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  1. Article: An Assessment of the Bivalent Vaccine as a Second Booster for COVID-19.

    Gupta, Sneh Lata / Jaiswal, Rishi K

    Vaccines

    2022  Volume 11, Issue 1

    Abstract: In the USA, two monovalent COVID-19 mRNA vaccines are primarily used for vaccination [ ... ]. ...

    Abstract In the USA, two monovalent COVID-19 mRNA vaccines are primarily used for vaccination [...].
    Language English
    Publishing date 2022-12-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11010079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neutralizing antibody: a savior in the Covid-19 disease.

    Gupta, Sneh Lata / Jaiswal, Rishi Kumar

    Molecular biology reports

    2022  Volume 49, Issue 3, Page(s) 2465–2474

    Abstract: Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is ... ...

    Abstract Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is important. The spike protein is the most immunogenic component of the virus. Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. Neutralizing antibodies are generated by the humoral immune system and reduce the viral load by binding to spike protein components. Neutralizing antibodies are the proteins secreted by plasma cells and serve as an important part of the defense mechanism. In the recent Covid-19 infection, neutralizing antibodies can be utilized for both diagnostic such as immune surveillance and therapeutic tools such as plasma therapy. So far, many monoclonal antibodies are in the clinical trial phase, and few of them are already in use. In this review, we have discussed details about neutralizing antibodies and their role in combating Covid-19 disease.
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/therapy ; Clinical Trials as Topic ; Enzyme-Linked Immunosorbent Assay ; Epitopes/immunology ; Forecasting ; Germinal Center/immunology ; Humans ; Immunization, Passive ; Immunoglobulin Isotypes/immunology ; Immunologic Memory ; Immunologic Surveillance ; Macaca mulatta ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Antigens, Viral ; Epitopes ; Immunoglobulin Isotypes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-01-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-07020-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Relevant of neutralizing antibody during SARS-CoV-2 infection and their therapeutic usage.

    Gupta, Sneh Lata / Jaiswal, Rishi K

    Molecular biology reports

    2022  Volume 49, Issue 10, Page(s) 10137–10140

    MeSH term(s) Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; COVID-19 ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-05-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07493-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Neutralizing antibody: a savior in the Covid-19 disease

    Gupta, Sneh Lata / Jaiswal, Rishi Kumar

    Molecular biology reports. 2022 Mar., v. 49, no. 3

    2022  

    Abstract: Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is ... ...

    Abstract Coronavirus outbreak was declared a pandemic by World Health Organization (WHO) in March 2020. The pandemic has led to a devastating loss of life. It has shown us how infectious diseases can cause human existence at stake, and community health is important. The spike protein is the most immunogenic component of the virus. Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. Neutralizing antibodies are generated by the humoral immune system and reduce the viral load by binding to spike protein components. Neutralizing antibodies are the proteins secreted by plasma cells and serve as an important part of the defense mechanism. In the recent Covid-19 infection, neutralizing antibodies can be utilized for both diagnostic such as immune surveillance and therapeutic tools such as plasma therapy. So far, many monoclonal antibodies are in the clinical trial phase, and few of them are already in use. In this review, we have discussed details about neutralizing antibodies and their role in combating Covid-19 disease.
    Keywords COVID-19 infection ; Orthocoronavirinae ; World Health Organization ; clinical trials ; community health ; humans ; lungs ; molecular biology ; monitoring ; pandemic ; therapeutics ; vaccine development ; viral load ; viruses
    Language English
    Dates of publication 2022-03
    Size p. 2465-2474.
    Publishing place Springer Netherlands
    Document type Article
    Note Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-07020-6
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    In stock of ZB MED Bonn / Germany

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  5. Article: B-Cell-Based Immunotherapy: A Promising New Alternative.

    Gupta, Sneh Lata / Khan, Naeem / Basu, Srijani / Soni, Vijay

    Vaccines

    2022  Volume 10, Issue 6

    Abstract: The field of immunotherapy has undergone radical conceptual changes over the last decade. There are various examples of immunotherapy, including the use of monoclonal antibodies, cancer vaccines, tumor-infecting viruses, cytokines, adjuvants, and ... ...

