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  1. AU="H.Middleton, "
  2. AU="Buskulic, D."
  3. AU=Root William B
  4. AU="Nurkeeva, Z S"
  5. AU="Jamey R. Guess"
  6. AU="Tandogan, Tamer"
  7. AU="Elisa S. Gallo"
  8. AU="Zhong, Luer"
  9. AU=Srivastava Shalabh
  10. AU="Shah, Neil"
  11. AU="Kong, Pingping"
  12. AU="Kakiuchi, Nobuyuki"
  13. AU=Ojelade Moriam
  14. AU="Gibson, D"
  15. AU="Hsu, Yi-Fan"
  16. AU="Tamoni, Alessandro"
  17. AU=Alexander Michael J
  18. AU="Mosazghi, Asmerom"

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  1. Artikel ; Online: Remarkable Resilience of Forest Structure and Biodiversity Following Fire in the Peri-Urban Bushland of Sydney, Australia

    Elise Pendall / Alison Hewitt / Matthias M. Boer / Yolima Carrillo / Nancy F. Glenn / Anne Griebel / Jason H. Middleton / Peter J. Mumford / Peter Ridgeway / Paul D. Rymer / Greg L. Steenbeeke

    Climate, Vol 10, Iss 86, p

    2022  Band 86

    Abstract: In rapidly urbanizing areas, natural vegetation becomes fragmented, making conservation planning challenging, particularly as climate change accelerates fire risk. We studied urban forest fragments in two threatened eucalypt-dominated (scribbly gum ... ...

    Abstract In rapidly urbanizing areas, natural vegetation becomes fragmented, making conservation planning challenging, particularly as climate change accelerates fire risk. We studied urban forest fragments in two threatened eucalypt-dominated (scribbly gum woodland, SGW, and ironbark forest, IF) communities across ~2000 ha near Sydney, Australia, to evaluate effects of fire frequency (0–4 in last 25 years) and time since fire (0.5 to >25 years) on canopy structure, habitat quality and biodiversity (e.g., species richness). Airborne lidar was used to assess canopy height and density, and ground-based surveys of 148 (400 m 2 ) plots measured leaf area index (LAI), plant species composition and habitat metrics such as litter cover and hollow-bearing trees. LAI, canopy density, litter, and microbiotic soil crust increased with time since fire in both communities, while tree and mistletoe cover increased in IF. Unexpectedly, plant species richness increased with fire frequency, owing to increased shrub richness which offset decreased tree richness in both communities. These findings indicate biodiversity and canopy structure are generally resilient to a range of times since fire and fire frequencies across this study area. Nevertheless, reduced arboreal habitat quality and subtle shifts in community composition of resprouters and obligate seeders signal early concern for a scenario of increasing fire frequency under climate change. Ongoing assessment of fire responses is needed to ensure that biodiversity, canopy structure and ecosystem function are maintained in the remaining fragments of urban forests under future climate change which will likely drive hotter and more frequent fires.
    Schlagwörter Cumberland Plain ; disturbance ; Eucalyptus ; fire regime ; habitat ; leaf area index ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A slow axon antidromic blockade hypothesis for tremor reduction via deep brain stimulation.

    Míriam R García / Barak A Pearlmutter / Peter E Wellstead / Richard H Middleton

    PLoS ONE, Vol 8, Iss 9, p e

    2013  Band 73456

    Abstract: Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via ... ...

    Abstract Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena, and makes a variety of novel predictions.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Extreme coastal erosion enhanced by anomalous extratropical storm wave direction

    Mitchell D. Harley / Ian L. Turner / Michael A. Kinsela / Jason H. Middleton / Peter J. Mumford / Kristen D. Splinter / Matthew S. Phillips / Joshua A. Simmons / David J. Hanslow / Andrew D. Short

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Band 9

    Abstract: Abstract Extratropical cyclones (ETCs) are the primary driver of large-scale episodic beach erosion along coastlines in temperate regions. However, key drivers of the magnitude and regional variability in rapid morphological changes caused by ETCs at the ...

