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Article ; Online: Identification of differentially expressed miRNA in the rat hippocampus during adolescence through an epigenome-wide analysis.

Vázquez-Ágredos, Ana / Rovira, Paula / Gutiérrez, Blanca / Gámiz, Fernando / Gallo, Milagros

2024

Abstract: Introduction: Epigenetic mechanisms involving microRNAs (miRNAs) play a fundamental role in many biological processes, particularly during prenatal and early postnatal development. Their role in adolescent brain development, however, has been poorly ... ...

Abstract	Introduction: Epigenetic mechanisms involving microRNAs (miRNAs) play a fundamental role in many biological processes, particularly during prenatal and early postnatal development. Their role in adolescent brain development, however, has been poorly described. The present study aims to explore miRNA expression in the hippocampus during adolescence compared to adulthood in rats. Method: The brains of female and male Wistar rats were extracted and the hippocampus was freshly dissected at postnatal day 41 (adolescence) and postnatal day 98 (adulthood). An epigenome-wide analysis was conducted to identify the miRNAs significantly expressed in adolescence compared to adulthood. Additionally, target genes of such miRNAs were considered to perform an exploratory gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results: We identified 16 differentially expressed miRNAs in adolescent male rats compared with adult male rats, and 4 differentially expressed miRNAs in adolescent females compared with adult females. Enrichment analysis reinforced that the target genes found are related to neurodevelopmental processes such as cell proliferation, cell migration and nervous system development. Conclusion: Our findings suggest a complex pattern of miRNA expression during adolescence, which differs from that in adulthood. The differential expression of miRNA in the hippocampus during adolescence may be associated with the late developmental changes occurring in this brain region. Furthermore, the observed sex differences in miRNA expression patterns indicate potential sexual differentiation in hippocampal development. Further comprehensive investigations are needed to elucidate the roles of miRNA in normal brain development.
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	556887-0
ISSN	1421-9859 ; 0378-5866
ISSN (online)	1421-9859
ISSN	0378-5866
DOI	10.1159/000538168
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Article ; Online: Psychotic symptoms associate inversely with social support, social autonomy and psychosocial functioning: A community-based study.

Guerrero-Jiménez, Margarita / Gutiérrez, Blanca / Cervilla, Jorge A

The International journal of social psychiatry

2021 Volume 68, Issue 4, Page(s) 898–907

Abstract: Background: Population-based studies exploring psychotic symptoms (PS) show that their prevalence in the community is higher than previously thought. Psychosocial functioning and social support are poorer among people presenting clinical and subclinical ...

Abstract	Background: Population-based studies exploring psychotic symptoms (PS) show that their prevalence in the community is higher than previously thought. Psychosocial functioning and social support are poorer among people presenting clinical and subclinical PS. Aims: We aimed to estimate the prevalence rate of PS in Andalusia and to explore the association between PS and psychosocial functioning, social support and social autonomy in a Southern European population. Material and methods: This is a cross-sectional study. We undertook multi-stage sampling using different standard stratification techniques. Out of 5496 households approached, we interviewed 4507 (83.7%) randomly selected participants living in the autonomous region of Andalusia (Southern Spain). The Spanish version of the MINI International Neuropsychiatric Interview was used to elicit PS. We also gathered information on socio-demographic factors, suicidality risk, psychosocial functioning, social support and social autonomy. Results: The overall prevalence of PS was 6.7% (95% CI: 5.99-6.45). PS were associated with lower age (OR 0.975; 95% CI (0.967-0.983); Conclusions: Social outcomes seem to be strongly inversely associated with PS in spite of presumed higher levels of social support among Southern European cultures.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Male ; Psychosocial Functioning ; Psychotic Disorders/epidemiology ; Social Support ; Spain/epidemiology
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	3062-4
ISSN	1741-2854 ; 0020-7640
ISSN (online)	1741-2854
ISSN	0020-7640
DOI	10.1177/00207640211011198
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Article ; Online: An epidemiological survey on personality disorder in Andalusia (the PISMA-ep PD study).

Muñoz-Negro, José Eduardo / Gutiérrez, Blanca / Rivera, Margarita / Molina, Esther / González Díaz, Manuel / Jabalera Ruz, Paula / Cervilla, Jorge A

The International journal of social psychiatry

2023 Volume 70, Issue 1, Page(s) 209–217

Abstract: Background: Despite a significant clinical and social burden, there is a relative scarcity of epidemiological studies on Personality Disorder (PD).: Aim: To determine the current prevalence of PD and the psychosocial correlates associated with this ... ...

