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Article ; Online: Research on the Allocation Efficiency and Influencing Factors of Scientific and Technological Resources in the Yangtze River Delta City Group

Yuhong H. Cao / Jianxin X. You / Yongjiang J. Shi / Wei Hu

Sustainability, Vol 13, Iss 7951, p

2021 Volume 7951

Abstract: Through the establishment of a comprehensive evaluation index system, this paper analyzes the allocation of science and technology resources in the Yangtze River Delta urban agglomeration from 2014 to 2020, evaluates the allocation efficiency of science ... ...

Abstract	Through the establishment of a comprehensive evaluation index system, this paper analyzes the allocation of science and technology resources in the Yangtze River Delta urban agglomeration from 2014 to 2020, evaluates the allocation efficiency of science and technology resources from the perspective of multi input and output, and understands the advantages and disadvantages of regional resource allocation. The research results show that: (1) under the guidance of the national strategic policy of actively promoting the development of world-class urban agglomerations, the allocation efficiency of science and technology resources in various provinces and cities of the Yangtze River Delta continues to optimize, and the allocation level of some regions shows a rapid development trend; (2) R&D personnel and R&D funds are the core factors that affect the efficiency of science and technology resource allocation; (3) the marketization of resource allocation is helpful to improve its allocation efficiency; and (4) improving the transformation rate of scientific and technological achievements, opening up the channel for innovative products, technologies, and services to enter the market, and enabling innovative enterprises to make profits can provide strong and lasting incentives for the improvement of scientific and technological resource allocation efficiency. Based on the research conclusions, this paper puts forward countermeasures and suggestions to improve the allocation efficiency of scientific and technological resources in the Yangtze River Delta urban agglomeration from the aspects of human resources and material resources, and provides a theoretical reference for the coordinated and sustainable development of the Yangtze River Delta City Group under the background of the implementation of the urban agglomeration strategy and the construction of a scientific and technological infrastructure platform.
Keywords	Yangtze River Delta city group ; allocation of science and technology resources ; efficiency evaluation and optimization ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epstein-Barr virus-related dacryocystitis: a case report.

Sternberg, J / Lambiel, S / Van, H Cao / Massa, H / Landis, B N

Journal of medical case reports

2022 Volume 16, Issue 1, Page(s) 430

Abstract: Background and objective: Acute dacryocystitis is an atypical and rare manifestation of pediatric mononucleosis still widely underdiagnosed in clinical practice. We report this rare condition and describe challenges in its diagnosis and treatment on the ...

Abstract	Background and objective: Acute dacryocystitis is an atypical and rare manifestation of pediatric mononucleosis still widely underdiagnosed in clinical practice. We report this rare condition and describe challenges in its diagnosis and treatment on the basis of a presented case. Case presentation: A 6-year-old Caucasian girl without any ophthalmic history was admitted for right preseptal cellulitis requiring intravenous antibiotic therapy. During hospitalization, she developed a fluctuating lump in the nasolacrimal region which resembled an abscess, both clinically and radiologically. There was no spontaneous purulent discharge. Serology was positive for acute mononucleosis and Epstein-Barr virus-related dacryocystitis was diagnosed. Following multidisciplinary discussion, she was treated conservatively with digital lacrimal sac massages and intravenous antibiotic therapy with an excellent outcome. Discussion: This rare form of Epstein-Barr virus is poorly documented in the literature, and thus barely known. As initial symptoms are nonspecific (rhinitis, fever, eyelid edema and erythema lack of purulent discharge, and moderate bilateral cervical lymphadenopathy), diagnosis is often difficult. Nevertheless, differentiating between dacryocystitis and abscess is crucial to select the appropriate treatment and avoid unnecessary, potentially harmful surgery. Conservative management of dacryocystitis appears to be the gold standard of treatment. Conclusion: Acute dacryocystitis in children free of ophthalmic history should raise suspicion of primary Epstein-Barr virus infection. With conservative treatment, prognosis appears to be excellent; therefore, surgery should be avoided as much as possible.
MeSH term(s)	Female ; Humans ; Child ; Herpesvirus 4, Human ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Abscess/complications ; Dacryocystitis/diagnosis ; Dacryocystitis/etiology ; Dacryocystitis/surgery ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-11-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-022-03646-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility

Meng Zou / Kevin D. Mangum / Justin C. Magin / Heidi H. Cao / Michael T. Yarboro / Elaine L. Shelton / Joan M. Taylor / Jeff Reese / Terrence S. Furey / Christopher P. Mack

JCI Insight, Vol 8, Iss

2023 Volume 5

Abstract: Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout ... ...

