1459903-x |
| ISSN | 1521-7035 ; 1521-6616 |
| ISSN (online) | 1521-7035 |
| ISSN | 1521-6616 |
| DOI | 10.1016/j.clim.2023.109750 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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