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  1. AU="Haack, Beatrice"
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  1. Article ; Online: Edema related to treatment with psychotropic drugs.

    Engel, Johanna / Haack, Beatrice / Zolk, Oliver / Greiner, Timo / Heinze, Martin / Toto, Sermin / Seifert, Johanna / Bleich, Stefan / Glocker, Catherine / Grohmann, Renate / Schneider, Michael / Stübner, Susanne

    Journal of neural transmission (Vienna, Austria : 1996)

    2024  Volume 131, Issue 3, Page(s) 253–266

    Abstract: Edema as an adverse drug reaction is a commonly underestimated yet potentially debilitating condition. This study analyzes the incidence of severe psychotropic drug-induced edema (e.g., edema affecting the face, legs, or multiple body parts and lasting ... ...

    Abstract Edema as an adverse drug reaction is a commonly underestimated yet potentially debilitating condition. This study analyzes the incidence of severe psychotropic drug-induced edema (e.g., edema affecting the face, legs, or multiple body parts and lasting for more than 1 week, or in any case necessitating subsequent diuretic use) among psychiatric inpatients. The cases under examination are derived from an observational pharmacovigilance program conducted in German-speaking countries ("Arzneimittelsicherheit in der Psychiatrie", AMSP) from 1993 to 2016. Among the 462,661 inpatients monitored, severe edema was reported in 231 cases, resulting in an incidence of 0.05%. Edema occurred more frequently in women (80% of all cases) and older patients (mean age 51.8 years). Pregabalin had the highest incidence of severe edema, affecting 1.46‰ of patients treated with pregabalin, followed by mirtazapine (0.8‰). The majority of edema cases showed a positive response to appropriate countermeasures, such as dose reduction and drug discontinuation, and resolved by the end of the observation period. While most instances of drug-induced edema are reversible, they can have a significant impact on patient well-being and potentially result in decreased treatment adherence. It is, therefore, crucial to remain vigilant regarding risk-increasing circumstances during treatment with psychotropic drugs.
    MeSH term(s) Female ; Humans ; Middle Aged ; Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions ; Edema/chemically induced ; Edema/epidemiology ; Edema/drug therapy ; Pregabalin ; Psychotropic Drugs/adverse effects ; Pharmacovigilance
    Chemical Substances Pregabalin (55JG375S6M) ; Psychotropic Drugs
    Language English
    Publishing date 2024-02-14
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-024-02738-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.150: Show issues Location:
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  2. Article ; Online: Pharmacotherapy of psychiatric inpatients with adjustment disorder: current status and changes between 2000 and 2016.

    Greiner, Timo / Haack, Beatrice / Toto, Sermin / Bleich, Stefan / Grohmann, Renate / Faltraco, Frank / Heinze, Martin / Schneider, Michael

    European archives of psychiatry and clinical neuroscience

    2019  Volume 270, Issue 1, Page(s) 107–117

    Abstract: Adjustment disorder is a temporary change in behaviour or emotion as a reaction to a stress factor. Therapy consists of psychotherapy, and pharmacotherapy can be advised. However, data on the real-life pharmacological treatment are sparse. Prescription ... ...