Abstract	Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout mouse models. Although SMC-specific depletion of Prdm6 in adult mice was well tolerated, Prdm6 depletion in Wnt1-expressing cells during development resulted in perinatal lethality and a completely penetrant patent ductus arteriosus (DA) phenotype. Lineage tracing experiments in Wnt1Cre2 Prdm6fl/fl ROSA26LacZ mice revealed normal neural crest–derived SMC investment of the outflow tract. In contrast, myography measurements on DA segments isolated from E18.5 embryos indicated that Prdm6 depletion significantly reduced DA tone and contractility. RNA-Seq analyses on DA and ascending aorta samples at E18.5 identified a DA-enriched gene program that included many SMC-selective contractile associated proteins that was downregulated by Prdm6 depletion. Chromatin immunoprecipitation–sequencing experiments in outflow tract SMCs demonstrated that 50% of the genes Prdm6 depletion altered contained Prdm6 binding sites. Finally, using several genome-wide data sets, we identified an SMC-selective enhancer within the Prdm6 third intron that exhibited allele-specific activity, providing evidence that rs17149944 may be the causal SNP for a cardiovascular disease GWAS locus identified within the human PRDM6 gene.
Keywords	Vascular biology ; Medicine ; R
Subject code	570
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of step-quenching on the α″ martensitic transformation, α precipitation, and mechanical properties of multiphase Ti–10Mo alloy

Wang, C.H / H. Jiang / G. H. Cao

Journal of materials science. 2018 Aug., v. 53, no. 16

2018

Abstract: The effects of step-quenching on the microstructure and mechanical properties of a binary Ti–10Mo (wt%) alloy were investigated by transmission electron microscopy. The step-quenching treatment, consisting of solution treatment in the β phase field at ... ...

Abstract	The effects of step-quenching on the microstructure and mechanical properties of a binary Ti–10Mo (wt%) alloy were investigated by transmission electron microscopy. The step-quenching treatment, consisting of solution treatment in the β phase field at 850 °C followed by step-quenching to the α/β two-phase region at 650 °C and holding for 0.5 h, was employed before water-quenching the alloy to room temperature. Direct quenching from 850 °C to room temperature with or without an aging step at 650 °C was also conducted for comparison. Microstructural observation revealed that step-quenching favored the formation of α precipitates thinner than 20 nm in the absence of α″ or ω heterogeneous nucleation agents and effectively moderated the subsequent α″ martensitic transformation by increasing the stability of the β phase. Step-quenching generated a multiphase microstructure comprising α″, β, ω, and α phases by balancing the competitive martensitic α″ and diffusional α transformations. Only α″ martensite was formed in the β matrix after direct water-quenching; the mixture of α″ + β phases was transformed to a lamellar α + β microstructure with 5 min aging. The kinetics of α precipitation was calculated to illustrate the temperature dependence of α precipitation behavior during step-quenching. Direct water-quenching produced a tensile strength of 688 MPa and 36% ductility. After aging, the tensile strength was increased to 837–867 MPa, while the ductility was decreased to 5%. By step-quenching, the high tensile strength of 790 MPa and ductility of 23% were achieved.
Keywords	alloys ; ambient temperature ; microstructure ; tensile strength ; transmission electron microscopy
Language	English
Dates of publication	2018-08
Size	p. 11765-11778.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-018-2438-6
Database	NAL-Catalogue (AGRICOLA)

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Article: Single Molecule Profiling of Molecular Recognition at a Model Electrochemical Biosensor

Gu, Qufei / Warren Nanney / Huan H. Cao / Haiyang Wang / Tao Ye

Journal of the American Chemical Society. 2018 Oct. 06, v. 140, no. 43

2018

Abstract: The spatial arrangement of target and probe molecules on the biosensor is a key aspect of the biointerface structure that ultimately determines the properties of interfacial molecular recognition and the performance of the biosensor. However, the spatial ...

