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  1. Article ; Online: Effect of repeated prolonged exercise on liver fat content and visceral adipose tissue in well-trained older men.

    Poggi, Axel Illeris / Andreasen, Martin Winther / Sahl, Ronni Eg / Hansen, Mikkel Thunestvedt / Rømer, Tue / Frandsen, Jacob / Linden, Frederik Hvid / Høgh-Schmidt, Erik / Boesen, Mikael Ploug / Ostrowski, Sisse Rye / Larsen, Steen / Dela, Flemming / Helge, Jørn Wulff

    Scandinavian journal of medicine & science in sports

    2024  Volume 34, Issue 4, Page(s) e14612

    Abstract: Introduction: Liver fat (LF) and visceral adipose tissue (VAT) content decreases with training, however, this has mainly been investigated in sedentary obese or healthy participants. The aim of this study was to investigate the effects of repeated ... ...

    Abstract Introduction: Liver fat (LF) and visceral adipose tissue (VAT) content decreases with training, however, this has mainly been investigated in sedentary obese or healthy participants. The aim of this study was to investigate the effects of repeated prolonged exercise on LF and VAT content in well-trained older men and to compare baseline LF and VAT content to recreationally active older men.
    Method: A group of five well-trained older men were tested before and after cycling a total distance of 2558 km in 16 consecutive days. VAT content and body composition was measured using DXA before a bicycle ergometer test was performed to determine maximal fat oxidation (MFO), maximal oxygen consumption (
    Results: The well-trained older men had lower VAT (p = 0.02), and a tendency toward lower LF content (p = 0.06) compared with the control group. The intervention resulted in decreased LF content (p = 0.02), but VAT, fat mass, and lean mass remained unchanged.
    Conclusion: The study found that repeated prolonged exercise reduced LF content, but VAT and
    MeSH term(s) Male ; Humans ; Aged ; Intra-Abdominal Fat ; Exercise ; Obesity/metabolism ; Liver/diagnostic imaging ; Exercise Test ; Adipose Tissue/metabolism ; Oxygen Consumption
    Language English
    Publishing date 2024-01-31
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1077418-x
    ISSN 1600-0838 ; 0905-7188
    ISSN (online) 1600-0838
    ISSN 0905-7188
    DOI 10.1111/sms.14612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3247: Show issues Location:
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  2. Article ; Online: Change in abdominal obesity after colon cancer surgery - effects of left-sided and right-sided colonic resection.

    Kays Mohammed Ali, Younes / Dolin, Troels Gammeltoft / Damm Nybing, Janus / Lykke, Jakob / Hvid Linden, Frederik / Høgh-Schmidt, Erik / Sørensen, Thorkild I A / Christensen, Jesper Frank / Nielsen, Yousef J W / Stenfatt Larsen, Jim / Madsbad, Sten / Sidenius Johansen, Julia / Svane, Maria Saur / Lang Lehrskov, Louise

    International journal of obesity (2005)

    2024  Volume 48, Issue 4, Page(s) 533–541

    Abstract: Background: Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots.: Material and methods!# ...

    Abstract Background: Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots.
    Material and methods: Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately.
    Results: A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2-9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI: 2-6%, p < 0.001) increase in SAT and a 5% increase (95% CI: 2-7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI: 4-9%, p < 0.001) increase in SAT and a 4% (95% CI: 1-7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI: 2-10%, p < 0.01) after 3 years.
    Conclusion: After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT.
    MeSH term(s) Male ; Humans ; Female ; Obesity, Abdominal/complications ; Obesity, Abdominal/diagnostic imaging ; Obesity, Abdominal/surgery ; Obesity/complications ; Obesity/surgery ; Obesity/epidemiology ; Subcutaneous Fat ; Tomography, X-Ray Computed ; Colonic Neoplasms/surgery ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/metabolism
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-023-01445-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1325: Show issues Location:
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  3. Article ; Online: Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms.

    Richter, Michael M / Kemp, Ida M / Heebøll, Sara / Winther-Sørensen, Marie / Kjeldsen, Sasha A S / Jensen, Nicole J / Nybing, Janus D / Linden, Frederik H / Høgh-Schmidt, Erik / Boesen, Mikael P / Madsbad, Sten / Schiødt, Frank Vinholt / Nørgaard, Kirsten / Schmidt, Signe / Gluud, Lise Lotte / Haugaard, Steen B / Holst, Jens J / Nielsen, Søren / Rungby, Jørgen /
    Wewer Albrechtsen, Nicolai J

    Metabolism: clinical and experimental

    2024  , Page(s) 155915

    Abstract: Introduction: Glucagon receptor agonism is currently explored for the treatment of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The metabolic effects of glucagon receptor agonism may in part be mediated by increases in ... ...

    Abstract Introduction: Glucagon receptor agonism is currently explored for the treatment of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The metabolic effects of glucagon receptor agonism may in part be mediated by increases in circulating levels of Fibroblast Growth Factor 21 (FGF21) and Growth Differentiation Factor 15 (GDF15). The effect of glucagon agonism on FGF21 and GDF15 levels remains uncertain, especially in the context of elevated insulin levels commonly observed in metabolic diseases.
    Methods: We investigated the effect of a single bolus of glucagon and a continuous infusion of glucagon on plasma concentrations of FGF21 and GDF15 in conditions of endogenous low or high insulin levels. The studies included individuals with overweight with and without MASLD, healthy controls (CON) and individuals with type 1 diabetes (T1D). The direct effect of glucagon on FGF21 and GDF15 was evaluated using our in-house developed isolated perfused mouse liver model.
    Results: FGF21 and GDF15 correlated with plasma levels of insulin, but not glucagon, and their secretion were highly increased in MASLD compared with CON and T1D. Furthermore, FGF21 levels in individuals with overweight with or without MASLD did not increase after glucagon stimulation when insulin levels were kept constant. FGF21 and GDF15 levels were unaffected by direct stimulation with glucagon in the isolated perfused mouse liver.
    Conclusion: The glucagon-induced secretion of FGF21 and GDF15 are augmented in MASLD and may depend on insulin. Thus, glucagon receptor agonism may augment its metabolic benefits in patients with MASLD through enhanced secretion of FGF21 and GDF15.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2024.155915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol

    Kjeldsen, Sasha A.S. / Richter, Michael M. / Jensen, Nicole J. / Nilsson, Malin S.D. / Heinz, Niklas / Nybing, Janus D. / Linden, Frederik H. / Høgh-Schmidt, Erik / Boesen, Mikael P. / Madsbad, Sten / Vilstrup, Hendrik / Schiødt, Frank Vinholt / Møller, Andreas / Nørgaard, Kirsten / Schmidt, Signe / Rashu, Elias B. / Gluud, Lise L. / Haugaard, Steen B. / Holst, Jens J. /
    Rungby, Jørgen / Wewer Albrechtsen, Nicolai J.

    Peptides. 2023 Mar., v. 161 p.170938-

    2023  

    Abstract: A physiological feedback system exists between hepatocytes and the alpha cells, termed the liver-alpha cell axis and refers to the relationship between amino acid-stimulated glucagon secretion and glucagon-stimulated amino acid catabolism. Several ... ...

    Abstract A physiological feedback system exists between hepatocytes and the alpha cells, termed the liver-alpha cell axis and refers to the relationship between amino acid-stimulated glucagon secretion and glucagon-stimulated amino acid catabolism. Several reports indicate that non-alcoholic fatty liver disease (NAFLD) disrupts the liver-alpha cell axis, because of impaired glucagon receptor signaling (glucagon resistance). However, no experimental test exists to assess glucagon resistance in humans. The objective was to develop an experimental test to determine glucagon sensitivity with respect to amino acid and glucose metabolism in humans. The proposed glucagon sensitivity test (comprising two elements: 1) i.v. injection of 0.2 mg glucagon and 2) infusion of mixed amino acids 331 mg/hour/kg) is based on nine pilot studies which are presented. Calculation of a proposed glucagon sensitivity index with respect to amino acid catabolism is also described. Secondly, we describe a complete study protocol (GLUSENTIC) according to which the glucagon sensitivity test will be applied in a cross-sectional study currently taking place. 65 participants including 20 individuals with a BMI 18.6–25 kg/m², 30 individuals with a BMI ≥ 25–40 kg/m², and 15 individuals with type 1 diabetes with a BMI between 18.6 and 40 kg/m² will be included. Participants will be grouped according to their degree of hepatic steatosis measured by whole-liver magnetic resonance imaging (MRI). The primary outcome measure will be differences in the glucagon sensitivity index between individuals with and without hepatic steatosis. Developing a glucagon sensitivity test and index may provide insight into the physiological and pathophysiological mechanism of glucagon action and glucagon-based therapies.
    Keywords amino acid metabolism ; amino acids ; cross-sectional studies ; fatty liver ; glucagon ; glucagon receptors ; glucose ; hepatocytes ; insulin-dependent diabetes mellitus ; magnetism ; secretion ; NAFLD ; Type 1 diabetes ; Metabolism ; The liver-alpha cell axis ; Study protocol
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2022.170938
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 1649: Show issues Location:
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  5. Article ; Online: Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol.

    Kjeldsen, Sasha A S / Richter, Michael M / Jensen, Nicole J / Nilsson, Malin S D / Heinz, Niklas / Nybing, Janus D / Linden, Frederik H / Høgh-Schmidt, Erik / Boesen, Mikael P / Madsbad, Sten / Vilstrup, Hendrik / Schiødt, Frank Vinholt / Møller, Andreas / Nørgaard, Kirsten / Schmidt, Signe / Rashu, Elias B / Gluud, Lise L / Haugaard, Steen B / Holst, Jens J /
    Rungby, Jørgen / Wewer Albrechtsen, Nicolai J

    Peptides

    2022  Volume 161, Page(s) 170938

    Abstract: A physiological feedback system exists between hepatocytes and the alpha cells, termed the liver-alpha cell axis and refers to the relationship between amino acid-stimulated glucagon secretion and glucagon-stimulated amino acid catabolism. Several ... ...

    Abstract A physiological feedback system exists between hepatocytes and the alpha cells, termed the liver-alpha cell axis and refers to the relationship between amino acid-stimulated glucagon secretion and glucagon-stimulated amino acid catabolism. Several reports indicate that non-alcoholic fatty liver disease (NAFLD) disrupts the liver-alpha cell axis, because of impaired glucagon receptor signaling (glucagon resistance). However, no experimental test exists to assess glucagon resistance in humans. The objective was to develop an experimental test to determine glucagon sensitivity with respect to amino acid and glucose metabolism in humans. The proposed glucagon sensitivity test (comprising two elements: 1) i.v. injection of 0.2 mg glucagon and 2) infusion of mixed amino acids 331 mg/hour/kg) is based on nine pilot studies which are presented. Calculation of a proposed glucagon sensitivity index with respect to amino acid catabolism is also described. Secondly, we describe a complete study protocol (GLUSENTIC) according to which the glucagon sensitivity test will be applied in a cross-sectional study currently taking place. 65 participants including 20 individuals with a BMI 18.6-25 kg/m
    MeSH term(s) Humans ; Glucagon/metabolism ; Cross-Sectional Studies ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Amino Acids
    Chemical Substances Glucagon (9007-92-5) ; Amino Acids
    Language English
    Publishing date 2022-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2022.170938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1649: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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