    Abstract Adjustment disorder is a temporary change in behaviour or emotion as a reaction to a stress factor. Therapy consists of psychotherapy, and pharmacotherapy can be advised. However, data on the real-life pharmacological treatment are sparse. Prescription data for 4.235 psychiatric inpatients diagnosed with adjustment disorder in the time period 2000-2016 were analysed. The data were obtained from the Drug Safety Programme in Psychiatry (AMSP). Data were collected on two reference days per year; prescription patterns and changes over time were analysed. Of all patients, 81.2% received some type of psychotropic drug. Mostly antidepressants (59.8%), antipsychotics (35.5%), and tranquilisers (22.6%) were prescribed. Prescription rates for antidepressants decreased slightly over the years, while rates for antipsychotics increased, especially for atypical antipsychotics. It is important to note that the diagnosis "adjustment disorder" is most likely a working diagnosis that is used for patients in immediate need of psychiatric aid. Overall, pharmacotherapy for inpatients with this diagnosis is mostly symptom-oriented and focuses on depressive moods, agitation and anxiety. Therapy regimes changed over time and show an increased use of atypical antipsychotics with sedative properties. However, for most of the medication, there are neither evidence-based studies nor guidelines, and drugs might be contraindicated in some cases.
    MeSH term(s) Adjustment Disorders/drug therapy ; Adjustment Disorders/epidemiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antidepressive Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Austria/epidemiology ; Comorbidity ; Drug Monitoring/statistics & numerical data ; Drug Prescriptions/statistics & numerical data ; Female ; Germany/epidemiology ; Humans ; Inpatients/statistics & numerical data ; Male ; Mental Disorders/epidemiology ; Middle Aged ; Practice Patterns, Physicians'/statistics & numerical data ; Practice Patterns, Physicians'/trends ; Psychotropic Drugs/therapeutic use ; Switzerland/epidemiology ; Tranquilizing Agents/therapeutic use ; Young Adult
    Chemical Substances Antidepressive Agents ; Antipsychotic Agents ; Psychotropic Drugs ; Tranquilizing Agents
    Language English
    Publishing date 2019-08-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-019-01058-1
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    In stock of ZB MED Cologne/Königswinter

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  3. Conference proceedings: Pharmacotherapy of psychiatric inpatients with adjustment disorder – current status and changes between 2000 and 2016

    Greiner, Timo / Haack, Beatrice / Toto, Sermin / Bleich, Stefan / Grohmann, Renate / Heinze, Martin / Schneider, Michael

    2019  , Page(s) 19gaa09

    Event/congress 26. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie; Bonn/Bad Godesberg; Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA); 2019
    Keywords Medizin, Gesundheit
    Publishing date 2019-11-19
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19gaa09
    Database German Medical Science

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  4. Article ; Online: Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice.

    Karikari, Akua A / McFleder, Rhonda L / Ribechini, Eliana / Blum, Robert / Bruttel, Valentin / Knorr, Susanne / Gehmeyr, Mona / Volkmann, Jens / Brotchie, Jonathan M / Ahsan, Fadhil / Haack, Beatrice / Monoranu, Camelia-Maria / Keber, Ursula / Yeghiazaryan, Rima / Pagenstecher, Axel / Heckel, Tobias / Bischler, Thorsten / Wischhusen, Jörg / Koprich, James B /
    Lutz, Manfred B / Ip, Chi Wang

    Brain, behavior, and immunity

    2022  Volume 101, Page(s) 194–210

    Abstract: Background: Antigen-specific neuroinflammation and neurodegeneration are characteristic for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is a known culprit. Evidence for α-synuclein-specific T cell responses was ... ...

    Abstract Background: Antigen-specific neuroinflammation and neurodegeneration are characteristic for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is a known culprit. Evidence for α-synuclein-specific T cell responses was recently obtained in PD. Still, a causative link between these α-synuclein responses and dopaminergic neurodegeneration had been lacking. We thus addressed the functional relevance of α-synuclein-specific immune responses in PD in a mouse model.
    Methods: We utilized a mouse model of PD in which an Adeno-associated Vector 1/2 serotype (AAV1/2) expressing human mutated A53T-α-Synuclein was stereotactically injected into the substantia nigra (SN) of either wildtype C57BL/6 or Recombination-activating gene 1 (RAG1)
    Results: AAV-based overexpression of pathogenic human A53T-α-synuclein in dopaminergic neurons of the SN stimulated T cell infiltration. RNA-sequencing of immune cells from PD mouse brains confirmed a pro-inflammatory gene profile. T cell responses were directed against A53T-α-synuclein-peptides in the vicinity of position 53 (68-78) and surrounding the pathogenically relevant S129 (120-134). T cells were required for α-synuclein-induced neurodegeneration in vivo and in vitro, while B cell deficiency did not protect from dopaminergic neurodegeneration.
    Conclusions: Using T cell and/or B cell deficient mice and a newly developed A53T-α-synuclein-expressing neuronal cell culture/immune cell assay, we confirmed in vivo and in vitro that pathogenic α-synuclein peptide-specific T cell responses can cause dopaminergic neurodegeneration and thereby contribute to PD-like pathology.
    MeSH term(s) Animals ; Disease Models, Animal ; Dopamine ; Dopaminergic Neurons/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Parkinson Disease/pathology ; RNA ; Substantia Nigra/metabolism ; T-Lymphocytes/metabolism ; alpha-Synuclein/metabolism
    Chemical Substances alpha-Synuclein ; RNA (63231-63-0) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-01-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2022.01.007
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    Zs.A 2276: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 327: Show issues

