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  1. Article ; Online: Selenstatus in Thüringer Pferdehaltungen in Abhängigkeit des Einsatzes selenhaltiger Mineral- und Ergänzungsfuttermittel.

    Langner, Katharina / Hörügel, Uwe / Donat, Karsten / Vervuert, Ingrid

    Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere

    2020  Volume 48, Issue 6, Page(s) 398–405

    Abstract: Objective: Screening of commercial mineral feeds and mineral licks on the German market containing selenium (Se) in relation to the Se status in equines in Thuringia with different forms of Se supplementation.: Material and methods: Commercially ... ...

    Title translation Assessment of selenium status in relation to the supplementation of selenium enriched mineral licks and mineral feeds in equines in Thuringia.
    Abstract Objective: Screening of commercial mineral feeds and mineral licks on the German market containing selenium (Se) in relation to the Se status in equines in Thuringia with different forms of Se supplementation.
    Material and methods: Commercially available Se-containing minerals for horses identified by an online research were evaluated for their Se concentration, Se source, flavour carrier and recommended dosage according to the manufacturer's labelling. Furthermore, serum Se status in 8 equine farms was regularly monitored over the period of one year. The sampled horses either received no Se supplement or Se was supplemented by a mineral lick, a mineral feed or supplementary feed.
    Results: In 29.7 % of the mineral licks, the manufacturers provided a label with information on the maximal daily Se dosage, all of which exceeded the current recommendations of daily Se intake for a 600 kg horse under maintenance conditions. According to the manufacturers' labelled dosage, 67.5 % of the mineral feeds also exceeded the recommended daily Se intake taking the daily Se requirement of a 600 kg horse under maintenance conditions into consideration. The declarations of the feeds, especially in the case of mineral licks, were frequently not in conformity with the Regulation (EC) Nr. 767/2009 on commercial market introduction and use of feed. Concerning the horses' Se status, only horses receiving Se supplementation either via mineral lick with a Se concentration ≥ 20-50 mg/kg or a mineral or supplementary feed exhibited median serum Se concentrations within the reference range. In 2 of 10 horses with access to mineral licks with molasses containing Se concentrations ≥ 45 mg/kg, serum Se concentration exceeded the reference range at at least at one sampling time point.
    Conclusion and clinical relevance: Due to difficulties in their dosaging, the use of mineral licks should be only considered in extensively managed farms with limited access to the individual horse. The recommended Se concentration in mineral licks is recommended to lie in the range of 40-50 mg/kg. In order to attain improved control over Se intake, this trace element ought to be provided by individual feeding using either a mineral supplement or a supplementary feed.
    MeSH term(s) Animal Feed/standards ; Animal Husbandry ; Animals ; Dietary Supplements ; Germany ; Horses/physiology ; Nutritional Status/physiology ; Selenium/administration & dosage ; Selenium/blood
    Chemical Substances Selenium (H6241UJ22B)
    Language German
    Publishing date 2020-12-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2178387-1
    ISSN 2567-5834 ; 1434-1220
    ISSN (online) 2567-5834
    ISSN 1434-1220
    DOI 10.1055/a-1274-9045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Selenstatus in Thüringer Pferdehaltungen in Abhängigkeit des Einsatzes selenhaltiger Mineral- und Ergänzungsfuttermittel

    Langner, Katharina / Hörügel, Uwe / Donat, Karsten / Vervuert, Ingrid

    Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere

    2020  Volume 48, Issue 06, Page(s) 398–405

    Abstract: Gegenstand und Ziel: Überprüfung der auf dem deutschen Markt erhältlichen selenhaltigen Mineralleckmassen und Mineralfuttermittel in Bezug zum Selenstatus in thüringischen Pferdebetrieben bei unterschiedlichen Formen der Supplementierung von Selen (Se).! ...

