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  1. Article: Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis.

    Ozturk, Nazli Begum / Dinc, Ece Janet / Swami, Abhishek / Gurakar, Ahmet

    Journal of clinical medicine

    2023  Volume 13, Issue 1

    Abstract: Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis. Hepatorenal syndrome (HRS) is a type of AKI known as HRS-AKI. It is a severe complication of cirrhosis with high morbidity and mortality. While certain vasoconstrictor ... ...

    Abstract Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis. Hepatorenal syndrome (HRS) is a type of AKI known as HRS-AKI. It is a severe complication of cirrhosis with high morbidity and mortality. While certain vasoconstrictor medications have been shown to improve HRS-AKI, no clear transplant-free survival benefit has been reported with medical therapies. Patients with HRS-AKI should be considered for urgent liver transplantation evaluation. In this review, we discuss the most recent updates on the definition, diagnosis, and management of AKI in cirrhosis, with special a emphasis on HRS.
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure.

    Ozturk, Nazli Begum / Herdan, Emre / Saner, Fuat H / Gurakar, Ahmet

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: Acute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be ...

    Abstract Acute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be given to hemodynamics and metabolic parameters along with the active surveillance of infections. Timely transfer and supportive management are important in an intensive care unit in a liver transplant center. Identifying patients who will and will not improve with medical management and may need emergent liver transplantation is critical. In this review, we provide a comprehensive update on the etiology, diagnosis, and management of ALF.
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The use of HCV positive donors among non-HCV infected liver transplant recipients.

    Zaffar, Duha / Muhammad, Haris / Gurakar, Ahmet

    Hepatology forum

    2022  Volume 3, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2022-01-12
    Publishing country Turkey
    Document type Editorial
    ISSN 2757-7392
    ISSN (online) 2757-7392
    DOI 10.14744/hf.2021.2021.0048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Practice patterns and considerations in liver transplantation from living donors with high BMI: A review.

    Samaha, Carl / Chaaban, Hadi / Simsek, Cem / Danis, Nilay / Lin, Jessica S / Gurakar, Ahmet

    Hepatology forum

    2023  Volume 4, Issue 3, Page(s) 145–149

    Abstract: Living Donor Liver Transplantation (LDLT) is a valuable solution to the shortage of donor organs for patients with end-stage liver disease. However, the eligibility of obese donors for LDLT remains a subject of debate. This literature review explores ... ...

    Abstract Living Donor Liver Transplantation (LDLT) is a valuable solution to the shortage of donor organs for patients with end-stage liver disease. However, the eligibility of obese donors for LDLT remains a subject of debate. This literature review explores global practices and perceptions of LDLT, identifies donor eligibility criteria, and discusses special considerations and ethical caveats. The review highlights the need for standardized guidelines for donor selection, considering the global distribution of Body mass index and variations in population-specific criteria. It also emphasizes the importance of non-invasive testing and pre-operative optimization of liver steatosis for select obese donors. Furthermore, the review examines the outcomes and complications associated with obese donors in LDLT. The findings of this review contribute to the ongoing discussion on the inclusion of obese donors in LDLT and provide insights for future research and guideline development.
    Language English
    Publishing date 2023-09-20
    Publishing country Turkey
    Document type Journal Article ; Review
    ISSN 2757-7392
    ISSN (online) 2757-7392
    DOI 10.14744/hf.2023.2023.0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel indications for referral and care for simultaneous liver kidney transplant recipients.

    Lum, Erik L / Bunnapradist, Suphamai / Wiseman, Alexander C / Gurakar, Ahmet / Ferrey, Antoney / Reddy, Uttam / Al Ammary, Fawaz

    Current opinion in nephrology and hypertension

    2024  Volume 33, Issue 3, Page(s) 354–360

    Abstract: Purpose of review: Kidney dysfunction is challenging in liver transplant candidates to determine whether it is reversible or not. This review focuses on the pertinent data on how to best approach liver transplant candidates with kidney dysfunction in ... ...