    Abstract Abstract Extratropical cyclones (ETCs) are the primary driver of large-scale episodic beach erosion along coastlines in temperate regions. However, key drivers of the magnitude and regional variability in rapid morphological changes caused by ETCs at the coast remain poorly understood. Here we analyze an unprecedented dataset of high-resolution regional-scale morphological response to an ETC that impacted southeast Australia, and evaluate the new observations within the context of an existing long-term coastal monitoring program. This ETC was characterized by moderate intensity (for this regional setting) deepwater wave heights, but an anomalous wave direction approximately 45 degrees more counter-clockwise than average. The magnitude of measured beach volume change was the largest in four decades at the long-term monitoring site and, at the regional scale, commensurate with that observed due to extreme North Atlantic hurricanes. Spatial variability in morphological response across the study region was predominantly controlled by alongshore gradients in storm wave energy flux and local coastline alignment relative to storm wave direction. We attribute the severity of coastal erosion observed due to this ETC primarily to its anomalous wave direction, and call for greater research on the impacts of changing storm wave directionality in addition to projected future changes in wave heights.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 535
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Cumulative signal transmission in nonlinear reaction-diffusion networks.

    Diego A Oyarzún / Fernando López-Caamal / Míriam R García / Richard H Middleton / Andrea Y Weiße

    PLoS ONE, Vol 8, Iss 5, p e

    2013  Band 62834

    Abstract: Quantifying signal transmission in biochemical systems is key to uncover the mechanisms that cells use to control their responses to environmental stimuli. In this work we use the time-integral of chemical species as a measure of a network's ability to ... ...

    Abstract Quantifying signal transmission in biochemical systems is key to uncover the mechanisms that cells use to control their responses to environmental stimuli. In this work we use the time-integral of chemical species as a measure of a network's ability to cumulatively transmit signals encoded in spatiotemporal concentrations. We identify a class of nonlinear reaction-diffusion networks in which the time-integrals of some species can be computed analytically. The derived time-integrals do not require knowledge of the solution of the reaction-diffusion equation, and we provide a simple graphical test to check if a given network belongs to the proposed class. The formulae for the time-integrals reveal how the kinetic parameters shape signal transmission in a network under spatiotemporal stimuli. We use these to show that a canonical complex-formation mechanism behaves as a spatial low-pass filter, the bandwidth of which is inversely proportional to the diffusion length of the ligand.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 515
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Serum autoantibody measurement for the detection of hepatocellular carcinoma.

    Catrin H Middleton / William Irving / John F R Robertson / Andrea Murray / Celine B Parsy-Kowalska / Isabel K Macdonald / Jane McElveen / Jared Allen / Graham F Healey / Brian J Thomson / Stephen J Ryder / Stefan Holdenrieder / Caroline J Chapman

    PLoS ONE, Vol 9, Iss 8, p e

    2014  Band 103867

    Abstract: BACKGROUND: Individuals with liver disease, and especially those with Hepatitis B or C, are at an increased risk of developing hepatocellular carcinoma (HCC) which is the third most common cause of cancer-related death worldwide. Inadequate screening ... ...

    Abstract BACKGROUND: Individuals with liver disease, and especially those with Hepatitis B or C, are at an increased risk of developing hepatocellular carcinoma (HCC) which is the third most common cause of cancer-related death worldwide. Inadequate screening tests largely account for presentation of advanced tumours and high mortality rates. Early detection of HCC amongst high-risk groups is paramount in improving prognosis. This research aimed to further characterise the previously described humoral immune response raised to tumour-associated antigens (TAAs) in the serum of patients with HCC. METHODS: Serum from 96 patients with confirmed HCC, 96 healthy controls matched for age and sex, 78 patients with confirmed liver cirrhosis and 91 patients with confirmed chronic liver disease were analysed for the presence of IgG autoantibodies raised to 41 recombinant TAAs/antigen fragments by ELISA. RESULTS: Varying autoantibody specificities (97-100%) and sensitivities (0-10%) were observed to individual TAAs. A 21-antigen panel achieved a specificity of 92% and sensitivity of 45% for the detection of HCC. This same panel identified 21% of 169 high-risk controls as having elevated autoantibody levels. A reproducible panel of 10 antigens achieved a specificity of 91% and sensitivity of 41% in HCC. 15% of 152 high-risk controls gave positive results with this panel. CONCLUSIONS: This minimally invasive blood test has the potential to offer advantages over currently available tools for the identification of HCC amongst pre-disposed patients. Results are comparable to current gold standards in HCC (Ultrasonography) and to similar tests in other cancers (EarlyCDT-Lung).
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Bay sedimentation as controlled by regional crustal behaviour, local tectonics and eustatic sea-level changes