    Abstract Gegenstand und Ziel: Überprüfung der auf dem deutschen Markt erhältlichen selenhaltigen Mineralleckmassen und Mineralfuttermittel in Bezug zum Selenstatus in thüringischen Pferdebetrieben bei unterschiedlichen Formen der Supplementierung von Selen (Se).
    Material und Methoden: Über eine Online-Recherche gefundene Se-haltige Supplemente für Pferde wurden mit den deklarierten Se-Gehalten, Se-Verbindungen und den Dosierungsempfehlungen der Hersteller erfasst. Das Weiteren wurde in 8 thüringischen Pferdebeständen der Serum-Se-Status in regelmäßigen Abständen über ein Jahr dokumentiert. Die beprobten Pferde erhielten entweder keine Se-Ergänzung oder eine Se-Supplementierung über eine Mineralleckmasse bzw. ein Se-haltiges Mineral- oder Ergänzungsfutter.
    Ergebnisse: Bei den Mineralleckmassen gaben 29,7 % der Hersteller Empfehlungen zur maximalen Se-Aufnahmemenge pro Tag, die ausnahmslos den täglichen Se-Bedarf eines 600 kg schweren Pferdes unter Erhaltungsbedingungen überschritten. Bei 67,5 % der untersuchten Mineralfutter lag die maximal empfohlene Dosierung für ein 600 kg schweres Pferd ebenfalls über dem Erhaltungsbedarf für Se. Die Deklaration der Futtermittel war vor allem bei den Mineralleckmassen vielfach nicht gesetzeskonform gemäß der Futtermittelverkehrsverordnung VO 767/2009. Bei der Überprüfung des Se-Status in Pferdehaltungen zeigten lediglich Tiere, bei denen Se über Mineralleckmassen mit Se-Gehalten ≥ 20–50 mg/kg oder durch Ergänzungs- oder Mineralfuttermitteln supplementiert wurde, mediane Serum-Se-Konzentrationen im Referenzbereich. Bei 2 von 10 Pferden, denen melassehaltige Mineralleckmassen mit einem Se-Gehalt ≥ 45 mg/kg angeboten wurden, lag zu einem Beprobungszeitpunkt die Serum-Se-Konzentration oberhalb des Referenzbereichs.
    Schlussfolgerungen und klinische Relevanz: Die Se-Ergänzung über eine Mineralleckmasse sollte aufgrund der schlechten Dosierbarkeit nur bei extensiven Haltungsformen mit fehlender Möglichkeit zur individuellen Fütterung erfolgen. Wenn eine Mineralleckmasse eingesetzt wird, ist eine Se-Konzentration von 40–50 mg/kg zu empfehlen. Aufgrund der besseren Steuerbarkeit der Se-Aufnahme sollte die Se-Supplementierung optimalerweise über ein individuell zugeteiltes Mineral- oder Ergänzungsfutter erfolgen.
    Keywords Supplementierung ; Ergänzungsfutter ; Spurenelemente ; Pferd ; Supplementation ; complementary feed ; trace elements ; horse
    Language German
    Publishing date 2020-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2178387-1
    ISSN 2567-5834 ; 1434-1220
    ISSN (online) 2567-5834
    ISSN 1434-1220
    DOI 10.1055/a-1274-9045
    Database Thieme publisher's database

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  3. Article ; Online: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020.

    Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W / Hörügel, Uwe / Groschup, Martin H / Lohmann, Katharina L

    Viruses

    2022  Volume 14, Issue 6

    Abstract: West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study's overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and ... ...

    Abstract West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study's overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (
    MeSH term(s) Animals ; Antibodies, Viral ; Encephalitis Viruses, Tick-Borne ; Enzyme-Linked Immunosorbent Assay ; Horse Diseases/epidemiology ; Horses ; Humans ; Immunoglobulin M ; Risk Factors ; Seroepidemiologic Studies ; West Nile Fever/epidemiology ; West Nile Fever/veterinary ; West Nile virus
    Chemical Substances Antibodies, Viral ; Immunoglobulin M
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14061191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020

    Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W. / Hörügel, Uwe / Groschup, Martin H. / Lohmann, Katharina L.