Abstract	The spatial arrangement of target and probe molecules on the biosensor is a key aspect of the biointerface structure that ultimately determines the properties of interfacial molecular recognition and the performance of the biosensor. However, the spatial patterns of single molecules on practical biosensors have been unknown, making it difficult to rationally engineer biosensors. Here, we have used high-resolution atomic force microscopy to map closely spaced individual probes as well as discrete hybridization events on a functioning electrochemical DNA sensor surface. We also applied spatial statistical methods to characterize the spatial patterns at the single molecule level. We observed the emergence of heterogeneous spatiotemporal patterns of surface hybridization of hairpin probes. The clustering of target capture suggests that hybridization may be enhanced by proximity of probes and targets that are about 10 nm away. The unexpected enhancement was rationalized by the complex interplay between the nanoscale spatial organization of probe molecules, the conformational changes of the probe molecules, and target binding. Such molecular level knowledge may allow one to tailor the spatial patterns of the biosensor surfaces to improve the sensitivity and reproducibility.
Keywords	DNA ; atomic force microscopy ; biosensors ; electrochemistry ; models ; nucleic acid hybridization ; statistical analysis
Language	English
Dates of publication	2018-1006
Size	p. 14134-14143.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.8b07325
Database	NAL-Catalogue (AGRICOLA)

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Article: First Report of Colletotrichum truncatum Causing Anthracnose of Begonia in China

Zhai, Y. X / B. Q. Zhang / H. Cao / X. J. Hao

Plant disease. 2018 June, v. 102, no. 6

2018

Abstract: The begonia (Begonia × semperflorens) is one of the most important ornamental plants in the horticultural trade and is cultivated widely as a potted plant in China. In March 2017, we received diseased begonia plants from a greenhouse in Taigu (37°30′32 ... ...

Abstract	The begonia (Begonia × semperflorens) is one of the most important ornamental plants in the horticultural trade and is cultivated widely as a potted plant in China. In March 2017, we received diseased begonia plants from a greenhouse in Taigu (37°30′32.82′′N, 112°38′4.55′′E), Shanxi province of China. Anthracnose symptoms including large, sunken, brown lesions with numerous black acervuli were observed on begonia stems. Leaves were also infected. Foliar symptoms first appeared at the leaf margin. Infected leaves developed brown lesions with acervuli, and the entire leaf could become blighted as the lesions coalesced. Severe infection usually resulted in the death of plants. The disease affected approximately 80% of the begonia plants in that greenhouse. Pure cultures were obtained by picking single spores from sporulating acervuli on tissue from different plants and transferring them to potato dextrose agar (PDA) at 25°C for 10 days. Colonies grown on PDA were gray white at first, subsequently turning grayish to dark gray with smooth margins and sparse aerial mycelium. The average daily radial growth was 11.2 mm. Abundant acervuli with mucilaginous, salmon pink spore masses were observed in the cultures after 10 days of incubation. Conidia were hyaline, one-celled, falcate, with a prominent clear area in the center of highly granular cytoplasm, and measured 18.5 to 27.6 × 1.9 to 4.7 μm (mean = 23 × 3.2 μm). Setae were straight, dark brown, and septate. The isolates were identified as Colletotrichum truncatum on the basis of the cultural and morphological characteristics (Sawant et al. 2012) and deposited in Laboratory of Plant Pathology in Shanxi Agricultural University. Sequences of the internal transcribed spacer (ITS1/ITS4), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and β-tubulin (TUB2) regions of three representative isolates (TGBC1, TGBC2, and TGBC3) were amplified and submitted to GenBank. Sequence analysis of the ITS-rDNA (GenBank nos. MG009236, MG009237, and MG009238), GAPDH (MG686558, MG686559, and MG686560), β-tubulin (MG686561, MG686562, and MG686563) obtained from the three representative isolates revealed 99 to 100% sequence identity with C. truncatum strains (KP748222, KP823799, and KF697365 from GenBank). Pathogenicity tests of three isolates were performed by spraying conidial suspensions (106 conidia/ml) until runoff onto leaf and stem surfaces of begonia plants. Noninoculated plants sprayed with sterile distilled water served as controls. Plants were placed in a moist chamber at 25°C with a 12-h photoperiod. After 5 days, initial symptoms of the disease were observed on stems and leaves of inoculated begonias, and control plants did not show any symptoms of infection. Five plants were inoculated with each isolate and the tests repeated twice. C. truncatum was consistently reisolated from symptomatic tissue, thereby completing Koch’s postulates. C. truncatum causes economically important anthracnose diseases and has a broad host range, including many leguminous and solanaceous plants (Damm et al. 2009). To our knowledge, this is the first report of C. truncatum affecting begonia in China. The spread of C. truncatum could be a new potential threat to begonia production and may cause major economic losses to begonia growers in China.
Keywords	anthracnose ; Begonia ; Colletotrichum truncatum ; conidia ; container-grown plants ; culture media ; cytoplasm ; death ; Fabaceae ; financial economics ; glyceraldehyde-3-phosphate dehydrogenase ; greenhouses ; horticulture ; host range ; internal transcribed spacers ; leaves ; mycelium ; ornamental plants ; pathogenicity ; photoperiod ; plant pathology ; runoff ; sequence analysis ; spraying ; stems ; trade ; tubulin ; China
Language	English
Dates of publication	2018-06
Size	p. 1177.
Publishing place	Plant Disease
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-10-17-1520-PDN
Database	NAL-Catalogue (AGRICOLA)

