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Article ; Online: Effects of parental job loss on psychotropic drug use in children: Long-term effects, timing, and cumulative exposure.

Högberg, Björn / Baranowska-Rataj, Anna

2024 Volume 60, Page(s) 100607

Abstract: Intra-family crossover effects triggered by job losses have received growing attention across scientific disciplines, but existing research has reached discrepant conclusions concerning if, and if so how, parental job losses affect child mental health. ... ...

Abstract	Intra-family crossover effects triggered by job losses have received growing attention across scientific disciplines, but existing research has reached discrepant conclusions concerning if, and if so how, parental job losses affect child mental health. Drawing on sociological models of stress and life course epidemiology, we ask if parental job losses have long-term effects on child mental health, and if these effects are conditional on the timing of, or the cumulative exposure to, job losses. We use intergenerationally linked Swedish register data combined with entropy balance and structural nested mean models for the analyses. The data allow us to track 400,000 children over 14 years and thereby test different life-course models of cross-over effects. We identify involuntary job losses using information on workplace closures, thus reducing the risk of confounding. Results show that paternal but not maternal job loss significantly increases the risk of psychotropic drug use among children, that the average effects are modest in size (less than 4% in relative terms), that they may persist for up to five years, and that they are driven by children aged 6-10 years. Moreover, cumulative exposure to multiple job losses are more harmful than zero or one job loss.
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2474504-2
ISSN	1879-6974 ; 1569-4909
ISSN (online)	1879-6974
ISSN	1569-4909
DOI	10.1016/j.alcr.2024.100607
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Article ; Online: Educational stressors and secular trends in school stress and mental health problems in adolescents.

Högberg, Björn

Social science & medicine (1982)

2020 Volume 270, Page(s) 113616

Abstract: Increasing mental health problems among adolescents have been have reported in several countries over the last decades. Yet, little is known regarding the societal changes underlying secular trends in adolescent mental health. The educational stressors ... ...

Abstract	Increasing mental health problems among adolescents have been have reported in several countries over the last decades. Yet, little is known regarding the societal changes underlying secular trends in adolescent mental health. The educational stressors hypothesis states that educational expansion and a shift to knowledge economies makes life chances of adolescents more dependent on their educational performance, thus generating more school stress and, in turn, mental health problems. The present study tests this hypothesis using multilevel analyses and panel data techniques to analyse data from the Health Behavior in School-aged Children (HBSC) survey, including more than 150,000 adolescents in 33 European countries over 12 years. Results show that economic change, as measured by changes in national gross domestic product, but not educational expansion, contributes to more school stress in adolescents. Both economic change and educational expansion makes school stress more consequential for mental health problems, such that the effect of stress on mental health problems becomes stronger as countries grow richer and more educated. I conclude that, consistent with the educational stressors hypothesis, economic change and educational expansion has likely contributed to increasing mental health problems in adolescents.
MeSH term(s)	Adolescent ; Adolescent Health ; Child ; Educational Status ; Europe/epidemiology ; Humans ; Mental Health ; Schools
Language	English
Publishing date	2020-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2020.113616
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Article ; Online: An error correction strategy for image reconstruction by DNA sequencing microscopy.

Kloosterman, Alexander / Baars, Igor / Högberg, Björn

Nature computational science

2024 Volume 4, Issue 2, Page(s) 119–127

Abstract: By pairing adjacent molecules in situ and then mapping these pairs, DNA microscopy could substantially reduce the workload in spatial omics methods by directly inferring geometry from sequencing data alone. However, experimental artifacts can lead to ... ...

Abstract	By pairing adjacent molecules in situ and then mapping these pairs, DNA microscopy could substantially reduce the workload in spatial omics methods by directly inferring geometry from sequencing data alone. However, experimental artifacts can lead to errors in the adjacency data, which distort the spatial reconstruction. Here we describe a method to correct two such errors: spurious crosslinks formed between any two nodes, and fused nodes that are formed out of multiple molecules. We build on the principle that spatially close molecules should be connected and show that these errors violate this principle, allowing for their detection and correction. Our method corrects errors in simulated data, even in the presence of up to 20% errors, and proves to be more efficient at removing errors from experimental data than a read count filter. Integrating this method in DNA microscopy will substantially improve the accuracy of spatial reconstructions with lower data loss.
MeSH term(s)	Microscopy ; Sequence Analysis, DNA/methods ; Artifacts ; Image Processing, Computer-Assisted/methods ; DNA/genetics
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ISSN	2662-8457
ISSN (online)	2662-8457
DOI	10.1038/s43588-023-00589-x
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Article ; Online: Remote control of nanoscale devices.