Abstract	Background: Despite a significant clinical and social burden, there is a relative scarcity of epidemiological studies on Personality Disorder (PD). Aim: To determine the current prevalence of PD and the psychosocial correlates associated with this in the Andalusian population. Method: We carried out a cross-sectional population mental-health survey in Andalusia, southern Spain. Thus, 4,518 randomly selected participants were interviewed following sampling using different standard stratification levels. We used the Spanish version of the SAPAS to estimate PD prevalence. In addition, a full battery of other instruments was utilized to explore global functionality, childhood abuse, maltreatment, threatening life events, personality traits (neuroticism, impulsivity and paranoia), medical and psychiatric comorbidities, family history of psychological problems and other potential risk factors for PD. Results: PD prevalence (10.8%; 95% CI [9.8, 11.7]) and ran two different multivariate models for PD. We obtained the highest PD prevalence in those affected by any mental disorder plus those reporting having suffered childhood abuse, particularly sexual abuse. Additional potential risk factors or correlates of PD identified were: younger age, lower levels of functioning, less social support, poorer general health, having suffered maltreatment, threatening life events, higher suicidal risk scores and higher levels of both neuroticism and impulsivity. Conclusions: This study reports PD prevalence and risk correlates in consonance with similar findings reported in other Western populations. However, longitudinal studies are needed to elicit a more thorough group of prospective determinants of PD.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Personality Disorders/epidemiology ; Personality Disorders/psychology ; Risk Factors
Language	English
Publishing date	2023-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	3062-4
ISSN	1741-2854 ; 0020-7640
ISSN (online)	1741-2854
ISSN	0020-7640
DOI	10.1177/00207640231204216
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Article ; Online: Prevalence and correlates of suicidality in Andalusia (Spain): Results of the epidemiological study PISMA-ep.

Huertas, Paloma / Moreno-Küstner, Berta / Gutiérrez, Blanca / Cervilla, Jorge A

Journal of affective disorders

2020 Volume 266, Page(s) 503–511

Abstract: Background: Suicidality is an important public health problem. Hence, the aims of this study are to report prevalence rates and correlates of suicidality in Andalusia (Southern Spain).: Methods: This is a cross-sectional household survey conducted on ...

Abstract	Background: Suicidality is an important public health problem. Hence, the aims of this study are to report prevalence rates and correlates of suicidality in Andalusia (Southern Spain). Methods: This is a cross-sectional household survey conducted on a representative sample of adults living in Andalusia. 4507 subjects were interviewed using the Mini International Neuropsychiatric Interview (MINI) to assess suicidality and standardized instruments were employed to evaluate associated variables. A multivariate logistic regression analysis was used to explore independent associations with suicidality. Results: Current prevalence of suicidality was 6.4%, 4.4% showed death wish, 1.4% had ideas of self-harm, 2.4% had suicidal thoughts, 1.1% had a suicidal plan, 0.6% had attempted suicide during the month prior to the interview, and, lastly, 2.6% reported to have had any sort of suicide attempt during his/her previous life. Independent factors associated with suicidality were being female, older age, not having a stable couple, lower levels of social support, having had physical childhood abuse experience, having experienced an increasing number of stressful life events, higher neuroticism scores, having a family history of mental disorder and nicotine or drugs dependence. Limitations: The instrument employed to measure suicidality is a screening tool rather than a more in-depth diagnostic measure. We have not included all potential correlates of suicidality. This is a cross-sectional study which cannot establish causal relationships between exposures and outcomes. Conclusions: This is the first epidemiological study in Andalusia on suicidality offering important results of clinical interest for suicide prevention.
MeSH term(s)	Adult ; Aged ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Prevalence ; Risk Factors ; Spain/epidemiology ; Suicidal Ideation ; Suicide ; Suicide, Attempted
Language	English
Publishing date	2020-01-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2020.01.115
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Article ; Online: A population-based cross-sectional study of cognitive deficits in paranoia.

Ibanez-Casas, Inmaculada / Carmen Maura, Carrillo de Albornoz Calahorro / Gutiérrez, Blanca / Cervilla, Jorge A

Psychiatry research

2021 Volume 299, Page(s) 113820

Abstract: This study sought to investigate the association between paranoia and performance in a range of neurocognitive domains using a large community sample. We conducted a cross-sectional survey of 4507 individuals within the PISMA-ep Study. We used a large ... ...

