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Article: Phase-Amplitude Coupling Localizes Pathologic Brain with Aid of Behavioral Staging in Sleep.

Berry, Brent / Varatharajah, Yogatheesan / Kremen, Vaclav / Kucewicz, Michal / Guragain, Hari / Brinkmann, Benjamin / Duque, Juliano / Carvalho, Diego Z / Stead, Matt / Sieck, Gary / Worrell, Gregory

Life (Basel, Switzerland)

2023 Volume 13, Issue 5

Abstract: Low frequency brain rhythms facilitate communication across large spatial regions in the brain and high frequency rhythms are thought to signify local processing among nearby assemblies. A heavily investigated mode by which these low frequency and high ... ...

Abstract	Low frequency brain rhythms facilitate communication across large spatial regions in the brain and high frequency rhythms are thought to signify local processing among nearby assemblies. A heavily investigated mode by which these low frequency and high frequency phenomenon interact is phase-amplitude coupling (PAC). This phenomenon has recently shown promise as a novel electrophysiologic biomarker, in a number of neurologic diseases including human epilepsy. In 17 medically refractory epilepsy patients undergoing phase-2 monitoring for the evaluation of surgical resection and in whom temporal depth electrodes were implanted, we investigated the electrophysiologic relationships of PAC in epileptogenic (seizure onset zone or SOZ) and non-epileptogenic tissue (non-SOZ). That this biomarker can differentiate seizure onset zone from non-seizure onset zone has been established with ictal and pre-ictal data, but less so with interictal data. Here we show that this biomarker can differentiate SOZ from non-SOZ interictally and is also a function of interictal epileptiform discharges. We also show a differential level of PAC in slow-wave-sleep relative to NREM1-2 and awake states. Lastly, we show AUROC evaluation of the localization of SOZ is optimal when utilizing beta or alpha phase onto high-gamma or ripple band. The results suggest an elevated PAC may reflect an electrophysiology-based biomarker for abnormal/epileptogenic brain regions.
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13051186
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Article ; Online: Segmentation errors and intertest reliability in automated and manually traced hippocampal volumes.

Brinkmann, Benjamin H / Guragain, Hari / Kenney-Jung, Daniel / Mandrekar, Jay / Watson, Robert E / Welker, Kirk M / Britton, Jeffrey W / Witte, Robert J

Annals of clinical and translational neurology

2019 Volume 6, Issue 9, Page(s) 1807–1814

Abstract: Objective: To rigorously compare automated atlas-based and manual tracing hippocampal segmentation for accuracy, repeatability, and clinical acceptability given a relevant range of imaging abnormalities in clinical epilepsy.: Methods: Forty-nine ... ...

Abstract	Objective: To rigorously compare automated atlas-based and manual tracing hippocampal segmentation for accuracy, repeatability, and clinical acceptability given a relevant range of imaging abnormalities in clinical epilepsy. Methods: Forty-nine patients with hippocampal asymmetry were identified from our institutional radiology database, including two patients with significant anatomic deformations. Manual hippocampal tracing was performed by experienced technologists on 3T MPRAGE images, measuring hippocampal volume up to the tectal plate, excluding the hippocampal tail. The same images were processed using NeuroQuant and FreeSurfer software. Ten subjects underwent repeated manual hippocampal tracings by two additional technologists blinded to previous results to evaluate consistency. Ten patients with two clinical MRI studies had volume measurements repeated using NeuroQuant and FreeSurfer. Results: FreeSurfer raw volumes were significantly lower than NeuroQuant (P < 0.001, right and left), and hippocampal asymmetry estimates were lower for both automatic methods than manual tracing (P < 0.0001). Differences remained significant after scaling volumes to age, gender, and scanner matched normative percentiles. Volume reproducibility was fair (0.4-0.59) for manual tracing, and excellent (>0.75) for both automated methods. Asymmetry index reproducibility was excellent (>0.75) for manual tracing and FreeSurfer segmentation and fair (0.4-0.59) for NeuroQuant segmentation. Both automatic segmentation methods failed on the two cases with anatomic deformations. Segmentation errors were visually identified in 25 NeuroQuant and 27 FreeSurfer segmentations, and nine (18%) NeuroQuant and six (12%) FreeSurfer errors were judged clinically significant. Interpretation: Automated hippocampal volumes are more reproducible than hand-traced hippocampal volumes. However, these methods fail in some cases, and significant segmentation errors can occur.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Hippocampus/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Infant ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Size ; Reproducibility of Results ; Software ; Young Adult
Language	English
Publishing date	2019-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.50885
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Article: Epilepsy Personal Assistant Device-A Mobile Platform for Brain State, Dense Behavioral and Physiology Tracking and Controlling Adaptive Stimulation.