    J. P. Le Roux / D. M. Olivares / S. N. Nielsen / N. D. Smith / H. Middleton / J. Fenner / S. E. Ishman

    Sedimentary Geology

    Coquimbo Formation (Miocene–Pliocene), Bay of Tongoy, central Chile

    2006  

    Erscheinungsland de
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  7. Artikel: Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift During the LIGO-Virgo Run O3a

    Collaboration, The LIGO Scientific / R.Abbott, the Virgo Collaboration / T.D.Abbott, / S.Abraham, / F.Acernese, / K.Ackley, / C.Adams, / R.X.Adhikari, / V.B.Adya, / C.Affeldt, / M.Agathos, / K.Agatsuma, / N.Aggarwal, / O.D.Aguiar, / A.Aich, / L.Aiello, / A.Ain, / P.Ajith, / G.Allen, /
    A.Allocca, / P.A.Altin, / A.Amato, / S.Anand, / A.Ananyeva, / S.B.Anderson, / W.G.Anderson, / S.V.Angelova, / S.Ansoldi, / S.Antier, / S.Appert, / K.Arai, / M.C.Araya, / J.S.Areeda, / M.Arene, / N.Arnaud, / S.M.Aronson, / Y.Asali, / S.Ascenzi, / G.Ashton, / M.Assiduo, / S.M.Aston, / P.Astone, / F.Aubin, / P.Aufmuth, / K.AultONeal, / C.Austin, / V.Avendano, / S.Babak, / P.Bacon, / F.Badaracco, / M.K.M.Bader, / S.Bae, / A.M.Baer, / J.Baird, / F.Baldaccini, / G.Ballardin, / S.W.Ballmer, / A.Bals, / A.Balsamo, / G.Baltus, / S.Banagiri, / D.Bankar, / R.S.Bankar, / J.C.Barayoga, / C.Barbieri, / B.C.Barish, / D.Barker, / K.Barkett, / P.Barneo, / F.Barone, / B.Barr, / L.Barsotti, / M.Barsuglia, / D.Barta, / J.Bartlett, / I.Bartos, / R.Bassiri, / A.Basti, / M.Bawaj, / J.C.Bayley, / M.Bazzan, / B.B'ecsy, / M.Bejger, / I.Belahcene, / A.S.Bell, / D.Beniwal, / M.G.Benjamin, / J.D.Bentley, / F.Bergamin, / B.K.Berger, / G.Bergmann, / S.Bernuzzi, / C.P.L.Berry, / D.Bersanetti, / A.Bertolini, / J.Betzwieser, / R.Bhandare, / A.V.Bhandari, / A.Bianchi, / J.Bidler, / E.Biggs, / I.A.Bilenko, / G.Billingsley, / R.Birney, / O.Birnholtz, / S.Biscans, / M.Bischi, / S.Biscoveanu, / A.Bisht, / G.Bissenbayeva, / M.Bitossi, / M.A.Bizouard, / J.K.Blackburn, / J.Blackman, / C.D.Blair, / D.G.Blair, / R.M.Blair, / F.Bobba, / N.Bode, / M.Boer, / Y.Boetzel, / G.Bogaert, / F.Bondu, / E.Bonilla, / R.Bonnand, / P.Booker, / B.A.Boom, / R.Bork, / V.Boschi, / S.Bose, / V.Bossilkov, / J.Bosveld, / Y.Bouffanais, / A.Bozzi, / C.Bradaschia, / P.R.Brady, / A.Bramley, / M.Branchesi, / J.E.Brau, / M.Breschi, / T.Briant, / J.H.Briggs, / F.Brighenti, / A.Brillet, / M.Brinkmann, / P.Brockill, / A.F.Brooks, / J.Brooks, / D.D.Brown, / S.Brunett, / G.Bruno, / R.Bruntz, / A.Buikema, / T.Bulik, / H.J.Bulten, / A.Buonanno, / D.Buskulic, / R.L.Byer, / M.Cabero, / L.Cadonati, / G.Cagnoli, / C.Cahillane, / Bustillo, J.Calder'on / J.D.Callaghan, / T.A.Callister, / E.Calloni, / J.B.Camp, / M.Canepa, / Santoro, G.Caneva / K.C.Cannon, / H.Cao, / J.Cao, / G.Carapella, / F.Carbognani, / S.Caride, / M.F.Carney, / G.Carullo, / T.L.Carver, / Diaz, J.Casanueva / C.Casentini, / J.Castaneda, / S.Caudill, / M.Cavaglia, / F.Cavalier, / R.Cavalieri, / G.Cella, / P.Cerd'a-Dur'an, / E.Cesarini, / O.Chaibi, / K.Chakravarti, / C.Chan, / M.Chan, / S.Chao, / P.Charlton, / E.A.Chase, / E.Chassande-Mottin, / D.Chatterjee, / M.Chaturvedi, / H.Y.Chen, / X.Chen, / Y.Chen, / H.