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  1. AU="Guy Melamed"
  2. AU="Raikhel, Marina"
  3. AU="Bhatti, Hakikat Bir Singh"
  4. AU="Christian Molnár"
  5. AU="Montarello, Natalie"
  6. AU="Phan Nu Dieu Hong"
  7. AU="Polliack, Michael"
  8. AU="Ye, Tianai"
  9. AU="Galenson, Walter"
  10. AU="Nisar, Muhammad K"
  11. AU="Keshavarzi, Nahid"
  12. AU="Gabig, Theodore G"
  13. AU="Nixon, Ian J"
  14. AU="Huang Xiaoting"
  15. AU="Colturato, Virgílio Antônio Rensi"
  16. AU="Mahfouz, Amira Y"
  17. AU="Ayyappan, Sabarish"
  18. AU=Wang Kevin L-C
  19. AU="Lukas T. Hirschwald"
  20. AU="Morley-Davies, A"
  21. AU="Felsberg, Gary J"
  22. AU="Bogen, Oliver"
  23. AU="de Portu, Simona"
  24. AU="Janssens, Rick"

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  1. Artikel ; Online: Sarcopenia as Manifested by L3SMI Is Associated with Increased Long-Term Mortality amongst Internal Medicine Patients—A Prospective Cohort Study

    Doron Portal / Guy Melamed / Gad Segal / Edward Itelman

    Journal of Clinical Medicine, Vol 11, Iss 3500, p

    2022  Band 3500

    Abstract: Background: Sarcopenia and Frailty are syndromes that affect the clinical outcomes of patients suffering from a wide range of diseases. The use of Computed Tomography (CT) is well established for Sarcopenia evaluation via estimation of the Skeletal ... ...

    Abstract Background: Sarcopenia and Frailty are syndromes that affect the clinical outcomes of patients suffering from a wide range of diseases. The use of Computed Tomography (CT) is well established for Sarcopenia evaluation via estimation of the Skeletal Muscle Index (SMI) at the level of the third lumbar vertebra (L3SMI). Nevertheless, the association of more readily available biomarkers of Sarcopenia and clinical outcomes is desired. Recent studies have associated low Alanine amino-transferase ALT (SGPT) levels with Sarcopenia and frailty. The current study aimed to establish the association between low L3SMI and the aforementioned indices of Sarcopenia, frailty and poor clinical outcomes. Methods: A cohort study of patients admitted to the internal medicine department at a tertiary medical center. Sarcopenia was determined as L3SMI, lower than 53 cm 2 /m 2 in men and 41 cm 2 /m 2 in women. Clinical and mortality data was collected from the medical record. Results: Of the 187 patients recruited (mean age 70.4 ± 9.2, 59% males), 116 (62%) had Sarcopenia, based on L3SMI values. Sarcopenic patients were older, predominantly male, had lower BMI, lower mid-arm muscle circumference (MAMC) and low ALT values upon admission. L3SMI values significantly correlated with age and MAMC among males (R = −0.38, p < 0.001, R = 0.35, p < 0.001, respectively). Sarcopenia was associated with higher, one-year mortality (HR = 2.60, 95% CI 1.06–6.37, p = 0.036) and shorter all-time survival (HR = 2.91, 95% CI 1.35–6.29, p = 0.007). The association with all-time survival remained after adjusting for age and sex (HR = 2.38, 95% CI 1.07–5.29, p = 0.034). Conclusion : As defined by low L3SMI value, Sarcopenia is a poor prognostic factor for the general internal ward patient population. As part of personalized medicine, physicians may benefit from measuring L3SMI value, as indicated by commonly performed CT scans, to objectively assess their patient’s risk of suffering from Sarcopenia and frailty-associated complications.
    Schlagwörter sarcopenia ; frailty ; L3SMI ; mortality ; internal medicine ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Polymethylmethacrylate (PMMA) Hosts Microbiome Associated with Oral Malodor

    Ofir Rosner / Guy Melamed / Naama Friedenberg / Neta Dagan / Uziel Jeffet / Nir Sterer

    Applied Sciences, Vol 13, Iss 1780, p

    2023  Band 1780

    Abstract: Previous study suggested that fixed dental prostheses (crowns) increase oral malodor production. There might be a role to temporary acrylic crowns contributing to oral malodor. In the current study, we analyzed the microbiome associated with malodorous ... ...

    Abstract Previous study suggested that fixed dental prostheses (crowns) increase oral malodor production. There might be a role to temporary acrylic crowns contributing to oral malodor. In the current study, we analyzed the microbiome associated with malodorous temporary dental crowns. The study population comprised nineteen patients (mean age 45.8 ± 10.9, 8 females) who visited the Tel Aviv University dental clinic. Temporary crowns were scored by an odor judge using a 6-point malodor organoleptic scale (0–5) and temporary crowns that were scored 2 and above were assigned as malodor positive. Microbial DNA was extracted from the temporary dental crowns and analyzed using next generation 16S rDNA sequencing. Taxa identified could be classified into 11 phyla, 50 genera and 119 core species. Malodor positive samples demonstrated higher abundance of the phyla Proteobacteria and Actinobacteria and the genera Tannerella , Alloprevotella , Treponema , Olsenella and Bifidobacterium . Malodorous samples showed higher bacterial diversity and significant differences in microbial population. Taken together these results suggest a difference between the microbial populations of malodorous and non-malodorous temporary dental crowns both in composition and diversity.
    Schlagwörter malodor ; temporary dental crowns ; microbiome ; 16S deep sequencing ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 670
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Pre-Disinfection of Poly-Methyl-Methacrylate (PMMA) Reduces Volatile Sulfides Compounds (VSC) Production in Experimental Biofilm In Vitro

    Ofir Rosner / Guy Melamed / Shiri Livne / Uziel Jeffet / Eran Dolev / Gil Ben Izhack / Hadas Heller / Nir Sterer

    Applied Sciences, Vol 12, Iss 1947, p

    2022  Band 1947

    Abstract: Temporary dental crowns and bridges are commonly made of poly-methylmethacrylate (PMMA), a porous material attracting the microbial biofilm associated with malodor production. The purpose of the present study was to test pre-disinfection of PMMA on ... ...