Högberg, Björn

Science (New York, N.Y.)

2018 Volume 359, Issue 6373, Page(s) 279

Language	English
Publishing date	2018--19
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aar6580
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Does fear-of-failure mediate the relationship between educational expectations and stress-related complaints among Swedish adolescents? A structural equation modelling approach.

Cashman, Matthew R / Strandh, Mattias / Högberg, Björn

European journal of public health

2023 Volume 34, Issue 1, Page(s) 101–106

Abstract: Background: This study investigated the possible mediating role of fear-of-failure between educational expectations and adolescent stress-related complaints with a specific focus on gender differences among Swedish adolescents, and related these ... ...

Abstract	Background: This study investigated the possible mediating role of fear-of-failure between educational expectations and adolescent stress-related complaints with a specific focus on gender differences among Swedish adolescents, and related these findings more broadly to school-related demands and stress-related complaints. Methods: A total of N = 5504 Swedish adolescents (Mage = 15 years, SD = 0.0 years, 50.2% girls) were drawn from the 2018 Swedish Programme for International Student Assessment study for our investigation. We used structural equation models to explore if fear-of-failure mediates the relationship between educational expectations and negative affect, with a specific focus on gender differences. Educational expectations were utilized in the measurement model. Fear-of-failure was constructed as a latent mediating variable. Negative affect was constructed as a latent variable and utilized as an outcome variable. We subsequently undertook bootstrapping tests of indirect effects and non-linear comparisons of indirect effects to assess the reliability of the results. Results: Fear-of-failure partially mediated the association between educational expectations and negative affect (39%). Our gender-specific structural equation model demonstrated that this relationship was more pronounced for girls, suggesting girls are more vulnerable to negative affect as a result of experiencing higher levels of fear of failing. Conclusions: The findings suggest that fear-of-failure partially explains the association between educational expectations and negative affect and that this association is more pronounced for girls. This study provides insights into better understanding adolescent stress-related complaints, and the differential role fear of failing has in regards to gender.
MeSH term(s)	Female ; Humans ; Adolescent ; Male ; Motivation ; Sweden/epidemiology ; Latent Class Analysis ; Reproducibility of Results ; Fear
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1129243-x
ISSN	1464-360X ; 1101-1262
ISSN (online)	1464-360X
ISSN	1101-1262
DOI	10.1093/eurpub/ckad200
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Zs.A 3499: Show issues

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Article ; Online: Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges.

Lolaico, Marco / Blokhuizen, Sebbe / Shen, Boxuan / Wang, Yang / Högberg, Björn

ACS nano

2023 Volume 17, Issue 7, Page(s) 6565–6574

Abstract: In recent years, interest in wireframe DNA origami has increased, with different designs, software, and applications emerging at a fast pace. It is now possible to design a wide variety of shapes by starting with a 2D or 3D mesh and using different ... ...

Abstract	In recent years, interest in wireframe DNA origami has increased, with different designs, software, and applications emerging at a fast pace. It is now possible to design a wide variety of shapes by starting with a 2D or 3D mesh and using different scaffold routing strategies. The design choices of the edges in wireframe structures can be important in some applications and have already been shown to influence the interactions between nanostructures and cells. In this work, we increase the alternatives for the design of A-trail routed wireframe DNA structures by using four-helix bundles (4HB). Our approach is based on the incorporation of additional helices to the edges of the wireframe structure to create a 4HB on a square lattice. We first developed the software for the design of these structures, followed by a demonstration of the successful design and folding of a library of structures, and then, finally, we investigated the higher mechanical rigidity of the reinforced structures. In addition, the routing of the scaffold allows us to easily incorporate these reinforced edges together with more flexible, single helix edges, thereby allowing the user to customize the desired stiffness of the structure. We demonstrated the successful folding of this type of hybrid structure and the different stiffnesses of the different parts of the nanostructures using a combination of computational and experimental techniques.
MeSH term(s)	Nanotechnology/methods ; Nucleic Acid Conformation ; Nanostructures/chemistry ; DNA/chemistry ; Computer-Aided Design
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c11982
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Article ; Online: Trends in adolescent psychosomatic complaints: a quantile regression analysis of Swedish HBSC data 1985-2017.

