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  1. Article ; Online: The control of transcriptional memory by stable mitotic bookmarking

    Maëlle Bellec / Jérémy Dufourt / George Hunt / Hélène Lenden-Hasse / Antonio Trullo / Amal Zine El Aabidine / Marie Lamarque / Marissa M. Gaskill / Heloïse Faure-Gautron / Mattias Mannervik / Melissa M. Harrison / Jean-Christophe Andrau / Cyril Favard / Ovidiu Radulescu / Mounia Lagha

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Using quantitative imaging and monitoring transcription in living embryos, Bellec et al., provide evidence that the pioneer factor GAF acts as a stable mitotic bookmarker during early Drosophila development. ...

    Abstract Using quantitative imaging and monitoring transcription in living embryos, Bellec et al., provide evidence that the pioneer factor GAF acts as a stable mitotic bookmarker during early Drosophila development.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ

    Wei Yu / Chloé Lescale / Loelia Babin / Marie Bedora-Faure / Hélène Lenden-Hasse / Ludivine Baron / Caroline Demangel / José Yelamos / Erika Brunet / Ludovic Deriano

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Depending on the cell cycle stage, cells can repair their genome via different pathways. Here the authors reveal mechanistic insights into repair of double strand breaks induced during G1 in an error-prone manner by Pol θ-dependent and PARP1-independent ... ...

    Abstract Depending on the cell cycle stage, cells can repair their genome via different pathways. Here the authors reveal mechanistic insights into repair of double strand breaks induced during G1 in an error-prone manner by Pol θ-dependent and PARP1-independent alt NHEJ during the SG2/M phases of the cell cycle
    Keywords Science ; Q
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

    Chloé Lescale / Hélène Lenden Hasse / Andrew N. Blackford / Gabriel Balmus / Joy J. Bianchi / Wei Yu / Léa Bacoccina / Angélique Jarade / Christophe Clouin / Rohan Sivapalan / Bernardo Reina-San-Martin / Stephen P. Jackson / Ludovic Deriano

    Cell Reports, Vol 16, Iss 11, Pp 2967-

    2016  Volume 2979

    Abstract: Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V( ... ...

    Abstract Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its interaction with Ku. Importantly, we show that, unlike XLF, the role of PAXX during the repair of DNA breaks does not overlap with ATM and the RAG complex. Our findings illuminate the role of PAXX in V(D)J recombination and support a model in which PAXX and XLF function during NHEJ repair of DNA breaks, whereas XLF, the RAG complex, and the ATM-dependent DNA damage response promote end joining by stabilizing DNA ends.
    Keywords V(D)J recombination ; DNA repair ; NHEJ ; PAXX ; XLF ; XRCC4 ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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