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Article ; Online: Exploring the Substrate Specificity of a Sugar Transporter with Biosensors and Cheminformatics.

Park, Jihyun / Abramowitz, Ryan G / Gwon, Sojeong / Cheung, Lily S

ACS synthetic biology

2023 Volume 12, Issue 2, Page(s) 565–571

Abstract: Sugars will eventually be exported transporters (SWEETs) are conserved sugar transporters that play crucial roles in plant physiology and biotechnology. The genomes of flowering plants typically encode about 20 SWEET paralogs that can be classified into ... ...

Abstract	Sugars will eventually be exported transporters (SWEETs) are conserved sugar transporters that play crucial roles in plant physiology and biotechnology. The genomes of flowering plants typically encode about 20 SWEET paralogs that can be classified into four clades. Clades I, II, and IV have been reported to favor hexoses, while clade III SWEETs prefer sucrose. However, the molecular features of substrates required for recognition by members of this family have not been investigated in detail. Here, we show that SweetTrac1, a previously reported biosensor constructed from the Clade I
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Biological Transport ; Cheminformatics ; Membrane Transport Proteins/metabolism ; Monosaccharide Transport Proteins/genetics ; Plant Proteins/metabolism ; Substrate Specificity ; Sucrose/metabolism ; Biosensing Techniques
Chemical Substances	Arabidopsis Proteins ; Membrane Transport Proteins ; Monosaccharide Transport Proteins ; Plant Proteins ; Sucrose (57-50-1) ; SWEET1 protein, Arabidopsis
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.2c00571
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Article ; Online: The Arabidopsis SWEET1 and SWEET2 uniporters recognize similar substrates while differing in subcellular localization.

Gwon, Sojeong / Park, Jihyun / Huque, Akm Mahmudul / Cheung, Lily S

The Journal of biological chemistry

2023 Volume 299, Issue 12, Page(s) 105389

Abstract: Sugars Will Eventually be Exported Transporters (SWEETs) are central for sugar allocation in plants. The SWEET family has approximately 20 homologs in most plant genomes, and despite extensive research on their structures and molecular functions, it is ... ...

Abstract	Sugars Will Eventually be Exported Transporters (SWEETs) are central for sugar allocation in plants. The SWEET family has approximately 20 homologs in most plant genomes, and despite extensive research on their structures and molecular functions, it is still unclear how diverse SWEETs recognize different substrates. Previous work using SweetTrac1, a biosensor constructed by the intramolecular fusion of a conformation-sensitive fluorescent protein in the plasma membrane transporter SWEET1 from Arabidopsis thaliana, identified common features in the transporter's substrates. Here, we report SweetTrac2, a new biosensor based on the Arabidopsis vacuole membrane transporter SWEET2, and use it to explore the substrate specificity of this second protein. Our results show that SWEET1 and SWEET2 recognize similar substrates but some with different affinities. Sequence comparison and mutagenesis analysis support the conclusion that the differences in affinity depend on nonspecific interactions involving previously uncharacterized residues in the substrate-binding pocket. Furthermore, SweetTrac2 can be an effective tool for monitoring sugar transport at vacuolar membranes that would be otherwise challenging to study.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Biological Transport ; Gene Expression Regulation, Plant ; Membrane Transport Proteins/metabolism ; Monosaccharide Transport Proteins/metabolism ; Plant Proteins/metabolism ; Sugars/metabolism
Chemical Substances	Arabidopsis Proteins ; Membrane Transport Proteins ; Monosaccharide Transport Proteins ; Plant Proteins ; Sugars ; SWEET1 protein, Arabidopsis ; SWEET2 protein, Arabidopsis
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.105389
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Article ; Online: Development and quantitative analysis of a biosensor based on the Arabidopsis SWEET1 sugar transporter.

Park, Jihyun / Chavez, Taylor M / Guistwhite, Jordan A / Gwon, Sojeong / Frommer, Wolf B / Cheung, Lily S

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 4

Abstract: SWEETs are transporters with homologs in Archeae, plants, some fungi, and animals. As the only transporters known to facilitate the cellular release of sugars in plants, SWEETs play critical roles in the allocation of sugars from photosynthetic leaves to ...

Abstract	SWEETs are transporters with homologs in Archeae, plants, some fungi, and animals. As the only transporters known to facilitate the cellular release of sugars in plants, SWEETs play critical roles in the allocation of sugars from photosynthetic leaves to storage tissues in seeds, fruits, and tubers. Here, we report the design and use of genetically encoded biosensors to measure the activity of SWEETs. We created a SweetTrac1 sensor by inserting a circularly permutated green fluorescent protein into the
MeSH term(s)	Arabidopsis/physiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Biological Transport ; Biosensing Techniques/methods ; Monosaccharide Transport Proteins/genetics ; Monosaccharide Transport Proteins/metabolism ; Sugars/metabolism
Chemical Substances	Arabidopsis Proteins ; Monosaccharide Transport Proteins ; SWEET1 protein, Arabidopsis ; Sugars
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2119183119
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Article: Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases.

