LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice

    Jie Gao / Shumei Ren / Gabrielle Choonoo / Guoying Chen / Davor Frleta / Jun Zhong / Namita Gupta / Prachi Sharma / Adelekan Oyejide / Gurinder S. Atwal / Lynn Macdonald / Andrew Murphy / Frank Kuhnert

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 10

    Keywords sezary syndrome ; ctcl ; il-15 ; pdx ; humanized mice ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

    Qi Su / Sun Y. Kim / Funmi Adewale / Ye Zhou / Christina Aldler / Min Ni / Yi Wei / Michael E. Burczynski / Gurinder S. Atwal / Mark W. Sleeman / Andrew J. Murphy / Yurong Xin / Xiping Cheng

    iScience, Vol 24, Iss 11, Pp 103233- (2021)

    2021  

    Abstract: Summary: Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes (scRNA-seq) across different NAFLD stages were profiled, ...

    Abstract Summary: Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes (scRNA-seq) across different NAFLD stages were profiled, identifying hepatocytes and 12 other non-parenchymal cell (NPC) types. scRNA-seq revealed insights into the cellular and molecular mechanisms of the disease. We discovered a dual role for hepatic stellate cells in gene expression regulation and in the potential to trans-differentiate into myofibroblasts. We uncovered distinct expression profiles of Kupffer cells versus monocyte-derived macrophages during NAFLD progression. Kupffer cells showed stronger immune responses, while monocyte-derived macrophages demonstrated a capability for differentiation. Three chimeric NPCs were identified including endothelial-chimeric stellate cells, hepatocyte-chimeric endothelial cells, and endothelial-chimeric Kupffer cells. Our work identified unanticipated aspects of mouse with NAFLD at the single-cell level and advanced the understanding of cellular heterogeneity in NAFLD livers.
    Keywords Animal physiology ; Cell biology ; Transcriptomics ; Science ; Q
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: AdRoit is an accurate and robust method to infer complex transcriptome composition

    Tao Yang / Nicole Alessandri-Haber / Wen Fury / Michael Schaner / Robert Breese / Michael LaCroix-Fralish / Jinrang Kim / Christina Adler / Lynn E. Macdonald / Gurinder S. Atwal / Yu Bai

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Yang et al. present AdRoit, a method for deconvoluting bulk RNA sequencing and spatial transcriptomics data. AdRoit performs well on datasets from complex tissues with many different cell types. ...

    Abstract Yang et al. present AdRoit, a method for deconvoluting bulk RNA sequencing and spatial transcriptomics data. AdRoit performs well on datasets from complex tissues with many different cell types.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

    Asiel A. Benitez / Sara Khalil-Agüero / Anjali Nandakumar / Namita T. Gupta / Wen Zhang / Gurinder S. Atwal / Andrew J. Murphy / Matthew A. Sleeman / Sokol Haxhinasto

    Communications Biology, Vol 3, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Benitez et al. show that mice lacking the autoimmune regulator Aire, which is important for T cell central tolerance, show an improved anti-tumor response and expansion of T cell clones with high tumor reactivity after anti-PD1 antibody treatment ... ...

    Abstract Benitez et al. show that mice lacking the autoimmune regulator Aire, which is important for T cell central tolerance, show an improved anti-tumor response and expansion of T cell clones with high tumor reactivity after anti-PD1 antibody treatment compared to wild-type mice. This study suggests a path towards improved immunotherapy strategies.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

    Casandra Panea / Ruoyu Zhang / Jeffrey VanValkenburgh / Min Ni / Christina Adler / Yi Wei / Francisca Ochoa / Jennifer Schmahl / Yajun Tang / Chia-Jen Siao / William Poueymirou / Jennifer Espert / Wei Keat Lim / Gurinder S. Atwal / Andrew J. Murphy / Matthew A. Sleeman / Zaruhi Hovhannisyan / Sokol Haxhinasto

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-deficient γδ ...

    Abstract Panea et al showed that epithelia-specific butyrophilinlike 2 (Btnl2) suppressed homeostatic proliferation of γδ intraepithelial lymphocytes (IELs) preferentially in the ileum and used high throughput transcriptomic characterization of Btnl2-deficient γδ IELs to demonstrate that Btnl2 impacts γδ TCR specificities and repertoire diversity of ileal γδ IELs. In addition, they showed that Btnl2-deficient mice exhibited increased inflammation and delayed mucosal repair in the colon, suggesting that it plays a key immunological function in intestinal diseases.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

    Parsa Akbari / Olukayode A. Sosina / Jonas Bovijn / Karl Landheer / Jonas B. Nielsen / Minhee Kim / Senem Aykul / Tanima De / Mary E. Haas / George Hindy / Nan Lin / Ian R. Dinsmore / Jonathan Z. Luo / Stefanie Hectors / Benjamin Geraghty / Mary Germino / Lampros Panagis / Prodromos Parasoglou / Johnathon R. Walls /
    Gabor Halasz / Gurinder S. Atwal / Regeneron Genetics Center / DiscovEHR Collaboration / Marcus Jones / Michelle G. LeBlanc / Christopher D. Still / David J. Carey / Alice Giontella / Marju Orho-Melander / Jaime Berumen / Pablo Kuri-Morales / Jesus Alegre-Díaz / Jason M. Torres / Jonathan R. Emberson / Rory Collins / Daniel J. Rader / Brian Zambrowicz / Andrew J. Murphy / Suganthi Balasubramanian / John D. Overton / Jeffrey G. Reid / Alan R. Shuldiner / Michael Cantor / Goncalo R. Abecasis / Manuel A. R. Ferreira / Mark W. Sleeman / Viktoria Gusarova / Judith Altarejos / Charles Harris / Aris N. Economides

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 17

    Abstract: Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with ... ...

    Abstract Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with favorable fat distribution and protection from type 2 diabetes.
    Keywords Science ; Q
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top