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Book: Kronstadts medizinisch-pharmazeutische Bibliographie der Jahre 1530 - 1930

Huttmann, Arnold

(Veröffentlichungen des Südostdeutschen Kulturwerks : Reihe B, Wissenschaftliche Arbeiten ; 77)

2000

Author's details	Arnold Huttmann
Series title	Veröffentlichungen des Südostdeutschen Kulturwerks : Reihe B, Wissenschaftliche Arbeiten ; 77 Veröffentlichungen des Südostdeutschen Kulturwerks Veröffentlichungen des Südostdeutschen Kulturwerks ; Reihe B, Wissenschaftliche Arbeiten
Collection	Veröffentlichungen des Südostdeutschen Kulturwerks Veröffentlichungen des Südostdeutschen Kulturwerks ; Reihe B, Wissenschaftliche Arbeiten
Keywords	Braşov ; Medizin ; Tiermedizin ; Pharmazie
Subject	Tierheilkunde ; Veterinärmedizin ; Humanmedizin ; Heilkunst ; Medicine ; Arzneikunde ; Arzneimittelkunde
Language	German
Size	159 S. : Ill.
Publisher	Verl. Südostdt. Kulturwerk
Publishing place	München
Publishing country	Germany
Document type	Book
HBZ-ID	HT012765844
ISBN	3-88356-150-9 ; 978-3-88356-150-9
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Neutropenia-related aspergillosis in non-transplant haematological patients hospitalised under ambient air versus purified air conditions.

Friese, Christina / Breuckmann, Katharina / Hüttmann, Andreas / Eisele, Lewin / Dührsen, Ulrich

Mycoses

2023 Volume 66, Issue 6, Page(s) 505–514

Abstract: Background: To reduce the risk of invasive aspergillosis (IA), air purification by high-efficiency particulate air filtration and laminar air flow (HEPA/LAF) is standard of care in allogeneic blood stem cell transplantation. Its use in non-transplant ... ...

Abstract	Background: To reduce the risk of invasive aspergillosis (IA), air purification by high-efficiency particulate air filtration and laminar air flow (HEPA/LAF) is standard of care in allogeneic blood stem cell transplantation. Its use in non-transplant haematological patients is inconsistent. Objectives: We sought to assess the incidence and outcome of pulmonary IA in non-transplant patients with life-threatening neutropenia by comparing an ambient air hospitalisation period (2008-2011) with a subsequent HEPA/LAF hospitalisation period (2012-2014). Patients and methods: We compared 204 consecutive patients with acute myeloid leukaemia, acute lymphoblastic leukaemia or aplastic anaemia completing 534 neutropenia-related hospitalisations under ambient air conditions with 126 such patients completing 437 neutropenia-related hospitalisations under HEPA/LAF conditions. IA was defined using the 2008 EORTC/MSG criteria. Results: Within a 7-year study period, we observed one 'proven', three 'probable' and 73 'possible' IAs, most often during acute leukaemia remission induction. Their frequency rose with increasing duration of life-threatening neutropenia (1-10 days, 1.8%; >40 days, 35.2%) and concomitant severe anaemia (0 days, 3.2%; >20 days, 31.0%). Multiple logistic regression revealed a strong correlation between IA incidence and hospitalisation under HEPA/LAF conditions (odds ratio [OR], 0.368 [95% confidence interval, 0.207-0.654]; p < .001) and duration of neutropenia (OR, 1.043 [1.023-1.062] per day; p < .001) and anaemia (OR, 1.044 [1.008-1.081] per day; p = .016). IA-associated fatal outcomes were non-significantly reduced under HEPA/LAF (OR, 0.077 [0.005-1.151]; p = .063). The protective effect of HEPA/LAF was not seen under posaconazole prophylaxis (OR, 0.856 [0.376-1.950]; p = .711). Conclusions: Implementation of HEPA/LAF was associated with a significant reduction in neutropenia-related IA in non-transplant haematological patients.
MeSH term(s)	Humans ; Aspergillosis/drug therapy ; Hematology ; Neutropenia/complications ; Invasive Pulmonary Aspergillosis/etiology ; Invasive Pulmonary Aspergillosis/complications ; Leukemia, Myeloid, Acute/complications
Language	English
Publishing date	2023-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.13576
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Book ; Thesis: Untersuchungen zur Pharmakokinetik und Pharmakodynamik des Podophyllotoxinderivates NK 611

Hüttmann, Andreas

Resultate der Phase-I-Studie

1995

Author's details	vorgelegt von Andreas Hüttmann
Language	German
Size	99 Bl. : graph. Darst.
Edition	[Mikrofiche-Ausg.]
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hamburg, Univ., Diss., 1995
Note	Mikrofiche-Ausg.: 1 Mikrofiche : 24x
HBZ-ID	HT007461184
Database	Catalogue ZB MED Medicine, Health

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Article: Report on important cardiovascular work from Romanian literature.