Pal Attia, Tal / Crepeau, Daniel / Kremen, Vaclav / Nasseri, Mona / Guragain, Hari / Steele, Steven W / Sladky, Vladimir / Nejedly, Petr / Mivalt, Filip / Herron, Jeffrey A / Stead, Matt / Denison, Timothy / Worrell, Gregory A / Brinkmann, Benjamin H

Frontiers in neurology

2021 Volume 12, Page(s) 704170

Abstract: Epilepsy is one of the most common neurological disorders, and it affects almost 1% of the population worldwide. Many people living with epilepsy continue to have seizures despite anti-epileptic medication therapy, surgical treatments, and ... ...

Abstract	Epilepsy is one of the most common neurological disorders, and it affects almost 1% of the population worldwide. Many people living with epilepsy continue to have seizures despite anti-epileptic medication therapy, surgical treatments, and neuromodulation therapy. The unpredictability of seizures is one of the most disabling aspects of epilepsy. Furthermore, epilepsy is associated with sleep, cognitive, and psychiatric comorbidities, which significantly impact the quality of life. Seizure predictions could potentially be used to adjust neuromodulation therapy to prevent the onset of a seizure and empower patients to avoid sensitive activities during high-risk periods. Long-term objective data is needed to provide a clearer view of brain electrical activity and an objective measure of the efficacy of therapeutic measures for optimal epilepsy care. While neuromodulation devices offer the potential for acquiring long-term data, available devices provide very little information regarding brain activity and therapy effectiveness. Also, seizure diaries kept by patients or caregivers are subjective and have been shown to be unreliable, in particular for patients with memory-impairing seizures. This paper describes the design, architecture, and development of the Mayo Epilepsy Personal Assistant Device (EPAD). The EPAD has bi-directional connectivity to the implanted investigational Medtronic Summit RC+S
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.704170
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Article ; Online: Multi-feature localization of epileptic foci from interictal, intracranial EEG.

Cimbalnik, Jan / Klimes, Petr / Sladky, Vladimir / Nejedly, Petr / Jurak, Pavel / Pail, Martin / Roman, Robert / Daniel, Pavel / Guragain, Hari / Brinkmann, Benjamin / Brazdil, Milan / Worrell, Greg

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2019 Volume 130, Issue 10, Page(s) 1945–1953

Abstract: Objective: When considering all patients with focal drug-resistant epilepsy, as high as 40-50% of patients suffer seizure recurrence after surgery. To achieve seizure freedom without side effects, accurate localization of the epileptogenic tissue is ... ...