    Abstract Temporary dental crowns and bridges are commonly made of poly-methylmethacrylate (PMMA), a porous material attracting the microbial biofilm associated with malodor production. The purpose of the present study was to test pre-disinfection of PMMA on malodor-related parameters in an experimental oral biofilm. PMMA discs were pre-soaked in anti-malodor disinfecting solutions and controls: (i) Saline, (ii) essential oils (EO), (iii) herbal extracts (HE), and (iv) chlorhexidine (CHX). Following, discs were subjected to a salivary incubation assay and monitored for malodor-producing bacteria within the biofilm using confocal microscopy (CLSM), malodor production (organoleptic scale 0–5), volatile sulfide levels (Halimeter), and salivary protein degradation (SDS-PAGE). Results showed that disinfection solutions were significantly effective in reducing malodor-related parameters (CHX > HE > EO > Saline). Taken together, these results suggest that pre-disinfection may help to reduce malodor production in PMMA temporary dental restorations.
    Schlagwörter poly-methylmethacrylate ; malodor ; biofilm ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Long-Term Prosthetic Aftercare of Two- vs. Four-Ball Attachment Implant-Supported Mandibular Overdentures

    Ofir Rosner / Eran Zenziper / Hadas Heller / Joseph Nissan / Guy Melamed / Shahar Har-Ness / Ari Glikman / Shlomo Matalon

    Applied Sciences, Vol 11, Iss 8974, p

    2021  Band 8974

    Abstract: Little is reported about the prosthetic aftercare of implant-supported mandibular overdentures regarding the number of implants placed. The purpose of this study was to evaluate the prosthetic aftercare among edentulous patients restored with two vs. ... ...

    Abstract Little is reported about the prosthetic aftercare of implant-supported mandibular overdentures regarding the number of implants placed. The purpose of this study was to evaluate the prosthetic aftercare among edentulous patients restored with two vs. four mandibular implant-retained overdentures (MISOD). Forty-six consecutive edentulous patients treated by a new MISOD were retrospectively studied. Twenty-five patients had two-ball attachment MISOD (Group A), and 21 had four-ball attachment MISOD (Group B). The total amount of aftercare visits was recorded, as well as the type of treatments required (pressure sore spots relief, attachment liner replacement due to loss of retention, and metal ball attachment replacement due to wear). The mean follow-up duration was 93 ± 57 months (range 9–246 months). None of the implants was lost. There were significantly more visits for pressure sore spots relief in Group A vs. Group B (6.2 ± 2 in group A and 4.09 ± 1.54 in group B, p < 0.0001). Differences in the other two tested parameters (number of visits for liner replacement (2.3 ± 1.84 in group A and 2.4 ± 1.63 in group B) and attachment replacement (2.36 ± 1.85 in group A vs. 2.48 ± 1.63 in group B) yielded a non-significant outcome ( p = 0.814 for liner replacement and p = 1.000 for attachment replacement). The use of four-ball attachments in MISOD was more beneficial than two-ball attachments with regards to the aftercare of pressure sore spots. The number of implants did not influence the mechanical wear.
    Schlagwörter mandibular implant overdenture ; number of implants ; aftercare ; sore spots ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Effect of Mixing and Impression Techniques Using Vinyl Polysiloxane (VPS) on the Accuracy of Fixed Partial Dentures

    Helena Zelikman / Ofir Rosner / Sarit Naishlos / Hanaa Azem / Isabelle Meinster / Ari Glikman / Guy Melamed / Gil Ben-Izhack / Joseph Nissan / Shlomo Matalon

    Applied Sciences, Vol 11, Iss 7845, p

    2021  Band 7845

    Abstract: Two critical factors that influence the accuracy of an impression include the proper manipulation of the impression materials and the technique used to make the impression. The purpose of this study was to clinically evaluate the effect of different ... ...

    Abstract Two critical factors that influence the accuracy of an impression include the proper manipulation of the impression materials and the technique used to make the impression. The purpose of this study was to clinically evaluate the effect of different mixing techniques on the accuracy of vinyl polysiloxane (VPS) impressions by assessing metal framework fit of fixed partial restorations. The study included 92 consecutive patients diagnosed with partial edentulism and treated with fixed partial denture restorations. The mixing technique was one of the two following mixing methods: hand mixing technique (45 patients), with the putty material mixed according to the manufacturer’s instructions; or mechanical mixing technique (47 patients), with the putty material mixed by a Pentamix device. Under both mixing methods, vinyl polysiloxane was used as the impression material. Two impression techniques were randomly used by the operators (One/Two-stage putty –wash impression techniques). The accuracy of the metal framework restorations was tested clinically and radiologically, resulting in significant statistical difference ( p = 0.04) between different mixing techniques. The mechanical mixing produced more accurate restorations (metal framework misfit only in 14.9% of patients vs. hand mixing 31.1%). Regarding the impression techniques, the two-stage impression technique was found to be significantly more accurate ( p = 0.04), resulting in 14.6% ill-fitted metal frameworks vs. 31.8%, in the one-stage technique. It can be concluded that mechanical mixing yields more accurate impressions leading to more accurate restorations, especially when combined with two-stage impression technique.
    Schlagwörter vinyl poly siloxane ; mixing techniques ; impression techniques ; marginal fit accuracy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 621
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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