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  1. Book ; Online ; E-Book: Zahnärztliche Chirurgie

    Jackowski, Jochen / Peters, Hajo / Hölzle, Frank

    2017  

    Author's details Jochen Jackowski, Hajo Peters, Frank Hölzle Hrsg
    Keywords Dentistry ; Oral surgery ; Maxillofacial surgery
    Subject code 617.6
    Language German
    Size 1 Online-Ressource (XXVII, 832 Seiten)
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019441131
    ISBN 978-3-642-54754-6 ; 9783642547539 ; 3-642-54754-0 ; 3642547532
    DOI 10.1007/978-3-642-54754-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Raising of Microvascular Flaps

    Wolff, K.-D. / Hölzle, Frank

    A Systematic Approach

    2005  

    Author's details by K.-D. Wolff, Frank Hölzle
    Keywords Head/Surgery ; Otorhinolaryngology ; Surgery
    Language English
    Publisher Springer-Verlag Berlin Heidelberg
    Publishing place Berlin, Heidelberg
    Document type Book ; Online
    HBZ-ID TT050387510
    ISBN 978-3-540-21849-4 ; 978-3-540-27005-8 ; 3-540-21849-1 ; 3-540-27005-1
    DOI 10.1007/b138423
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Eine anatomische und histologische Untersuchung an Gefäßstielen verschiedener freier Transplantate

    Hölzle, Frank

    1995  

    Author's details vorgelegt von Frank Hölzle
    Language German
    Size 175 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1995
    HBZ-ID HT007432587
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Full-thickness skin graft versus split-thickness skin graft for radial forearm free flap donor site closure: protocol for a systematic review and meta-analysis.

    Moors, Jasper J E / Xu, Zhibin / Xie, Kunpeng / Rashad, Ashkan / Egger, Jan / Röhrig, Rainer / Hölzle, Frank / Puladi, Behrus

    Systematic reviews

    2024  Volume 13, Issue 1, Page(s) 74

    Abstract: Background: The radial forearm free flap (RFFF) serves as a workhorse for a variety of reconstructions. Although there are a variety of surgical techniques for donor site closure after RFFF raising, the most common techniques are closure using a split- ... ...

    Abstract Background: The radial forearm free flap (RFFF) serves as a workhorse for a variety of reconstructions. Although there are a variety of surgical techniques for donor site closure after RFFF raising, the most common techniques are closure using a split-thickness skin graft (STSG) or a full-thickness skin graft (FTSG). The closure can result in wound complications and function and aesthetic compromise of the forearm and hand. The aim of the planned systematic review and meta-analysis is to compare the wound-related, function-related and aesthetics-related outcome associated with full-thickness skin grafts (FTSG) and split-thickness skin grafts (STSG) in radial forearm free flap (RFFF) donor site closure.
    Methods: A systematic review and meta-analysis will be conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be followed. Electronic databases and platforms (PubMed, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI)) and clinical trial registries (ClinicalTrials.gov, the German Clinical Trials Register, the ISRCTN registry, the International Clinical Trials Registry Platform) will be searched using predefined search terms until 15 January 2024. A rerun of the search will be carried out within 12 months before publication of the review. Eligible studies should report on the occurrence of donor site complications after raising an RFFF and closure of the defect. Included closure techniques are techniques that use full-thickness skin grafts and split-thickness skin grafts. Excluded techniques for closure are primary wound closure without the use of skin graft. Outcomes are considered wound-, functional-, and aesthetics-related. Studies that will be included are randomized controlled trials (RCTs) and prospective and retrospective comparative cohort studies. Case-control studies, studies without a control group, animal studies and cadaveric studies will be excluded. Screening will be performed in a blinded fashion by two reviewers per study. A third reviewer resolves discrepancies. The risk of bias in the original studies will be assessed using the ROBINS-I and RoB 2 tools. Data synthesis will be done using Review Manager (RevMan) 5.4.1. If appropriate, a meta-analysis will be conducted. Between-study variability will be assessed using the I
    Discussion: This study's findings may help us understand both closure techniques' complication rates and may have important implications for developing future guidelines for RFFF donor site management. If available data is limited and several questions remain unanswered, additional comparative studies will be needed.
    Systematic review registration: The protocol was developed in line with the PRISMA-P extension for protocols and was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 17 September 2023 (registration number CRD42023351903).
    MeSH term(s) Humans ; Skin Transplantation/methods ; Forearm/surgery ; Free Tissue Flaps ; Systematic Reviews as Topic ; Meta-Analysis as Topic
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-024-02471-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: New Tumor Budding Evaluation in Head and Neck Squamous Cell Carcinomas.

