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  1. Article ; Online: The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits?

    Ha, Christina

    The American journal of gastroenterology

    2021  Volume 116, Issue 4, Page(s) 671–672

    Abstract: This editorial comments on the study by Khan et al. that describes potential risk of acute myeloid leukemia or myeloproliferative disorder among thiopurine therapy. ...

    Abstract This editorial comments on the study by Khan et al. that describes potential risk of acute myeloid leukemia or myeloproliferative disorder among thiopurine therapy.
    MeSH term(s) Azathioprine/adverse effects ; Humans ; Incidence ; Inflammatory Bowel Diseases ; Leukemia, Myeloid, Acute/drug therapy ; Myelodysplastic Syndromes
    Chemical Substances Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001199
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  2. Article ; Online: Evidence-Based Approach to the Management of Mild Crohn's Disease.

    Elmasry, Sandra / Ha, Christina

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 22, Issue 3, Page(s) 480–483

    MeSH term(s) Humans ; Crohn Disease/therapy ; Crohn Disease/drug therapy ; Glucocorticoids/therapeutic use ; Gastrointestinal Agents/therapeutic use
    Chemical Substances Glucocorticoids ; Gastrointestinal Agents
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.11.011
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  3. Article ; Online: A large-scale causal analysis of gut microbiota and endometriosis associated infertility: A Mendelian randomization study.

    Wang, Yan / Li, Wangshu / Ha, Chunfang

    Medicine

    2024  Volume 103, Issue 12, Page(s) e37383

    Abstract: Endometriosis is a prevalent condition with notable impacts on fertility. Recent studies have implicated gut microbiota in the development of endometriosis associated infertility (EAI). This study employs Mendelian randomization (MR) to elucidate the ... ...

    Abstract Endometriosis is a prevalent condition with notable impacts on fertility. Recent studies have implicated gut microbiota in the development of endometriosis associated infertility (EAI). This study employs Mendelian randomization (MR) to elucidate the causal relationship between specific gut microbes and EAI. Using MR, we selected single nucleotide polymorphisms associated with 211 gut microbiota taxa from large-scale genome-wide association studies summary data. We applied statistical methods including inverse variance weighting, weighted median, and MR-Egger for analysis. Outliers were identified through the leave-one-out method. MR-Egger intercept tests were conducted to address horizontal pleiotropy, while Cochran Q and P values assessed heterogeneity. The false discovery rate method was used for multiple testing correction. Sensitivity analysis and F statistics evaluated the reliability and potential biases of our results. The inverse variance weighting method indicated a significant association of the genus Actinomyces (OR = 1.657, 95% CI: 1.187-2.312, P = .00298) with an increased risk of EAI. Conversely, genera Holdemania (OR = 0.630, 95% CI: 0.444-0.894, P = .00969) and Ruminococcaceae NK4A214 group (OR = 0.689, 95% CI: 0.481-0.999, P = .0439) appeared as protective factors. MR-PRESSO global test and MR-Egger regression indicated no significant horizontal pleiotropy (P > .05). Leave-one-out analysis confirmed the robustness of these findings. Our study provides evidence of a causal relationship between specific gut microbiome taxa and EAI. These findings offer novel insights and may guide the development of new preventive and therapeutic strategies for managing EAI.
    MeSH term(s) Female ; Humans ; Gastrointestinal Microbiome/genetics ; Endometriosis/complications ; Endometriosis/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Reproducibility of Results ; Infertility
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037383
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  4. Article ; Online: A novel approach to spinal anaesthesia to avoid aerosol-generating procedures in a patient with COVID-19 presenting for laser prostate surgery.

    Oon, Z / Ha, C

    Anaesthesia reports

    2020  Volume 8, Issue 2, Page(s) e12065

    Abstract: General anaesthesia involves aerosol-generating procedures which, in the context of the coronavirus 2019 (COVID-19) pandemic, increases the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission from patients to staff. This ... ...

