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  1. Article: Real-World Administration of Once-Daily MeltDose

    Willuweit, Katharina / Frey, Alexandra / Hörster, Anne / Saner, Fuat / Herzer, Kerstin

    Journal of clinical medicine

    2020  Volume 10, Issue 1

    Abstract: The calcineurin inhibitor tacrolimus is included in most immunosuppressive protocols after liver transplantation. This retrospective, observational 24-month study investigated the tolerability of once-daily ... ...

    Abstract The calcineurin inhibitor tacrolimus is included in most immunosuppressive protocols after liver transplantation. This retrospective, observational 24-month study investigated the tolerability of once-daily MeltDose
    Language English
    Publishing date 2020-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10010124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safe for Mother, Baby, and Graft? Pregnancy After Liver Transplant: A Single-Center Experience.

    Rashidi-Alavijeh, Jassin / Frey, Alexandra / Hörster, Anne / Nguyen, Buu-Phuc / Iannaccone, Antonella / Saner, Fuat / Lange, Christian M / Willuweit, Katharina

    Transplantation proceedings

    2022  Volume 54, Issue 3, Page(s) 744–748

    Abstract: Background: Although fertility is reduced in patients with liver cirrhosis, recovery of menstrual cycle is acquired after liver transplantation (LT) in most patients, and pregnancy in LT recipients is not unusual. The aim of this study was to evaluate ... ...

    Abstract Background: Although fertility is reduced in patients with liver cirrhosis, recovery of menstrual cycle is acquired after liver transplantation (LT) in most patients, and pregnancy in LT recipients is not unusual. The aim of this study was to evaluate the outcomes of pregnancies in LT recipients in our center.
    Methods: Data of 24 pregnancies in 14 LT recipients were collected and statistically analyzed. Demographic and clinical data were documented in each trimester of pregnancy and thereafter. The analysis was conducted in accordance with the 1975 Declaration of Helsinki and was approved by the ethics committee of the University Hospital Essen.
    Results: Median patient age was 21.5 years (range, 2-32 years) at LT and 31 years (range, 19-41 years) at conception. Median time between LT and conception was 126 months (range, 38-332 months), and median gestation time of completed pregnancies was 38 weeks (range, 29-40 weeks). Seven pregnancies terminated in abortions (29%). Of all deliveries, 6 resulted in preterm births (35%) with median gestation time of 34.5 weeks (range, 29-37 weeks). Gestational diabetes mellitus was the most common maternal complication, occurring in 4 patients (17%). One patient suffered from preeclampsia (4%). Pregnancy-induced hypertension or acute cellular rejection was not reported in our cohort. None of the children had serious complications.
    Conclusions: Our data show favorable outcome for pregnancy in LT recipients for mother and offspring. However, these patients are still at risk, particularly regarding high rates of preterm delivery, and preconception counseling and multidisciplinary monitoring are crucial to manage possible complications.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Graft Rejection ; Humans ; Infant ; Infant, Newborn ; Liver Transplantation/adverse effects ; Mothers ; Pregnancy ; Pregnancy Complications/etiology ; Pregnancy Outcome ; Premature Birth ; Young Adult
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Implications of anaemia and response to anaemia treatment on outcomes in patients with cirrhosis.

    Rashidi-Alavijeh, Jassin / Nuruzade, Nargiz / Frey, Alexandra / Huessler, Eva-Maria / Hörster, Anne / Zeller, Amos Cornelius / Schütte, Andreas / Schmidt, Hartmut / Willuweit, Katharina / Lange, Christian Markus

    JHEP reports : innovation in hepatology

    2023  Volume 5, Issue 4, Page(s) 100688

    Abstract: Background & aims: Anaemia is frequently observed in patients with cirrhosis and was identified as a predictor of adverse outcomes, such as increased mortality and occurrence of acute-on-chronic liver failure. To date, the possible effects of iron ... ...

    Abstract Background & aims: Anaemia is frequently observed in patients with cirrhosis and was identified as a predictor of adverse outcomes, such as increased mortality and occurrence of acute-on-chronic liver failure. To date, the possible effects of iron supplementation on these adverse outcomes are not well described. We therefore aimed to assess the role of iron supplementation in patients with cirrhosis and its capability to improve prognosis.
    Methods: Laboratory diagnostics were performed in consecutive outpatients with cirrhosis admitted between July 2018 and December 2019 to the University Hospital Essen. Associations with transplant-free survival were assessed in regression models.
    Results: A total of 317 outpatients with cirrhosis were included, of whom 61 received a liver transplant (n = 19) or died (n = 42). In multivariate Cox regression analysis, male sex (hazard ratio [HR] = 3.33, 95% CI [1.59, 6.99],
    Conclusions: An increase of haemoglobin levels is associated with improvement of transplant-free survival in patients with cirrhosis. Because the prediction of haemoglobin increase significantly depends on rifaximin and iron supplementation, application of these two medications can have an important impact on the outcome of these patients.
    Impact and implications: Anaemia is very common in patients with cirrhosis and is known to be a predictor of negative outcomes, but little is known about the effect of iron substitution in these individuals. In our cohort, increase of haemoglobin levels improved transplant-free survival of patients with cirrhosis. The increase of haemoglobin levels was mainly induced by iron supplementation and was even stronger in the case of concomitant use of iron and rifaximin.
    Clinical trial registration: UME-ID-10042.
    Language English
    Publishing date 2023-01-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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