Abstract	This study sought to investigate the association between paranoia and performance in a range of neurocognitive domains using a large community sample. We conducted a cross-sectional survey of 4507 individuals within the PISMA-ep Study. We used a large community sample selected after multistage sampling using standard stratification techniques. Socio-demographic variables such as age, gender, educational level, urbanicity, and geographical region were recorded. The Spanish version of the Green Paranoid Thought Scale (S-GPTS) was used to assess paranoid thoughts. The Screening for Cognitive Impairment in Psychiatry (SCIP) was used to assess neurocognitive performance both globally and by domains (i.e., immediate and delayed verbal learning, working memory, verbal fluency and processing speed). Individuals with high S-GPTS paranoia scores showed significantly lower performance on global cognitive function and also on immediate (but not delayed) verbal learning, working memory, verbal fluency and processing speed. These results held statistical significance even after controlling for the effects of education and estimated IQ. We propose that cognitive deficits may be mediators of paranoid thinking formation and need to be considered when assessing patients with high levels of paranoia.
MeSH term(s)	Cognition ; Cognitive Dysfunction ; Cross-Sectional Studies ; Humans ; Neuropsychological Tests ; Paranoid Disorders
Language	English
Publishing date	2021-02-24
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2021.113820
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Article ; Online: Paranoia and Suicidality: A Cross-Sectional Study in the General Population.

Carrillo de Albornoz, Carmen M / Gutiérrez, Blanca / Ibanez-Casas, Inmaculada / Cervilla, Jorge A

Archives of suicide research : official journal of the International Academy for Suicide Research

2021 Volume 26, Issue 3, Page(s) 1587–1599

Abstract: Paranoia and suicidality seem to be common traits expressing in the general population to varying degrees. This study aims to explore the association between both and to identify determinants of comorbidity. We interviewed a representative sample of the ... ...

Abstract	Paranoia and suicidality seem to be common traits expressing in the general population to varying degrees. This study aims to explore the association between both and to identify determinants of comorbidity. We interviewed a representative sample of the population in Andalusia (n = 4507) and assessed paranoia and suicidality utilizing the Spanish Green's Paranoid Thoughts Scale (S-GPTS) and the suicidality section of the MINI Neuropsychiatric Interview, respectively. We gathered data on socio-demographics, personality, substance abuse, social support, and environmental distress. We found that paranoia and suicidality were rather common with 6.4% (95% CI: 5.7-7.12) of the sample admitting to some (vs. none) level of suicidality. We also found a robust association between paranoia and suicidality, independent of age and sex (F:298.2; p =.0001; Eta
MeSH term(s)	Cross-Sectional Studies ; Humans ; Paranoid Disorders/epidemiology ; Paranoid Disorders/psychology ; Personality Disorders/epidemiology ; Suicidal Ideation ; Suicide
Language	English
Publishing date	2021-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283671-0
ISSN	1543-6136 ; 1381-1118
ISSN (online)	1543-6136
ISSN	1381-1118
DOI	10.1080/13811118.2021.1950589
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Article ; Online: Interaction Effect between Physical Activity and the

Zarza-Rebollo, Juan Antonio / Molina, Esther / López-Isac, Elena / Pérez-Gutiérrez, Ana M / Gutiérrez, Blanca / Cervilla, Jorge A / Rivera, Margarita

International journal of environmental research and public health

2022 Volume 19, Issue 4

Abstract: The relationship between depression and the Val66Met polymorphism at the brain-derived neurotrophic factor gene ( ...

Abstract	The relationship between depression and the Val66Met polymorphism at the brain-derived neurotrophic factor gene (
MeSH term(s)	Brain-Derived Neurotrophic Factor/genetics ; Depression/epidemiology ; Depression/genetics ; Exercise ; Female ; Gene-Environment Interaction ; Genotype ; Humans ; Polymorphism, Single Nucleotide
Chemical Substances	Brain-Derived Neurotrophic Factor
Language	English
Publishing date	2022-02-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19042068
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Article ; Online: Paranoia and risk of personality disorder in the general population.

Muñoz-Negro, José E / Prudent, Cécile / Gutiérrez, Blanca / Cervilla, Jorge A

Personality and mental health

2019 Volume 13, Issue 2, Page(s) 107–116

Abstract: Background: We hypothesized that paranoia is associated with personality disorder (PD) in the general population.: Method: This was a population-based cross-sectional survey carried out in Andalusia (Spain) using a representative sample of 4 507 ... ...

