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  1. Article ; Online: Rapidly Growing Solitary Osteochondroma in the Adult Finger A Case Report.

    Niemeier, Julia K / Guzzetta, Melissa B / Paksima, Nader

    Bulletin of the Hospital for Joint Disease (2013)

    2022  Volume 80, Issue 2, Page(s) 171–174

    Abstract: Osteochondromas are common benign bone tumors that are most commonly found in children and adolescents. They are usually slow-growing and located at the metaphysis of the long bones. When present in adults in atypical locations or with concerning ... ...

    Abstract Osteochondromas are common benign bone tumors that are most commonly found in children and adolescents. They are usually slow-growing and located at the metaphysis of the long bones. When present in adults in atypical locations or with concerning features, such as thickened cartilage cap and rapid growth, osteochondromas warrant imaging to assess the risk of malignant transformation into chondrosar- coma and may require surgical excision. Here, we describe the unusual case of an adult male with a rapidly growing osteochondroma of the proximal phalanx that subsequently underwent surgical excision.
    MeSH term(s) Adolescent ; Adult ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Bone Neoplasms/surgery ; Child ; Diagnostic Imaging ; Fingers ; Humans ; Male ; Osteochondroma/diagnostic imaging ; Osteochondroma/pathology ; Osteochondroma/surgery
    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390411-8
    ISSN 2328-5273 ; 1936-9727 ; 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    ISSN (online) 2328-5273 ; 1936-9727
    ISSN 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigating the spectrum of dermatologic manifestations in COVID-19 infection in severely ill patients: A series of four cases.

    Occidental, Michael / Flaifel, Abdallah / Lin, Lawrence H / Guzzetta, Melissa / Thomas, Kristen / Jour, George

    Journal of cutaneous pathology

    2020  Volume 48, Issue 1, Page(s) 110–115

    Abstract: COVID-19, an infectious disease caused by the novel coronavirus, was initially identified in Wuhan, China, in December 2019. By March 2020, it was declared a pandemic by the World Health Organization. Although most findings have been reported in the ... ...

    Abstract COVID-19, an infectious disease caused by the novel coronavirus, was initially identified in Wuhan, China, in December 2019. By March 2020, it was declared a pandemic by the World Health Organization. Although most findings have been reported in the lungs, primarily due to catastrophic respiratory decline, other organs, including the skin, are affected. Recent reports have been published describing the clinical spectrum of COVID-19-related lesions. In addition, recent case series have described a subset of these lesions having underlying thrombotic microangiopathy with increased complement activation characterized by increased C4d deposition within the blood vessel walls. Herein, we describe a series of COVID-19-related cutaneous manifestations found at autopsy examination and their underlying histopathologic findings. Although the clinical manifestations seen in these lesions vary widely, the underlying etiology of thrombotic microangiopathy remains consistent and reproducible.
    MeSH term(s) COVID-19/complications ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Skin Diseases, Viral/pathology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.13867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1043: Show issues Location:
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  3. Article ; Online: Clostridium Sordellii as an Uncommon Cause of Fatal Toxic Shock Syndrome in a Postpartum 33-Year-Old Asian Woman, and the Need for Antepartum Screening for This Clostridia Species in the General Female Population.

    Guzzetta, Melissa / Williamson, Alex / Duong, Scott

    Laboratory medicine

    2016  Volume 47, Issue 3, Page(s) 251–254

    Abstract: Clostridium sordellii (C. sordellii) is an anaerobic gram-positive rod most commonly found in the soil and sewage but also as part of the normal flora of the gastrointestinal tract and vagina of a small percentage of healthy individuals. C. sordellii ... ...

    Abstract Clostridium sordellii (C. sordellii) is an anaerobic gram-positive rod most commonly found in the soil and sewage but also as part of the normal flora of the gastrointestinal tract and vagina of a small percentage of healthy individuals. C. sordellii infection is considered to result from childbirth, abortion, and/or gynecological procedures. Although many strains of C. sordellii are nonpathogenic, virulent toxin-producing strains exist. Infection with this organism typically manifests as a patient experiencing septic shock rapidly followed by end-organ failure. Identification of C. sordelli has been successful by traditional culture, mass spectrometry methods, and via molecular methods. Herein, we present a fatal case of C. sordellii infection of a postpartum 33-year-old Asian woman. The organism was isolated by culture and identified using matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) technology. With the advent of rapid detection methods, antepartum screening for the fatal Clostridium species should be implemented in the general female population.
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmw025
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    Zs.B 1013: Show issues Location:
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  4. Article ; Online: Primary CNS T-cell lymphoma of the spinal cord: case report and literature review.