Abstract	Objective: When considering all patients with focal drug-resistant epilepsy, as high as 40-50% of patients suffer seizure recurrence after surgery. To achieve seizure freedom without side effects, accurate localization of the epileptogenic tissue is crucial before its resection. We investigate an automated, fast, objective mapping process that uses only interictal data. Methods: We propose a novel approach based on multiple iEEG features, which are used to train a support vector machine (SVM) model for classification of iEEG electrodes as normal or pathologic using 30 min of inter-ictal recording. Results: The tissue under the iEEG electrodes, classified as epileptogenic, was removed in 17/18 excellent outcome patients and was not entirely resected in 8/10 poor outcome patients. The overall best result was achieved in a subset of 9 excellent outcome patients with the area under the receiver operating curve = 0.95. Conclusion: SVM models combining multiple iEEG features show better performance than algorithms using a single iEEG marker. Multiple iEEG and connectivity features in presurgical evaluation could improve epileptogenic tissue localization, which may improve surgical outcome and minimize risk of side effects. Significance: In this study, promising results were achieved in localization of epileptogenic regions by SVM models that combine multiple features from 30 min of inter-ictal iEEG recordings.
MeSH term(s)	Adult ; Aged ; Electrodes, Implanted ; Electroencephalography/instrumentation ; Electroencephalography/methods ; Epilepsies, Partial/diagnosis ; Epilepsies, Partial/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2019-08-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2019.07.024
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Article ; Online: Probing circuit of Papez with stimulation of anterior nucleus of the thalamus and hippocampal evoked potentials.

Wang, Yu-Chi / Kremen, Vaclav / Brinkmann, Benjamin H / Middlebrooks, Erik H / Lundstrom, Brian N / Grewal, Sanjeet S / Guragain, Hari / Wu, Min-Hsien / Van Gompel, Jamie J / Klassen, Bryan T / Stead, Matt / Worrell, Gregory A

Epilepsy research

2019 Volume 159, Page(s) 106248

Abstract: Purpose: Despite documented clinical effectiveness, deep brain stimulation (DBS) therapy for drug-resistant epilepsy rarely yields long-term seizure free outcomes.: Methods: This pilot study in five patients investigated circuit of Papez evoked ... ...

Abstract	Purpose: Despite documented clinical effectiveness, deep brain stimulation (DBS) therapy for drug-resistant epilepsy rarely yields long-term seizure free outcomes. Methods: This pilot study in five patients investigated circuit of Papez evoked potentials (EPs) using hippocampal sensing during anterior nucleus of the thalamus (ANT) electrical stimulation. We hypothesize that hippocampal EP is a potential biomarker that could be useful for ANT electrode targeting and improving seizure reduction. We obtained bilateral circuit of Papez EPs in five patients with bilateral temporal lobe epilepsy (TLE). The circuit of Papez EPs were measured and assessed by signal amplitude. Volumetric analysis of relevant mesial temporal structures and ANT stimulation analysis was performed on immediate post-implantation images. Results: The patient with the most favorable seizure outcome, which meant long-term seizure reduction greater than 50 % compared to baseline, had strong bilateral EPs and normal hippocampal structure. Conversely, those without clinical benefit with ANT DBS had absent or weak bilateral EPs as well as MRI findings consistent with mesial temporal sclerosis (MTS). Conclusion: The data support the hypothesis that hippocampal EPs with ANT stimulation may be used to as a surrogate marker to probe circuit of Papez and predict ANT DBS efficacy.
MeSH term(s)	Adult ; Anterior Thalamic Nuclei/physiopathology ; Electric Stimulation ; Epilepsy, Temporal Lobe/physiopathology ; Evoked Potentials/physiology ; Female ; Hippocampus/physiopathology ; Humans ; Male ; Neural Pathways/physiopathology ; Pilot Projects ; Seizures/physiopathology
Language	English
Publishing date	2019-11-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2019.106248
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Article: Semi-supervised Training Data Selection Improves Seizure Forecasting in Canines with Epilepsy.

Nasseri, Mona / Kremen, Vaclav / Nejedly, Petr / Kim, Inyong / Chang, Su-Youne / Joon Jo, Hang / Guragain, Hari / Nelson, Nathaniel / Patterson, Edward / Sturges, Beverly K / Crowe, Chelsea M / Denison, Tim / Brinkmann, Benjamin H / Worrell, Gregory A

Biomedical signal processing and control

2019 Volume 57

Abstract: Objective: Conventional selection of pre-ictal EEG epochs for seizure prediction algorithm training data typically assumes a continuous pre-ictal brain state preceding a seizure. This is carried out by defining a fixed duration, pre-ictal time period ... ...