    Viruses. 2022 May 30, v. 14, no. 6

    2022  

    Abstract: West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and ... ...

    Abstract West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (p = 0.005). The risk factor analysis showed breed type (pony), housing in counties with previously registered infections, housing type (24 h turn-out), and presence of outdoor shelter as the main significant risk factors for seropositivity. In conclusion, we estimated the extent of WNV infection in the resident horse population in Eastern Germany and showed that seroprevalence was higher in counties with previously registered equine WNV infections.
    Keywords Tick-borne encephalitis virus ; Usutu virus ; West Nile virus ; blood serum ; factor analysis ; horses ; neutralization tests ; questionnaires ; regression analysis ; risk factors ; seroprevalence ; Germany
    Language English
    Dates of publication 2022-0530
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14061191
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Horses as sentinels for the circulation of flaviviruses in eastern-central Germany

    Gothe, Leonard M. R. / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L. / Sieg, Michael / Vahlenkamp, Thomas W. / Hörügel, Uwe / Pfeffer, Martin*

    2023  

    Keywords abstract_or_summary ; Text ; ddc:570 ; vector-borne zoonoses -- specific antibodies -- risk factors -- Usutu- ; West Nile- and Tick-Borne Encephalitis-Virus
    Language English
    Publishing date 2023-10-09
    Publisher MDPI AG
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Horses as Sentinels for the Circulation of Flaviviruses in Eastern-Central Germany.

    Gothe, Leonard M R / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L / Sieg, Michael / Vahlenkamp, Thomas W / Groschup, Martin H / Hörügel, Uwe / Pfeffer, Martin

    Viruses

    2023  Volume 15, Issue 5

    Abstract: Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern-central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV ... ...

    Abstract Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern-central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV and related flaviviruses transmission, such as tick-borne encephalitis virus (TBEV) and Usutu virus (USUV), and consequently help to estimate the risk of human infections. Hence, the aim of our study was to follow the seropositive ratio against these three viruses in horses in Saxony, Saxony Anhalt, and Brandenburg and to describe their geographic distribution for the year 2021. In early 2022, i.e., before the virus transmission season, sera from 1232 unvaccinated horses were tested using a competitive pan-flavivirus ELISA (cELISA). In order to estimate the true seropositive ratio of infection with WNV, TBEV, and USUV for 2021, positive and equivocal results were confirmed by a virus neutralization test (VNT). In addition, possible risk factors for seropositivity using questionnaires were analyzed using logistic regression based on questionnaires similar to our previous study from 2020. In total, 125 horse sera reacted positive in the cELISA. Based on the VNT, 40 sera showed neutralizing antibodies against WNV, 69 against TBEV, and 5 against USUV. Three sera showed antibodies against more than one virus, and eight were negative based on the VNT. The overall seropositive ratio was 3.3% (95% CI: 2.38-4.40) for WNV, 5.6% (95% CI: 4.44-7.04) for TBEV, and 0.4% (95% CI: 0.14-0.98) for USUV infections. While age and number of horses on the holding were factors predicting TBEV seropositivity, no risk factors were discovered for WNV seropositivity. We conclude that horses are useful sentinels to determine the flavivirus circulation in eastern-central Germany, as long as they are not vaccinated against WNV.
    MeSH term(s) Horses ; Animals ; Humans ; West Nile virus ; Seroepidemiologic Studies ; Horse Diseases/epidemiology ; Antibodies, Viral ; Flavivirus ; West Nile Fever/epidemiology ; West Nile Fever/veterinary ; Encephalitis Viruses, Tick-Borne ; Flavivirus Infections/epidemiology ; Flavivirus Infections/veterinary
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-04-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15051108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020

    Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W. / Hörügel, Uwe / Groschup, Martin H. / Lohmann, Katharina L.

    2022  

    Abstract: West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and ... ...

