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  1. Book: Gynäkologie und Urologie für Studium und Praxis

    Haag, Petra / Hanhart, Norbert / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Sexualmedizin, Andrologie u. Venerologie : unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den ärztlichen Prüfungen

    2016  

    Author's details P. Haag, N. Hanhart, M. Müller und Mitarbeiter
    Keywords Gynäkologie ; Urologie
    Subject Frauenheilkunde
    Language German
    Size X, 466 Seiten, Illustrationen
    Edition 8. Auflage
    Publisher Medizinische Verlags- und Informationsdienste
    Publishing place Breisach
    Publishing country Germany
    Document type Book
    Accompanying material 1 GYN-Karte
    HBZ-ID HT018891765
    ISBN 978-3-929851-77-9 ; 3-929851-77-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1125 available for loan (reading room) Lesesaal EG
    2016 MQ 9 <<[Begleitmaterial]>> order for loan Magazin
    [Nutzung nur in der ZB MED]

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Gynäkologie und Urologie für Studium und Praxis

    Haag, Petra / Hanhart, Norbert / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Sexualmedizin, Andrologie u. Venerologie ; unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den ärztlichen Prüfungen ; 2014/15

    2014  

    Author's details P. Haag ; N. Hanhart ; M. Müller
    Language German
    Size X, 464 S. : Ill., graph. Darst.
    Edition 7. Aufl.
    Publisher Med. Verl.- und Informationsdienste
    Publishing place Breisach
    Publishing country Germany
    Document type Book
    Accompanying material 1 Gyn-Taschenkarte
    HBZ-ID HT018131258
    ISBN 978-3-929851-76-2 ; 3-929851-76-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 253 available for loan (reading room) Lesesaal EG
    2017 A 1117 available for loan (reading room) Lesesaal EG
    2014 MQ 3 <<[Begleitmaterial]>> order for loan Magazin
    2014 MQ 14 <<[Begleitmaterial]>> order for loan Magazin

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Gynäkologie und Urologie für Studium und Praxis - 2005/06

    Haag, Petra / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Andrologie und Venerologie ; unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den Ärztlichen Prüfungen

    2005  

    Author's details Petra Haag ... Hrsg.: Markus Müller
    Language German
    Size XI, 434 S. : Ill., graph. Darst.
    Edition 2., Aufl.
    Publisher Medizinische Vlgs- u. Inform.-Dienste
    Publishing place Breisach am Rhein
    Publishing country Germany
    Document type Book
    Accompanying material 1 Beil.
    HBZ-ID HT014305955
    ISBN 3-929851-71-7 ; 978-3-929851-71-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 1049 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: Gynäkologie und Urologie für Studium und Praxis

    Haag, Petra / Hanhart, Norbert / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Sexualmedizin, Andrologie u. Venerologie ; unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den ärztlichen Prüfungen ; 2010/11

    2009  

    Author's details P. Haag ; N. Hanhart ; M. Müller
    Language German
    Size XI, 450 S. : Ill. ; graph Darst.
    Edition 5. Aufl.
    Publisher Med. Verl.- und Informationsdienste
    Publishing place Breisach
    Publishing country Germany
    Document type Book
    Accompanying material 1 Gyn-Karte
    HBZ-ID HT016150898
    ISBN 978-3-929851-74-8 ; 3-929851-74-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 1606 order for loan Magazin
    2010 MQ 12 <<[Begleitmaterial]>> order for loan Magazin

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book: Gynäkologie und Urologie für Studium und Praxis

    Haag, Petra / Hanhart, Norbert / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Sexualmedizin, Andrologie u. Venerologie ; unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den ärztlichen Prüfungen ; 2012/13

