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  1. AU="Hüls, Anke"
  2. AU="Poondru, Srinivasu"
  3. AU="Coca, Daniel"
  4. AU="Lebeau, Paul"
  5. AU="Dehghani, Sedigheh"
  6. AU="Ishibashi, Kenji"
  7. AU="Xu, Yanhua"
  8. AU="Matera, Katarzyna"
  9. AU="Ait-Ouarab, Slimane"
  10. AU="Nicola, Coppede"
  11. AU="Dewitt, John M"
  12. AU="Sorin M. Dudea"
  13. AU="Tanusha D. Ramdin"
  14. AU="Hao, Zehui"
  15. AU="Chauhan, Aman"

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Treffer 1 - 10 von insgesamt 98

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  1. Artikel ; Online: Improvement of air quality has a positive impact on lung growth, particularly during puberty.

    Hüls, Anke

    The European respiratory journal

    2023  Band 61, Heft 5

    Mesh-Begriff(e) Humans ; Child ; Adolescent ; Young Adult ; Air Pollution/adverse effects ; Respiratory Physiological Phenomena ; Organogenesis ; Lung ; Puberty
    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland England
    Dokumenttyp Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00345-2023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Konferenzbeitrag: Polygenic Risk Score Approaches for Methylation Data in Multi-Ethnic Populations

    Huels, Anke

    2021  , Seite(n) Abstr. 317

    Veranstaltung/Kongress 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS); Berlin; Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 2020
    Schlagwörter Medizin, Gesundheit ; epigenetics ; polygenic risk scores ; genetic epidemiology
    Erscheinungsdatum 2021-02-26
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/20gmds372
    Datenquelle German Medical Science

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  3. Artikel ; Online: Invited Perspective: Challenges and Opportunities for Missing Data in the Context of Environmental Mixture Methods.

    Eick, Stephanie M / Hüls, Anke

    Environmental health perspectives

    2022  Band 130, Heft 11, Seite(n) 111305

    Sprache Englisch
    Erscheinungsdatum 2022-11-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP12118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Intergenerational transmission of trauma: A biological perspective.

    Jovanovic, Tanja / Roberts, Andrea / Huels, Anke

    Journal of traumatic stress

    2023  Band 36, Heft 4, Seite(n) 662–664

    Abstract: This commentary is based on an invited panel for the 2022 International Society of Traumatic Stress Studies (ISTSS) annual meeting entitled "Perspective Discourses On…Intergenerational Transmission of Trauma: A Biological Perspective." This was a new ... ...

    Abstract This commentary is based on an invited panel for the 2022 International Society of Traumatic Stress Studies (ISTSS) annual meeting entitled "Perspective Discourses On…Intergenerational Transmission of Trauma: A Biological Perspective." This was a new format introduced by ISTSS to facilitate discussion around timely topics. This session included scholars from different backgrounds (e.g., epidemiology, neuroscience, environmental health) who shared their approaches to understanding the biological bases of the intergenerational transmission of trauma. Specifically, the panel presented information about putative direct and indirect mechanisms of transmission, including epigenetic and environmental factors, and pointed to behavioral and neurobiological outcomes in offspring. This commentary synthesizes some of the current knowledge gained by these different approaches and identifies key areas to advance in future work.
    Mesh-Begriff(e) Humans ; Historical Trauma
    Sprache Englisch
    Erscheinungsdatum 2023-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639478-4
    ISSN 1573-6598 ; 0894-9867
    ISSN (online) 1573-6598
    ISSN 0894-9867
    DOI 10.1002/jts.22938
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Impact of Environmental Injustice on Children's Health-Interaction between Air Pollution and Socioeconomic Status.

    Mathiarasan, Sahana / Hüls, Anke

    International journal of environmental research and public health

    2021  Band 18, Heft 2

    Abstract: Air pollution disproportionately affects marginalized populations of lower socioeconomic status. There is little literature on how socioeconomic status affects the risk of exposure to air pollution and associated health outcomes, particularly for ... ...

