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  1. Article: Cyanotic congenital heart disease - Not always blue to provide a clue: Time to replace cyanosis with arterial desaturation!

    Gupta, Saurabh Kumar

    Annals of pediatric cardiology

    2023  Volume 15, Issue 5-6, Page(s) 511–514

    Abstract: Despite right-to-left shunt, not all patients with so-called cyanotic congenital heart disease (CHD) are cyanosed at all times. Moreover, despite undisputed clinical utility, cyanosis is unreliable for the detection of arterial desaturation. Pulse ... ...

    Abstract Despite right-to-left shunt, not all patients with so-called cyanotic congenital heart disease (CHD) are cyanosed at all times. Moreover, despite undisputed clinical utility, cyanosis is unreliable for the detection of arterial desaturation. Pulse oximetry, on the other hand, provides a much easier, reliable, and accurate method for detecting arterial desaturation. For optimal detection, therefore, it is perhaps sensible to replace cyanosis with pulse oximetry-based detection of arterial desaturation in all cases with suspected CHD.
    Language English
    Publishing date 2023-03-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.apc_226_21
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  2. Article: Stereo virtual dissection: An innovative 3D visualization technique.

    Gupta, Saurabh Kumar

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S20–S21

    MeSH term(s) Humans ; Imaging, Three-Dimensional/methods ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2153_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reciprocal impulses of junctional origin causing trigeminy.

    Murugesan, Praveen / Gupta, Saurabh Kumar

    BMJ case reports

    2023  Volume 16, Issue 12

    Abstract: Reciprocal impulses of junctional origin were seen in a patient with left isomerism who had undergone Kawashima repair in infancy. Heterotaxy syndromes are associated with disturbances in sinus node function. Junctional rhythm is hence common in this ... ...

    Abstract Reciprocal impulses of junctional origin were seen in a patient with left isomerism who had undergone Kawashima repair in infancy. Heterotaxy syndromes are associated with disturbances in sinus node function. Junctional rhythm is hence common in this group. Junctional rhythm can conduct both anterogradely, to the ventricles, and retrogradely, back to the atrium. When it conducts retrogradely, it is termed as atrial echo, which can further conduct back to the ventricle. Our patient had a junctional rhythm with atrial echo beats that conduct to the ventricle, along with an ectopic atrial focus that does not conduct to the ventricle. This is due to variation in the RP interval [between R wave and subsequent P wave] of the echo beat and the atrial ectopic beat with respect to the preceding QRS complex. The timing of the P wave after the QRS complex determines the refractoriness of the atrioventricular node. This exhibits a trigeminal rhythm in our patient.
    MeSH term(s) Humans ; Atrioventricular Node ; Arrhythmias, Cardiac/etiology ; Heart Atria/diagnostic imaging ; Heart Ventricles ; Electrocardiography
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-257278
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  4. Article ; Online: CADD Studies in the Discovery of Potential ARI (Aldose Reductase Inhibitors) Agents for the Treatment of Diabetic Complications.

    Gupta, Saurabh Kumar / Tripathi, Pushpendra Kumar

    Current diabetes reviews

    2022  Volume 19, Issue 9, Page(s) e180822207672

    Abstract: The lack of currently available drugs for treating diabetes complications has stimulated our interest in finding new Aldose Reductase inhibitors (ARIs) with more beneficial biological properties. One metabolic method uses aldose reductase inhibitors in ... ...

    Abstract The lack of currently available drugs for treating diabetes complications has stimulated our interest in finding new Aldose Reductase inhibitors (ARIs) with more beneficial biological properties. One metabolic method uses aldose reductase inhibitors in the first step of the polyol pathway to control excess glucose flux in diabetic tissues. Computer-aided drug discovery (CADD) is key in finding and optimizing potential lead substances. AR inhibitors (ARI) have been widely discussed in the literature. For example, Epalrestat is currently the only ARI used to treat patients with diabetic neuropathy in Japan, India, and China. Inhibiting R in patients with severe to moderate diabetic autonomic neuropathy benefits heart rate variability. AT-001, an AR inhibitor, is now being tested in COVID-19 to see how safe and effective it reduces inflammation and cardiac damage. In summary, these results from animal and human studies strongly indicate that AR can cause cardiovascular complications in diabetes. The current multi-center, large-scale randomized human study of the newly developed powerful ARI may prove its role in diabetic cardiovascular disease to establish therapeutic potential. During the recent coronavirus disease (COVID-19) outbreak in 2019, diabetes and cardiovascular disease were risk factors for severely negative clinical outcomes in patients with COVID19. New data shows that diabetes and obesity are among the strongest predictors of COVID-19 hospitalization. Patients and risk factors for severe morbidity and mortality of COVID- 19.
    MeSH term(s) Animals ; Humans ; Aldehyde Reductase/antagonists & inhibitors ; Cardiovascular Diseases/drug therapy ; COVID-19/complications ; Diabetes Complications/drug therapy ; Diabetes Complications/chemically induced ; Diabetes Mellitus/drug therapy ; Diabetic Neuropathies ; Enzyme Inhibitors/therapeutic use ; Enzyme Inhibitors/pharmacology
    Chemical Substances Aldehyde Reductase (EC 1.1.1.21) ; caficrestat (E8I3O45DDU) ; Enzyme Inhibitors
    Language English
    Publishing date 2022-07-14
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6417
    ISSN (online) 1875-6417
    DOI 10.2174/1573399819666220818163758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The impact of COVID-19 on the conduct of medical conferences: A paradigm shift Highlights on Pediatric Cardiac Society of India (PCSI) 2021.