HUTTMANN, A

Zeitschrift fur Kreislaufforschung

2007 Volume 37, Issue 15-16, Page(s) 461–467

Title translation	Bericht über wichtige Herz- und Kreislaufarbeiten aus der rumänischen Literatur.
MeSH term(s)	Blood Circulation ; Cardiology ; Ethnic Groups ; Humans ; Romania
Language	German
Publishing date	2007-12-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124482-6
ISSN	0044-295X
ISSN	0044-295X
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Book ; Online: Erfolgreich studieren mit Soft Skills

Hüttmann, Andrea

Die eigene Persönlichkeit wirkungsvoll stärken

2016

Abstract: Wie kann ich mein Studium erfolgreich meistern? Studiere ich überhaupt das Richtige? Wie funktioniert effektives Lernen? Sind Praktika wirklich so wichtig? - Es gibt viele Fragen, die Studierende hierzulande umtreiben. Nur ein Teil von ihnen scheint ... ...

Author's details	von Andrea Hüttmann
Abstract	Wie kann ich mein Studium erfolgreich meistern? Studiere ich überhaupt das Richtige? Wie funktioniert effektives Lernen? Sind Praktika wirklich so wichtig? - Es gibt viele Fragen, die Studierende hierzulande umtreiben. Nur ein Teil von ihnen scheint befriedigende Antworten zu finden, denn immerhin bricht in Deutschland jeder dritte Hochschul- und jeder vierte Fachhochschulstudent sein Studium ab. Andrea Hüttmann ist eine - gerade im Coaching von Studenten - erfahrene Expertin. Sie räumt mit diversen Mythen rund um das Studieren auf und zeigt Ihnen, wie Sie mit der richtigen Anwendung von Soft Skills erfolgreich und mit Freude studieren. Sie lernen Ihr Selbstbild zu überprüfen, Ihre Persönlichkeit zu festigen, für sich selbst Verantwortung zu übernehmen und erfolgreich mit anderen zu kommunizieren und zu kooperieren. Viele Beispiele und konkrete Verhaltenstipps erleichtern Ihnen die Umsetzung in die Praxis. Der Inhalt • Die Kunst sich selbst zu führen • Die Kunst zu kooperieren • Studentische Kompetenzen • Die wichtigsten Lebensprinzipien Die Autorin Andrea Hüttmann ist Professorin an der accadis Hochschule Bad Homburg sowie Leiterin des Fachbereichs „Communication Skills“ und der Internen Hochschulkommunikation. Sie ist Expertin f ür Soft Skills, Persönlichkeitsentwicklung sowie Human- und Unternehmenskommunikation. Als Coach berät und begleitet sie Studierende, Privatpersonen und Unternehmen bei Veränderungsvorhaben, Entwicklungswünschen und in Fragen der Kommunikation.
Keywords	Business ; Careers ; Success in business
Language	German
Size	Online-Ressource (XX, 232 S. 32 Abb), online resource
Edition	1. Aufl. 2016
Publisher	Springer Fachmedien Wiesbaden
Publishing place	Wiesbaden ;s.l
Document type	Book ; Online
ISBN	9783658099695 ; 9783658099701 ; 3658099690 ; 3658099704
DOI	10.1007/978-3-658-09970-1
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Rituximab bei der CD20-positiven akuten lymphatischen Leukämie. Stellenwert des gegen CD20 gerichteten Antikörpers Rituximab

Hüttmann, Andreas

Wtz-Journal

2016 Volume -, Issue 1, Page(s) 10

Language	German
Document type	Article
ZDB-ID	2530214-0
ISSN	1869-5892
Database	Current Contents Medicine

