Article ; Online: Shedding light on key pharmacological knowledge and strategies for pediatric atopic dermatitis.
Expert review of clinical pharmacology
2023 Volume 16, Issue 2, Page(s) 119–131
Abstract: Introduction: Atopic dermatitis (AD) is an inflammatory disease affecting over 20% of the pediatric population, with 85% of cases presenting before the age of five. Recently, therapeutic options in pediatric patients have evolved rapidly, following ... ...
| Abstract | Introduction: Atopic dermatitis (AD) is an inflammatory disease affecting over 20% of the pediatric population, with 85% of cases presenting before the age of five. Recently, therapeutic options in pediatric patients have evolved rapidly, following extensive development in adult treatments. Areas covered: This review will encompass relevant molecular drivers, along with an overlook on treatment modalities in pediatric AD, as well as a summary of pipeline treatments in clinical trials for pediatric patients from PubMed, Google Scholar, and Clinicaltrials.gov up to July 2022. Topical corticosteroids are the mainstay for AD flares in adults and children. Topical approved agents in pediatric AD are calcineurin inhibitors, crisaborolecrisaborole, and ruxolitinib. Dupilumab is the only FDA approved biologic for patients with AD from six months of age. A Janus kinase inhibitor, upadacitinib, is a systemic treatment approved for pediatric AD patients (age >12 years). Systemic immunosuppressants used in pediatric AD include methotrexate, azathioprine, cyclosporinecyclosporine, and mycophenolate mofetil. Expert opinion: Data regarding disease prevention are conflicting, however, an abundance of research has transpired regarding amelioration of symptoms and induction of disease clearance by targeting numerous pathological mechanisms. Understanding the pediatric AD phenotype will further advance the field and the development of improved therapeutics. |
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| MeSH term(s) | Child ; Humans ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Calcineurin Inhibitors/pharmacology ; Administration, Cutaneous ; Dermatologic Agents |
| Chemical Substances | Immunosuppressive Agents ; Calcineurin Inhibitors ; Dermatologic Agents |
| Language | English |
| Publishing date | 2023-02-06 |
| Publishing country | England |
| Document type | Review ; Journal Article |
| ISSN | 1751-2441 |
| ISSN (online) | 1751-2441 |
| DOI | 10.1080/17512433.2023.2173172 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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