    Abstract The field of immunotherapy has undergone radical conceptual changes over the last decade. There are various examples of immunotherapy, including the use of monoclonal antibodies, cancer vaccines, tumor-infecting viruses, cytokines, adjuvants, and autologous T cells carrying chimeric antigen receptors (CARs) that can bind cancer-specific antigens known as adoptive immunotherapy. While a lot has been achieved in the field of T-cell immunotherapy, only a fraction of patients (20%) see lasting benefits from this mode of treatment, which is why there is a critical need to turn our attention to other immune cells. B cells have been shown to play both anti- and pro-tumorigenic roles in tumor tissue. In this review, we shed light on the dual nature of B cells in the tumor microenvironment. Furthermore, we discussed the different factors affecting the biology and function of B cells in tumors. In the third section, we described B-cell-based immunotherapies and their clinical applications and challenges. These current studies provide a springboard for carrying out future mechanistic studies to help us unleash the full potential of B cells in immunotherapy.
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10060879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Role of Immunoglobulin A in COVID-19 and Influenza Infections.

    Tyagi, Rohit / Basu, Srijani / Dhar, Atika / Gupta, Suman / Gupta, Sneh Lata / Jaiswal, Rishi K

    Vaccines

    2023  Volume 11, Issue 11

    Abstract: Immunoglobulin A (IgA) is critical in the immune response against respiratory infections like COVID-19 and influenza [ ... ]. ...

    Abstract Immunoglobulin A (IgA) is critical in the immune response against respiratory infections like COVID-19 and influenza [...].
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11111647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Children's SARS-CoV-2 Infection and Their Vaccination.

    Gupta, Sneh Lata / Tyagi, Rohit / Dhar, Atika / Oswal, Neelam / Khandelwal, Ankita / Jaiswal, Rishi Kumar

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: SARS-CoV-2, a novel coronavirus, causes respiratory tract infections and other complications in affected individuals, and has resulted in numerous deaths worldwide. The unprecedented pace of its transmission worldwide, and the resultant heavy burden on ... ...

    Abstract SARS-CoV-2, a novel coronavirus, causes respiratory tract infections and other complications in affected individuals, and has resulted in numerous deaths worldwide. The unprecedented pace of its transmission worldwide, and the resultant heavy burden on healthcare systems everywhere, prompted efforts to have effective therapeutic strategies and vaccination candidates available to the global population. While aged and immunocompromised individuals form a high-risk group for COVID-19 and have severe disease outcome, the rate of infections among children has also increased with the emergence of the Omicron variant. In addition, recent reports of threatening SARS-CoV-2-associated complications in children have brought to the forefront an urgent necessity for vaccination. In this article, we discuss the current scenario of SARS-CoV-2 infections in children with a special focus on the differences in their immune system response as compared to adults. Further, we describe the various available COVID-19 vaccines, including the recent bivalent vaccines for children, in detail, intending to increase willingness for their acceptance.
    Language English
    Publishing date 2023-02-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020418
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  8. Article ; Online: Immunotherapy: an alternative promising therapeutic approach against cancers.

    Gupta, Sneh Lata / Basu, Srijani / Soni, Vijay / Jaiswal, Rishi K

    Molecular biology reports

    2022  Volume 49, Issue 10, Page(s) 9903–9913

    Abstract: The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer ... ...

    Abstract The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer cells can help device new and alternate therapeutic strategies. Many immunotherapeutic methodologies, including adaptive cancer therapy, cancer peptide vaccines, monoclonal antibodies, and immune checkpoint treatment, have transformed the traditional cancer treatment landscape. However, many questions remain unaddressed. The development of personalized combination therapy and neoantigen-based cancer vaccines would be the avant-garde approach to cancer treatment. Desirable chemotherapy should be durable, safe, and target-specific. Managing both tumor (intrinsic factors) and its microenvironment (extrinsic factors) are critical for successful immunotherapy. This review describes current approaches and their advancement related to monoclonal antibody-related clinical trials, new cytokine therapy, a checkpoint inhibitor, adoptive T cell therapy, cancer vaccine, and oncolytic virus.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Cancer Vaccines/therapeutic use ; Cytokines ; Humans ; Immunologic Factors ; Immunotherapy/methods ; Immunotherapy, Adoptive ; Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Antibodies, Monoclonal ; Cancer Vaccines ; Cytokines ; Immunologic Factors
    Language English
    Publishing date 2022-06-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07525-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immunotherapy: an alternative promising therapeutic approach against cancers