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  5. Book ; Thesis: Der Einfluss von hochmolekularem Natriumhyaluronat auf die Kollagenfibrillendurchmesser der gesunden, tiefen Beugesehne des Pferdes

    Haack, Beatrice

    1992  

    Title translation The influence of high-molecular weight sodium hyaluronate on the diameter of collagen fibrils of the horses' healthy deep flexor tendons.
    Author's details vorgelegt von Beatrice Haack
    Keywords veterinary medicine ; animal health ; animal physiology
    Language German
    Size 78 p. :, ill. ;, 21 cm.
    Publisher s.n.
    Publishing place Hannover
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Thesis (doctoral)--Tierärztliche Hochschule Hannover, 1992
    Note Summary in English.
    Database NAL-Catalogue (AGRICOLA)

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  6. Book ; Thesis: Der Einfluβ von hochmolekularem Natriumhyaluronat auf die Kollagenfibrillendurchmesser der gesunden, tiefen Beugesehne des Pferdes

    Haack, Beatrice

    1992  

    Author's details von Beatrice Haack
    Language Undetermined
    Size 78 S, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Hannover, Tierärztl. Hochsch., Diss. : 1992
    Database Special collection on veterinary medicine and general parasitology

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  7. Article ; Online: Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment.

    Haake, Markus / Haack, Beatrice / Schäfer, Tina / Harter, Patrick N / Mattavelli, Greta / Eiring, Patrick / Vashist, Neha / Wedekink, Florian / Genssler, Sabrina / Fischer, Birgitt / Dahlhoff, Julia / Mokhtari, Fatemeh / Kuzkina, Anastasia / Welters, Marij J P / Benz, Tamara M / Sorger, Lena / Thiemann, Vincent / Almanzar, Giovanni / Selle, Martina /
    Thein, Klara / Späth, Jacob / Gonzalez, Maria Cecilia / Reitinger, Carmen / Ipsen-Escobedo, Andrea / Wistuba-Hamprecht, Kilian / Eichler, Kristin / Filipski, Katharina / Zeiner, Pia S / Beschorner, Rudi / Goedemans, Renske / Gogolla, Falk Hagen / Hackl, Hubert / Rooswinkel, Rogier W / Thiem, Alexander / Roche, Paula Romer / Joshi, Hemant / Pühringer, Dirk / Wöckel, Achim / Diessner, Joachim E / Rüdiger, Manfred / Leo, Eugen / Cheng, Phil F / Levesque, Mitchell P / Goebeler, Matthias / Sauer, Markus / Nimmerjahn, Falk / Schuberth-Wagner, Christine / von Felten, Stefanie / Mittelbronn, Michel / Mehling, Matthias / Beilhack, Andreas / van der Burg, Sjoerd H / Riedel, Angela / Weide, Benjamin / Dummer, Reinhard / Wischhusen, Jörg

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4253

    Abstract: Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based ... ...

    Abstract Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don't respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models and analyses of human melanoma patients, we show that the cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion of T cells to activated endothelial cells, which is a pre-requisite of T cell extravasation. In melanoma patients, GDF-15 serum levels strongly correlate with failure of PD-1-based immune checkpoint blockade therapy. Neutralization of GDF-15 improves both T cell trafficking and therapy efficiency in murine tumor models. Thus GDF-15, beside its known role in cancer-related anorexia and cachexia, emerges as a regulator of T cell extravasation into the tumor microenvironment, which provides an even stronger rationale for therapeutic anti-GDF-15 antibody development.
    MeSH term(s) Humans ; Mice ; Animals ; T-Lymphocytes/pathology ; Lymphocyte Function-Associated Antigen-1 ; Endothelial Cells/pathology ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Melanoma/pathology ; Immunotherapy ; Tumor Microenvironment
    Chemical Substances Lymphocyte Function-Associated Antigen-1 ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39817-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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