    2012  

    Author's details P. Haag ; N. Hanhart ; M. Müller
    Language German
    Size XI, 462 S. : Ill., graph. Darst.
    Edition 6. Aufl.
    Publisher Med. Verl.- und Informationsdienste
    Publishing place Breisach
    Publishing country Germany
    Document type Book
    Accompanying material 1 Gyn-Taschenkarte
    HBZ-ID HT017069661
    ISBN 978-3-929851-75-5 ; 3-929851-75-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 685 order for loan Magazin
    2012 MQ 9 <<[Begleitmaterial]>> order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Gynäkologie und Urologie für Studium und Praxis - 2007/08

    Haag, Petra / Hanhart, Norbert / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Sexualmedizin, Andrologie u. Venerologie ; unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den ärztlichen Prüfungen

    2006  

    Author's details Petra Haag ; Norbert Hanhart ; Markus Müller
    Keywords Gynäkologie ; Urologie
    Subject Frauenheilkunde
    Language German
    Size XI, 434 S. : Ill., graph. Darst.
    Edition 3. Aufl.
    Publisher Med. Verl.- u. Informationsdienste
    Publishing place Breisach
    Publishing country Germany
    Document type Book
    Accompanying material 1 Gyn-Karte
    HBZ-ID HT014807647
    ISBN 978-3-929851-72-4 ; 3-929851-72-5
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 4403 order for loan Magazin
    2006 MQ 38 <<[Begleitmaterial]>> order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book: Gynäkologie und Urologie - Für Studium und Praxis 2008/09

    Haag, Petra / Hanhart, Norbert / Müller, Markus

    inkl. Geburtshilfe, Reproduktionsmedizin, Sexualmedizin, Andrologie u. Venerologie ; unter Berücksichtigung des Gegenstandskataloges und der mündlichen Examina in den ärztlichen Prüfungen

    2008  

    Author's details Petra Haag ; Norbert Hanhart ; Markus Müller ; Hrsg. Markus Müller
    Language German
    Size XI, 436 S. : Ill., graph. Darst
    Edition 4. Aufl.
    Publisher Medizinische Verlags- u. Inform.-Dienste
    Publishing place Breisach am Rhein
    Publishing country Germany
    Document type Book
    Accompanying material 1 Gyn-Karte
    HBZ-ID HT015508610
    ISBN 978-3-929851-73-1 ; 3-929851-73-3
    Database Catalogue ZB MED Medicine, Health

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 MQ 102 <<[Begleitmaterial]>> order for loan Magazin
    2008 A 2790 order for loan Magazin

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book ; Thesis: Die radikale axilläre Lymphonodektomie beim Mammakarzinom

    Haag, Petra

    eine Nutzen-Risiko-Analyse

    1995  

    Author's details vorgelegt von Petra Haag
    Language German
    Size 105 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1995
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT006681855
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 MB 1791 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Analyses of single extracellular vesicles from non-small lung cancer cells to reveal effects of epidermal growth factor receptor inhibitor treatments

    Stridfeldt, Fredrik / Cavallaro, Sara / Haag, Petra / Lewensohn, Rolf / Linnros, J. / Viktorsson, Kristina / Dev, Apurba

    Talanta. 2023 July, v. 259 p.124553-

    2023  

    Abstract: Precision cancer medicine has changed the treatment landscape of non-small cell lung cancer (NSCLC) as illustrated by the introduction of tyrosine kinase inhibitors (TKIs) towards mutated epidermal growth factor receptor (EGFR). However, as responses to ... ...

