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  1. AU="Gur, Rachel E"
  2. AU=Shanmugam Harshitha
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  1. Article ; Online: Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.

    Dima, Danai / Modabbernia, Amirhossein / Papachristou, Efstathios / Doucet, Gaelle E / Agartz, Ingrid / Aghajani, Moji / Akudjedu, Theophilus N / Albajes-Eizagirre, Anton / Alnaes, Dag / Alpert, Kathryn I / Andersson, Micael / Andreasen, Nancy C / Andreassen, Ole A / Asherson, Philip / Banaschewski, Tobias / Bargallo, Nuria / Baumeister, Sarah / Baur-Streubel, Ramona / Bertolino, Alessandro /
    Bonvino, Aurora / Boomsma, Dorret I / Borgwardt, Stefan / Bourque, Josiane / Brandeis, Daniel / Breier, Alan / Brodaty, Henry / Brouwer, Rachel M / Buitelaar, Jan K / Busatto, Geraldo F / Buckner, Randy L / Calhoun, Vincent / Canales-Rodríguez, Erick J / Cannon, Dara M / Caseras, Xavier / Castellanos, Francisco X / Cervenka, Simon / Chaim-Avancini, Tiffany M / Ching, Christopher R K / Chubar, Victoria / Clark, Vincent P / Conrod, Patricia / Conzelmann, Annette / Crespo-Facorro, Benedicto / Crivello, Fabrice / Crone, Eveline A / Dannlowski, Udo / Dale, Anders M / Davey, Christopher / de Geus, Eco J C / de Haan, Lieuwe / de Zubicaray, Greig I / den Braber, Anouk / Dickie, Erin W / Di Giorgio, Annabella / Doan, Nhat Trung / Dørum, Erlend S / Ehrlich, Stefan / Erk, Susanne / Espeseth, Thomas / Fatouros-Bergman, Helena / Fisher, Simon E / Fouche, Jean-Paul / Franke, Barbara / Frodl, Thomas / Fuentes-Claramonte, Paola / Glahn, David C / Gotlib, Ian H / Grabe, Hans-Jörgen / Grimm, Oliver / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Gruner, Patricia / Gur, Rachel E / Gur, Ruben C / Hahn, Tim / Harrison, Ben J / Hartman, Catharine A / Hatton, Sean N / Heinz, Andreas / Heslenfeld, Dirk J / Hibar, Derrek P / Hickie, Ian B / Ho, Beng-Choon / Hoekstra, Pieter J / Hohmann, Sarah / Holmes, Avram J / Hoogman, Martine / Hosten, Norbert / Howells, Fleur M / Hulshoff Pol, Hilleke E / Huyser, Chaim / Jahanshad, Neda / James, Anthony / Jernigan, Terry L / Jiang, Jiyang / Jönsson, Erik G / Joska, John A / Kahn, Rene / Kalnin, Andrew / Kanai, Ryota / Klein, Marieke / Klyushnik, Tatyana P / Koenders, Laura / Koops, Sanne / Krämer, Bernd / Kuntsi, Jonna / Lagopoulos, Jim / Lázaro, Luisa / Lebedeva, Irina / Lee, Won Hee / Lesch, Klaus-Peter / Lochner, Christine / Machielsen, Marise W J / Maingault, Sophie / Martin, Nicholas G / Martínez-Zalacaín, Ignacio / Mataix-Cols, David / Mazoyer, Bernard / McDonald, Colm / McDonald, Brenna C / McIntosh, Andrew M / McMahon, Katie L / McPhilemy, Genevieve / Meinert, Susanne / Menchón, José M / Medland, Sarah E / Meyer-Lindenberg, Andreas / Naaijen, Jilly / Najt, Pablo / Nakao, Tomohiro / Nordvik, Jan E / Nyberg, Lars / Oosterlaan, Jaap / de la Foz, Víctor Ortiz-García / Paloyelis, Yannis / Pauli, Paul / Pergola, Giulio / Pomarol-Clotet, Edith / Portella, Maria J / Potkin, Steven G / Radua, Joaquim / Reif, Andreas / Rinker, Daniel A / Roffman, Joshua L / Rosa, Pedro G P / Sacchet, Matthew D / Sachdev, Perminder S / Salvador, Raymond / Sánchez-Juan, Pascual / Sarró, Salvador / Satterthwaite, Theodore D / Saykin, Andrew J / Serpa, Mauricio H / Schmaal, Lianne / Schnell, Knut / Schumann, Gunter / Sim, Kang / Smoller, Jordan W / Sommer, Iris / Soriano-Mas, Carles / Stein, Dan J / Strike, Lachlan T / Swagerman, Suzanne C / Tamnes, Christian K / Temmingh, Henk S / Thomopoulos, Sophia I / Tomyshev, Alexander S / Tordesillas-Gutiérrez, Diana / Trollor, Julian N / Turner, Jessica A / Uhlmann, Anne / van den Heuvel, Odile A / van den Meer, Dennis / van der Wee, Nic J A / van Haren, Neeltje E M / Van't Ent, Dennis / van Erp, Theo G M / Veer, Ilya M / Veltman, Dick J / Voineskos, Aristotle / Völzke, Henry / Walter, Henrik / Walton, Esther / Wang, Lei / Wang, Yang / Wassink, Thomas H / Weber, Bernd / Wen, Wei / West, John D / Westlye, Lars T / Whalley, Heather / Wierenga, Lara M / Williams, Steven C R / Wittfeld, Katharina / Wolf, Daniel H / Worker, Amanda / Wright, Margaret J / Yang, Kun / Yoncheva, Yulyia / Zanetti, Marcus V / Ziegler, Georg C / Thompson, Paul M / Frangou, Sophia