    Ramakrishnan, Sivasubramanian / Gupta, Saurabh Kumar

    Annals of pediatric cardiology

    2022  Volume 15, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2022-06-14
    Publishing country India
    Document type Editorial
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.apc_61_22
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  6. Article ; Online: Anaglyph stereo virtual dissection: a novel inexpensive method for stereoscopic visualisation of intracardiac anatomy on CT angiogram.

    Gupta, Saurabh Kumar / Gupta, Priyanka

    Cardiology in the young

    2021  Volume 31, Issue 12, Page(s) 1958–1961

    Abstract: Three-dimensional visualisation is invaluable for evaluating cardiac anatomy. Patient-specific three-dimensional printed models of the heart are useful but require significant infrastructure. The three-dimensional virtual models, derived from 3D ... ...

    Abstract Three-dimensional visualisation is invaluable for evaluating cardiac anatomy. Patient-specific three-dimensional printed models of the heart are useful but require significant infrastructure. The three-dimensional virtual models, derived from 3D echocardiography, computed tomographic (CT) angiography or cardiac magnetic resonance (CMR), permit excellent visualisation of intracardiac anatomy, but viewing on a two-dimensional screen obscures the third dimension. Various forms of extended reality, such as virtual reality and augmented reality, augment the third dimension but only using expensive equipment. Herein, we report a simple technique of anaglyph stereoscopic visualisation of three-dimensional virtual cardiac models. The feasibility of achieving stereovision on a personal computer, using open-source software, and the need for inexpensive anaglyph glasses for viewing make it extremely cost-effective. Further, the retained depth perception of resulting stereo images in electronic and printed format makes sharing with other members of the team easy and effective.
    MeSH term(s) Angiography ; Dissection ; Humans ; Imaging, Three-Dimensional ; Tomography, X-Ray Computed ; Virtual Reality
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951121001323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
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  7. Article ; Online: Comparative evaluation of divergent concoction of NGF, BDNF, EGF, and FGF growth factor's role in enhancing neuronal differentiation of adipose-derived mesenchymal stem cells.

    Choudhary, Princy / Gupta, Ayushi / Gupta, Saurabh Kumar / Dwivedi, Shrey / Singh, Sangeeta

    International journal of biological macromolecules

    2024  Volume 260, Issue Pt 2, Page(s) 129561

    Abstract: MSCs (Mesenchymal Stem Cells) can differentiate into various lineages, including neurons and glial cells. In the past few decades, MSCs have been well explored in the context of neuronal differentiation and have been reported to have the immense ... ...

    Abstract MSCs (Mesenchymal Stem Cells) can differentiate into various lineages, including neurons and glial cells. In the past few decades, MSCs have been well explored in the context of neuronal differentiation and have been reported to have the immense potential to form distinct kinds of neurons. The distinguishing features of MSCs make them among the most desired cell sources for stem cell therapy. This study involved the trans-differentiation of Adipose-derived human Mesenchymal Stem Cells (ADMSCs) into neurons. The protocol employs a cocktail of chemical inducers in different combinations, including Brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), and Nerve growth factor (NGF) Fibroblastic growth factor (FGF), in induction media. Both types have been successfully differentiated into neurons, confirmed by morphological aspects and the presence of neural-specific markers through RT-PCR (Reverse transcription polymerase chain reaction) studies and immunocytochemistry assay. They have shown excellent morphology with long neurites, synaptic connections, and essential neural markers to validate their identity. The results may significantly contribute to cell replacement therapy for neurological disorders.
    MeSH term(s) Humans ; Brain-Derived Neurotrophic Factor/genetics ; Epidermal Growth Factor/pharmacology ; Epidermal Growth Factor/metabolism ; Nerve Growth Factor/pharmacology ; Nerve Growth Factor/metabolism ; Cell Differentiation/physiology ; Mesenchymal Stem Cells ; Cells, Cultured
    Chemical Substances Brain-Derived Neurotrophic Factor ; Epidermal Growth Factor (62229-50-9) ; Nerve Growth Factor (9061-61-4)
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129561
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    Zs.B 2374: Show issues Location:
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  8. Article ; Online: Understanding the diabetes self-care behaviour in rural areas: Perspective of patients with type 2 diabetes mellitus and healthcare professionals.