    Abstract Air pollution disproportionately affects marginalized populations of lower socioeconomic status. There is little literature on how socioeconomic status affects the risk of exposure to air pollution and associated health outcomes, particularly for children's health. The objective of this article was to review the existing literature on air pollution and children's health and discern how socioeconomic status affects this association. The concept of environmental injustice recognizes how underserved communities often suffer from higher air pollution concentrations in addition to other underlying risk factors for impaired health. This exposure then exerts larger effects on their health than it does in the average population, affecting the whole body, including the lungs and the brain. Children, whose organs and mind are still developing and who do not have the means of protecting themselves or creating change, are the most vulnerable to the detrimental effects of air pollution and environmental injustice. The adverse health effects of air pollution and environmental injustice can harm children well into adulthood and may even have transgenerational effects. There is an urgent need for action in order to ensure the health and safety of future generations, as social disparities are continuously increasing, due to social discrimination and climate change.
    Mesh-Begriff(e) Adult ; Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/adverse effects ; Air Pollution/analysis ; Child ; Child Development/physiology ; Child Health ; Climate Change ; Cognition/physiology ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Humans ; Social Class ; Socioeconomic Factors
    Chemische Substanzen Air Pollutants
    Sprache Englisch
    Erscheinungsdatum 2021-01-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18020795
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Estimating the Relative Contribution of Environmental and Genetic Risk Factors to Different Aging Traits by Combining Correlated Variables into Weighted Risk Scores.

    Wigmann, Claudia / Hüls, Anke / Krutmann, Jean / Schikowski, Tamara

    International journal of environmental research and public health

    2022  Band 19, Heft 24

    Abstract: Genetic and exposomal factors contribute to the development of human aging. For example, genetic polymorphisms and exposure to environmental factors (air pollution, tobacco smoke, etc.) influence lung and skin aging traits. For prevention purposes it is ... ...

    Abstract Genetic and exposomal factors contribute to the development of human aging. For example, genetic polymorphisms and exposure to environmental factors (air pollution, tobacco smoke, etc.) influence lung and skin aging traits. For prevention purposes it is highly desirable to know the extent to which each category of the exposome and genetic factors contribute to their development. Estimating such extents, however, is methodologically challenging, mainly because the predictors are often highly correlated. Tackling this challenge, this article proposes to use weighted risk scores to assess combined effects of categories of such predictors, and a measure of relative importance to quantify their relative contribution. The risk score weights are determined via regularized regression and the relative contributions are estimated by the proportion of explained variance in linear regression. This approach is applied to data from a cohort of elderly Caucasian women investigated in 2007-2010 by estimating the relative contribution of genetic and exposomal factors to skin and lung aging. Overall, the models explain 17% (95% CI: [9%, 28%]) of the outcome's variance for skin aging and 23% ([11%, 34%]) for lung function parameters. For both aging traits, genetic factors make up the largest contribution. The proposed approach enables us to quantify and rank contributions of categories of exposomal and genetic factors to human aging traits and facilitates risk assessment related to common human diseases in general. Obtained rankings can aid political decision making, for example, by prioritizing protective measures such as limit values for certain exposures.
    Mesh-Begriff(e) Aged ; Female ; Humans ; Aging/genetics ; Environmental Exposure/adverse effects ; Exposome ; Risk Assessment ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2022-12-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192416746
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Methodological challenges in constructing DNA methylation risk scores.

    Hüls, Anke / Czamara, Darina

    Epigenetics

    2019  Band 15, Heft 1-2, Seite(n) 1–11

    Abstract: Polygenic approaches often access more variance of complex traits than is possible by single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for risk prediction as well as in association and interaction studies. Recently, ...