Abstract	Objective: Conventional selection of pre-ictal EEG epochs for seizure prediction algorithm training data typically assumes a continuous pre-ictal brain state preceding a seizure. This is carried out by defining a fixed duration, pre-ictal time period before seizures from which pre-ictal training data epochs are uniformly sampled. However, stochastic physiological and pathological fluctuations in EEG data characteristics and underlying brain states suggest that pre-ictal state dynamics may be more complex, and selection of pre-ictal training data segments to reflect this could improve algorithm performance. Methods: We propose a semi-supervised technique to select pre-ictal training data most distinguishable from interictal EEG according to pre-specified data characteristics. The proposed method uses hierarchical clustering to identify optimal pre-ictal data epochs. Results: In this paper we compare the performance of a seizure forecasting algorithm with and without hierarchical clustering of pre-ictal periods in chronic iEEG recordings from six canines with naturally occurring epilepsy. Hierarchical clustering of training data improved results for Time In Warning (TIW) (0.18 vs. 0.23) and False Positive Rate (FPR) (0.5 vs. 0.59) when evaluated across all subjects (p<0.001, n=6). Results were mixed when evaluating TIW, FPR, and Sensitivity for individual dogs. Conclusion: Hierarchical clustering is a helpful method for training data selection overall, but should be evaluated on a subject-wise basis. Significance: The clustering method can be used to optimize results of forecasting towards sensitivity or TIW or FPR, and therefore can be useful for epilepsy management.
Language	English
Publishing date	2019-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2241886-6
ISSN	1746-8108 ; 1746-8094
ISSN (online)	1746-8108
ISSN	1746-8094
DOI	10.1016/j.bspc.2019.101743
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Article ; Online: Deep-learning for seizure forecasting in canines with epilepsy.

Nejedly, Petr / Kremen, Vaclav / Sladky, Vladimir / Nasseri, Mona / Guragain, Hari / Klimes, Petr / Cimbalnik, Jan / Varatharajah, Yogatheesan / Brinkmann, Benjamin H / Worrell, Gregory A

Journal of neural engineering

2019 Volume 16, Issue 3, Page(s) 36031

Abstract: Objective: This paper introduces a fully automated, subject-specific deep-learning convolutional neural network (CNN) system for forecasting seizures using ambulatory intracranial EEG (iEEG). The system was tested on a hand-held device (Mayo Epilepsy ... ...

Abstract	Objective: This paper introduces a fully automated, subject-specific deep-learning convolutional neural network (CNN) system for forecasting seizures using ambulatory intracranial EEG (iEEG). The system was tested on a hand-held device (Mayo Epilepsy Assist Device) in a pseudo-prospective mode using iEEG from four canines with naturally occurring epilepsy. Approach: The system was trained and tested on 75 seizures collected over 1608 d utilizing a genetic algorithm to optimize forecasting hyper-parameters (prediction horizon (PH), median filter window length, and probability threshold) for each subject-specific seizure forecasting model. The trained CNN models were deployed on a hand-held tablet computer and tested on testing iEEG datasets from four canines. The results from the iEEG testing datasets were compared with Monte Carlo simulations using a Poisson random predictor with equal time in warning to evaluate seizure forecasting performance. Main results: The results show the CNN models forecasted seizures at rates significantly above chance in all four dogs (p < 0.01, with mean 0.79 sensitivity and 18% time in warning). The deep learning method presented here surpassed the performance of previously reported methods using computationally expensive features with standard machine learning methods like logistic regression and support vector machine classifiers. Significance: Our findings principally support the feasibility of deploying trained CNN models on a hand-held computational device (Mayo Epilepsy Assist Device) that analyzes streaming iEEG data for real-time seizure forecasting.
MeSH term(s)	Animals ; Deep Learning ; Dogs ; Electrocorticography/instrumentation ; Electrocorticography/methods ; Electrodes, Implanted ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Forecasting ; Seizures/diagnosis ; Seizures/physiopathology
Language	English
Publishing date	2019-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ab172d
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Article ; Online: Spatial variation in high-frequency oscillation rates and amplitudes in intracranial EEG.