    Cacchi, Claudio / Fischer, Henrike J / Wermker, Kai / Rashad, Ashkan / Jonigk, Danny D / Hölzle, Frank / Klein, Maurice

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Background: Tumor budding (TB) is a histomorphological characteristic of the tumor invasion front and it has an impact on the tumor outcome prediction for head and neck squamous cell carcinoma (HNSCC) aetiopathology.: Patients and methods: The ... ...

    Abstract Background: Tumor budding (TB) is a histomorphological characteristic of the tumor invasion front and it has an impact on the tumor outcome prediction for head and neck squamous cell carcinoma (HNSCC) aetiopathology.
    Patients and methods: The average TB score (TB rel) of all tumor-positive marginal sections (n = 443) in the primary tumor was analyzed in the FFPE-fixed tumor slices of 66 patients with HNSCC, and they were compared with cryo-fixed sections.
    Results: TB rel correlates with tumor aggressiveness (i.e., lymph node metastasis quantity, lymph node ratio, extra capsular growth, Pn1, pV1, grading). The TB scores often vary between the different tumor margins of FFPE sections in the same patient, and in many cases, they differ depending on the fixation method.
    Conclusion: Our data show that a randomly selected marginal cut cannot reliably mirror the TB score, and thus, they cannot predict the prognostic outcome. However, TB rel could be a tool that compensates for differences in TB score analysis. TB score determination in cryo sections seems to be inaccurate compared with TB determination in FFPE.
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of bone contact area and intercondylar distance changes in orthognathic surgery - a comparison between BSSO and HSSO technique depending on mandibular displacement extent.

    Möhlhenrich, Stephan Christian / Kniha, Kristian / Peters, Florian / Heitzer, Marius / Szalma, Josef / Prescher, Andreas / Danesh, Gholamreza / Hölzle, Frank / Modabber, Ali

    Clinical oral investigations

    2024  Volume 28, Issue 3, Page(s) 182

    Abstract: Objectives: The present study aims to assess the impact of bilateral and high oblique sagittal split osteotomy (BSSO/HSSO), as well as displacement distances and directions on the expected and achievable bone contact area (BCA) and changes in the ... ...

    Abstract Objectives: The present study aims to assess the impact of bilateral and high oblique sagittal split osteotomy (BSSO/HSSO), as well as displacement distances and directions on the expected and achievable bone contact area (BCA) and changes in the intercondylar distance (ICD). The primary question addressed is whether mandibular splitting through BSSO results in a greater BCA and/or ICD when compared to splitting through HSSO.
    Materials and methods: Totally 80 mandibular displacements were performed on 20 fresh cadavers, for each subject, four splints were produces to facilitate mandibular advancement as well as setbacks of 4 and 8 mm. Pre- and postoperative CBCT scans were performed to plan the surgical procedures and to analyze the expected and achieved BCA and ICD.
    Results: Regarding the maximum mandibular displacement, the expected BCA for HSSO/BSSO were 352.58 ± 96.55mm
    Conclusions: Compared to the virtual planning, the predictability regarding BCA and ICD was limited. ICD showed smaller clinical changes, BCA decreased significantly in the BSSO group.
    Clinical relevance: BCA and ICD might have been less important in choosing the suitable split technique. in orthognathic surgery.
    MeSH term(s) Humans ; Orthognathic Surgery ; Osteotomy, Sagittal Split Ramus/methods ; Mandible/surgery ; Malocclusion ; Mandibular Advancement ; Sitosterols
    Chemical Substances beta-sitosterol oleate (3712-16-1) ; Sitosterols
    Language English
    Publishing date 2024-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-024-05584-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of the Electrolyte Heterogeneity of Tissues in Mandibular Bone-Infiltrating Head and Neck Cancer Using Laser-Induced Breakdown Spectroscopy.

