Article: TLR2 agonism reverses chemotherapy-induced neutropenia in
2017 Volume 1, Issue 26, Page(s) 2553–2562
Abstract: Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is known to ...
Abstract | Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is known to stimulate neutrophil production and is widely used as a treatment of chemotherapy-induced neutropenia. A small-molecule G-CSF secretagogue without a requirement for refrigerated supply chain would offer a more convenient and cost-effective treatment of chemotherapy-induced neutropenia. Bacterial lipopeptides activate innate immune responses through Toll-like receptor 2 (TLR2) and induce the release of cytokines, including G-CSF, from macrophages, monocytes, and endothelial. Pam |
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Language | English |
Publishing date | 2017-12-12 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2876449-3 |
ISSN | 2473-9537 ; 2473-9529 |
ISSN (online) | 2473-9537 |
ISSN | 2473-9529 |
DOI | 10.1182/bloodadvances.2017010611 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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