-P.Cheng, / C.K.Cheong, / H.Y.Chia, / F.Chiadini, / R.Chierici, / A.Chincarini, / A.Chiummo, / G.Cho, / H.S.Cho, / M.Cho, / N.Christensen, / Q.Chu, / S.Chua, / K.W.Chung, / S.Chung, / G.Ciani, / P.Ciecielag, / M.Cie'slar, / A.A.Ciobanu, / R.Ciolfi, / F.Cipriano, / A.Cirone, / F.Clara, / J.A.Clark, / P.Clearwater, / S.Clesse, / F.Cleva, / E.Coccia, / P.-F.Cohadon, / D.Cohen, / M.Colleoni, / C.G.Collette, / C.Collins, / M.Colpi, / M.Constancio, / L.Conti, / S.J.Cooper, / P.Corban, / T.R.Corbitt, / I.Cordero-Carri'on, / S.Corezzi, / K.R.Corley, / N.Cornish, / D.Corre, / A.Corsi, / S.Cortese, / C.A.Costa, / R.Cotesta, / M.W.Coughlin, / S.B.Coughlin, / J.-P.Coulon, / S.T.Countryman, / P.Couvares, / P.B.Covas, / D.M.Coward, / M.J.Cowart, / D.C.Coyne, / R.Coyne, / J.D.E.Creighton, / T.D.Creighton, / J.Cripe, / M.Croquette, / S.G.Crowder, / J.-R.Cudell, / T.J.Cullen, / A.Cumming, / R.Cummings, / L.Cunningham, / E.Cuoco, / M.Curylo, / Canton, T.Dal / G.D'alya, / A.Dana, / L.M.Daneshgaran-Bajastani, / B.D'Angelo, / S.L.Danilishin, / S.D'Antonio, / K.Danzmann, / C.Darsow-Fromm, / A.Dasgupta, / L.E.H.Datrier, / V.Dattilo, / I.Dave, / M.Davier, / G.S.Davies, / D.Davis, / E.J.Daw, / D.DeBra, / M.Deenadayalan, / J.Degallaix, / Laurentis, M.De / S.Del'eglise, / M.Delfavero, / Lillo, N.De / Pozzo, W.Del / L.M.DeMarchi, / V.D'Emilio, / N.Demos, / T.Dent, / Pietri, R.De / Rosa, R.De / Rossi, C.De / R.DeSalvo, / Varona, O.de / S.Dhurandhar, / M.C.D'iaz, / M.Diaz-Ortiz, / T.Dietrich, / Fiore, L.Di / Fronzo, C.Di / Giorgio, C.Di / Giovanni, F.Di / Giovanni, M.Di / Girolamo, T.Di / Lieto, A.Di / B.Ding, / Pace, S.Di / Palma, I.Di / Renzo, F.Di / A.K.Divakarla, / A.Dmitriev, / Z.Doctor, / F.Donovan, / K.L.Dooley, / S.Doravari, / I.Dorrington, / T.P.Downes, / M.Drago, / J.C.Driggers, / Z.Du, / J.-G.Ducoin, / P.Dupej, / O.Durante, / D.D'Urso, / S.E.Dwyer, / P.J.Easter, / G.Eddolls, / B.Edelman, / T.B.Edo, / O.Edy, / A.Effler, / P.Ehrens, / J.Eichholz, / S.S.Eikenberry, / M.Eisenmann, / R.A.Eisenstein, / A.Ejlli, / L.Errico, / R.C.Essick, / H.Estelles, / D.Estevez, / Z.B.Etienne, / T.Etzel, / M.Evans, / T.M.Evans, / B.E.Ewing, / V.Fafone, / S.Fairhurst, / X.Fan, / S.Farinon, / B.Farr, / W.M.Farr, / E.J.Fauchon-Jones, / M.Favata, / M.Fays, / M.Fazio, / J.Feicht, / M.M.Fejer, / F.Feng, / E.Fenyvesi, / D.L.Ferguson, / A.Fernandez-Galiana, / I.Ferrante, / E.C.Ferreira, / T.A.Ferreira, / F.Fidecaro, / I.Fiori, / D.Fiorucci, / M.Fishbach, / R.P.Fisher, / R.Fittipaldi, / M.Fitz-Axen, / V.Fiumara, / R.Flaminio, / E.Floden, / E.Flynn, / H.Fong, / J.A.Font, / P.W.F.Forsyth, / J.