Guragain, Hari / Cimbalnik, Jan / Stead, Matt / Groppe, David M / Berry, Brent M / Kremen, Vaclav / Kenney-Jung, Daniel / Britton, Jeffrey / Worrell, Gregory A / Brinkmann, Benjamin H

Neurology

2018 Volume 90, Issue 8, Page(s) e639–e646

Abstract: Objective: To assess the variation in baseline and seizure onset zone interictal high-frequency oscillation (HFO) rates and amplitudes across different anatomic brain regions in a large cohort of patients.: Methods: Seventy patients who had wide- ... ...

Abstract	Objective: To assess the variation in baseline and seizure onset zone interictal high-frequency oscillation (HFO) rates and amplitudes across different anatomic brain regions in a large cohort of patients. Methods: Seventy patients who had wide-bandwidth (5 kHz) intracranial EEG (iEEG) recordings during surgical evaluation for drug-resistant epilepsy between 2005 and 2014 who had high-resolution MRI and CT imaging were identified. Discrete HFOs were identified in 2-hour segments of high-quality interictal iEEG data with an automated detector. Electrode locations were determined by coregistering the patient's preoperative MRI with an X-ray CT scan acquired immediately after electrode implantation and correcting electrode locations for postimplant brain shift. The anatomic locations of electrodes were determined using the Desikan-Killiany brain atlas via FreeSurfer. HFO rates and mean amplitudes were measured in seizure onset zone (SOZ) and non-SOZ electrodes, as determined by the clinical iEEG seizure recordings. To promote reproducible research, imaging and iEEG data are made freely available (msel.mayo.edu). Results: Baseline (non-SOZ) HFO rates and amplitudes vary significantly in different brain structures, and between homologous structures in left and right hemispheres. While HFO rates and amplitudes were significantly higher in SOZ than non-SOZ electrodes when analyzed regardless of contact location, SOZ and non-SOZ HFO rates and amplitudes were not separable in some lobes and structures (e.g., frontal and temporal neocortex). Conclusions: The anatomic variation in SOZ and non-SOZ HFO rates and amplitudes suggests the need to assess interictal HFO activity relative to anatomically accurate normative standards when using HFOs for presurgical planning.
MeSH term(s)	Brain/diagnostic imaging ; Brain/physiopathology ; Brain Mapping ; Cohort Studies ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/physiopathology ; Drug Resistant Epilepsy/therapy ; Electrocorticography ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Periodicity ; Preoperative Care ; Seizures/diagnostic imaging ; Seizures/physiopathology ; Seizures/therapy ; Signal Processing, Computer-Assisted ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000004998
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Article ; Online: Visually validated semi-automatic high-frequency oscillation detection aides the delineation of epileptogenic regions during intra-operative electrocorticography.

Weiss, Shennan Aibel / Berry, Brent / Chervoneva, Inna / Waldman, Zachary / Guba, Jonathan / Bower, Mark / Kucewicz, Michal / Brinkmann, Benjamin / Kremen, Vaclav / Khadjevand, Fatemeh / Varatharajah, Yogatheesan / Guragain, Hari / Sharan, Ashwini / Wu, Chengyuan / Staba, Richard / Engel, Jerome / Sperling, Michael / Worrell, Gregory

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

2018 Volume 129, Issue 10, Page(s) 2089–2098

Abstract: Objective: To test the utility of a novel semi-automated method for detecting, validating, and quantifying high-frequency oscillations (HFOs): ripples (80-200 Hz) and fast ripples (200-600 Hz) in intra-operative electrocorticography (ECoG) recordings.!## ...