Högberg, Björn / Strandh, Mattias / Johansson, Klara / Petersen, Solveig

Scandinavian journal of public health

2022 Volume 51, Issue 4, Page(s) 619–627

MeSH term(s)	Child ; Humans ; Adolescent ; Sweden/epidemiology ; Cross-Sectional Studies ; Psychophysiologic Disorders/epidemiology ; Psychophysiologic Disorders/psychology ; Surveys and Questionnaires ; Regression Analysis
Language	English
Publishing date	2022-05-07
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1475054-5
ISSN	1651-1905 ; 1403-4948
ISSN (online)	1651-1905
ISSN	1403-4948
DOI	10.1177/14034948221094497
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Zs.A 884: Show issues

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Article ; Online: Solid Phase Synthesis of DNA Nanostructures in Heavy Liquid.

Smyrlaki, Ioanna / Shaw, Alan / Yang, Yunshi / Shen, Boxuan / Högberg, Björn

Small (Weinheim an der Bergstrasse, Germany)

2022 Volume 19, Issue 4, Page(s) e2204513

Abstract: Introduction of the solid phase method to synthesize biopolymers has revolutionized the field of biological research by enabling efficient production of peptides and oligonucleotides. One of the advantages of this method is the ease of removal of excess ... ...

Abstract	Introduction of the solid phase method to synthesize biopolymers has revolutionized the field of biological research by enabling efficient production of peptides and oligonucleotides. One of the advantages of this method is the ease of removal of excess production materials from the desired product, as it is immobilized on solid substrate. The DNA origami method utilizes the nature of nucleotide base-pairing to construct well-defined objects at the nanoscale, and has become a potent tool for manipulating matter in the fields of chemistry, physics, and biology. Here, the development of an approach to synthesize DNA nanostructures directly on magnetic beads, where the reaction is performed in heavy liquid to maintain the beads in suspension is reported. It is demonstrated that the method can achieve high folding yields of up to 90% for various DNA shapes, comparable to standard folding. At the same time, this establishes an easy, fast, and efficient way to further functionalize the DNA origami in one-pot, as well as providing a built-in purification method for easy removal of excess by-products such as non-integrated DNA strands and residual functionalization molecules.
MeSH term(s)	Nanotechnology/methods ; Solid-Phase Synthesis Techniques ; Nucleic Acid Conformation ; Nanostructures/chemistry ; DNA/chemistry
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-11-27
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202204513
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Article ; Online: Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides.

Wang, Yang / Baars, Igor / Fördös, Ferenc / Högberg, Björn

ACS nano

2021 Volume 15, Issue 6, Page(s) 9614–9626

Abstract: The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can induce specific arrangements of these receptors on cell surfaces would ...

Abstract	The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can induce specific arrangements of these receptors on cell surfaces would give us an opportunity to study these effects in detail. To achieve this, we introduce DNA origami nanostructures that precisely scaffold the patterning of TNF-related apoptosis-inducing ligand-mimicking peptides at nanoscale level. Stimulating human breast cancer cells with these patterns, we find that around 5 nm is the critical interligand distance of hexagonally patterned peptides to induce death receptor clustering and a resulting apoptosis. We thus offer a strategy to reverse the non-efficacy of current ligand- and antibody-based methods for TNF superfamily activation.
MeSH term(s)	Apoptosis ; Cluster Analysis ; Humans ; Peptides ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha
Chemical Substances	Peptides ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; TNF-Related Apoptosis-Inducing Ligand ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-05-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c10104
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Article ; Online: Gender and secular trends in adolescent mental health over 24 years - The role of school-related stress.

Högberg, Björn / Strandh, Mattias / Hagquist, Curt

Social science & medicine (1982)

2020 Volume 250, Page(s) 112890

Abstract: Increasing levels of psychosomatic symptoms, and other mental health problems, among adolescents, and especially among girls, have been reported across various countries. The "educational stressors hypothesis" states that this trend can be explained by ... ...

Abstract	Increasing levels of psychosomatic symptoms, and other mental health problems, among adolescents, and especially among girls, have been reported across various countries. The "educational stressors hypothesis" states that this trend can be explained by an increasing amount of stressors in the school environment. This study tests this hypothesis, using repeated cross-sectional data, between the years 1993-2017, from the Health Behaviours of School-aged Children (HBSC) survey. Regression and decomposition techniques are used to investigate the role of school stress for trends in psychosomatic symptoms, and for gender differences in symptoms. Results show that the effects of school stress on psychosomatic symptoms have become stronger over time, but that they can only account for a small share of the overall increase in symptoms since 1993. However, school stress has increased more among girls than among boys, and it explains about half of the growth of the gender gap in symptoms. Thus, school stress accounts for a substantial portion of the increase in symptoms for girls, but only a minor share of the increase for boys. In sum, we found weak evidence for the educational stressors hypothesis in regard to the overall trend in symptoms, but strong evidence for it in explaining the growing gender gap.
Language	English
Publishing date	2020-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2020.112890
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