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Book: Medizin im alten Siebenbürgen

Huttmann, Arnold / Huttmann, Georg-Valentin / Offner, Robert

Beiträge zur Geschichte der Medizin in Siebenbürgen

2000

Author's details	Arnold Huttmann. Hrsg. von Robert Offner
Keywords	Siebenbürgen ; Medizin ; Geschichte ; Gesundheitswesen ; Huttmann, Arnold
Subject	Gesundheitsdienst ; Gesundheitssystem ; Gesundheitswirtschaft ; Medizinalwesen ; Medizinalsystem ; Humanmedizin ; Heilkunst ; Medicine
Language	German
Size	574 S., Ill., 24 cm
Publisher	Ed. hora
Publishing place	Hermannstadt/Sibiu
Publishing country	Romania
Document type	Book
Note	Literaturangaben. - Bibliogr. A. Huttmann S. 473 - 523
HBZ-ID	HT012898265
ISBN	973-99187-7-8 ; 978-973-99187-7-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Follicular lymphoma grade 3B and diffuse large B-cell lymphoma present a histopathological and molecular continuum lacking features of progression/ transformation.

Koch, Karoline / Richter, Julia / Hanel, Christoph / Huttmann, Andreas / Duhrsen, Ulrich / Klapper, Wolfram

Haematologica

2022 Volume 107, Issue 9, Page(s) 2144–2153

Abstract: The sole distinguishing feature of follicular lymphoma grade 3B and diffuse large B-cell lymphoma is the growth pattern assessed by histopathology. Diffuse growth defines diffuse large B-cell lymphoma but the clinical relevance of this finding when ... ...

Abstract	The sole distinguishing feature of follicular lymphoma grade 3B and diffuse large B-cell lymphoma is the growth pattern assessed by histopathology. Diffuse growth defines diffuse large B-cell lymphoma but the clinical relevance of this finding when occurring in follicular lymphoma grade 3B is uncertain. To address this issue, individual and coexisting follicular lymphoma grade 3B and diffuse large B-cell lymphoma were separated and analyzed for immunophenotype and molecular genetic features by fluorescence in situ hybridization, targeted sequencing and gene expression profiling. Clinical features of follicular lymphoma grade 3B with and without coexisting diffuse large B-cell lymphoma were studied in homogeneously treated patients from a prospective randomized trial. Follicular lymphoma grade 3B and diffuse large B-cell lymphoma frequently show an intermediate growth pattern and/or occur simultaneously in the same tissue at the time of initial diagnosis. When occurring simultaneously follicular lymphoma grade 3B and diffuse large B-cell lymphoma do not differ significantly for genetic aberrations or phenotype but have distinct gene expression features reflecting a divergent microenvironment. Follicular lymphoma grade 3B with and without coexisting diffuse large B-cell lymphoma do not differ for major clinical parameters such as International Prognostic Index, response to immuno-chemotherapy, progression or overall survival. Follicular lymphoma grade 3B and simultaneous diffuse large B-cell lymphoma are molecularly homogenous. Histological detection of diffuse large B-cell lymphoma is not associated with features of a more aggressive disease and does not reflect transformation or progression of follicular lymphoma grade 3B.
MeSH term(s)	Humans ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/genetics ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Prospective Studies ; Tumor Microenvironment/genetics
Language	English
Publishing date	2022-09-01
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2021.279351
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Article ; Online: Treatment Outcome in Patients with Primary or Secondary Transformed Indolent B-Cell Lymphomas.

Demirdas, Sedat / Hense, Jörg / Dührsen, Ulrich / Hüttmann, Andreas

Oncology research and treatment

2019 Volume 42, Issue 11, Page(s) 580–588

Abstract: Background: Histologic transformation (HT) of indolent B-cell lymphomas into an aggressive form can occur simultaneously (primary HT, pHT) or sequentially after a preceding diagnosis of indolent lymphoma (secondary HT, sHT). The clinical course after ... ...