Abstract	Objective: To test the utility of a novel semi-automated method for detecting, validating, and quantifying high-frequency oscillations (HFOs): ripples (80-200 Hz) and fast ripples (200-600 Hz) in intra-operative electrocorticography (ECoG) recordings. Methods: Sixteen adult patients with temporal lobe epilepsy (TLE) had intra-operative ECoG recordings at the time of resection. The computer-annotated ECoG recordings were visually inspected and false positive detections were removed. We retrospectively determined the sensitivity, specificity, positive and negative predictive value (PPV/NPV) of HFO detections in unresected regions for determining post-operative seizure outcome. Results: Visual validation revealed that 2.81% of ripple and 43.68% of fast ripple detections were false positive. Inter-reader agreement for false positive fast ripple on spike classification was good (ICC = 0.713, 95% CI: 0.632-0.779). After removing false positive detections, the PPV of a single fast ripple on spike in an unresected electrode site for post-operative non-seizure free outcome was 85.7 [50-100%]. Including false positive detections reduced the PPV to 64.2 [57.8-69.83%]. Conclusions: Applying automated HFO methods to intraoperative electrocorticography recordings results in false positive fast ripple detections. True fast ripples on spikes are rare, but predict non-seizure free post-operative outcome if found in an unresected site. Significance: Semi-automated HFO detection methods are required to accurately identify fast ripple events in intra-operative ECoG recordings.
MeSH term(s)	Adolescent ; Adult ; Brain Waves ; Electrocorticography/instrumentation ; Electrocorticography/methods ; Epilepsy/physiopathology ; Epilepsy/surgery ; Female ; Humans ; Intraoperative Neurophysiological Monitoring/instrumentation ; Intraoperative Neurophysiological Monitoring/methods ; Male ; Middle Aged
Language	English
Publishing date	2018-07-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1463630-x
ISSN	1872-8952 ; 0921-884X ; 1388-2457
ISSN (online)	1872-8952
ISSN	0921-884X ; 1388-2457
DOI	10.1016/j.clinph.2018.06.030
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Article: Integrating Brain Implants With Local and Distributed Computing Devices: A Next Generation Epilepsy Management System.

Kremen, Vaclav / Brinkmann, Benjamin H / Kim, Inyong / Guragain, Hari / Nasseri, Mona / Magee, Abigail L / Pal Attia, Tal / Nejedly, Petr / Sladky, Vladimir / Nelson, Nathanial / Chang, Su-Youne / Herron, Jeffrey A / Adamski, Tom / Baldassano, Steven / Cimbalnik, Jan / Vasoli, Vince / Fehrmann, Elizabeth / Chouinard, Tom / Patterson, Edward E /

Litt, Brian / Stead, Matt / Van Gompel, Jamie / Sturges, Beverly K / Jo, Hang Joon / Crowe, Chelsea M / Denison, Timothy / Worrell, Gregory A

IEEE journal of translational engineering in health and medicine

2018 Volume 6, Page(s) 2500112

Abstract: Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson's disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted ... ...

Abstract	Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson's disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted electrodes. Interfacing implantable brain devices with local and cloud computing resources have the potential to improve electrical stimulation efficacy, disease tracking, and management. Epilepsy, in particular, is a neurological disease that might benefit from the integration of brain implants with off-the-body computing for tracking disease and therapy. Recent clinical trials have demonstrated seizure forecasting, seizure detection, and therapeutic electrical stimulation in patients with drug-resistant focal epilepsy. In this paper, we describe a next-generation epilepsy management system that integrates local handheld and cloud-computing resources wirelessly coupled to an implanted device with embedded payloads (sensors, intracranial EEG telemetry, electrical stimulation, classifiers, and control policy implementation). The handheld device and cloud computing resources can provide a seamless interface between patients and physicians, and realtime intracranial EEG can be used to classify brain state (wake/sleep, preseizure, and seizure), implement control policies for electrical stimulation, and track patient health. This system creates a flexible platform in which low demand analytics requiring fast response times are embedded in the implanted device and more complex algorithms are implemented in offthebody local and distributed cloud computing environments. The system enables tracking and management of epileptic neural networks operating over time scales ranging from milliseconds to months.
Language	English
Publishing date	2018-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2696555-0
ISSN	2168-2372
ISSN	2168-2372
DOI	10.1109/JTEHM.2018.2869398
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