-D.Fournier, / S.Frasca, / F.Frasconi, / Z.Frei, / A.Freise, / R.Frey, / V.Frey, / P.Fritschel, / V.V.Frolov, / G.Fronze, / P.Fulda, / M.Fyffe, / H.A.Gabbard, / B.U.Gadre, / S.M.Gaebel, / J.R.Gair, / S.Galaudage, / D.Ganapathy, / S.G.Gaonkar, / C.Garc'ia-Quir'os, / F.Garufi, / B.Gateley, / S.Gaudio, / V.Gayathri, / G.Gemme, / E.Genin, / A.Gennai, / D.George, / J.George, / L.Gergely, / S.Ghonge, / Ghosh, Abhirup / Ghosh, Archisman / S.Ghosh, / B.Giacomazzo, / J.A.Giaime, / K.D.Giardina, / D.R.Gibson, / C.Gier, / K.Gill, / J.Glanzer, / J.Gniesmer, / P.Godwin, / E.Goetz, / R.Goetz, / N.Gohlke, / B.Goncharov, / G.Gonz'alez, / A.Gopakumar, / S.E.Gossan, / M.Gosselin, / R.Gouaty, / B.Grace, / A.Grado, / M.Granata, / A.Grant, / S.Gras, / P.Grassia, / C.Gray, / R.Gray, / G.Greco, / A.C.Green, / R.Green, / E.M.Gretarsson, / H.L.Griggs, / G.Grignani, / A.Grimaldi, / S.J.Grimm, / H.Grote, / S.Grunewald, / P.Gruning, / G.M.Guidi, / A.R.Guimaraes, / 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    Abstract: We search for gravitational-wave transients associated with gamma-ray bursts detected by the Fermi and Swift satellites during the first part of the third observing run of Advanced LIGO and Advanced Virgo (1 April 2019 15:00 UTC - 1 October 2019 15:00 ... ...

    Abstract We search for gravitational-wave transients associated with gamma-ray bursts detected by the Fermi and Swift satellites during the first part of the third observing run of Advanced LIGO and Advanced Virgo (1 April 2019 15:00 UTC - 1 October 2019 15:00 UTC). 105 gamma-ray bursts were analyzed using a search for generic gravitational-wave transients; 32 gamma-ray bursts were analyzed with a search that specifically targets neutron star binary mergers as short gamma-ray burst progenitors. We describe a method to calculate the probability that triggers from the binary merger targeted search are astrophysical and apply that method to the most significant gamma-ray bursts in that search. We find no significant evidence for gravitational-wave signals associated with the gamma-ray bursts that we followed up, nor for a population of unidentified subthreshold signals. We consider several source types and signal morphologies, and report for these lower bounds on the distance to each gamma-ray burst.
    Schlagwörter covid19
    Verlag ArXiv
    Dokumenttyp Artikel
    Datenquelle COVID19

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