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  1. Article ; Online: Role of Education in Antimicrobial Stewardship.

    Gyssens, Inge C

    The Medical clinics of North America

    2018  Volume 102, Issue 5, Page(s) 855–871

    Abstract: The ability to treat infectious diseases with antimicrobials is an essential component of medical management. Antimicrobial therapy is based on the characteristics of the patient, drug, microorganisms causing the infection, and colonizing flora. Prudent ... ...

    Abstract The ability to treat infectious diseases with antimicrobials is an essential component of medical management. Antimicrobial therapy is based on the characteristics of the patient, drug, microorganisms causing the infection, and colonizing flora. Prudent antibiotic use is the only option to delay the emergence of resistance. Training in infectious diseases and knowledge of the principles of responsible antibiotic prescribing and uses must be improved. To change practice, health care professionals should be educated at all levels of their training.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Antimicrobial Stewardship/organization & administration ; Communication ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Microbial/drug effects ; Education, Medical, Continuing/organization & administration ; Guideline Adherence ; Health Education/organization & administration ; Health Personnel/education ; Humans ; Infection Control/organization & administration ; Practice Guidelines as Topic
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2018-08-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2018.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Antimicrobial Stewardship in Low- and Middle-Income Countries.

    Gyssens, Inge C / Wertheim, Heiman F

    Frontiers in public health

    2020  Volume 8, Page(s) 617000

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Developing Countries ; Income
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-12-02
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.617000
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  3. Article: Virulence Factor Genes in Invasive

    D'Onofrio, Valentino / Cartuyvels, Reinoud / Messiaen, Peter E A / Barišić, Ivan / Gyssens, Inge C

    Microorganisms

    2023  Volume 11, Issue 7

    Abstract: Background: Escherichia coli: Methods: Patients presenting at the emergency department whose blood cultures were positive for : Results: In total, 103 : Conclusions: Microcins, toxins, and fimbriae were associated with disease severity. ... ...

    Abstract Background: Escherichia coli
    Methods: Patients presenting at the emergency department whose blood cultures were positive for
    Results: In total, 103
    Conclusions: Microcins, toxins, and fimbriae were associated with disease severity. Adhesins and iron uptake proteins seemed to be protective. Two genes were associated with worse clinical outcome. These findings contribute to a better understanding of host-pathogen interactions and could help identifying patients most at risk for a worse outcome.
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11071827
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  4. Book ; Thesis: Optimizing antimicrobial drug utilization

    Gyssens, Ingeborg Carla Jorina

    studies and interventions in a university hospital

    1996  

    Author's details door Ingeborg Carla Jorina Gyssens
    Language English
    Size 187 S. : graph. Darst.
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Nijmegen, Kath. Univ., Diss., 1996
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT007189602
    ISBN 90-900-9492-X ; 978-90-900-9492-2
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: An observational study on lifestyle and environmental risk factors in patients with acute appendicitis

    Peeters, Toon / Houben, Bert / Cools, Peter / Thys, Yati / D'Onofrio, Valentino / Martens, Sandrina / Jaeger, Martin / Doppenberg-Oosting, Marije / Netea, Mihai G. / Gyssens, Inge C.

    Heliyon. 2023 Apr. 01, p.e15131-

    2023  

    Abstract: Acute appendicitis is a common abdominal emergency worldwide. This study aimed at characterizing environmental risk factors influencing the development and severity of acute appendicitis. Patients from a Belgian acute appendicitis cohort (n = 374) and ... ...

    Abstract Acute appendicitis is a common abdominal emergency worldwide. This study aimed at characterizing environmental risk factors influencing the development and severity of acute appendicitis. Patients from a Belgian acute appendicitis cohort (n = 374) and healthy controls from the 500 functional genomics (500FG) cohort (n = 513) were compared. Individuals with a history of appendectomy (n = 1067) and without a history of appendectomy (n = 8656) were available from the Nijmegen Biomedical Study (NBS). Questionnaires on demographics, lifestyle and environment were available. Binary logistic regression was used for prediction models. Fifteen risk factors for developing acute appendicitis were identified. Binary logistic regression showed that 7 were independent risk factors: family history of acute appendicitis, having grown up in a rural environment, having a lower education, probiotic use as well as antibiotic use increased the risk of developing appendicitis. Fruit and fiber-rich vegetable consumption decreased the risk. Findings on vegetable consumption, smoking and level of education were replicated in the NBS population. Independent risk factors for complicated appendicitis were being male, higher age, and a delay to diagnosis of more than 48 h. Environmental exposures influence the risk of developing appendicitis. Further research into these factors is needed.
    Keywords antibiotics ; demographic statistics ; educational status ; fruits ; genomics ; lifestyle ; males ; observational studies ; prediction ; probiotics ; regression analysis ; risk ; rural areas ; vegetable consumption ; Appendicitis ; Environment ; Demography
    Language English
    Dates of publication 2023-0401
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15131
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Antibiotic policy.