Abstract	Background: Histologic transformation (HT) of indolent B-cell lymphomas into an aggressive form can occur simultaneously (primary HT, pHT) or sequentially after a preceding diagnosis of indolent lymphoma (secondary HT, sHT). The clinical course after diagnosis of HT is variable. Objectives: To describe the outcome of treatment in pHT and sHT patients. Methods: We retrospectively analyzed HT cases with an underlying follicular lymphoma, nodal marginal zone lymphoma, extranodal marginal zone lymphoma, lymphoplasmacytic lymphoma, or small lymphocytic lymphoma at our institution. Kaplan-Meier estimates were used to calculate progression-free survival (PFS) and overall survival (OS). Results: Ninety-two HT patients were identified, 38 with pHT and 54 with sHT. In sHT, time-to-transformation was not influenced by the preceding treatment strategy of the indolent lymphoma component. In pHT, median PFS was 61 months (95% CI 27-61), and OS was not reached. In sHT, median PFS and OS was 14 months (95% CI 9-32) and 42 months (95% CI 16-90), respectively. Significant differences between pHT and sHT in PFS (p = 0.002; Hazard ratio [HR] 2.30, 95% CI 1.36-3.91) and OS (p = 0.0001; HR 3.30, 95% CI 1.81-6.03) were observed. Response to treatment for transformation was highly prognostic of PFS and OS (p < 0.0001). Conclusions: The outcome in pHT cases is favorable and signifi-cantly better than in sHT cases. Failure to achieve a remission after treatment for transformation confers a dismal pro-gnosis.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Combined Modality Therapy ; Female ; Humans ; Lymphoma, B-Cell, Marginal Zone/diagnosis ; Lymphoma, B-Cell, Marginal Zone/mortality ; Lymphoma, B-Cell, Marginal Zone/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2019-09-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2760274-6
ISSN	2296-5262 ; 2296-5270
ISSN (online)	2296-5262
ISSN	2296-5270
DOI	10.1159/000502754
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Article ; Online: Efficacy of the GMALL-B-ALL/NHL2002 protocol in Burkitt leukemia/lymphoma and aggressive non-Hodgkin-lymphomas with or without CNS involvement.

Sakarou, Maria / Eisele, Lewin / Dührsen, Ulrich / Hüttmann, Andreas

European journal of haematology

2019 Volume 102, Issue 3, Page(s) 241–250

Abstract: Objectives: The GMALL-B-ALL/NHL2002 protocol is effective in Burkitt lymphoma/leukemia (BL). Its role in other aggressive lymphomas and in patients with simultaneous central nervous system (CNS) and peripheral involvement is unclear.: Methods: This ... ...

Abstract	Objectives: The GMALL-B-ALL/NHL2002 protocol is effective in Burkitt lymphoma/leukemia (BL). Its role in other aggressive lymphomas and in patients with simultaneous central nervous system (CNS) and peripheral involvement is unclear. Methods: This is a retrospective outcome analysis in 76 patients with BL (n = 26), B-lymphoblastic lymphoma (B-LBL; n = 3), diffuse large B-cell lymphoma (DLBCL; n = 31), mantle cell lymphoma (MCL; n = 6), transformed B-cell non-Hodgkin lymphomas (tB-NHL; n = 7), and T-cell NHL (T-NHL; n = 3) treated with the GMALL-B-ALL/NHL2002 protocol. Results: 73.1% of scheduled chemotherapy cycles were administered. Treatment was discontinued in 38 patients (50.0%) due to progression (n = 14), toxicities (n = 11), scheduled treatment change (n = 6), and unknown reasons (n = 7). All BL/B-LBL patients were treated first-line, and at a median follow-up of 124.7 months, median progression-free survival was not reached. In DLBCL, median PFS was 68.4 months in first-line treated patients and 3.7 months in relapsed/refractory patients. CNS involvement was present in 10 non-BL/B-LBL cases and did not have a negative impact on survival in first-line treated patients but was fatal in all relapsed/refractory patients. Conclusion: This study confirmed the activity of the GMALL-B-ALL/NHL2002 protocol in BL/B-LBL. It was also effective in first-line treated non-BL/B-LBL lymphomas with and without simultaneous CNS-/peripheral involvement, but ineffective in relapsed/refractory disease.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Burkitt Lymphoma/drug therapy ; Burkitt Lymphoma/mortality ; Burkitt Lymphoma/pathology ; Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/secondary ; Drug Resistance, Neoplasm ; Female ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/mortality ; Lymphoma, Non-Hodgkin/pathology ; Male ; Medication Adherence ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Recurrence ; Survival Analysis ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13199
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