    Abstract Precision cancer medicine has changed the treatment landscape of non-small cell lung cancer (NSCLC) as illustrated by the introduction of tyrosine kinase inhibitors (TKIs) towards mutated epidermal growth factor receptor (EGFR). However, as responses to EGFR-TKIs are heterogenous among NSCLC patients, there is a need for ways to early monitor changes in treatment response in a non-invasive way e.g., in patient's blood samples. Recently, extracellular vesicles (EVs) have been identified as a source of tumor biomarkers which could improve on non-invasive liquid biopsy-based diagnosis of cancer. However, the heterogeneity in EVs is high. Putative biomarker candidates may be hidden in the differential expression of membrane proteins in a subset of EVs hard to identify using bulk techniques. Using a fluorescence-based approach, we demonstrate that a single-EV technique can detect alterations in EV surface protein profiles. We analyzed EVs isolated from an EGFR-mutant NSCLC cell line, which is refractory to EGFR-TKIs erlotinib and responsive to osimertinib, before and after treatment with these drugs and after cisplatin chemotherapy. We studied expression level of five proteins; two tetraspanins (CD9, CD81), and three markers of interest in lung cancer (EGFR, programmed death-ligand 1 (PD-L1), human epidermal growth factor receptor 2 (HER2)). The data reveal alterations induced by the osimertinib treatment compared to the other two treatments. These include the growth of the PD-L1/HER2-positive EV population, with the largest increase in vesicles exclusively expressing one of the two proteins. The expression level per EV decreased for these markers. On the other hand, both the TKIs had a similar effect on the EGFR-positive EV population.
    Keywords biomarkers ; blood ; cell lines ; cisplatin ; drug therapy ; epidermal growth factor receptors ; erbB-2 receptor ; gene expression regulation ; landscapes ; liquids ; lung neoplasms ; medicine ; patients ; surface proteins ; tyrosine ; Extracellular vesicles ; Fluorescence microscopy ; Single EV analysis ; Immunostaining ; Non-small cell lung cancer ; EGFR-TKIs
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.124553
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Analyses of single extracellular vesicles from non-small lung cancer cells to reveal effects of epidermal growth factor receptor inhibitor treatments.

    Stridfeldt, Fredrik / Cavallaro, Sara / Hååg, Petra / Lewensohn, Rolf / Linnros, Jan / Viktorsson, Kristina / Dev, Apurba

    Talanta

    2023  Volume 259, Page(s) 124553

    Abstract: Precision cancer medicine has changed the treatment landscape of non-small cell lung cancer (NSCLC) as illustrated by the introduction of tyrosine kinase inhibitors (TKIs) towards mutated epidermal growth factor receptor (EGFR). However, as responses to ... ...

    Abstract Precision cancer medicine has changed the treatment landscape of non-small cell lung cancer (NSCLC) as illustrated by the introduction of tyrosine kinase inhibitors (TKIs) towards mutated epidermal growth factor receptor (EGFR). However, as responses to EGFR-TKIs are heterogenous among NSCLC patients, there is a need for ways to early monitor changes in treatment response in a non-invasive way e.g., in patient's blood samples. Recently, extracellular vesicles (EVs) have been identified as a source of tumor biomarkers which could improve on non-invasive liquid biopsy-based diagnosis of cancer. However, the heterogeneity in EVs is high. Putative biomarker candidates may be hidden in the differential expression of membrane proteins in a subset of EVs hard to identify using bulk techniques. Using a fluorescence-based approach, we demonstrate that a single-EV technique can detect alterations in EV surface protein profiles. We analyzed EVs isolated from an EGFR-mutant NSCLC cell line, which is refractory to EGFR-TKIs erlotinib and responsive to osimertinib, before and after treatment with these drugs and after cisplatin chemotherapy. We studied expression level of five proteins; two tetraspanins (CD9, CD81), and three markers of interest in lung cancer (EGFR, programmed death-ligand 1 (PD-L1), human epidermal growth factor receptor 2 (HER2)). The data reveal alterations induced by the osimertinib treatment compared to the other two treatments. These include the growth of the PD-L1/HER2-positive EV population, with the largest increase in vesicles exclusively expressing one of the two proteins. The expression level per EV decreased for these markers. On the other hand, both the TKIs had a similar effect on the EGFR-positive EV population.
    MeSH term(s) Humans ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; B7-H1 Antigen/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Mutation ; ErbB Receptors/genetics
    Chemical Substances osimertinib (3C06JJ0Z2O) ; B7-H1 Antigen ; Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.124553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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