    Abstract West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study’s overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (p = 0.005). The risk factor analysis showed breed type (pony), housing in counties with previously registered infections, housing type (24 h turn-out), and presence of outdoor shelter as the main significant risk factors for seropositivity. In conclusion, we estimated the extent of WNV infection in the resident horse population in Eastern Germany and showed that seroprevalence was higher in counties with previously registered equine WNV infections.
    Keywords Text ; ddc:570 ; West Nile virus -- horses -- seroprevalence -- Germany -- epidemiology -- risk factors -- tick-borne encephalitis virus -- Usutu virus
    Subject code 630
    Language English
    Publishing date 2022-05-31
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Stark machen gegen Herpes

    Hörügel, Uwe

    pferde spiegel

    2006  Volume 9, Issue 04, Page(s) 195–196

    Language German
    Publishing date 2006-04-01
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 1868-0445 ; 1860-3203
    ISSN (online) 1868-0445
    ISSN 1860-3203
    DOI 10.1055/s-0029-1237244
    Database Thieme publisher's database

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  9. Article ; Online: Horses as Sentinels for the Circulation of Flaviviruses in Eastern–Central Germany

    Gothe, Leonard M. R. / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L. / Sieg, Michael / Vahlenkamp, Thomas W. / Groschup, Martin H. / Hörügel, Uwe / Pfeffer, Martin

    2023  

    Abstract: Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern–central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV ... ...

    Abstract Since 2018, autochthonous West Nile virus (WNV) infections have been regularly reported in eastern–central Germany. While clinically apparent infections in humans and horses are not frequent, seroprevalence studies in horses may allow the tracing of WNV and related flaviviruses transmission, such as tick-borne encephalitis virus (TBEV) and Usutu virus (USUV), and consequently help to estimate the risk of human infections. Hence, the aim of our study was to follow the seropositive ratio against these three viruses in horses in Saxony, Saxony Anhalt, and Brandenburg and to describe their geographic distribution for the year 2021. In early 2022, i.e., before the virus transmission season, sera from 1232 unvaccinated horses were tested using a competitive pan-flavivirus ELISA (cELISA). In order to estimate the true seropositive ratio of infection with WNV, TBEV, and USUV for 2021, positive and equivocal results were confirmed by a virus neutralization test (VNT). In addition, possible risk factors for seropositivity using questionnaires were analyzed using logistic regression based on questionnaires similar to our previous study from 2020. In total, 125 horse sera reacted positive in the cELISA. Based on the VNT, 40 sera showed neutralizing antibodies against WNV, 69 against TBEV, and 5 against USUV. Three sera showed antibodies against more than one virus, and eight were negative based on the VNT. The overall seropositive ratio was 3.3% (95% CI: 2.38–4.40) for WNV, 5.6% (95% CI: 4.44–7.04) for TBEV, and 0.4% (95% CI: 0.14–0.98) for USUV infections. While age and number of horses on the holding were factors predicting TBEV seropositivity, no risk factors were discovered for WNV seropositivity. We conclude that horses are useful sentinels to determine the flavivirus circulation in eastern–central Germany, as long as they are not vaccinated against WNV.
    Keywords Text ; ddc:570 ; flaviviruses -- West Nile virus -- horses -- seroprevalence -- Germany -- risk factors -- tick-borne encephalitis virus -- Usutu virus -- virus neutralization test -- vector-borne zoonoses
    Subject code 630
    Language English
    Publishing date 2023-04-30
    Publisher MDPI AG
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Thesis: Wechselbeziehungen zwischen Säure-Basen- und Elektrolyt-Haushalt bei Milchkühen im peripartalen Zeitraum mit Hinblick auf die hypokalzämische Gebärparese

    Hörügel, Uwe

    1998  

    Author's details eingereicht von Uwe Hörügel
    Language German
    Size 86, [13] S, graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Leipzig, 1998
    Database Former special subject collection: coastal and deep sea fishing

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