Article ; Online: Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation.
2024 Volume 43, Issue 4, Page(s) 114062
Abstract: The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against ... ...
| Abstract | The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) patients and controls to investigate whether TCR diversity against varicella-zoster virus (VZV) influences the risk of HZ. We show that CD4 |
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| MeSH term(s) | Humans ; Herpes Zoster/immunology ; Herpes Zoster/virology ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell/immunology ; Lymphocyte Activation/immunology ; Herpesvirus 3, Human/immunology ; Female ; Middle Aged ; Male ; CD4-Positive T-Lymphocytes/immunology ; Aged ; Adult ; Epitopes, T-Lymphocyte/immunology |
| Chemical Substances | Receptors, Antigen, T-Cell ; Epitopes, T-Lymphocyte |
| Language | English |
| Publishing date | 2024-04-07 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2649101-1 |
| ISSN | 2211-1247 ; 2211-1247 |
| ISSN (online) | 2211-1247 |
| ISSN | 2211-1247 |
| DOI | 10.1016/j.celrep.2024.114062 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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