    Winnand, Philipp / Boernsen, Klaus Olaf / Ooms, Mark / Heitzer, Marius / Vohl, Nils / Lammert, Matthias / Hölzle, Frank / Modabber, Ali

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal ... ...

    Abstract Laser-induced breakdown spectroscopy (LIBS) was recently introduced as a rapid bone analysis technique in bone-infiltrating head and neck cancers. Research efforts on laser surgery systems with controlled tissue feedback are currently limited to animal specimens and the use of nontumorous tissues. Accordingly, this study aimed to characterize the electrolyte composition of tissues in human mandibular bone-infiltrating head and neck cancer. Mandible cross-sections from 12 patients with bone-invasive head and neck cancers were natively investigated with LIBS. Representative LIBS spectra (n = 3049) of the inferior alveolar nerve, fibrosis, tumor stroma, and cell-rich tumor areas were acquired and histologically validated. Tissue-specific differences in the LIBS spectra were determined by receiver operating characteristics analysis and visualized by principal component analysis. The electrolyte emission values of calcium (Ca) and potassium (K) significantly (
    MeSH term(s) Animals ; Humans ; Spectrum Analysis/methods ; Lasers ; Head and Neck Neoplasms ; Electrolytes ; Mandible ; Fibrosis
    Chemical Substances Electrolytes
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Improving detection of oral lesions: Eye tracking insights from a randomized controlled trial comparing standardized to conventional approach.

    Puladi, Behrus / Coldewey, Beatrice / Volmerg, Julia S / Grunert, Kim / Berens, Jeff / Rashad, Ashkan / Hölzle, Frank / Röhrig, Rainer / Lipprandt, Myriam

    Head & neck

    2024  

    Abstract: Background: Early detection of oral cancer (OC) or its precursors is the most effective measure to improve outcome. The reasons for missing them on conventional oral examination (COE) or possible countermeasures are still unclear.: Methods: In this ... ...

    Abstract Background: Early detection of oral cancer (OC) or its precursors is the most effective measure to improve outcome. The reasons for missing them on conventional oral examination (COE) or possible countermeasures are still unclear.
    Methods: In this randomized controlled trial, we investigated the effects of standardized oral examination (SOE) compared to COE. 49 dentists, specialists, and dental students wearing an eye tracker had to detect 10 simulated oral lesions drawn into a volunteer's oral cavity.
    Results: SOE had a higher detection rate at 85.4% sensitivity compared to 78.8% in the control (p = 0.017) due to higher completeness (p < 0.001). Detection rate correlated with examination duration (p = 0.002).
    Conclusions: A standardized approach can improve systematics and thereby detection rates in oral examinations. It should take at least 5 min. Perceptual and cognitive errors and improper technique cause oral lesions to be missed. Its wide implementation could be an additional strategy to enhance early detection of OC.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A potential new biomarker in HNSCC: metastasis suppressor protein 1 (MTSS1).

    Klein, Maurice / Wermker, Kai / Rashad, Ashkan / Fischer, Henrike J / Jonigk, Danny D / Hölzle, Frank / Cacchi, Claudio

    Oral surgery, oral medicine, oral pathology and oral radiology

    2024  Volume 137, Issue 4, Page(s) 391–401

    Abstract: Objective: Metastasis suppressor protein 1 (MTSS1) is a prognostic tumour marker in different malignant epithelial tumour entities and previously mainly the MTSS1 expression was analysed. This study evaluated the best analysis method as a prognosis and ... ...