Abstract	Background: We hypothesized that paranoia is associated with personality disorder (PD) in the general population. Method: This was a population-based cross-sectional survey carried out in Andalusia (Spain) using a representative sample of 4 507 participants. Paranoia was measured using the Green Paranoid Thought Scale, and risk of having a PD was screened using the Standardized Assessment of Personality Abbreviated Scale whilst borderline personality disorder (BPD) was measured with the CEPER-III Exploratory Interview of Personality disorder. Adjusted Pearsons' correlations between paranoia and PD or BPD were calculated. Results: Paranoia was associated with the risk of having PD and, more robustly, with BPD. Both associations held true for both personality outcomes (PD and BPD) when tested for two Green Paranoid Thought Scale paranoia subtypes (persecutory and reference) after accounting for the effects of age, sex and child abuse. Conclusions: Paranoia seems to either augment the risk for, or be part of, PD/BPD. © 2019 John Wiley & Sons, Ltd.
MeSH term(s)	Adolescent ; Adult ; Aged ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Paranoid Disorders/epidemiology ; Personality Disorders/epidemiology ; Risk ; Spain/epidemiology ; Young Adult
Language	English
Publishing date	2019-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2481770-3
ISSN	1932-863X ; 1932-8621
ISSN (online)	1932-863X
ISSN	1932-8621
DOI	10.1002/pmh.1443
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Zs.A 6783: Show issues

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Article ; Online: Multi-omic study to unmask genes involved in prostate cancer development in a multi-case family.

Chica-Redecillas, Lucia / Cuenca-Lopez, Sergio / Andres-Leon, Eduardo / Terron-Camero, Laura Carmen / Cano-Gutierrez, Blanca / Cozar, Jose Manuel / Lorente, Jose Antonio / Vazquez-Alonso, Fernando / Martinez-Gonzalez, Luis Javier / Alvarez-Cubero, Maria Jesus

Cancer communications (London, England)

2023 Volume 44, Issue 3, Page(s) 443–447

MeSH term(s)	Male ; Humans ; Multiomics ; Genomics ; Prostatic Neoplasms/genetics
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Letter
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1002/cac2.12501
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Article ; Online: Epidemiology of social phobia in Andalusia.

González-Domenech, Pablo / Gutiérrez, Blanca / Muñoz-Negro, José Eduardo / Molina, Esther / Rivera, Margarita / Cervilla, Jorge A

Spanish journal of psychiatry and mental health

2021 Volume 17, Issue 2, Page(s) 88–94

Abstract: Introduction: Population studies on social anxiety disorder (SAD) are relatively scarce and there is no previous reported evidence on prevalence or correlates of SAD in an Andalusian general population sample.: Material and methods: We used a random ... ...

Abstract	Introduction: Population studies on social anxiety disorder (SAD) are relatively scarce and there is no previous reported evidence on prevalence or correlates of SAD in an Andalusian general population sample. Material and methods: We used a random representative sample previously identified via standard stratification procedures. Thus, a final sample of 4507 participants were included (response rate 83.7%). Interviewees were thoroughly assessed on sociodemographic, clinical and psychosocial factors, including: exposures to threatening life events (TLEs), childhood abuse, personality disorder and traits (neuroticism, impulsivity, paranoia), global functioning, physical health and toxics consumption. SAD diagnosis was ascertained using the Mini International Neuropsychiatric Interview. Both, pooled prevalences (with 95% confidence intervals) and risk correlates for SAD were estimated using binary logistic regression. Results: Estimated prevalence for SAD was 1.1% (95% CI=0.8-1.4). Having a SAD diagnosis was independently and significantly associated with younger age, poorer global functioning, higher neuroticism and paranoia personality traits, having suffered childhood abuse and exposure to previous TLEs. Furthermore, SAD was significantly associated with comorbid personality disorder, major depression, panic disorder and alcohol abuse. Conclusions: Among this large Andalusian population sample, the prevalence of SAD and its associated factors are relatively similar to previously reported international studies, although no population study had previously reported such a strong association with paranoia.
MeSH term(s)	Humans ; Phobia, Social/epidemiology ; Phobia, Social/psychology ; Female ; Male ; Adult ; Middle Aged ; Spain/epidemiology ; Prevalence ; Young Adult ; Adolescent ; Comorbidity ; Aged ; Personality Disorders/epidemiology ; Personality Disorders/psychology
Language	English
Publishing date	2021-10-14
Publishing country	Spain
Document type	Journal Article
ISSN	2950-2853
ISSN (online)	2950-2853
DOI	10.1016/j.rpsm.2021.09.006
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