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Article: Simplified method for calculating inflow into a deep excavation with consideration of the effects of cutoff walls

Luo, G. Y / J. S. Qiu / H. Cao / H. Pan

Hydrogeology journal. 2018 Dec., v. 26, no. 8

2018

Abstract: Water inflow into deep excavations is a key parameter in the evaluation of environmental impact, and a simplified method is needed to calculate the inflow with adequate accuracy, especially for a deep excavation with a cutoff wall around it. This paper ... ...

Title translation	Méthode simplifiée pour calculer l’afflux hydrique dans une excavation profonde en considérant les effet des parois taillées Método simplificado para calcular el flujo entrante en una excavación profunda con consideración de los efectos de los muros de corte 考虑止水帷幕作用的基坑涌水量简化计算方法 Método simplificado para calcular fluxo em escavações profundas considerando efeitos de parede de contenção
Abstract	Water inflow into deep excavations is a key parameter in the evaluation of environmental impact, and a simplified method is needed to calculate the inflow with adequate accuracy, especially for a deep excavation with a cutoff wall around it. This paper presents a model for calculating inflow based on the method of fragments, assuming two-dimensional sectional flow. The effects of cutoff wall thickness (w), wall penetration, and excavation width on the inflow are well considered in this model. Explicit formulas for the form factor are given. The accuracy and scope of this method are discussed. The method can be applied in both flooding and no flooding cases. Extensive verification shows that, for the flooding case and when one of four conditions is satisfied, the error of the proposed method will be within 10%. These conditions are b/d ≥ 0.8 or w/d ≥ 0.03 or s/d ≥ 0.2 or s₁/d ≥ 0.2, for which b is the half width of the excavation, d is the thickness of the soil layer underlying the wall, and s and s₁ are the wall penetration depths on the non-excavation side and excavation side, respectively. For the case of no flooding and when the ratio of the distance from the recharge boundary to the aquifer thickness (a/T) is ≥2, the error does not exceed 15%.
Keywords	aquifers ; environmental impact ; models ; soil
Language	English
Dates of publication	2018-12
Size	p. 2853-2865.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1227482-3
ISSN	0941-2816 ; 1431-2174
ISSN	0941-2816 ; 1431-2174
DOI	10.1007/s10040-018-1808-0
Database	NAL-Catalogue (AGRICOLA)

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Article: Overcoming the strength-conductivity trade-off dilemma in carbon nanotube/aluminum-copper fibers by diffusion interface and chemical reaction interface

Wang, G.J / Y.J. Ma / Y.P. Cai / Z.H. Cao / X.K. Meng

Carbon. 2019 May, v. 146

2019

Abstract: The carbon nanotube fiber has not shown its advantage and been widely used in many applications due to low conductivity. Depositing a metallic layer on the carbon nanotube fiber surface became an effective method. However, the strength of the carbon ... ...

Abstract	The carbon nanotube fiber has not shown its advantage and been widely used in many applications due to low conductivity. Depositing a metallic layer on the carbon nanotube fiber surface became an effective method. However, the strength of the carbon nanotube fiber decreases with increasing conductivity and coating thickness. Here, we deposited nanocrystalline metal coating on carbon nanotube fibers by magnetron sputtering. The coating consists of an ultrathin Al transitional layer and a Cu layer. After annealing, the Al atoms and Cu atoms diffused into the carbon nanotube fiber to form diffuse interface and chemical reaction interface, leading to the sliding resistance increase and contact resistance decrease between carbon nanotubes. As a result, the new composite fiber with a 2 μm thick Cu layer can exhibit a superhigh effective strength of 996 MPa and electrical conductivity of 2.6 × 107 S/m. This structure achieves both conductivity and strength increasing simultaneously.
Keywords	aluminum ; annealing ; carbon ; carbon nanotubes ; chemical reactions ; coatings ; copper ; copper nanoparticles ; electrical conductivity ; nanocrystals
Language	English
Dates of publication	2019-05
Size	p. 293-300.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0008-6223
DOI	10.1016/j.carbon.2019.01.111
Database	NAL-Catalogue (AGRICOLA)

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Article: Residential willingness to pay for deep decarbonization of electricity supply: Contingent valuation evidence from Hong Kong

Cheng, Y.S / A. Yatchew / C.K. Woo / K.H. Cao

Energy policy. 2017 Oct., v. 109

2017

Abstract: Motivated by the government's proposed target of reducing CO2 emissions by 30% of the 2005 level in the year 2020, we estimate the residential willingness-to-pay (WTP) for deep decarbonization of Hong Kong's electricity supply, which is heavily dependent ...