Vo, Thuy-Trang T / Kong, Gyeyeong / Kim, Chaeyeong / Juang, Uijin / Gwon, Suhwan / Jung, Woohyeong / Nguyen, Huonggiang / Kim, Seon-Hwan / Park, Jongsun

Toxicological research

2023 Volume 39, Issue 3, Page(s) 341–353

Abstract: Scavenger Receptor Class F Member 2 ( ...

Abstract	Scavenger Receptor Class F Member 2 (
Language	English
Publishing date	2023-04-14
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2727978-9
ISSN	2234-2753 ; 1976-8257
ISSN (online)	2234-2753
ISSN	1976-8257
DOI	10.1007/s43188-023-00176-2
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Article ; Online: MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review).

Jung, Woohyeong / Juang, Uijin / Gwon, Suhwan / Nguyen, Hounggiang / Huang, Qingzhi / Lee, Soohyeon / Lee, Beomwoo / Kwon, So-Hee / Kim, Seon-Hwan / Park, Jongsun

Molecular medicine reports

2024 Volume 29, Issue 6

Abstract: Muscular atrophy, which results in loss of muscle mass and strength, is a significant concern for patients with various diseases. It is crucial to comprehend the molecular mechanisms underlying this condition to devise targeted treatments. MicroRNAs ( ... ...

Abstract	Muscular atrophy, which results in loss of muscle mass and strength, is a significant concern for patients with various diseases. It is crucial to comprehend the molecular mechanisms underlying this condition to devise targeted treatments. MicroRNAs (miRNAs) have emerged as key regulators of gene expression, serving vital roles in numerous cellular processes, including the maintenance of muscle stability. An intricate network of miRNAs finely regulates gene expression, influencing pathways related to muscle protein production, and muscle breakdown and regeneration. Dysregulation of specific miRNAs has been linked to the development of muscular atrophy, affecting important signaling pathways including the protein kinase B/mTOR and ubiquitin‑proteasome systems. The present review summarizes recent work on miRNA patterns associated with muscular atrophy under various physiological and pathological conditions, elucidating its intricate regulatory networks. In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle, Skeletal/metabolism ; Muscular Atrophy/genetics ; Muscular Atrophy/therapy ; Muscular Atrophy/metabolism ; Muscular Diseases ; Signal Transduction/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-04-12
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2024.13222
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Book ; Online: VizAbility

Gorniak, Joshua / Kim, Yoon / Gwon, Stephen / Wei, Donglai / Kim, Nam Wook

Multimodal Accessible Data Visualization with Keyboard Navigation and Conversational Interaction

2023

Abstract: Data visualization serves as a crucial tool for communicating important information in our society. Yet, as visualizations grow more complex, they become less accessible to individuals with visual impairments. Traditional accessibility approaches like ... ...

Abstract	Data visualization serves as a crucial tool for communicating important information in our society. Yet, as visualizations grow more complex, they become less accessible to individuals with visual impairments. Traditional accessibility approaches like alternative text and data tables often fall short of capturing the full potential of data visualization. To bridge this gap, we introduce VizAbility, a novel multimodal accessible system that combines keyboard navigation with conventional interaction, enabling individuals with visual impairments to actively engage with and explore data visualizations. VizAbility utilizes an LLM-based pipeline, seamlessly integrating data, chart structures, user locality, and web-based information to provide comprehensive answers. Our quantitative evaluation validates the LLM-based question-and-answer pipeline, and a user study involving six participants underscores the promising potential of VizAbility's multimodal approach. We discuss how current visualization tools can integrate VizAbility to enhance the accessibility of data visualizations online. Comment: 13 pages, 7 figures
Keywords	Computer Science - Human-Computer Interaction
Subject code	306
Publishing date	2023-10-14
Publishing country	us
Document type	Book ; Online
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Article ; Online: Correlation between the C-C Cross-Coupling Activity and C-to-Ni Charge Transfer Transition of High-Valent Ni Complexes.

Shin, Jeongcheol / Gwon, Suyeon / Kim, Samhwan / Lee, Jiseon / Park, Kiyoung

Journal of the American Chemical Society

2020 Volume 142, Issue 9, Page(s) 4173–4183

Abstract: High-valent Ni complexes have proven to be good platforms for diverse cross-coupling reactions that are otherwise difficult to be achieved with conventional low-valent catalysts. However, their reductive elimination (RE) activities are still ... ...

Abstract	High-valent Ni complexes have proven to be good platforms for diverse cross-coupling reactions that are otherwise difficult to be achieved with conventional low-valent catalysts. However, their reductive elimination (RE) activities are still significantly variable by up to 5 orders of magnitude, depending on the supporting ligand and oxidation state of the Ni center. To elucidate frontier molecular orbitals (FMOs) that determine the RE activity of the Ni center, the electronic structures of cycloneophyl (CH
Language	English
Publishing date	2020-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b10405
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Article: Combined Effects of Set Retarders and Polymer Powder on the Properties of Calcium Sulfoaluminate Blended Cement Systems.