    Abstract Purpose of review: Kidney dysfunction is challenging in liver transplant candidates to determine whether it is reversible or not. This review focuses on the pertinent data on how to best approach liver transplant candidates with kidney dysfunction in the current era after implementing the simultaneous liver kidney (SLK) allocation policy and safety net.
    Recent findings: The implementation of the SLK policy inverted the steady rise in SLK transplants and improved the utilization of high-quality kidneys. Access to kidney transplantation following liver transplant alone (LTA) increased with favorable outcomes. Estimating GFR in liver transplant candidates remains challenging, and innovative methods are needed. SLK provided superior patient and graft survival compared to LTA only for patients with advanced CKD and dialysis at least 3 months. SLK can provide immunological protection against kidney rejection in highly sensitized candidates. Post-SLK transplant care is complex, with an increased risk of complications and hospitalization.
    Summary: The SLK policy improved kidney access and utilization. Transplant centers are encouraged, under the safety net, to reserve SLK for liver transplant candidates with advanced CKD or dialysis at least 3 months while allowing lower thresholds for highly sensitized patients. Herein, we propose a practical approach to liver transplant candidates with kidney dysfunction.
    MeSH term(s) Humans ; Kidney Transplantation/methods ; Renal Dialysis/adverse effects ; Risk Factors ; Kidney ; Renal Insufficiency ; Graft Survival ; Liver ; Referral and Consultation ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/surgery
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Recipient Survival among Living Donor vs. Deceased Donor Liver Transplants for Acute Liver Failure in the United States.

    Moughames, Eric / Gurakar, Merve / Khan, Amir / Alsaqa, Marwan / Ozturk, N Begum / Bonder, Alan / Gurakar, Ahmet / Saberi, Behnam

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Approach to Liver Transplantation: Is There a Difference between East and West?

    Ozturk, Nazli Begum / Bartosek, Nathanial / Toruner, Merih Deniz / Mumtaz, Aymen / Simsek, Cem / Dao, Doan / Saberi, Behnam / Gurakar, Ahmet

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: Liver transplantation (LT) remains the only curative treatment for end-stage liver disease as well as acute liver failure. With the exponential increase in organ demand due to the increasing incidence and prevalence of liver diseases, the need to ... ...

    Abstract Liver transplantation (LT) remains the only curative treatment for end-stage liver disease as well as acute liver failure. With the exponential increase in organ demand due to the increasing incidence and prevalence of liver diseases, the need to overcome the supply and demand mismatch has arisen. In this review, we discuss the current universal status of LT, emphasizing various LT practices worldwide.
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Update on liver transplantation-newer aspects

    Metin, Olga / Şimşek, Cem / Gürakar, Ahmet

    Turkish journal of medical sciences

    2020  Volume 50, Issue SI-2, Page(s) 1642–1650

    Abstract: Liver transplantation (LT) remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT ...

    Abstract Liver transplantation (LT) remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT is the simple fact that there are not enough adequate livers for all the potential patients that could benefit from LT. Despite efforts to expand the donor pool to include living and deceased donors, organ shortage is still a major problem in many countries. To solve this problem, the use of marginal liver grafts has become an inevitable choice. Although the definition of marginal grafts or criteria for expanded donor selection has not been clarified yet, they are usually defined as grafts that may potentially cause primary nonfunction, impaired function, or late loss of function. These include steatotic livers, older donors, donors with positive viral serology, split livers, and donation after cardiac death (DCD). Therefore, to get the best outcome from these liver grafts, donor-recipient selection should be vigilant. Alcohol- related liver disease (ALD) is one of the most common indications for LT in Europe and North America. Traditionally, LT for alcoholic liver disease was kept limited for patients who have achieved 6 months of abstinence, in part due to social and ethical concerns regarding the use of a limited resource. However, the majority of patients with severe alcoholic hepatitis who fail medical therapy will not live long enough to meet this requirement. Besides, the initial results of early liver transplantation (ELT) without waiting for 6 months of abstinence period are satisfactory in severe alcoholic hepatitis (SAH). It will be important to take care of these patients from a newer perspective.
    MeSH term(s) Age Factors ; End Stage Liver Disease/surgery ; HIV Infections ; Hepatitis, Alcoholic ; Humans ; Liver Transplantation ; Obesity ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2020-11-03
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2002-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3242: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Liver transplantation in developing countries.