    Guzzetta, Melissa / Drexler, Steven / Buonocore, Brian / Donovan, Virginia

    Laboratory medicine

    2015  Volume 46, Issue 2, Page(s) 159–163

    Abstract: Primary central nervous system lymphoma (PCNSL) accounts for 1% of all lymphoma diagnoses and as many as 6% of all central nervous system (CNS) tumors. Most cases of PCNSL are of B-cell type; few are of T-cell lineage. PCNSL mainly occurs intracranially; ...

    Abstract Primary central nervous system lymphoma (PCNSL) accounts for 1% of all lymphoma diagnoses and as many as 6% of all central nervous system (CNS) tumors. Most cases of PCNSL are of B-cell type; few are of T-cell lineage. PCNSL mainly occurs intracranially; primary spinal-cord lymphoma only occurs rarely. Moreover, intramedullary presentation without intracranial lesions is virtually unknown. Herein, we present a case of primary T-cell CNS lymphoma limited to the intramedullary spinal cord in an 82-year-old white man, along with a review of the literature on this condition and similar conditions.
    MeSH term(s) Aged, 80 and over ; Antigens, CD/metabolism ; Humans ; Lymphoma, T-Cell/pathology ; Magnetic Resonance Imaging ; Male ; Spinal Cord Neoplasms/pathology
    Chemical Substances Antigens, CD
    Language English
    Publishing date 2015
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1309/LM85GPXDT8NJSDAB
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Testicular Changes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

    Flaifel, Abdallah / Guzzetta, Melissa / Occidental, Michael / Najari, Bobby B / Melamed, Jonathan / Thomas, Kristen M / Deng, Fang-Ming

    Archives of pathology & laboratory medicine

    2020  Volume 145, Issue 1, Page(s) 8–9

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/pathology ; Cadaver ; Epididymis/pathology ; Epididymis/virology ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Testis/pathology ; Testis/virology ; Young Adult
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Letter
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2020-0487-LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.36: Show issues Location:
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  6. Article: Investigating the spectrum of dermatologic manifestations in COVID-19 infection in severely ill patients: A series of four cases

    Occidental, Michael / Flaifel, Abdallah / Lin, Lawrence H / Guzzetta, Melissa / Thomas, Kristen / Jour, George

    J. cutan. pathol

    Abstract: COVID-19, an infectious disease caused by the novel coronavirus, was initially identified in Wuhan, China, in December 2019. By March 2020, it was declared a pandemic by the World Health Organization. Although most findings have been reported in the ... ...

    Abstract COVID-19, an infectious disease caused by the novel coronavirus, was initially identified in Wuhan, China, in December 2019. By March 2020, it was declared a pandemic by the World Health Organization. Although most findings have been reported in the lungs, primarily due to catastrophic respiratory decline, other organs, including the skin, are affected. Recent reports have been published describing the clinical spectrum of COVID-19-related lesions. In addition, recent case series have described a subset of these lesions having underlying thrombotic microangiopathy with increased complement activation characterized by increased C4d deposition within the blood vessel walls. Herein, we describe a series of COVID-19-related cutaneous manifestations found at autopsy examination and their underlying histopathologic findings. Although the clinical manifestations seen in these lesions vary widely, the underlying etiology of thrombotic microangiopathy remains consistent and reproducible.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #748638
    Database COVID19

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  7. Article ; Online: Investigating the spectrum of dermatologic manifestations in COVID ‐19 infection in severely ill patients

    Occidental, Michael / Flaifel, Abdallah / Lin, Lawrence H. / Guzzetta, Melissa / Thomas, Kristen / Jour, George

    Journal of Cutaneous Pathology ; ISSN 0303-6987 1600-0560

    A series of four cases

    2020  

    Keywords Pathology and Forensic Medicine ; Histology ; Dermatology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/cup.13867
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths.

    Leitner, Dominique F / McGuone, Declan / William, Christopher / Faustin, Arline / Askenazi, Manor / Snuderl, Matija / Guzzetta, Melissa / Jarrell, Heather S / Maloney, Katherine / Reichard, Ross / Smith, Colin / Weedn, Victor / Wisniewski, Thomas / Gould, Laura / Devinsky, Orrin

    Neuropathology and applied neurobiology

    2021  Volume 48, Issue 1, Page(s) e12746

    Abstract: Aims: Hippocampal findings are implicated in the pathogenesis of sudden unexplained death in childhood (SUDC), although some studies have identified similar findings in sudden explained death in childhood (SEDC) cases. We blindly reviewed hippocampal ... ...