    Gupta, Saurabh Kumar / Lakshmi, P V M / Chakrapani, Venkatesan / Rastogi, Ashu / Kaur, Manmeet

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297132

    Abstract: Background: Diabetes self-care behaviour plays a crucial role in managing the diabetes effectively and preventing complications. Patients with type 2 diabetes mellitus (T2DM) and health care professionals (HCPs) of rural areas often face unique ... ...

    Abstract Background: Diabetes self-care behaviour plays a crucial role in managing the diabetes effectively and preventing complications. Patients with type 2 diabetes mellitus (T2DM) and health care professionals (HCPs) of rural areas often face unique challenges when it comes to diabetes self-care practices (SCPs). Therefore, this study aim to explore the perspectives of patients with T2DM and HCPs on diabetes SCPs.
    Methods: Eight focus group discussions (FGDs) among individuals with T2DM and In-depth interviews (IDIs) with 15 HCPs were conducted in rural areas of Punjab, North India. Capability, Opportunity, Motivation, and Behaviour model (COM-B) was employed for thematic framework analyses.
    Results: The study participants perceived that a limited understanding of diabetes mellitus (DM), beliefs in alternative therapies, drug side effects, attitudes towards DM (psychological capability), comorbidities (physical capability), family support (social opportunity), financial and time constraints, and weather conditions (physical opportunity) contributed to lack of DM SCPs. Physicians' guidance and support were motivating them to adhere to SCPs, especially when aligned with their sense of self-efficacy (reflective motivation). HCPs constraints in providing patient-centred care are due to training limitations (psychological capability) and a lack of essential resources (physical opportunities). Participants expressed need for comprehensive diabetes care (automatic motivation) through structured diabetes education intervention to improve diabetes SCPs.
    Conclusions: The study findings indicate that various factors influence diabetes SCPs from the perspectives of both patients with T2DM and HCPs and emphasizes the need for a multi-faceted approach to improve diabetes SCPs in rural areas. Implementing a structured diabetes self-care intervention strategy in rural areas may help for preventing and mitigating the impact of diabetes-related complications in rural areas.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Diabetes Mellitus, Type 2/psychology ; Self Care ; Motivation ; Health Personnel/psychology ; Attitude of Health Personnel ; Qualitative Research
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297132
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  9. Article ; Online: Recanalized vein of marshall following bidirectional glenn surgery.

    Agstam, Sourabh / John, Lydia / Ramakrishnan, Sivasubramanian / Gupta, Saurabh Kumar

    The Journal of invasive cardiology

    2023  Volume 35, Issue 10

    Abstract: A 6-year-old boy with a case of double outlet right ventricle with large non-routable ventricle septal defect and severe pulmonary stenosis was deemed unsuitable for biventricular repair on a prior evaluation. Hence, a bidirectional Glenn (BDG) shunt was ...

    Abstract A 6-year-old boy with a case of double outlet right ventricle with large non-routable ventricle septal defect and severe pulmonary stenosis was deemed unsuitable for biventricular repair on a prior evaluation. Hence, a bidirectional Glenn (BDG) shunt was performed at 3 years of age following cardiac catheterization.
    MeSH term(s) Male ; Humans ; Child ; Vena Cava, Superior/surgery ; Fontan Procedure/adverse effects ; Pulmonary Artery/surgery ; Heart Septal Defects, Ventricular/diagnosis ; Heart Septal Defects, Ventricular/surgery ; Cardiac Catheterization ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/surgery
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
    DOI 10.25270/jic/23.00182
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    Zs.A 3701: Show issues Location:
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    Zs.MG 31: Show issues

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  10. Article ; Online: Cobra head deformity of atrial septal occluder: blessing in disguise.

    Karuru, Uma Devi / Gupta, Saurabh Kumar

    Cardiology in the young

    2020  Volume 31, Issue 3, Page(s) 488–489

    Abstract: It is not uncommon to have prolapse of the atrial septal occluder device despite accurate measurement of atrial septal defect and an appropriately chosen device. This is particularly a problem in cases with large atrial septal defect with absent aortic ... ...

    Abstract It is not uncommon to have prolapse of the atrial septal occluder device despite accurate measurement of atrial septal defect and an appropriately chosen device. This is particularly a problem in cases with large atrial septal defect with absent aortic rim. Various techniques have been described for successful implantation of atrial septal occluder in such a scenario. The essence of all these techniques is to prevent prolapse of the left atrial disc through the defect while the right atrial disc is being deployed. In this brief report, we illustrate the use of cobra head deformity of the device to successfully deploy the device across the atrial septum.
    MeSH term(s) Atrial Septum ; Cardiac Catheterization ; Echocardiography, Transesophageal ; Heart Septal Defects, Atrial/diagnosis ; Heart Septal Defects, Atrial/surgery ; Humans ; Septal Occluder Device ; Treatment Outcome
    Language English
    Publishing date 2020-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951120004084
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