    Abstract General anaesthesia involves aerosol-generating procedures which, in the context of the coronavirus 2019 (COVID-19) pandemic, increases the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission from patients to staff. This risk can be minimised by performing spinal or regional anaesthesia instead of general anaesthesia where possible. We report the successful management of a patient utilising spinal anaesthesia in a patient with COVID-19 undergoing urgent holmium laser enucleation of prostate for symptomatic benign prostatic hyperplasia. A combination of bupivacaine, diamorphine and midazolam was administered intrathecally which provided adequate anaesthesia despite the prolonged surgical duration. Nebulised lidocaine was also given to prevent coughing during the procedure. This report demonstrates that it is possible and safe to use spinal anaesthesia to perform prolonged surgical procedures that are normally conducted under general anaesthesia using a combination of intrathecal adjuncts to facilitate effective block duration. In addition, the novel use of nebulised lidocaine for its antitussive effects in a patient with COVID-19 is highlighted.
    Keywords covid19
    Language English
    Publishing date 2020-10-16
    Publishing country England
    Document type Case Reports
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12065
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  5. Article ; Online: The effectiveness of lifestyle interventions on ecological literacy: A contribution to the underlying mechanism in linguistic ecology.

    Ha, Changchen / Chen, Yang / Zhang, Jiaen / Dong, Shumin

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287286

    Abstract: In today's society, citizens' ecological literacy (ecoliteracy) is critical for their understanding of sustainable development. This study used a questionnaire designed to quantitatively assess ecoliteracy from a linguistic ecology perspective. First, an ...

    Abstract In today's society, citizens' ecological literacy (ecoliteracy) is critical for their understanding of sustainable development. This study used a questionnaire designed to quantitatively assess ecoliteracy from a linguistic ecology perspective. First, an underlying mechanism model for ecoliteracy was designed based on the results of previous studies. Then, the ecoliteracy level assessment scores of Guiyang inhabitants were combined with the respondents' corresponding lifestyle characteristics to explore the effectiveness of interventions in affecting the participants' ecoliteracy levels. The results showed that the formation and development of ecoliteracy is a dynamic and circular process that revolves around variables of independent, dependent, mediating, moderating and control. The various factors in the model interact and operate evenly along a particular path. As for the level of lifestyle characteristics, participants' ecoliteracy levels had a statistically significant relationship with their attitudes regarding the importance of nature, participating in outdoor activities, and improving their ecoliteracy levels; as well as the frequencies regarding daily outdoor activity, the main activities in ecological areas, participation in volunteer activities, and use of ecological knowledge. The respondents with the highest levels of ecoliteracy had the most positive attitudes and engaged in ecological actions with the highest frequency. The lifestyle intervention features here are of great significance to the harmonious coexistence between humans and the natural environment and are also helpful for improving human health.
    MeSH term(s) Humans ; Literacy ; China ; Environment ; Life Style ; Linguistics
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287286
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  6. Article ; Online: Self-regulated learning strategies and academic achievement in South Korean 6th-graders: A two-level hierarchical linear modeling analysis.

    Ha, Cheyeon / Roehrig, Alysia D / Zhang, Qian

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284385

    Abstract: The aim of the study was to explain the relationships between self-regulated learning strategy use and academic achievement of 6th-grade students in South Korea. An existing database (i.e., the Korean Educational Longitudinal Study; KELS) with 6th-grade ... ...

    Abstract The aim of the study was to explain the relationships between self-regulated learning strategy use and academic achievement of 6th-grade students in South Korea. An existing database (i.e., the Korean Educational Longitudinal Study; KELS) with 6th-grade students (n = 7,065) from 446 schools was used to run a series of 2-level hierarchical linear models (HLM). This large dataset enabled us to consider how the relationship between learners' self-regulated learning strategy use and academic achievement may differ at individual and school levels. We found that students' metacognition and effort regulation positively predicted their literacy and math achievement both within and across schools. The average literacy and math achievement were significantly higher in private schools than in public schools. Also, the math achievement of urban schools was significantly higher than in non-urban schools when controlling other cognitive and behavioral learning strategies. This study on 6th-grade learners' self-regulated learning (SRL) on academic achievement explores how their SRL strategies may be different from the features of successful adult learners from the previous findings, offering new insights into the development of SRL in elementary education.
    MeSH term(s) Adult ; Humans ; Academic Success ; Longitudinal Studies ; Educational Status ; Schools ; Learning/physiology
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284385
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  7. Article ; Online: Facilitators and barriers to the transition from registered nurse to nurse practitioner in Canada.