    Gupta, Sneh Lata / Basu, Srijani / Soni, Vijay / Jaiswal, Rishi K.

    Mol Biol Rep. 2022 Oct., v. 49, no. 10 p.9903-9913

    2022  

    Abstract: The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer ... ...

    Abstract The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer cells can help device new and alternate therapeutic strategies. Many immunotherapeutic methodologies, including adaptive cancer therapy, cancer peptide vaccines, monoclonal antibodies, and immune checkpoint treatment, have transformed the traditional cancer treatment landscape. However, many questions remain unaddressed. The development of personalized combination therapy and neoantigen-based cancer vaccines would be the avant-garde approach to cancer treatment. Desirable chemotherapy should be durable, safe, and target-specific. Managing both tumor (intrinsic factors) and its microenvironment (extrinsic factors) are critical for successful immunotherapy. This review describes current approaches and their advancement related to monoclonal antibody-related clinical trials, new cytokine therapy, a checkpoint inhibitor, adoptive T cell therapy, cancer vaccine, and oncolytic virus.
    Keywords T-lymphocytes ; cancer therapy ; cancer vaccines ; cytokines ; drug therapy ; immunotherapy ; landscapes ; neoplasms ; viruses
    Language English
    Dates of publication 2022-10
    Size p. 9903-9913.
    Publishing place Springer Netherlands
    Document type Article ; Online
    Note Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07525-8
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: IgA Determines Bacterial Composition in the Gut.

    Gupta, Suman / Gupta, Sneh Lata / Singh, Aashima / Oswal, Neelam / Bal, Vineeta / Rath, Satyajit / George, Anna / Basu, Srijani

    Crohn's & colitis 360

    2023  Volume 5, Issue 3, Page(s) otad030

    Abstract: Background: Classically, IgA in the gut prevents the invasion of microorganisms to systemic organs through the process of neutralization and immune exclusion. Interestingly, recent reports suggest that IgA might help in biofilm formation and promote ... ...

    Abstract Background: Classically, IgA in the gut prevents the invasion of microorganisms to systemic organs through the process of neutralization and immune exclusion. Interestingly, recent reports suggest that IgA might help in biofilm formation and promote bacterial growth inside the intestine.
    Methods: In this study, we used flow cytometry, ELISA, and chemical models of colitis to test whether the quality and quantity of IgA can select for bacterial persistence in the gut.
    Results: We found that members of Proteobacteria, such as γ-Proteobacteria and SFB, are preferentially coated by IgA in WT mice. In the partial absence of either T-dependent or -independent IgA responses, there are no significant differences in the frequency of bacteria coated with IgA in mice. However, Rag-/- mice that lack all antibodies had a severe reduction in Proteobacteria and were resistant to DSS-induced colitis, suggesting that secretory IgA might be essential for differential retention of these taxa in the mouse gut. Rag-/- littermates in the F2 generation generated from (B6 × Rag-/-) F1 mice acquired the underrepresented bacteria taxa such as γ-Proteobacteria through vertical transmission of flora. They died soon after weaning, possibly due to the acquired flora. Additionally, continued exposure of Rag-/- mice to B6 flora by cohousing mice led to the acquisition of γ-Proteobacteria and mortality.
    Conclusions: Together, our results indicate that host survival in the complete absence of an IgA response necessitates the exclusion of specific bacterial taxa from the gut microbiome.
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article
    ISSN 2631-827X
    ISSN (online) 2631-827X
    DOI 10.1093/crocol/otad030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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