Article ; Online: Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
eLife, Vol
2018 Volume 7
Abstract: Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2-FA is saturated, monounsaturated or polyunsaturated. Our ... ...
Abstract | Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2-FA is saturated, monounsaturated or polyunsaturated. Our understanding of the impact of phospholipid unsaturation on membrane flexibility and fission is fragmentary. Here, we provide a comprehensive view of the effects of the FA profile of phospholipids on membrane vesiculation by dynamin and endophilin. Coupled to simulations, this analysis indicates that: (i) phospholipids with two polyunsaturated FAs make membranes prone to vesiculation but highly permeable; (ii) asymmetric sn1-saturated-sn2-polyunsaturated phospholipids provide a tradeoff between efficient membrane vesiculation and low membrane permeability; (iii) When incorporated into phospholipids, docosahexaenoic acid (DHA; omega-3) makes membranes more deformable than arachidonic acid (omega-6). These results suggest an explanation for the abundance of sn1-saturated-sn2-DHA phospholipids in synaptic membranes and for the importance of the omega-6/omega-3 ratio on neuronal functions. |
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Keywords | polyunsaturated phospholipid ; Dynamin ; membrane curvature ; membrane fission ; membrane permeability ; omega-3 omega-6 PUFAs ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5 |
Subject code | 612 ; 571 |
Language | English |
Publishing date | 2018-03-01T00:00:00Z |
Publisher | eLife Sciences Publications Ltd |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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