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  1. AU="Guzmán, Luis"
  2. AU="Alipour, Elnaz"
  3. AU="Queiroz, Dayanna Joyce Marques"
  4. AU="Ramamurthy, Santosh"
  5. AU="Xueying Huang"
  6. AU="Cromwell, Howard C"
  7. AU="Spence, John C H"
  8. AU="Chapinal, Libertad"
  9. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
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  1. Article ; Online: Editorial: New laser technology in PAD: Is it ready for prime time?

    Guzman, Luis A

    Cardiovascular revascularization medicine : including molecular interventions

    2023  Volume 57, Page(s) 32–33

    MeSH term(s) Humans ; Lasers ; Technology
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2023.07.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5562: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pan-cancer analysis of non-oncogene addiction to DNA repair.

    Bermúdez-Guzmán, Luis

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 23264

    Abstract: Cancer cells usually depend on the aberrant function of one or few driver genes to initiate and promote their malignancy, an attribute known as oncogene addiction. However, cancer cells might become dependent on the normal cellular functions of certain ... ...

    Abstract Cancer cells usually depend on the aberrant function of one or few driver genes to initiate and promote their malignancy, an attribute known as oncogene addiction. However, cancer cells might become dependent on the normal cellular functions of certain genes that are not oncogenes but ensure cell survival (non-oncogene addiction). The downregulation or silencing of DNA repair genes and the consequent genetic and epigenetic instability is key to promote malignancy, but the activation of the DNA-damage response (DDR) has been shown to become a type of non-oncogene addiction that critically supports tumour survival. In the present study, a systematic evaluation of DNA repair addiction at the pan-cancer level was performed using data derived from The Cancer Dependency Map and The Cancer Genome Atlas (TCGA). From 241 DDR genes, 59 were identified as commonly essential in cancer cell lines. However, large differences were observed in terms of dependency scores in 423 cell lines and transcriptomic alterations across 18 cancer types. Among these 59 commonly essential genes, 14 genes were exclusively associated with better overall patient survival and 19 with worse overall survival. Notably, a specific molecular signature among the latter, characterized by DDR genes like UBE2T, RFC4, POLQ, BRIP1, and H2AFX showing the weakest dependency scores, but significant upregulation was strongly associated with worse survival. The present study supports the existence and importance of non-oncogenic addiction to DNA repair in cancer and may facilitate the identification of prognostic biomarkers and therapeutic opportunities.
    MeSH term(s) Biomarkers, Tumor/metabolism ; CRISPR-Cas Systems ; Cluster Analysis ; DNA Damage ; DNA Repair/genetics ; Gene Expression Regulation, Neoplastic ; Genome, Human ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogene Addiction/genetics ; Oncogenes ; RNA, Small Interfering/metabolism ; Transcriptome
    Chemical Substances Biomarkers, Tumor ; RNA, Small Interfering
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-02773-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chronic Total Occlusion Revascularization and Quality-of-Life Improvement Across All Levels of Left Ventricular Function: Many Questions Still Unanswered.

    Guzman, Luis A

    JACC. Cardiovascular interventions

    2018  Volume 11, Issue 22, Page(s) 2284–2286

    MeSH term(s) Coronary Occlusion ; Health Status ; Humans ; Quality of Life ; Registries ; Treatment Outcome ; Ventricular Function, Left
    Language English
    Publishing date 2018-10-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2018.08.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6669: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: CyberKnife Stereotactic Radiosurgery for Uveal Melanoma: First Case Series in Central America.

    Benavides, Raquel / Mejías, Ricardo / Blanco, Alejandro / Bermudez-Guzman, Luis

    Ocular oncology and pathology

    2023  Volume 10, Issue 1, Page(s) 25–31

    Abstract: Introduction: Uveal melanoma is the most common primary intraocular malignancy in adults, affecting primarily the choroid of the eye. Plaque brachytherapy is the most common procedure for the treatment of small choroidal melanoma, especially in ... ...

