Article ; Online: Effect of Systemic Administration of CD4
2023 Volume 73, Issue 4, Page(s) 285–293
Abstract: Immunodeficient mice engrafted with psoriatic human skin are widely used for the preclinical evaluation of new drug candidates. However, the T-cell activity, including the IL23/IL17 pathway, declines in the graft over time after engraftment, which likely ...
| Abstract | Immunodeficient mice engrafted with psoriatic human skin are widely used for the preclinical evaluation of new drug candidates. However, the T-cell activity, including the IL23/IL17 pathway, declines in the graft over time after engraftment, which likely affects the study data. Here, we investigated whether the T-cell activity could be sustained in xenografted psoriatic skin by local stimulation of T cells or systemic injection of autologous CD4 + T cells. We surgically transplanted human psoriatic skin from 5 untreated patients onto female NOG mice. Six days after surgery, mice received an intraperitoneal injection of autologous human CD4 |
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| MeSH term(s) | Humans ; Mice ; Female ; Animals ; T-Lymphocytes ; Heterografts ; Skin/pathology ; Psoriasis/drug therapy ; Psoriasis/pathology ; CD4-Positive T-Lymphocytes | |||||
| Language | English | |||||
| Publishing date | 2023-08-23 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2006425-1 | |||||
| ISSN | 2769-819X ; 0023-6764 ; 1532-0820 | |||||
| ISSN (online) | 2769-819X | |||||
| ISSN | 0023-6764 ; 1532-0820 | |||||
| DOI | 10.30802/AALAS-CM-23-000006 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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