Gwon, Seongwoo / Jang, Seung Yup / Shin, Myoungsu

Materials (Basel, Switzerland)

2018 Volume 11, Issue 5

Abstract: This study investigates the effects of set retarders on the properties of polymer-modified calcium sulfoaluminate (CSA) and Portland cement blend systems at early and long-term ages. The fast setting of the cement blend systems is typically adjusted by ... ...

Abstract	This study investigates the effects of set retarders on the properties of polymer-modified calcium sulfoaluminate (CSA) and Portland cement blend systems at early and long-term ages. The fast setting of the cement blend systems is typically adjusted by using retarders to ensure an adequate workability. However, how the addition of retarders influences the age-dependent characteristics of the cement blend systems was rarely investigated. This study particularly examines the effects of retarders on the microstructure and strength development of polymer-modified CSA and Portland cement blend pastes and mortars from 2 h to 90 days. The macro- and microstructural properties are characterized by compression testing, powder X-ray diffraction, mercury intrusion porosimetry, and scanning electron microscopy with energy dispersive spectroscopy. The test results reveal that the use of retarders delayed the strength development of the cement blend systems at the very early age by hindering the production of ettringite, which was cumulative to the delaying effect of polymer, but it increased the ultimate strength by creating denser and finer pore structures with the evolution of hydration products.
Language	English
Publishing date	2018-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma11050825
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Article ; Online: Factors influencing sexually transmitted infections among adolescents in South Korea.

Gwon, S H / Lee, C Y

International nursing review

2015 Volume 63, Issue 1, Page(s) 68–77

Abstract: Background: No data exist regarding the sexually transmitted infection (STI) rate in adolescents aged 12-15 in South Korea. Only a Korean few studies have attempted to investigate the factors influencing sexually transmitted infections among adolescents. ...

Abstract	Background: No data exist regarding the sexually transmitted infection (STI) rate in adolescents aged 12-15 in South Korea. Only a Korean few studies have attempted to investigate the factors influencing sexually transmitted infections among adolescents. Aim: The purpose of this study was to investigate the self-reported sexually transmitted infection contraction rate and analyse individual and family factors that influence this rate among middle school students aged 12-15 in South Korea. Methods: Using statistics from the 8th Korea Youth Risk Behavior Web-based Survey, secondary data analysis was conducted. The study sample consisted of 714 individuals who had reported initiating sexual intercourse. Results: The rate of self-reported sexually transmitted contraction was 13.5%. The following factors predicted STI contraction: second year of middle school, excellent academic achievement, habitual or purposeful drug use, first intercourse before middle school, intercourse after drinking alcohol, weekly allowance, and living without family predicted sexually transmitted infection contraction. Limitations: The parental data were collected by the self-reported surveys in a cross-sectional manner and questions of STI contraction and intercourse after drinking may have confused the subjects. Conclusion: We need to utilize these predictors in providing adolescents with sexual health interventions and establishing adolescent sexual health policies. Implications for nursing and health policies: Increased sex education and employment of a school nurse in each middle school are needed. High-risk students need to be monitored given the predictors of sexually transmitted infection contraction, and the school health personnel need to inform female students and their parents the importance of seeing a gynaecologist for regular check-ups.
MeSH term(s)	Adolescent ; Adolescent Behavior/psychology ; Adult ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Risk-Taking ; Safe Sex/psychology ; Sex Education/organization & administration ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/psychology
Language	English
Publishing date	2015-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	80342-x
ISSN	1466-7657 ; 0020-8132
ISSN (online)	1466-7657
ISSN	0020-8132
DOI	10.1111/inr.12206
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Article ; Online: South Korean Adolescents' Intention to Smoke.

Hyun Gwon, Seok / Yan, Guofen / Kulbok, Pamela A

American journal of health behavior

2017 Volume 41, Issue 2, Page(s) 163–170

Abstract: Objectives: The purpose of this study was to examine associations between intention to smoke, and 3 constructs of the Theory of Planed Behavior, including attitude, subjective norm, and perceived behavioral control related to smoking among adolescents ... ...

Abstract	Objectives: The purpose of this study was to examine associations between intention to smoke, and 3 constructs of the Theory of Planed Behavior, including attitude, subjective norm, and perceived behavioral control related to smoking among adolescents in South Korea. Methods: We used a cross-sectional correlational design. The survey was conducted on 13- to 15-year-old adolescents (N = 740) in Seoul, South Korea. Multilevel modeling was conducted to analyze the data. Results: After adjusting for socio-demographic and economic factors, attitude toward smoking, subjective norm about smoking, and perceived behavioral control about smoking were independent statistically significant predictors of in tention to smoke. When all 3 were considered together, attitude toward smoking and perceived behavioral control remained statistically significant, but subjective norm about smoking did not. The number of licensed tobacco retailers also predicted intention to smoke. Conclusions: Attitude, perceived behavioral control, and tobacco retailers around schools need to be considered when developing tobacco prevention and control programs and policies for adolescents.
Language	English
Publishing date	2017-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1312417-1
ISSN	1945-7359 ; 1087-3244 ; 0147-0353
ISSN (online)	1945-7359
ISSN	1087-3244 ; 0147-0353
DOI	10.5993/AJHB.41.2.7
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