    Abstract Introduction: Uveal melanoma is the most common primary intraocular malignancy in adults, affecting primarily the choroid of the eye. Plaque brachytherapy is the most common procedure for the treatment of small choroidal melanoma, especially in posteriorly located tumors. However, modern radiotherapy techniques, such as CyberKnife or Gamma knife stereotactic radiosurgery (SRS) and proton beam radiotherapy, have shown better results in tumor control and eye retention. Recent studies have indicated that SRS is a promising non-invasive, single-session treatment option, with most studies reporting the best outcomes when using ≥21-22 Gy. However, there is no consistent protocol for managing this pathology using CyberKnife, not only in terms of dose but also fractions.
    Case presentations: Here, we report the first case series of patients (
    Conclusions: Our findings suggest that future studies should evaluate the use of different prophylactic therapies to prevent the development of side effects. The clinical management of toxicities presented in our report can serve as a reference in the clinical practice of other centers. Our report supports the growing body of evidence showing that CyberKnife radiosurgery is a safe and effective therapeutic option for the treatment of UM.
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000534207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.

    Márquez-Hinojosa, Silvana / Noriega-Hoces, Luis / Guzmán, Luis

    JBRA assisted reproduction

    2022  Volume 26, Issue 3, Page(s) 432–443

    Abstract: Conventional embryo assessment is performed by removing embryos from incubators at least once a day. However, it is static and limited to specific time points, reducing the amount of information that could potentially be obtained. Fortunately, the time- ... ...

    Abstract Conventional embryo assessment is performed by removing embryos from incubators at least once a day. However, it is static and limited to specific time points, reducing the amount of information that could potentially be obtained. Fortunately, the time-lapse system is a powerful technology that enables to observe embryo development progression by image acquisition at recurrent time intervals, without interfering in the culture conditions. There are numerous studies that used time-lapse incubators, focusing on embryo kinetics, patient characteristics and clinical outcomes. This review aims to find agreements in the literature concerning embryo kinetics and patient characteristics: age, body mass index, smoking habit, polycystic ovary syndrome and endometriosis; as well as culture conditions that involved culture media and oxygen concentration. Furthermore, they showed differences according to ploidy status, direct/reverse cleavage, gender and the potential association between embryo collapse and clinical outcomes.
    MeSH term(s) Blastocyst ; Culture Media ; Embryo Culture Techniques ; Embryonic Development ; Female ; Humans ; Time-Lapse Imaging/methods
    Chemical Substances Culture Media
    Language English
    Publishing date 2022-08-04
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2856226-4
    ISSN 1518-0557 ; 1517-5693
    ISSN (online) 1518-0557
    ISSN 1517-5693
    DOI 10.5935/1518-0557.20210107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: CyberKnife Stereotactic Radiosurgery for an Unusual Case of Large Brain Metastases From Ewing's Sarcoma in a Pediatric Patient.

    Mejías, Ricardo / Bermúdez-Guzmán, Luis / Blanco, Alejandro

    Advances in radiation oncology

    2022  Volume 7, Issue 4, Page(s) 100979

    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Case Reports
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2022.100979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Optimized method for differential gene expression analysis in non-model species: Case of

    Aurelio, Aragón-Magadán Marco / Fabián, Calvillo-Aguilar Francisco / Carlos Iván, Cruz-Cárdenas / Felipe, Guzmán Luis

    MethodsX

    2023  Volume 11, Page(s) 102449

    Abstract: The following protocol introduces a targeted methodological approach of differential gene expression analysis, which is particularly beneficial in the context of non-model species. While we acknowledge that biological complexity often involves the ... ...

    Abstract The following protocol introduces a targeted methodological approach of differential gene expression analysis, which is particularly beneficial in the context of non-model species. While we acknowledge that biological complexity often involves the interplay of multiple genes in any given biological response our method provides a strategy to streamline this complexity, enabling researchers to focus on a more manageable subset of genes of interest. In this context, red cedar transcriptome (
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2023.102449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Gynecologic Imaging and Reporting Data System for classifying adnexal masses.

    Alcázar, Juan L / Rodriguez-Guzman, Luis / Vara, Julio / Amor, Fernando / Diaz, Linder / Vaccaro, Humberto

    Minerva obstetrics and gynecology

    2023  Volume 75, Issue 1, Page(s) 69–79

    Abstract: Introduction: To perform a systematic review and meta-analysis of the diagnostic performance of the so-called Gynecologic Imaging and Report Data System (GI-RADS) for classifying adnexal masses.: Evidence acquisition: A search for studies reporting ... ...