Abstract	Motivated by the government's proposed target of reducing CO2 emissions by 30% of the 2005 level in the year 2020, we estimate the residential willingness-to-pay (WTP) for deep decarbonization of Hong Kong's electricity supply, which is heavily dependent on coal-fired generation. Our contingent valuation survey conducted in 2016 of 1460 households yields dichotomous choice data based on the respondents’ answers to a series of closed-ended questions. Such data are less susceptible to the strategic bias that often plagues self-stated WTP data obtained by direct elicitation via open-ended questions. Using binary choice models, we find that average WTP is 48–51%, relative to current bills, if the decarbonization target is achieved via natural gas generation and renewable energy. However, estimated WTP declines to 32–42% when decarbonization entails additional nuclear imports from China. As the projected bill increase caused by the target's implementation is 40%, our WTP estimates support the government's fuel mix policy of using natural gas and renewable energy to displace Hong Kong's coal generation.
Keywords	carbon dioxide ; coal ; contingent valuation ; electricity ; greenhouse gas emissions ; households ; issues and policy ; models ; natural gas ; renewable energy sources ; surveys ; willingness to pay ; China
Language	English
Dates of publication	2017-10
Size	p. 218-227.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0301-4215
DOI	10.1016/j.enpol.2017.07.006
Database	NAL-Catalogue (AGRICOLA)

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Article: Response of Microcystis and Stephanodiscus to Alternative Flow Regimes of the Regulated River Nakdong (South Korea) Quantified By Model Ensembles Based on the Hybrid Evolutionary Algorithm (HEA)

Recknagel, F / D.âK. Kim / G.âJ. Joo / H. Cao

River research and applications. 2017 July, v. 33, no. 6

2017

Abstract: This study demonstrates the use of inferential models for scenario analyses by simulating direct and indirect effects of predictor variables on state variables through model ensembles. Two model ensembles have been designed to predict the response of the ...

Abstract	This study demonstrates the use of inferential models for scenario analyses by simulating direct and indirect effects of predictor variables on state variables through model ensembles. Two model ensembles have been designed to predict the response of the cyanobacterium Microcystis aeruginosa and the diatom Stephanodiscus hantzschii to modified flow regimes of the River Nakdong (Korea) by a scenario analysis. Whilst flowâindependent predictor variables of growth of Microcystis and Stephanodiscus such as water temperature and pH remain unchanged during the scenario analysis, flowâdependent predictor variables such as turbidity, electrical conductivity, phosphate, nitrate, silica and chlorophyll a are forecasted by inferential models. In the course of scenario analysis, flowâindependent and flowâdependent predictor variables feed into the Microcystis and Stephanodiscus models to make sure that both direct and indirect effects of altered flow regimes are taken into account. The eight inferential models that were incorporated into the model ensembles have been developed by the hybrid evolutionary algorithm based on 19Â years of timeâseries monitored in the River Nakdong between 1993 and 2012. The models achieved good accuracy in terms of timing and magnitudes reflected by coefficients of determination rÂ²Â =Â 0.94 for Microcystis and rÂ²Â =Â 0.83 for Stephanodiscus. The scenario analysis revealed that extreme summer blooms of Microcystis as observed between 1994 and 1997, and winter blooms of Stephanodiscus as observed between 1994 and 1997 and in 2004 can be prevented in the River Nakdong by adaptive management of seasonal water release from adjacent dams. Copyright Â© 2017 John Wiley & Sons, Ltd.
Keywords	Bacillariophyceae ; Microcystis aeruginosa ; Stephanodiscus ; adaptive management ; algorithms ; chlorophyll ; electrical conductivity ; models ; nitrates ; pH ; phosphates ; rivers ; silica ; summer ; time series analysis ; turbidity ; water temperature ; winter ; South Korea
Language	English
Dates of publication	2017-07
Size	p. 949-958.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2072626-0
ISSN	1535-1459
ISSN	1535-1459
DOI	10.1002/rra.3141
Database	NAL-Catalogue (AGRICOLA)

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