    El Hussein, Mohamed Toufic / Ha, Calla

    Journal of the American Association of Nurse Practitioners

    2023  Volume 35, Issue 6, Page(s) 359–365

    Abstract: Background: Understanding factors that affect integration of NPs is likely to address barriers and provide reform strategies that shape a cost-effective, sustainable, accessible, and efficient health care system. There are a limited number of current ... ...

    Abstract Background: Understanding factors that affect integration of NPs is likely to address barriers and provide reform strategies that shape a cost-effective, sustainable, accessible, and efficient health care system. There are a limited number of current and high-quality studies examining the transition process of registered nurses (RNs) to nurse practitioners (NPs), especially in Canada.
    Purpose: To explore the experiences of RNs transitioning to NPs in Canada.
    Methodology: Thematic analysis of audio-recorded semi-structured interviews was conducted to explore the experiences of 17 RNs as they transitioned to NPs. A purposive sampling of 17 participants was completed in 2022.
    Results: Six main themes emerged from analysis of 17 interviews. The content of themes varied according to NPs' years of experience and the NP school they attended.
    Conclusions: Peer support and mentorship programs were facilitators in the transition from RN to NP. Conversely, shortcomings in education, financial stressors, and the lack of NP role definition were seen as barriers. Legislation and regulations supportive of NPs, diverse and comprehensive education, and improved availability of mentorship programs may strengthen transition facilitators and help NPs overcome related barriers.
    Implications: Legislation and regulations supportive of the NP role are needed, focusing on defining the NP role and establishing an independent and consistent remuneration structure for NPs. A more in-depth and diversified educational curriculum is needed, with increased support from faculty and educators and continual encouragement of initiation and perpetuation of peer support. A mentorship program is beneficial to reduce transition shock from the role of the RN to the NP.
    MeSH term(s) Humans ; Canada ; Delivery of Health Care ; Qualitative Research ; Curriculum ; Nurse Practitioners/education
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2716317-9
    ISSN 2327-6924 ; 1745-7599 ; 2327-6886 ; 1041-2972
    ISSN (online) 2327-6924 ; 1745-7599
    ISSN 2327-6886 ; 1041-2972
    DOI 10.1097/JXX.0000000000000868
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    Zs.A 2909: Show issues Location:
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  8. Article: Teaching during a Pandemic: United States Teachers' Self-Efficacy During COVID-19.

    Pressley, Tim / Ha, Cheyeon

    Teaching and teacher education

    2021  Volume 106, Page(s) 103465

    Abstract: The COVID-19 pandemic had significant implications on schools during 2020, with districts moving to all virtual instruction during the spring and facing the debate of how to return safely to school in the fall. With these decisions, teachers, schools, ... ...

    Abstract The COVID-19 pandemic had significant implications on schools during 2020, with districts moving to all virtual instruction during the spring and facing the debate of how to return safely to school in the fall. With these decisions, teachers, schools, and districts faced many challenges when providing face-to-face, hybrid, and virtual teaching. The purpose of this study was to explore how the new teaching approaches and requirements have impacted teachers' self-efficacy, specifically instructional and engagement efficacy. The current study included 361 participants from across the United States who completed the Teacher Sense of Efficacy Scale (TSES) subsections of instruction and engagement. The results found the average teacher self-efficacy scores for both instruction and engagement were lower than TSES scores of instruction and engagement in previous studies. The results also indicated teachers who are teaching virtually had the lowest efficacy scores compared to teachers teaching in a hybrid or all in-person model. However, the results suggested no difference in efficacy score based on years of teaching experience, teacher location, previous accolades, or instruction level.
    Language English
    Publishing date 2021-07-20
    Publishing country England
    Document type Journal Article
    ISSN 0742-051X
    ISSN 0742-051X
    DOI 10.1016/j.tate.2021.103465
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  9. Article ; Online: A novel approach to spinal anaesthesia to avoid aerosol‐generating procedures in a patient with COVID‐19 presenting for laser prostate surgery

    Oon, Z. / Ha, C.

    Anaesthesia Reports

    2020  Volume 8, Issue 2

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 2637-3726
    DOI 10.1002/anr3.12065
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: To Operate or Not to Operate in Inflammatory Bowel Disease: Is Older Age the Only Question?

    Ha, Christina

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2016  Volume 14, Issue 9, Page(s) 1282–1284

    MeSH term(s) Colitis, Ulcerative ; Crohn Disease ; Humans ; Inflammatory Bowel Diseases
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2016.04.027
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