    Gyssens, Inge C

    International journal of antimicrobial agents

    2011  Volume 38 Suppl, Page(s) 11–20

    Abstract: There is a clear association between antibiotic use and resistance both on individual and population levels. In the European Union, countries with large antibiotic consumption have higher resistance rates. Antibiotic resistance leads to failed treatments, ...

    Abstract There is a clear association between antibiotic use and resistance both on individual and population levels. In the European Union, countries with large antibiotic consumption have higher resistance rates. Antibiotic resistance leads to failed treatments, prolonged hospitalisations, increased costs and deaths. With few new antibiotics in the Research & Development pipeline, prudent antibiotic use is the only option to delay the development of resistance. Antibiotic policy consists of prescribing strategies to optimise the indication, selection, dosing, route of administration, duration and timing of antibiotic therapy to maximise clinical cure or prevention of infection whilst limiting the unintended consequences of antibiotic use, including toxicity and selection of resistant microorganisms. A secondary goal is to reduce healthcare costs without adversely affecting the quality of care. The purpose of this paper is to provide the evidence base of prudent antibiotic policy. Special emphasis is placed on urinary tract infections. The value and support of antibiotic committees, guidelines, ID consultants and/or antimicrobial stewardship teams to prolong the efficacy of available antibiotics will be discussed.
    MeSH term(s) Anti-Bacterial Agents/economics ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Drug Prescriptions/economics ; Drug Prescriptions/standards ; Drug Resistance, Bacterial ; Drug Therapy/economics ; Drug Therapy/methods ; Drug Therapy/standards ; Drug Utilization/economics ; Drug Utilization/standards ; European Union ; Health Care Costs ; Health Policy ; Humans ; Organizational Policy ; Urinary Tract Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2011-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2011.09.002
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  7. Article ; Online: Impact of Human Genetic Variation on C-Reactive Protein Concentrations and Acute Appendicitis.

    Ricaño-Ponce, Isis / Peeters, Toon / Matzaraki, Vasiliki / Houben, Bert / Achten, Ruth / Cools, Peter / Netea, Mihai G / Gyssens, Inge C / Kumar, Vinod

    Frontiers in immunology

    2022  Volume 13, Page(s) 862742

    Abstract: Background: Acute appendicitis is one of the most common abdominal emergencies worldwide. Both environmental and genetic factors contribute to the disease. C-reactive protein (CRP) is an important biomarker in the diagnosis of acute appendicitis. CRP ... ...

    Abstract Background: Acute appendicitis is one of the most common abdominal emergencies worldwide. Both environmental and genetic factors contribute to the disease. C-reactive protein (CRP) is an important biomarker in the diagnosis of acute appendicitis. CRP concentrations are significantly affected by genetic variation. However, whether such genetic variation is causally related to appendicitis risk remains unclear. In this study, the causal relationship between single-nucleotide polymorphisms (SNPs) associated with circulating CRP concentrations and the risk and severity of acute appendicitis was investigated.
    Methods: CRP concentrations in serum of appendicitis patients (n = 325) were measured. Appendicitis was categorized as complicated/uncomplicated and gangrenous/non-gangrenous. Imputed SNP data (n = 287) were generated. A genome-wide association study (GWAS) on CRP concentrations and appendicitis severity was performed. Intersection and colocalization of the GWAS results were performed with appendicitis and CRP-associated loci from the Pan-UKBB cohort. A functional-genomics approach to prioritize genes was employed.
    Results: Thirteen percent of significant CRP quantitative trait loci (QTLs) that were previously identified in a large cohort of healthy individuals were replicated in our small patient cohort. Significant enrichment of CRP-QTLs in association with appendicitis was observed. Among these shared loci, the two top loci at chromosomes 1q41 and 8p23.1 were characterized. The top SNP at chromosome 1q41 is located within the promoter of H2.0 Like Homeobox (
    Conclusions: The results of this study prioritize
    MeSH term(s) Acute Disease ; Appendicitis/genetics ; C-Reactive Protein/metabolism ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.862742
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  8. Article ; Online: A case study on

    Monnier, Annelie A / Tacconelli, Evelina / Årdal, Christine / Cavaleri, Marco / Gyssens, Inge C

    JAC-antimicrobial resistance

    2020  Volume 2, Issue 2, Page(s) dlaa034

    Abstract: Objectives: This case study addresses: (i) antibiotic treatment options for : Methods: Evidence to address the aims was extracted from the following information sources: (i) EUCAST and CLSI recommendations, summaries of product characteristics (SPCs), ...