    Ozturk, Nazli Begum / Muhammad, Haris / Gurakar, Merve / Aslan, Alperen / Gurakar, Ahmet / Dao, Doan

    Hepatology forum

    2022  Volume 3, Issue 3, Page(s) 103–107

    Abstract: With the increasing incidence and prevalence of end-stage liver disease, demand for donor grafts continues to increase. Approaches on maximizing the potential donor grafts vary depending on the region. This review aims to summarize the current practice ... ...

    Abstract With the increasing incidence and prevalence of end-stage liver disease, demand for donor grafts continues to increase. Approaches on maximizing the potential donor grafts vary depending on the region. This review aims to summarize the current practice of liver transplantation with an emphasis on challenges encountered in developing countries.
    Language English
    Publishing date 2022-09-23
    Publishing country Turkey
    Document type Journal Article ; Review
    ISSN 2757-7392
    ISSN (online) 2757-7392
    DOI 10.14744/hf.2022.2022.0014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Racial Disparities in Candidates for Hepatocellular Carcinoma Liver Transplant After 6-Month Wait Policy Change.

    Saberi, Behnam / Gurakar, Ahmet / Tamim, Hani / Schneider, Carolin V / Sims, Omar T / Bonder, Alan / Fricker, Zachary / Alqahtani, Saleh A

    JAMA network open

    2023  Volume 6, Issue 11, Page(s) e2341096

    Abstract: Importance: Racial disparities in liver transplant (LT) for hepatocellular carcinoma (HCC) may be associated with unequal access to life-saving treatment.: Objective: To quantify racial disparities in LT for HCC and mortality after LT, adjusting for ... ...

    Abstract Importance: Racial disparities in liver transplant (LT) for hepatocellular carcinoma (HCC) may be associated with unequal access to life-saving treatment.
    Objective: To quantify racial disparities in LT for HCC and mortality after LT, adjusting for demographic, clinical, and socioeconomic factors.
    Design, setting, and participants: This cohort study was a retrospective analysis of United Network Organ Sharing/Organ Procurement Transplant Network (OPTN) data from 2003 to 2021. Participants were adult patients with HCC on the LT waiting list and those who received LT. Data were analyzed from March 2022 to September 2023.
    Exposures: Race and time before and after the 2015 OPTN policy change.
    Main outcomes and measures: Proportion of LT from wait-listed candidates, the proportion of waiting list removals, and mortality after LT.
    Results: Among 12 031 patients wait-listed for LT with HCC (mean [SD] age, 60.8 [7.4] years; 9054 [75.3%] male; 7234 [60.1%] White, 2590 [21.5%] Latinx/o/a, and 1172 [9.7%] Black or African American), this study found that after the 2015 model of end-stage liver disease (MELD) exception policy changes for HCC (era 2), the overall proportion of LT for HCC across all races decreased while the proportion of dropouts on the LT waiting list remained steady compared with patients who did not have HCC. In Kaplan-Meier analysis, Asian patients demonstrated the lowest dropout rates in both era 1 and era 2 (1-year dropout, 16% and 17%, respectively; P < .001). In contrast, Black or African American patients had the highest dropout rates in era 1 (1-year dropout, 24%), but comparable dropout rates (23%) with White patients (23%) and Latinx/o/a patients in era 2 (23%). In both eras, Asian patients had the highest survival after LT (5-year survival, 82% for era 1 and 86% for era 2), while Black or African American patients had the worst survival after LT (5-year survival, 71% for era 1 and 79% for era 2). In the multivariable analysis for HCC LT recipients, Black or African American race was associated with increased risk of mortality in both eras, compared with White race (HR for era 1, 1.17; 95% CI, 1.05-1.35; and HR for era 2, 1.31; 95% CI, 1.10-1.56).
    Conclusions and relevance: This cohort study of LT candidates in the US found that after the 2015 MELD exception policy change for HCC, the proportion of LT for HCC had decreased for all races. Black or African American patients had worse outcomes after LT than other races. Further research is needed to identify the underlying causes of this disparity and develop strategies to improve outcomes for HCC LT candidates.
    MeSH term(s) Adult ; Humans ; Male ; Middle Aged ; Female ; Liver Transplantation ; Carcinoma, Hepatocellular/surgery ; Cohort Studies ; Retrospective Studies ; Liver Neoplasms/surgery ; End Stage Liver Disease ; Policy
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.41096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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