    Abstract Introduction: To perform a systematic review and meta-analysis of the diagnostic performance of the so-called Gynecologic Imaging and Report Data System (GI-RADS) for classifying adnexal masses.
    Evidence acquisition: A search for studies reporting about the use of GI-RADS system for classifying adnexal masses from January 2009 to December 2021 was performed in Medline (Pubmed), Google Scholar, Scopus, Cochrane, and Web of Science databases. Pooled sensitivity, specificity, positive and negative likelihood ratios and diagnostic odd ratio (DOR) were calculated. Studies' quality was evaluated using QUADAS-2.
    Evidence synthesis: We identified 510 citations. Ultimately, 26 studies comprising 7350 masses were included. Mean prevalence of ovarian malignancy was 26%. The risk of bias was high in eight studies for domain "patient selection" and low for "index test," "reference test" domains for all studies. Overall, pooled estimated sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio and DOR of GI-RADS system for classifying adnexal masses were 94% (95% confidence interval [CI]=91-96%), 90% (95% CI=87-92%), 9.1 (95% CI=7.0-11.9), and 0.07 (95% CI=0.05-0.11), and 132 (95% CI=78-221), respectively. Heterogeneity was high for both sensitivity and specificity. Meta-regression showed that multiple observers and study's design explained this heterogeneity among studies.
    Conclusions: GI-RADS system has a good diagnostic performance for classifying adnexal masses.
    MeSH term(s) Female ; Humans ; Adnexal Diseases/diagnostic imaging ; Adnexal Diseases/pathology ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/epidemiology ; Sensitivity and Specificity ; Diagnostic Imaging
    Language English
    Publishing date 2023-02-15
    Publishing country Italy
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 3062815-5
    ISSN 2724-6450
    ISSN (online) 2724-6450
    DOI 10.23736/S2724-606X.22.05122-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.245: Show issues Location:
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  9. Article: DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria.

    Bermúdez-Guzmán, Luis / Leal, Alejandro

    Translational neurodegeneration

    2019  Volume 8, Page(s) 14

    Abstract: Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3'-phosphatase (PNKP) is an enzyme that is actively involved in DNA repair in both single and ...

    Abstract Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3'-phosphatase (PNKP) is an enzyme that is actively involved in DNA repair in both single and double strand break repair systems. Mutations in this protein or others in the same pathway are responsible for a complex group of diseases with a broad clinical spectrum. Besides, mitochondrial dysfunction also has been consolidated as a hallmark of brain degeneration. Here we provide evidence that supports a shared role between mitochondrial dysfunction and DNA repair defects in the pathogenesis of the nervous system. As models, we analyze PNKP-related disorders, focusing on Charcot-Marie-Tooth disease and ataxia. A better understanding of the molecular dynamics of this relationship could provide improved diagnosis and treatment for neurological diseases.
    Language English
    Publishing date 2019-05-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2653701-1
    ISSN 2047-9158
    ISSN 2047-9158
    DOI 10.1186/s40035-019-0156-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Controlled Release of Abscisic Acid (ABA) Utilizing Alginate-Chitosan Gel Blends: A Synergistic Approach for an Enhanced Small-Molecule Delivery Controller.

    Valdes, Oscar / Bustos, Daniel / Guzmán, Luis / Muñoz-Vera, Marcelo / Urra, Gabriela / Castro, Ricardo I / Morales-Quintana, Luis

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 3

    Abstract: The integration of abscisic acid (ABA) into a chitosan-alginate gel blend unveils crucial insights into the formation and stability of these two substances. ABA, a key phytohormone in plant growth and stress responses, is strategically targeted for ... ...

    Abstract The integration of abscisic acid (ABA) into a chitosan-alginate gel blend unveils crucial insights into the formation and stability of these two substances. ABA, a key phytohormone in plant growth and stress responses, is strategically targeted for controlled release within these complexes. This study investigates the design and characterization of this novel controlled-release system, showcasing the potential of alginate-chitosan gel blends in ABA delivery. Computational methods, including molecular dynamics simulations, are employed to analyze the structural effects of microencapsulation, offering valuable insights into complex behavior under varying conditions. This paper focuses on the controlled release of ABA from these complexes, highlighting its strategic importance in drug delivery systems and beyond. This controlled release enables targeted and regulated ABA delivery, with far-reaching implications for pharmaceuticals, agriculture, and plant stress response studies. While acknowledging context dependency, the paper suggests that the liberation or controlled release of ABA holds promise in applications, urging further research and experimentation to validate its utility across diverse fields. Overall, this work significantly contributes to understanding the characteristics and potential applications of chitosan-alginate complexes, marking a noteworthy advancement in the field of controlled-release systems.
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10030185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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