    Abstract Objectives: This case study addresses: (i) antibiotic treatment options for
    Methods: Evidence to address the aims was extracted from the following information sources: (i) EUCAST and CLSI recommendations, summaries of product characteristics (SPCs), antibiotic treatment guidelines and the textbook
    Results: Current monotherapy treatment options for SAB include only three drug classes (β-lactams, glycopeptides and lipopeptides), of which two also cover MRSA bacteraemia (glycopeptides and lipopeptides). The analysis of the antibiotic pipeline and ongoing clinical trials revealed that several new antibiotics with
    Conclusions: Awareness of the problem of a limited antibiotic arsenal, together with incentives (e.g. push incentives), is needed to steer the R&D landscape towards the development of novel and effective antibiotics for treating SAB. In the meantime, responsible antibiotic use guided by quality indicators should preserve the effectiveness of currently available antibiotics for treating SAB.
    Language English
    Publishing date 2020-06-19
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlaa034
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  9. Article: Risk Factors for Mortality, Intensive Care Unit Admission, and Bacteremia in Patients Suspected of Sepsis at the Emergency Department: A Prospective Cohort Study.

    D'Onofrio, Valentino / Meersman, Agnes / Vijgen, Sara / Cartuyvels, Reinoud / Messiaen, Peter / Gyssens, Inge C

    Open forum infectious diseases

    2020  Volume 8, Issue 1, Page(s) ofaa594

    Abstract: Background: There is a clear need for a better assessment of independent risk factors for in-hospital mortality, intensive care unit admission, and bacteremia in patients presenting with suspected sepsis at the emergency department.: Methods: A ... ...

    Abstract Background: There is a clear need for a better assessment of independent risk factors for in-hospital mortality, intensive care unit admission, and bacteremia in patients presenting with suspected sepsis at the emergency department.
    Methods: A prospective observational cohort study including 1690 patients was performed. Two multivariable logistic regression models were used to identify independent risk factors.
    Results: Sequential organ failure assessment (SOFA) score of ≥2 and serum lactate of ≥2mmol/L were associated with all outcomes. Other independent risk factors were individual SOFA variables and systemic inflammatory response syndrome variables but varied per outcome. Mean arterial pressure <70 mmHg negatively impacted all outcomes.
    Conclusions: These readily available measurements can help with early risk stratification and prediction of prognosis.
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa594
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  10. Article: The Clinical Impact of Rapid Molecular Microbiological Diagnostics for Pathogen and Resistance Gene Identification in Patients With Sepsis: A Systematic Review.

    D'Onofrio, Valentino / Salimans, Lene / Bedenić, Branka / Cartuyvels, Reinoud / Barišić, Ivan / Gyssens, Inge C

    Open forum infectious diseases

    2020  Volume 7, Issue 10, Page(s) ofaa352

    Abstract: Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene ... ...

    Abstract Fast microbiological diagnostics (MDx) are needed to ensure early targeted antimicrobial treatment in sepsis. This systematic review focuses on the impact on antimicrobial management and patient outcomes of MDx for pathogen and resistance gene identification compared with blood cultures. PubMed was searched for clinical studies using either whole blood directly or after short-term incubation. Twenty-five articles were retrieved describing the outcomes of 8 different MDx. Three interventional studies showed a significant increase in appropriateness of antimicrobial therapy and a nonsignificant change in time to appropriate therapy. Impact on mortality was conflicting. Length of stay was significantly lower in 2 studies. A significant decrease in antimicrobial cost was demonstrated in 6 studies. The limitations of this systematic review include the low number and observed heterogeneity of clinical studies. In conclusion, potential benefits of MDx regarding antimicrobial management and some patient outcomes were reported. More rigorous intervention studies are needed focusing on the direct benefits for patients.
    Language English
    Publishing date 2020-08-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa352
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