    Human brain mapping

    2021  Volume 43, Issue 1, Page(s) 452–469

    Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or ... ...

    Abstract Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Amygdala/anatomy & histology ; Amygdala/diagnostic imaging ; Corpus Striatum/anatomy & histology ; Corpus Striatum/diagnostic imaging ; Hippocampus/anatomy & histology ; Hippocampus/diagnostic imaging ; Human Development/physiology ; Neuroimaging ; Thalamus/anatomy & histology ; Thalamus/diagnostic imaging
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.25320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.

    Frangou, Sophia / Modabbernia, Amirhossein / Williams, Steven C R / Papachristou, Efstathios / Doucet, Gaelle E / Agartz, Ingrid / Aghajani, Moji / Akudjedu, Theophilus N / Albajes-Eizagirre, Anton / Alnaes, Dag / Alpert, Kathryn I / Andersson, Micael / Andreasen, Nancy C / Andreassen, Ole A / Asherson, Philip / Banaschewski, Tobias / Bargallo, Nuria / Baumeister, Sarah / Baur-Streubel, Ramona /
    Bertolino, Alessandro / Bonvino, Aurora / Boomsma, Dorret I / Borgwardt, Stefan / Bourque, Josiane / Brandeis, Daniel / Breier, Alan / Brodaty, Henry / Brouwer, Rachel M / Buitelaar, Jan K / Busatto, Geraldo F / Buckner, Randy L / Calhoun, Vincent / Canales-Rodríguez, Erick J / Cannon, Dara M / Caseras, Xavier / Castellanos, Francisco X / Cervenka, Simon / Chaim-Avancini, Tiffany M / Ching, Christopher R K / Chubar, Victoria / Clark, Vincent P / Conrod, Patricia / Conzelmann, Annette / Crespo-Facorro, Benedicto / Crivello, Fabrice / Crone, Eveline A / Dale, Anders M / Dannlowski, Udo / Davey, Christopher / de Geus, Eco J C / de Haan, Lieuwe / de Zubicaray, Greig I / den Braber, Anouk / Dickie, Erin W / Di Giorgio, Annabella / Doan, Nhat Trung / Dørum, Erlend S / Ehrlich, Stefan / Erk, Susanne / Espeseth, Thomas / Fatouros-Bergman, Helena / Fisher, Simon E / Fouche, Jean-Paul / Franke, Barbara / Frodl, Thomas / Fuentes-Claramonte, Paola / Glahn, David C / Gotlib, Ian H / Grabe, Hans-Jörgen / Grimm, Oliver / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Gruner, Patricia / Gur, Rachel E / Gur, Ruben C / Hahn, Tim / Harrison, Ben J / Hartman, Catharine A / Hatton, Sean N / Heinz, Andreas / Heslenfeld, Dirk J / Hibar, Derrek P / Hickie, Ian B / Ho, Beng-Choon / Hoekstra, Pieter J / Hohmann, Sarah / Holmes, Avram J / Hoogman, Martine / Hosten, Norbert / Howells, Fleur M / Hulshoff Pol, Hilleke E / Huyser, Chaim / Jahanshad, Neda / James, Anthony / Jernigan, Terry L / Jiang, Jiyang / Jönsson, Erik G / Joska, John A / Kahn, Rene / Kalnin, Andrew / Kanai, Ryota / Klein, Marieke / Klyushnik, Tatyana P / Koenders, Laura / Koops, Sanne / Krämer, Bernd / Kuntsi, Jonna / Lagopoulos, Jim / Lázaro, Luisa / Lebedeva, Irina / Lee, Won Hee / Lesch, Klaus-Peter / Lochner, Christine / Machielsen, Marise W J / Maingault, Sophie / Martin, Nicholas G / Martínez-Zalacaín, Ignacio / Mataix-Cols, David / Mazoyer, Bernard / McDonald, Colm / McDonald, Brenna C / McIntosh, Andrew M / McMahon, Katie L / McPhilemy, Genevieve / Meinert, Susanne / Menchón, José M / Medland, Sarah E / Meyer-Lindenberg, Andreas / Naaijen, Jilly / Najt, Pablo / Nakao, Tomohiro / Nordvik, Jan E / Nyberg, Lars / Oosterlaan, Jaap / de la Foz, Víctor Ortiz-García / Paloyelis, Yannis / Pauli, Paul / Pergola, Giulio / Pomarol-Clotet, Edith / Portella, Maria J / Potkin, Steven G / Radua, Joaquim / Reif, Andreas / Rinker, Daniel A / Roffman, Joshua L / Rosa, Pedro G P / Sacchet, Matthew D / Sachdev, Perminder S / Salvador, Raymond / Sánchez-Juan, Pascual / Sarró, Salvador / Satterthwaite, Theodore D / Saykin, Andrew J / Serpa, Mauricio H / Schmaal, Lianne / Schnell, Knut / Schumann, Gunter / Sim, Kang / Smoller, Jordan W / Sommer, Iris / Soriano-Mas, Carles / Stein, Dan J / Strike, Lachlan T / Swagerman, Suzanne C / Tamnes, Christian K / Temmingh, Henk S / Thomopoulos, Sophia I / Tomyshev, Alexander S / Tordesillas-Gutiérrez, Diana / Trollor, Julian N / Turner, Jessica A / Uhlmann, Anne / van den Heuvel, Odile A / van den Meer, Dennis / van der Wee, Nic J A / van Haren, Neeltje E M / van 't Ent, Dennis / van Erp, Theo G M / Veer, Ilya M / Veltman, Dick J / Voineskos, Aristotle / Völzke, Henry / Walter, Henrik / Walton, Esther / Wang, Lei / Wang, Yang / Wassink, Thomas H / Weber, Bernd / Wen, Wei / West, John D / Westlye, Lars T / Whalley, Heather / Wierenga, Lara M / Wittfeld, Katharina / Wolf, Daniel H / Worker, Amanda / Wright, Margaret J / Yang, Kun / Yoncheva, Yulyia / Zanetti, Marcus V / Ziegler, Georg C / Thompson, Paul M / Dima, Danai

    Human brain mapping

    2021  Volume 43, Issue 1, Page(s) 431–451

    Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and ... ...

    Abstract Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/diagnostic imaging ; Cross-Sectional Studies ; Human Development/physiology ; Neuroimaging
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.25364
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

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