Article ; Online: Primary hyperammonaemia: Current diagnostic and therapeutic strategies.
Journal of mother and child
2020 Volume 24, Issue 2, Page(s) 32–38
Abstract: Primary hyperammonaemia is a term to describe an elevation of ammonia in blood or plasma due to a defect within the urea cycle, which is the pathway responsible for ammonia detoxification and arginine biosynthesis. Urea cycle disorders (UCDs) are rare ... ...
Abstract | Primary hyperammonaemia is a term to describe an elevation of ammonia in blood or plasma due to a defect within the urea cycle, which is the pathway responsible for ammonia detoxification and arginine biosynthesis. Urea cycle disorders (UCDs) are rare diseases caused by genetic defects affecting any of the six enzymes or two transporters that are directly involved in the urea cycle function.The clinical situation is variable and largely depends on the time of onset. Newborns who are often affected by hyper-ammonaemic encephalopathy carry a potential risk of severe brain damage, which may lead to death. Outside the neonatal period, symptoms are very unspecific but most often neurological (with wide variability), psychiatric and/or gastrointestinal. Early identification of patients is extremely important to start effective treatment modalities immediately. The acute management includes detoxification of ammonia, which often requires extracorporeal means such as haemodialysis, and the use of intravenous drugs that work as nitrogen scavengers. Long-term management of patients with UCDs consists of a low-protein diet, which needs to be balanced and supplemented to avoid deficiencies of essential amino acids, trace elements or vitamins and the use of nitrogen scavengers.The reader will find here a brief overview describing the most relevant aspects of the clinical management of UCDs in an attempt to raise awareness for this important group of rare diseases. |
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MeSH term(s) | Ammonia/blood ; Early Diagnosis ; Female ; Humans ; Hyperammonemia/complications ; Hyperammonemia/diagnosis ; Hyperammonemia/physiopathology ; Hyperammonemia/therapy ; Infant ; Infant, Newborn ; Male ; Renal Dialysis/methods ; Treatment Outcome ; Urea Cycle Disorders, Inborn/blood ; Urea Cycle Disorders, Inborn/diagnosis ; Urea Cycle Disorders, Inborn/therapy |
Chemical Substances | Ammonia (7664-41-7) |
Language | English |
Publishing date | 2020-10-02 |
Publishing country | Poland |
Document type | Journal Article ; Review |
ISSN | 2719-535X |
ISSN (online) | 2719-535X |
DOI | 10.34763/jmotherandchild.20202402si.2015.000006 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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