    Abstract Objective: Metastasis suppressor protein 1 (MTSS1) is a prognostic tumour marker in different malignant epithelial tumour entities and previously mainly the MTSS1 expression was analysed. This study evaluated the best analysis method as a prognosis and aggressiveness tumour marker in head and neck squamous cell carcinoma (HNSCC).
    Study design: MTSS1 expression, MTSS1 intensity, interpretation MTSS1 score and MTSS1 edging score were analysed in formalin-fixed paraffin-embedded tissue slices of 60 patients with proven HNSCC and correlated with clinical and pathological outcome parameters.
    Results: A lack of MTSS1 expression showed tumour aggressiveness, but surprisingly, mainly MTSS1 intensity was correlated with a worse patient outcome. There was a significant correlation between higher MTSS1 intensity and an increased risk for lymph node metastasis (P = .027) and a significant increased risk for extracapsular growth (P = .016). Furthermore, disease-specific survival was worse in cases with higher MTSS1 intensity (P = .001).
    Conclusion: MTSS1 intensity has a high scientific potential for further studies and could potentially be used as a prognostic marker in diagnostic and therapeutic decision-making.
    MeSH term(s) Humans ; Tumor Suppressor Proteins ; Squamous Cell Carcinoma of Head and Neck ; Microfilament Proteins/metabolism ; Biomarkers, Tumor/metabolism ; Prognosis ; Head and Neck Neoplasms ; Neoplasm Proteins
    Chemical Substances Tumor Suppressor Proteins ; Microfilament Proteins ; Biomarkers, Tumor ; MTSS1 protein, human ; Neoplasm Proteins
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.12.795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Development of a universal cutting guide for raising deep circumflex iliac artery flaps.

    Peters, Florian / Raith, Stefan / Bock, Anna / Kniha, Kristian / Möhlhenrich, Stephan Christian / Heitzer, Marius / Hölzle, Frank / Modabber, Ali

    International journal of computer assisted radiology and surgery

    2024  

    Abstract: Purpose: The deep circumflex iliac crest flap (DCIA) is used for the reconstruction of the jaw. For fitting of the transplant by computer-aided planning (CAD), a computerized tomography (CT) of the jaw and the pelvis is necessary. Ready-made cutting ... ...

    Abstract Purpose: The deep circumflex iliac crest flap (DCIA) is used for the reconstruction of the jaw. For fitting of the transplant by computer-aided planning (CAD), a computerized tomography (CT) of the jaw and the pelvis is necessary. Ready-made cutting guides save a pelvic CT and healthcare resources while maintaining the advantages of the CAD planning.
    Methods: A total of 2000 CTs of the pelvis were divided into groups of 500 by sex and age (≤ 45 and > 45 years). Three-dimensional (3D) pelvis models were aligned and averaged. Cutting guides were designed on the averaged pelvis for each group and an overall averaged pelvis. The cutting guides and 50 randomly selected iliac crests (10 from each group and 10 from the whole collective) were 3D printed. The appropriate cutting guide was mounted to the iliac crest and a cone beam CT was performed. The thickness of the space between the iliac crest and the cutting guide was evaluated.
    Results: Overall the mean thickness of the space was 2.137 mm and the mean volume of the space was 4513 mm
    Conclusion: Ready-made cutting guides for the DCIA flap fit to the iliac crest and make quick and accurate flap raising possible while radiation dose and resources can be saved. The cutting guides fit sufficient to the iliac crest and should keep the advantages of a standard CAD planning.
    Language English
    Publishing date 2024-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2365628-1
    ISSN 1861-6429 ; 1861-6410
    ISSN (online) 1861-6429
    ISSN 1861-6410
    DOI 10.1007/s11548-024-03144-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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