    Abstract Aims: Hippocampal findings are implicated in the pathogenesis of sudden unexplained death in childhood (SUDC), although some studies have identified similar findings in sudden explained death in childhood (SEDC) cases. We blindly reviewed hippocampal histology in SUDC and SEDC controls.
    Methods: Hippocampal haematoxylin and eosin (H&E) slides (n = 67; 36 SUDC, 31 controls) from clinical and forensic collaborators were evaluated by nine blinded reviewers: three board-certified forensic pathologists, three neuropathologists and three dual-certified neuropathologists/forensic pathologists.
    Results: Among nine reviewers, about 50% of hippocampal sections were rated as abnormal (52.5% SUDC, 53.0% controls), with no difference by cause of death (COD) (p = 0.16) or febrile seizure history (p = 0.90). There was little agreement among nine reviewers on whether a slide was within normal range (Fleiss' κ = 0.014, p = 0.47). Within reviewer groups, there were no findings more frequent in SUDC compared with controls, with variability in pyramidal neuron and dentate gyrus findings. Across reviewer groups, there was concordance for bilamination and granule cell loss. Neither SUDC (51.2%) nor control (55.9%) slides were considered contributory to determining COD (p = 0.41).
    Conclusions: The lack of an association of hippocampal findings in SUDC and controls, as well as inconsistency of observations by multiple blinded reviewers, indicates discrepancy with previous studies and an inability to reliably identify hippocampal maldevelopment associated with sudden death (HMASD). These findings underscore a need for larger studies to standardise evaluation of hippocampal findings, identifying the range of normal variation and changes unrelated to SUDC or febrile seizures. Molecular studies may help identify novel immunohistological markers that inform on COD.
    MeSH term(s) Brain/pathology ; Child ; Death, Sudden/pathology ; Hippocampus/pathology ; Humans ; Neuropathology ; Seizures, Febrile/complications ; Seizures, Febrile/pathology
    Language English
    Publishing date 2021-07-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80371-6
    ISSN 1365-2990 ; 0305-1846
    ISSN (online) 1365-2990
    ISSN 0305-1846
    DOI 10.1111/nan.12746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1241: Show issues Location:
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  9. Article ; Online: COVID-19-Induced Neurovascular Injury: a Case Series with Emphasis on Pathophysiological Mechanisms.

    Gutierrez Amezcua, Jose Manuel / Jain, Rajan / Kleinman, George / Muh, Carrie R / Guzzetta, Melissa / Folkerth, Rebecca / Snuderl, Matija / Placantonakis, Dimitris G / Galetta, Steven L / Hochman, Sarah / Zagzag, David

    SN comprehensive clinical medicine

    2020  Volume 2, Issue 11, Page(s) 2109–2125

    Abstract: Coronavirus disease 2019 (COVID-19) is associated with a high inflammatory burden that can induce severe respiratory disease among other complications; vascular and neurological damage has emerged as a key threat to COVID-19 patients. Risk of severe ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is associated with a high inflammatory burden that can induce severe respiratory disease among other complications; vascular and neurological damage has emerged as a key threat to COVID-19 patients. Risk of severe infection and mortality increases with age, male sex, and comorbidities including cardiovascular disease, hypertension, obesity, diabetes, and chronic pulmonary disease. We review clinical and neuroradiological findings in five patients with COVID-19 who suffered severe neurological disease and illustrate the pathological findings in a 7-year-old boy with COVID-19-induced encephalopathy whose brain tissue sample showed angiocentric mixed mononuclear inflammatory infiltrate. We summarize the structural and functional properties of the virus including the molecular processes that govern the binding to its membrane receptors and cellular entry. In addition, we review clinical and experimental evidence in patients and animal models that suggests coronaviruses enter into the central nervous system (CNS), either via the olfactory bulb or through hematogenous spread. We discuss suspected pathophysiological mechanisms including direct cellular infection and associated recruitment of immune cells and neurovirulence, at least in part, mediated by cytokine secretion. Moreover, contributing to the vascular and neurological injury, coagulopathic disorders play an important pathogenic role. We survey the molecular events that contribute to the thrombotic microangiopathy. We describe the neurological complications associated with COVID-19 with a focus on the potential mechanisms of neurovascular injury. Our thesis is that following infection, three main pathophysiological processes-inflammation, thrombosis, and vascular injury-are responsible for the neurological damage and diverse pathology seen in COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00598-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Testicular Changes Associated with SARS-CoV-2

    Flaifel, Abdallah / Guzzetta, Melissa / Occidental, Michael / Najari, Bobby B / Melamed, Jonathan / Thomas, Kristen M / Deng, Fang-Ming

    Arch. pathol. lab. med. (1976)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #782354
    Database COVID19

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