    Abstract Polygenic approaches often access more variance of complex traits than is possible by single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for risk prediction as well as in association and interaction studies. Recently, interest has been growing in transferring GRS approaches to DNA methylation data (methylation risk scores, MRS), which can be used 1) as biomarkers for environmental exposures, 2) in association analyses in which single CpG sites do not achieve significance, 3) as dimension reduction approach in interaction and mediation analyses, and 4) to predict individual risks of disease or treatment success. Most GRS approaches can directly be transferred to methylation data. However, since methylation data is more sensitive to confounding, e.g. by age and tissue, it is more complex to find appropriate external weights. In this review, we will outline the adaption of current GRS approaches to methylation data and highlight occurring challenges.
    Mesh-Begriff(e) DNA Methylation ; Epigenomics/methods ; Epigenomics/standards ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Genetic Testing/standards ; Humans ; Multifactorial Inheritance
    Sprache Englisch
    Erscheinungsdatum 2019-07-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2019.1644879
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease among a Cognitively Healthy Population-Based Cohort.

    Casey, Emma / Li, Zhenjiang / Liang, Donghai / Ebelt, Stefanie / Levey, Allan I / Lah, James J / Wingo, Thomas S / Hüls, Anke

    Environmental health perspectives

    2024  Band 132, Heft 4, Seite(n) 47001

    Abstract: Background: Epidemiological evidence suggests air pollution adversely affects cognition and increases the risk of Alzheimer's disease (AD), but little is known about the biological effects of fine particulate matter (: Objectives: We investigated the ...

    Abstract Background: Epidemiological evidence suggests air pollution adversely affects cognition and increases the risk of Alzheimer's disease (AD), but little is known about the biological effects of fine particulate matter (
    Objectives: We investigated the association between 1-, 3-, and 5-y exposure to ambient and traffic-related
    Methods: We conducted a cross-sectional analysis using data from 1,113 cognitively healthy adults (45-75 y of age) from the Emory Healthy Brain Study in Georgia in the United States. CSF biomarker concentrations of
    Results: Interquartile range (IQR;
    Conclusion: In our study, consistent trends were found between 1-y
    Mesh-Begriff(e) Adult ; Humans ; United States ; Particulate Matter/analysis ; Air Pollutants/analysis ; Alzheimer Disease/epidemiology ; Cross-Sectional Studies ; Environmental Exposure/analysis ; Air Pollution/analysis ; Biomarkers/analysis
    Chemische Substanzen Particulate Matter ; Air Pollutants ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP13503
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Air Pollution and Skin Aging.

    Schikowski, Tamara / Hüls, Anke

    Current environmental health reports

    2019  Band 7, Heft 1, Seite(n) 58–64

    Abstract: Purpose of the review: The evidence on the role of air pollution on skin aging has increased in recent years. The accumulating evidence is based on both, epidemiological and mechanistic studies. The purpose of this review is to evaluate the recent ... ...

    Abstract Purpose of the review: The evidence on the role of air pollution on skin aging has increased in recent years. The accumulating evidence is based on both, epidemiological and mechanistic studies. The purpose of this review is to evaluate the recent evidence on the impacts of air pollution on skin aging as well as identify knowledge gaps for future research.
    Recent findings: Traffic-related air pollution exposure (particulate matter (PM), soot and nitrogen dioxide (NO
    Mesh-Begriff(e) Air Pollutants/toxicity ; Environmental Exposure/statistics & numerical data ; Female ; Humans ; Male ; Nitrogen Dioxide/toxicity ; Ozone/toxicity ; Particulate Matter/toxicity ; Skin Aging/drug effects ; Soot/toxicity
    Chemische Substanzen Air Pollutants ; Particulate Matter ; Soot ; Ozone (66H7ZZK23N) ; Nitrogen Dioxide (S7G510RUBH)
    Sprache Englisch
    Erscheinungsdatum 2019-12-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ISSN 2196-5412
    ISSN (online) 2196-5412
    DOI 10.1007/s40572-020-00262-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Ambient particulate matter and COPD in China: a challenge for respiratory health research.

    Hüls, Anke / Schikowski, Tamara

    Thorax

    2017  Band 72, Heft 9, Seite(n) 771–772

    Sprache Englisch
    Erscheinungsdatum 2017-09
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2016-209687
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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